JP2018507910A5 - - Google Patents
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- Publication number
- JP2018507910A5 JP2018507910A5 JP2017560893A JP2017560893A JP2018507910A5 JP 2018507910 A5 JP2018507910 A5 JP 2018507910A5 JP 2017560893 A JP2017560893 A JP 2017560893A JP 2017560893 A JP2017560893 A JP 2017560893A JP 2018507910 A5 JP2018507910 A5 JP 2018507910A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- odc1
- genotype
- pharmacotherapy
- drug therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000585693 Homo sapiens Mitochondrial 2-oxodicarboxylate carrier Proteins 0.000 claims 14
- 101001041245 Homo sapiens Ornithine decarboxylase Proteins 0.000 claims 14
- 102100021079 Ornithine decarboxylase Human genes 0.000 claims 14
- 238000002651 drug therapy Methods 0.000 claims 12
- 238000001050 pharmacotherapy Methods 0.000 claims 12
- 108700028369 Alleles Proteins 0.000 claims 10
- 238000012360 testing method Methods 0.000 claims 8
- 102000052812 Ornithine decarboxylases Human genes 0.000 claims 7
- 108700005126 Ornithine decarboxylases Proteins 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical compound NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 102000004031 Carboxy-Lyases Human genes 0.000 claims 1
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 206010053552 allodynia Diseases 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 229960000590 celecoxib Drugs 0.000 claims 1
- FJPAMFNRCFEGSD-UHFFFAOYSA-N eflornithine hydrochloride monohydrate Chemical compound O.Cl.NCCCC(N)(C(F)F)C(O)=O FJPAMFNRCFEGSD-UHFFFAOYSA-N 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims 1
- 229960000894 sulindac Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- VLCYCQAOQCDTCN-ZCFIWIBFSA-N α-difluoromethylornithine Chemical compound NCCC[C@@](N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-ZCFIWIBFSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562115413P | 2015-02-12 | 2015-02-12 | |
| US62/115,413 | 2015-02-12 | ||
| US201562154804P | 2015-04-30 | 2015-04-30 | |
| US62/154,804 | 2015-04-30 | ||
| PCT/US2016/017751 WO2016130918A1 (en) | 2015-02-12 | 2016-02-12 | Methods for treating neuroblastoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018507910A JP2018507910A (ja) | 2018-03-22 |
| JP2018507910A5 true JP2018507910A5 (https=) | 2019-03-22 |
Family
ID=56615061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560893A Pending JP2018507910A (ja) | 2015-02-12 | 2016-02-12 | 神経芽細胞腫を治療する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20190046484A1 (https=) |
| EP (1) | EP3256117A4 (https=) |
| JP (1) | JP2018507910A (https=) |
| CA (1) | CA2976106A1 (https=) |
| HK (1) | HK1248133A1 (https=) |
| WO (1) | WO2016130918A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2889711A1 (en) | 2012-10-29 | 2014-05-08 | Arizona Board Of Regents On Behalf Of University Of Arizona | Predictive markers for polyamine inhibitor cancer therapies |
| WO2015195120A1 (en) | 2014-06-18 | 2015-12-23 | Arizona Board Of Regents On Behalf Of University Of Arizona | Carcinoma diagnosis and treatment based on odc1 genotype |
| WO2016130918A1 (en) | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| KR20260033630A (ko) | 2015-10-30 | 2026-03-10 | 캔서 프리벤션 파마수티컬스, 인코포레이티드 | 에플로르니틴 및 설린닥, 고정된 용량 조합 제제 |
| US12042477B2 (en) | 2016-02-23 | 2024-07-23 | Cancer Research Technology Limited | Dietary product devoid of at least two non essential amino acids |
| JP7262118B2 (ja) * | 2016-10-06 | 2023-04-21 | オーバス セラピューティクス インコーポレイテッド | 医薬組成物およびその使用 |
