JP2018507910A - 神経芽細胞腫を治療する方法 - Google Patents
神経芽細胞腫を治療する方法 Download PDFInfo
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- JP2018507910A JP2018507910A JP2017560893A JP2017560893A JP2018507910A JP 2018507910 A JP2018507910 A JP 2018507910A JP 2017560893 A JP2017560893 A JP 2017560893A JP 2017560893 A JP2017560893 A JP 2017560893A JP 2018507910 A JP2018507910 A JP 2018507910A
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- Prior art keywords
- patient
- dfmo
- genotype
- odc1
- cancer
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562115413P | 2015-02-12 | 2015-02-12 | |
| US62/115,413 | 2015-02-12 | ||
| US201562154804P | 2015-04-30 | 2015-04-30 | |
| US62/154,804 | 2015-04-30 | ||
| PCT/US2016/017751 WO2016130918A1 (en) | 2015-02-12 | 2016-02-12 | Methods for treating neuroblastoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018507910A true JP2018507910A (ja) | 2018-03-22 |
| JP2018507910A5 JP2018507910A5 (https=) | 2019-03-22 |
Family
ID=56615061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560893A Pending JP2018507910A (ja) | 2015-02-12 | 2016-02-12 | 神経芽細胞腫を治療する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20190046484A1 (https=) |
| EP (1) | EP3256117A4 (https=) |
| JP (1) | JP2018507910A (https=) |
| CA (1) | CA2976106A1 (https=) |
| HK (1) | HK1248133A1 (https=) |
| WO (1) | WO2016130918A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022505849A (ja) * | 2018-10-24 | 2022-01-14 | ナビター ファーマシューティカルズ, インコーポレイテッド | 多形化合物およびその使用 |
| JP2022532766A (ja) * | 2019-05-17 | 2022-07-19 | キャンサー プリベンション ファーマシューティカルズ,インコーポレイテッド | 家族性腺腫性ポリポーシスを処置するための方法 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2889711A1 (en) | 2012-10-29 | 2014-05-08 | Arizona Board Of Regents On Behalf Of University Of Arizona | Predictive markers for polyamine inhibitor cancer therapies |
| WO2015195120A1 (en) | 2014-06-18 | 2015-12-23 | Arizona Board Of Regents On Behalf Of University Of Arizona | Carcinoma diagnosis and treatment based on odc1 genotype |
| WO2016130918A1 (en) | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| KR20260033630A (ko) | 2015-10-30 | 2026-03-10 | 캔서 프리벤션 파마수티컬스, 인코포레이티드 | 에플로르니틴 및 설린닥, 고정된 용량 조합 제제 |
| US12042477B2 (en) | 2016-02-23 | 2024-07-23 | Cancer Research Technology Limited | Dietary product devoid of at least two non essential amino acids |
| JP7262118B2 (ja) * | 2016-10-06 | 2023-04-21 | オーバス セラピューティクス インコーポレイテッド | 医薬組成物およびその使用 |
| US12220402B2 (en) | 2020-06-03 | 2025-02-11 | Faeth Therapeutics, Inc. | Formulations for personalized methods of treatment |
| WO2021247923A1 (en) | 2020-06-04 | 2021-12-09 | Faeth Therapeutics, Inc. | Personalized methods of treating cancer |
| CN120548176A (zh) | 2022-11-20 | 2025-08-26 | 苏黎士大学 | 多胺途径抑制剂药物与脯氨酸/精氨酸饮食限制的组合 |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
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| JP2002526468A (ja) * | 1998-09-23 | 2002-08-20 | ロンザ アーゲー | (−)−α−ジフルオロメチルオルニチン・モノハイドロクロライド・一水和物の製造方法 |
| JP2005501881A (ja) * | 2001-08-29 | 2005-01-20 | ウィメン・ファースト・ヘルスケアー・インコーポレーテッド | α−ジフルオロメチルオルニチン(DFMO)の製造方法 |
