|
US3270960A
(en)
|
1964-09-11 |
1966-09-06 |
Sperry Rand Corp |
Fluid sensor
|
|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4747825A
(en)
|
1984-06-29 |
1988-05-31 |
Ferring Laboratories, Inc. |
Apparatus and methodology for pulsed administration of growth promoting agents
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5284763A
(en)
|
1985-03-22 |
1994-02-08 |
Genentech, Inc. |
Nucleic acid encoding TGF-β and its uses
|
|
AU4434585A
(en)
|
1985-03-30 |
1986-10-23 |
Marc Ballivet |
Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4948592A
(en)
|
1986-05-09 |
1990-08-14 |
Alza Corporation |
Pulsed drug delivery
|
|
US4723958A
(en)
|
1986-05-23 |
1988-02-09 |
Merck & Co., Inc. |
Pulsatile drug delivery system
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
US5763192A
(en)
|
1986-11-20 |
1998-06-09 |
Ixsys, Incorporated |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
US4965251A
(en)
|
1987-04-03 |
1990-10-23 |
The Board Of Regents Of The University Of Washington |
Pulse treatment of hemoglobinopathies with erythropoietin
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
EP0478627A4
(en)
|
1989-05-16 |
1992-08-19 |
William D. Huse |
Co-expression of heteromeric receptors
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
ATE139258T1
(de)
|
1990-01-12 |
1996-06-15 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
EP0617706B1
(en)
|
1991-11-25 |
2001-10-17 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
ATE249840T1
(de)
|
1991-12-13 |
2003-10-15 |
Xoma Corp |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
DE69334255D1
(de)
|
1992-02-06 |
2009-02-12 |
Novartis Vaccines & Diagnostic |
Marker für Krebs und biosynthetisches Bindeprotein dafür
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
EP0640094A1
(en)
|
1992-04-24 |
1995-03-01 |
The Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
KR970000862B1
(ko)
|
1992-06-09 |
1997-01-20 |
호프 아크티엔게젤샤프트 |
래치 및 잠금장치
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US5403590A
(en)
|
1992-12-21 |
1995-04-04 |
New England Deaconess Hospital Corporation |
Method of pulsatile drug infusion
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
|
US5565352A
(en)
|
1993-11-24 |
1996-10-15 |
Arch Development Corporation |
Deubiquitinating enzyme: compositions and methods
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
EP0822830B1
(en)
|
1995-04-27 |
2008-04-02 |
Amgen Fremont Inc. |
Human anti-IL-8 antibodies, derived from immunized xenomice
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
DE69800716T2
(de)
|
1997-04-14 |
2001-09-20 |
Micromet Gesellschaft Fuer Biomedizinische Forschung Mbh |
Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
US6891082B2
(en)
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
US6365185B1
(en)
|
1998-03-26 |
2002-04-02 |
University Of Cincinnati |
Self-destructing, controlled release peroral drug delivery system
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
WO2001024812A1
(en)
|
1999-10-06 |
2001-04-12 |
N.V. Nutricia |
USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA
|
|
US7935531B2
(en)
|
2000-02-22 |
2011-05-03 |
Board Of Trustees Of The University Of Arkansas |
Methods for the early diagnosis of ovarian cancer
|
|
DK1355919T3
(da)
|
2000-12-12 |
2011-03-14 |
Medimmune Llc |
Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
|
|
US7658921B2
(en)
|
2000-12-12 |
2010-02-09 |
Medimmune, Llc |
Molecules with extended half-lives, compositions and uses thereof
|
|
US6884619B2
(en)
|
2001-07-17 |
2005-04-26 |
Yale University |
Inhibition of BEHAB cleavage and primary central nervous system (CNS) tumors
|
|
US20040014194A1
(en)
|
2002-03-27 |
2004-01-22 |
Schering Corporation |
Beta-secretase crystals and methods for preparing and using the same
|
|
WO2004016643A2
(en)
|
2002-08-16 |
2004-02-26 |
Yeda Research And Development Co. Ltd. |
Tumor associated antigen, peptides thereof, and use of same as anti-tumor vaccines
|
|
US20080206219A1
(en)
|
2003-08-08 |
2008-08-28 |
The Regencts Of The University Of California |
Novel Indications for Transforming Growth Factor-Beta Regulators
|
|
EP1674480A4
(en)
|
2003-09-04 |
2007-06-20 |
Riken |
ANTIBODY RECOGNIZING THE REGIONAL SECTION CONTROLLING TGF-BETA ACTIVATION
|
|
MXPA06011199A
(es)
*
|
2004-03-31 |
2007-04-16 |
Genentech Inc |
Anticuerpos anti-tgf-beta humanizados.