| CN113164414A (zh) * | 2018-10-24 | 2021-07-23 | 纳维托制药有限公司 | 多晶型化合物和其用途 |
| JP2022532766A (ja) * | 2019-05-17 | 2022-07-19 | キャンサー プリベンション ファーマシューティカルズ，インコーポレイテッド | 家族性腺腫性ポリポーシスを処置するための方法 |
| US12220402B2 (en) | 2020-06-03 | 2025-02-11 | Faeth Therapeutics, Inc. | Formulations for personalized methods of treatment |
| WO2021247923A1 (en) | 2020-06-04 | 2021-12-09 | Faeth Therapeutics, Inc. | Personalized methods of treating cancer |
| CN120548176A (zh) | 2022-11-20 | 2025-08-26 | 苏黎士大学 | 多胺途径抑制剂药物与脯氨酸/精氨酸饮食限制的组合 |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309442A (en) | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
| US4413141A (en) | 1977-07-11 | 1983-11-01 | Merrell Toraude Et Compagnie | 2-(Difluoromethyl)-2,5-diaminopentanoic acid |
| US4330559A (en) | 1977-07-11 | 1982-05-18 | Merrell-Toraude Et Cie | Method of treating benign prostatic hypertrophy |
| US4499072A (en) | 1982-11-29 | 1985-02-12 | Merrell Dow Pharmaceuticals Inc. | Process for treating diseases with ODC inhibitors |
| US4859452A (en) | 1986-01-17 | 1989-08-22 | Board Of Regents, The University Of Texas System | Methods for the reduction of difluoromethylornithine associated toxicity |
| US4925835A (en) | 1986-05-01 | 1990-05-15 | Sloan-Kettering Institute For Cancer Research | Aziridinyl putrescine containing compositions and their uses in treating prostate cancer |
| US5002879A (en) | 1986-05-06 | 1991-03-26 | Merrell Dow Pharmaceuticals | Treatment of tumors with autologous LAK cells, interleukin-2 and an ornithine decarboxylase inhibitor |
| FR2706255B1 (fr) | 1993-06-17 | 1995-10-27 | Univ Rennes | Composition à usage alimentaire et/ou pharmaceutique pauvre en polyamines et applications thérapeutiques. |
| US5843929A (en) | 1996-03-22 | 1998-12-01 | Mayo Foundation For Medical Education And Research | Chemoprevention of metachronous adenomatous colorectal polyps |
| AU5200098A (en) | 1996-11-01 | 1998-05-29 | Ilex Oncology, Inc. | Sustained release formulation containing dfmo |
| WO1998025603A1 (en) | 1996-12-13 | 1998-06-18 | Ilex Oncology, Inc. | Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer |
| CA2325080A1 (en) | 1998-03-28 | 1999-10-07 | The Regents Of The University Of California | Dfmo and sulindac combination in cancer chemoprevention |
| US7700568B2 (en) | 1998-06-30 | 2010-04-20 | Sloan-Kettering Institute For Cancer Research | Uses of DNA-PK |
| KR20010079913A (ko) * | 1998-09-23 | 2001-08-22 | 토마스 케플러, 자비네 루츠 | (-)-α-(디플루오로메틸)오르니틴-모노히드로클로라이드일수화물의 제조 방법 |
| US6753422B2 (en) * | 1999-03-01 | 2004-06-22 | O'brien Thomas G. | Odc allelic analysis method for assessing carcinogenic susceptibility |
| CA2373931A1 (en) | 1999-05-17 | 2000-11-23 | Richard Love | Dfmo and celecoxib in combination for cancer chemoprevention and therapy |
| WO2001068076A2 (en) | 2000-03-07 | 2001-09-20 | Ilex Oncology, Inc. | D-enantiomer of dfmo and methods of use thereof for treating cancer |
| US6602910B2 (en) | 2000-03-07 | 2003-08-05 | Ilex Oncology, Inc. | D-enantiomer of DFMO and methods of use therefor |
| AU2001285232A1 (en) | 2000-08-24 | 2002-03-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Alpha-difluoromethylornithine (dfmo) use in the human prostate |
| US6730809B2 (en) * | 2001-08-29 | 2004-05-04 | Women First Healthcare, Inc. | Processes for the production of α-difluoromethyl ornithine (DFMO) |
| US7030126B2 (en) | 2001-11-16 | 2006-04-18 | Als Therapy Development Foundation, Inc. | Use of polyamine analogs for amyotrophic lateral sclerosis |
