JP6937984B2 - ペグ化ｉｌ−１１の組成物および方法 - Google Patents

ペグ化ｉｌ−１１の組成物および方法 Download PDF

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JP6937984B2
JP6937984B2 JP2017565038A JP2017565038A JP6937984B2 JP 6937984 B2 JP6937984 B2 JP 6937984B2 JP 2017565038 A JP2017565038 A JP 2017565038A JP 2017565038 A JP2017565038 A JP 2017565038A JP 6937984 B2 JP6937984 B2 JP 6937984B2
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polypeptide chain
peg
modified
induced
pharmaceutical composition
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JP2018508580A5 (enExample
JP2018508580A (ja
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ユ，クォ‐ミン
チョオ，クィ‐リム
フォック，マンソン
ラウ，ジョンソン，イゥ‐ナム
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Nansha Biologics Hong Kong Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2073—IL-11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017565038A 2015-03-03 2016-03-01 ペグ化ｉｌ−１１の組成物および方法 Active JP6937984B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021120139A JP7801104B2 (ja) 2015-03-03 2021-07-21 ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562127748P 2015-03-03 2015-03-03
US62/127,748 2015-03-03
PCT/US2016/020294 WO2016140983A1 (en) 2015-03-03 2016-03-01 Compositions and methods for pegylated il-11

Related Child Applications (1)

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JP2021120139A Division JP7801104B2 (ja) 2015-03-03 2021-07-21 ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法

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JP2018508580A JP2018508580A (ja) 2018-03-29
JP2018508580A5 JP2018508580A5 (enExample) 2019-04-11
JP6937984B2 true JP6937984B2 (ja) 2021-09-22

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JP2017565038A Active JP6937984B2 (ja) 2015-03-03 2016-03-01 ペグ化ｉｌ−１１の組成物および方法
JP2021120139A Active JP7801104B2 (ja) 2015-03-03 2021-07-21 ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法

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JP2021120139A Active JP7801104B2 (ja) 2015-03-03 2021-07-21 ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法

Country Status (7)

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US (4) US10335492B2 (enExample)
EP (1) EP3265479A4 (enExample)
JP (2) JP6937984B2 (enExample)
CN (2) CN107849108A (enExample)
HK (1) HK1246306A1 (enExample)
TW (2) TWI708611B (enExample)
WO (1) WO2016140983A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI708611B (zh) * 2015-03-03 2020-11-01 香港商南沙生物科技（香港）有限公司 聚乙二醇化介白素-１１之組合物及方法
US20240398843A1 (en) * 2021-09-28 2024-12-05 Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) Glycyrrhizin-branched polyethylene glycol conjugate for treating cancer
CN118388578B (zh) * 2024-04-01 2025-01-24 北京大学口腔医学院 一种用于聚乙二醇化蛋白质的方法、非共价聚乙二醇化蛋白及含有其的蛋白质药物和应用

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US7495087B2 (en) * 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
CN1316436A (zh) * 2000-04-06 2001-10-10 赵剑 水溶性缓释重组蛋白质的制备方法
RS20050501A (sr) * 2002-12-26 2007-08-03 Mountain View Pharmaceuticals Inc., Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora
WO2005085283A1 (ja) * 2004-03-03 2005-09-15 Yamanouchi Pharmaceutical Co., Ltd. 修飾インターロイキン−１１及びそれを含有する医薬組成物
JP2005281302A (ja) * 2004-03-03 2005-10-13 Astellas Pharma Inc 修飾インターロイキン−１１及びそれを含有する医薬組成物
KR101292740B1 (ko) * 2008-08-25 2013-08-05 주식회사 바이오폴리메드 인터루킨-11 유사체를 포함하는 생체중합체 결합체
JP2012528597A (ja) * 2009-06-03 2012-11-15 レガド・バイオサイエンシズ・インク 血小板グリコプロテインｖｉの核酸調節因子
JP5643824B2 (ja) * 2009-09-18 2014-12-17 プロセリクス メディスンズ ディベロプメント リミテッド 放出特性が改善されたｂａｂブロックポリマー
JP2013533217A (ja) * 2010-05-17 2013-08-22 セビックス・インコーポレイテッド Ｐｅｇ化ｃ−ペプチド
US9023791B2 (en) * 2010-11-19 2015-05-05 Novartis Ag Fibroblast growth factor 21 mutations
WO2013020079A2 (en) 2011-08-04 2013-02-07 Nektar Therapeutics Conjugates of an il-11 moiety and a polymer
WO2014008242A1 (en) * 2012-07-03 2014-01-09 The Trustees Of Columbia University In The City Of New York The use of interleukin-11 to protect against ischemia and reperfusion injury
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CN104073482A (zh) * 2013-12-30 2014-10-01 江苏众红生物工程创药研究院有限公司 聚乙二醇化的组织激肽释放酶及其制备方法和应用
TWI708611B (zh) * 2015-03-03 2020-11-01 香港商南沙生物科技（香港）有限公司 聚乙二醇化介白素-１１之組合物及方法

Also Published As

Publication number Publication date
HK1246306A1 (zh) 2018-09-07
US20190365908A1 (en) 2019-12-05
US10881739B2 (en) 2021-01-05
US20210268117A1 (en) 2021-09-02
TW201703793A (zh) 2017-02-01
US10946103B2 (en) 2021-03-16
JP2018508580A (ja) 2018-03-29
JP7801104B2 (ja) 2026-01-16
US20180036418A1 (en) 2018-02-08
EP3265479A1 (en) 2018-01-10
WO2016140983A1 (en) 2016-09-09
US10335492B2 (en) 2019-07-02
TW202103728A (zh) 2021-02-01
US20190365909A1 (en) 2019-12-05
CN107849108A (zh) 2018-03-27
TWI708611B (zh) 2020-11-01
US11931417B2 (en) 2024-03-19
JP2021176875A (ja) 2021-11-11
TWI849231B (zh) 2024-07-21
CN122167559A (zh) 2026-06-09
EP3265479A4 (en) 2018-11-14

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