| JP2007537719A (ja) * | 2004-01-22 | 2007-12-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 補体結合が低下した抗癌抗体 |
| JP2010505909A (ja) * | 2006-10-10 | 2010-02-25 | ユニベルシテ ドゥ ナント | 癌を治療するための、o−アセチル化型のgd2ガングリオシドに特異的なモノクローナル抗体の使用 |
| JP2012526852A (ja) * | 2009-05-14 | 2012-11-01 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | Odc1の遺伝子型に基づく癌腫診断及び治療 |
| WO2014144763A2 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan Kettering Cancer Center | High affinity anti-gd2 antibodies |
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| US4330559A (en) | 1977-07-11 | 1982-05-18 | Merrell-Toraude Et Cie | Method of treating benign prostatic hypertrophy |
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-
2016
- 2016-02-12 WO PCT/US2016/017751 patent/WO2016130918A1/en not_active Ceased
- 2016-02-12 CA CA2976106A patent/CA2976106A1/en not_active Abandoned
- 2016-02-12 EP EP16749956.5A patent/EP3256117A4/en not_active Withdrawn
- 2016-02-12 JP JP2017560893A patent/JP2018507910A/ja active Pending
- 2016-02-12 HK HK18107762.1A patent/HK1248133A1/zh unknown
- 2016-02-12 US US15/550,595 patent/US20190046484A1/en not_active Abandoned
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2021
- 2021-01-13 US US17/147,697 patent/US20210378999A1/en not_active Abandoned
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2023
- 2023-08-04 US US18/230,601 patent/US20240165063A1/en not_active Abandoned
-
2024
- 2024-12-23 US US18/999,227 patent/US12582625B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002526468A (ja) * | 1998-09-23 | 2002-08-20 | ロンザ アーゲー | (−)−α−ジフルオロメチルオルニチン・モノハイドロクロライド・一水和物の製造方法 |
| JP2005501881A (ja) * | 2001-08-29 | 2005-01-20 | ウィメン・ファースト・ヘルスケアー・インコーポレーテッド | α−ジフルオロメチルオルニチン(DFMO)の製造方法 |
| JP2007537719A (ja) * | 2004-01-22 | 2007-12-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 補体結合が低下した抗癌抗体 |
| JP2010505909A (ja) * | 2006-10-10 | 2010-02-25 | ユニベルシテ ドゥ ナント | 癌を治療するための、o−アセチル化型のgd2ガングリオシドに特異的なモノクローナル抗体の使用 |
| JP2012526852A (ja) * | 2009-05-14 | 2012-11-01 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | Odc1の遺伝子型に基づく癌腫診断及び治療 |
| WO2014144763A2 (en) * | 2013-03-15 | 2014-09-18 | Memorial Sloan Kettering Cancer Center | High affinity anti-gd2 antibodies |
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| JP2022505849A (ja) * | 2018-10-24 | 2022-01-14 | ナビター ファーマシューティカルズ, インコーポレイテッド | 多形化合物およびその使用 |
| JP2025000975A (ja) * | 2018-10-24 | 2025-01-07 | ナビター ファーマシューティカルズ, インコーポレイテッド | 多形化合物およびその使用 |
| JP7644002B2 (ja) | 2018-10-24 | 2025-03-11 | ナビター ファーマシューティカルズ, インコーポレイテッド | 多形化合物およびその使用 |
| JP2022532766A (ja) * | 2019-05-17 | 2022-07-19 | キャンサー プリベンション ファーマシューティカルズ,インコーポレイテッド | 家族性腺腫性ポリポーシスを処置するための方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3256117A4 (en) | 2018-10-10 |
| US20190046484A1 (en) | 2019-02-14 |
| US12582625B2 (en) | 2026-03-24 |
| CA2976106A1 (en) | 2016-08-18 |
| WO2016130918A1 (en) | 2016-08-18 |
| US20250127742A1 (en) | 2025-04-24 |
| US20240165063A1 (en) | 2024-05-23 |
| US20210378999A1 (en) | 2021-12-09 |
| HK1248133A1 (zh) | 2018-10-12 |
| EP3256117A1 (en) | 2017-12-20 |
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