|
|
BRPI0510883B8
(pt)
*
|
2004-06-01 |
2021-05-25 |
Genentech Inc |
composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação
|
|
WO2005120566A1
(en)
|
2004-06-11 |
2005-12-22 |
Tai-Gyu Kim |
Dendrite cells transduced with recombinant adenovirus advcea which generate cea-specific cytotoxic t lymphocytes, vaccine and pharmaceutical composition comprising the same
|
|
EP1850873B1
(en)
|
2005-02-08 |
2018-11-28 |
Genzyme Corporation |
Antibodies to tgfbeta
|
|
PL1874818T3
(pl)
|
2005-04-22 |
2011-09-30 |
Lilly Co Eli |
Przeciwciała swoiste wobec TGF-beta 1
|
|
EP1748067A1
(en)
|
2005-07-29 |
2007-01-31 |
Institut Pasteur |
Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
|
|
JP2009521496A
(ja)
|
2005-12-23 |
2009-06-04 |
イーライ リリー アンド カンパニー |
ＴＧＦ−β結合組成物
|
|
EP1989224B1
(en)
|
2006-02-24 |
2010-10-20 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Immunogenic peptides and methods of use
|
|
US8871211B2
(en)
|
2006-09-28 |
2014-10-28 |
Cedars-Sinai Medical Center |
Cancer vaccines and vaccination methods
|
|
WO2008127285A2
(en)
|
2006-10-05 |
2008-10-23 |
The Board Of Trustees Of The University Of Arkansas |
Target peptides for ovarian cancer immunotherapy
|
|
US20080227704A1
(en)
*
|
2006-12-21 |
2008-09-18 |
Kamens Joanne S |
CXCL13 binding proteins
|
|
US7732401B2
(en)
|
2007-03-08 |
2010-06-08 |
Riken |
Inhibitor of TGF-β activation reaction
|
|
EP2175884B8
(en)
|
2007-07-12 |
2017-02-22 |
GITR, Inc. |
Combination therapies employing gitr binding molecules
|
|
JP5470817B2
(ja)
|
2008-03-10 |
2014-04-16 |
日産自動車株式会社 |
電池用電極およびこれを用いた電池、並びにその製造方法
|
|
EP2267125B1
(en)
|
2008-03-27 |
2015-09-02 |
Tohoku University |
Cancer cell migration and cancer cell invasion inhibitor
|
|
ES2702049T3
(es)
|
2009-04-24 |
2019-02-27 |
Univ Vanderbilt |
Inducción anti-TGF-beta de crecimiento óseo
|
|
CN102482701B
(zh)
*
|
2009-09-16 |
2015-05-13 |
免疫医疗公司 |
I类抗-cea抗体及其使用
|
|
WO2011102483A1
(ja)
|
2010-02-19 |
2011-08-25 |
独立行政法人理化学研究所 |
ヒトTGF-βのLAPに結合する抗体
|
|
EP2378119A1
(de)
|
2010-04-15 |
2011-10-19 |
Mmi Ag |
Plungerpumpe mit manueller Eingriffsmöglichkeit für Volumen unter einem Mikroliter
|
|
AR087380A1
(es)
*
|
2011-07-27 |
2014-03-19 |
Baylor Res Inst |
Vacunas de celulas dendriticas (cd) para la terapia del cancer de pancreas
|
|
WO2013043569A1
(en)
*
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
US9782452B2
(en)
*
|
2011-11-22 |
2017-10-10 |
Cornell University |
Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling
|
|
US9518112B2
(en)
|
2012-03-08 |
2016-12-13 |
Ludwig Institute For Cancer Research Ltd |
TGF-β1 specific antibodies and methods and uses thereof
|
|
BR112015008118A2
(pt)
|
2012-10-12 |
2017-12-05 |
Brigham & Womens Hospital Inc |
reforço da resposta imune
|
|
US20150284455A1
(en)
|
2012-11-06 |
2015-10-08 |
Scholar Rock, Inc. |
Compositions and methods for modulating cell signaling
|
|
JP6136279B2
(ja)
|
2013-01-15 |
2017-05-31 |
株式会社ジェイテクト |
転がり軸受装置
|
|
TWI503850B
(zh)
|
2013-03-22 |
2015-10-11 |
Polytronics Technology Corp |
過電流保護元件
|
|
AU2014262843B2
(en)
*
|
2013-05-06 |
2017-06-22 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
US9574476B2
(en)
|
2013-08-01 |
2017-02-21 |
Elwha Llc |
Systems, methods, and apparatuses related to vehicles with reduced emissions
|
|
TWI510996B
(zh)
|
2013-10-03 |
2015-12-01 |
Acer Inc |
控制觸控面板的方法以及使用該方法的可攜式電腦
|
|
GB2557389B
(en)
*
|
2015-01-14 |
2020-12-23 |
Brigham & Womens Hospital Inc |
Treatment of cancer with anti-lap monoclonal antibodies
|
|
US9816280B1
(en)
|
2016-11-02 |
2017-11-14 |
Matthew Reitnauer |
Portable floor
|