| MXPA05005781A (es) | 2002-11-29 | 2005-12-12 | Forest Laboratories | Combinacion de ibuprofeno y oxicodona para alivio de dolor agudo. |
| PL1706428T3 (pl) * | 2004-01-22 | 2010-02-26 | Merck Patent Gmbh | Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza |
| US20100009929A1 (en) * | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| WO2007075673A1 (en) * | 2005-12-20 | 2007-07-05 | University Of Hawaii | Treatment regimen for n-myc, c-myc, and l-myc amplified and overexpressed tumors |
| ES2380747T3 (es) | 2006-07-18 | 2012-05-18 | Horizon Pharma Usa, Inc. | Métodos y medicamentos para administración de ibuprofeno |
| FR2906808B1 (fr) * | 2006-10-10 | 2012-10-05 | Univ Nantes | Utilisation d'anticorps monoclonaux specifiques de la forme o-acetylee du ganglioside gd2 dans le traitement de certains cancers |
| SG183010A1 (en) * | 2007-08-01 | 2012-08-30 | Sigma Tau Ind Farmaceuti | Treatment of pediatric tumors |
| US8283331B2 (en) | 2007-10-09 | 2012-10-09 | Children's Medical Center Corporation | Methods to regulate miRNA processing by targeting Lin-28 |
| US20100120727A1 (en) | 2008-11-12 | 2010-05-13 | Kyphia Pharmaceuticals, Inc. | Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof |
| AU2009333510A1 (en) | 2008-12-08 | 2011-06-30 | The Procter & Gamble Company | Personal care composition in the form of an article having a hydrophobic surface-resident coating |
| DK2430452T3 (da) * | 2009-05-14 | 2014-10-06 | Univ Arizona State | Carcinom-diagnose og behandlinger, baseret på odc1-genotype |
| CN102802729A (zh) * | 2009-05-20 | 2012-11-28 | 兰贝克赛实验室有限公司 | 异维a酸的液体剂型 |
| US20110256161A1 (en) * | 2010-04-19 | 2011-10-20 | Aminex Therapeutics Inc. | Methods for enhancing immune response |
| CA2800557A1 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
| CA2799431A1 (en) | 2010-05-14 | 2011-11-17 | Cancer Prevention Pharmaceuticals, Inc. | Cancer prevention and treatment methods based on dietary polyamine content |
| DK3323830T3 (da) * | 2010-06-19 | 2023-09-25 | Memorial Sloan Kettering Cancer Center | Anti-gd2 antibodies |
| CA2889711A1 (en) * | 2012-10-29 | 2014-05-08 | Arizona Board Of Regents On Behalf Of University Of Arizona | Predictive markers for polyamine inhibitor cancer therapies |
| GB2513299A (en) * | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
| CN105705165B (zh) | 2013-03-15 | 2020-04-24 | 纪念斯隆-凯特琳癌症中心 | 高亲和力抗gd2抗体 |
| WO2015195120A1 (en) * | 2014-06-18 | 2015-12-23 | Arizona Board Of Regents On Behalf Of University Of Arizona | Carcinoma diagnosis and treatment based on odc1 genotype |
| WO2016130918A1 (en) | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
| WO2017075576A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
-
2016
- 2016-02-12 WO PCT/US2016/017751 patent/WO2016130918A1/en not_active Ceased
- 2016-02-12 CA CA2976106A patent/CA2976106A1/en not_active Abandoned
- 2016-02-12 EP EP16749956.5A patent/EP3256117A4/en not_active Withdrawn
- 2016-02-12 JP JP2017560893A patent/JP2018507910A/ja active Pending
- 2016-02-12 HK HK18107762.1A patent/HK1248133A1/zh unknown
- 2016-02-12 US US15/550,595 patent/US20190046484A1/en not_active Abandoned
-
2021
- 2021-01-13 US US17/147,697 patent/US20210378999A1/en not_active Abandoned
-
2023
- 2023-08-04 US US18/230,601 patent/US20240165063A1/en not_active Abandoned
-
2024
- 2024-12-23 US US18/999,227 patent/US12582625B2/en active Active
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