JP2018506966A5 - - Google Patents
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- JP2018506966A5 JP2018506966A5 JP2017536549A JP2017536549A JP2018506966A5 JP 2018506966 A5 JP2018506966 A5 JP 2018506966A5 JP 2017536549 A JP2017536549 A JP 2017536549A JP 2017536549 A JP2017536549 A JP 2017536549A JP 2018506966 A5 JP2018506966 A5 JP 2018506966A5
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- Prior art keywords
- amino acid
- ebov
- acid sequence
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 130
- 241001115402 Ebolavirus Species 0.000 claims description 96
- 239000000427 antigen Substances 0.000 claims description 74
- 108091007433 antigens Proteins 0.000 claims description 74
- 102000036639 antigens Human genes 0.000 claims description 74
- 239000012634 fragment Substances 0.000 claims description 74
- 239000008194 pharmaceutical composition Substances 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 230000008685 targeting Effects 0.000 claims description 12
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 230000005593 dissociations Effects 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 8
- AMFDITJFBUXZQN-KUBHLMPHSA-N (2s,3s,4r,5r)-2-(4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol Chemical compound C=1NC=2C(N)=NC=NC=2C=1[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O AMFDITJFBUXZQN-KUBHLMPHSA-N 0.000 claims description 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 102000014150 Interferons Human genes 0.000 claims description 6
- 108010050904 Interferons Proteins 0.000 claims description 6
- 108020000999 Viral RNA Proteins 0.000 claims description 6
- WXJFKKQWPMNTIM-VWLOTQADSA-N [(2s)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid Chemical compound CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](CO)CN1C=CC(N)=NC1=O WXJFKKQWPMNTIM-VWLOTQADSA-N 0.000 claims description 6
- 230000000692 anti-sense effect Effects 0.000 claims description 6
- 239000003443 antiviral agent Substances 0.000 claims description 6
- 239000003246 corticosteroid Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims description 6
- 229940079322 interferon Drugs 0.000 claims description 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 4
- 108700012234 Ebola virus VP24 Proteins 0.000 claims description 4
- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 241001115400 Zaire ebolavirus Species 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 230000003013 cytotoxicity Effects 0.000 claims description 4
- 231100000135 cytotoxicity Toxicity 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 238000006386 neutralization reaction Methods 0.000 claims description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 230000002458 infectious effect Effects 0.000 claims description 3
- 208000004998 Abdominal Pain Diseases 0.000 claims description 2
- 208000005156 Dehydration Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010019233 Headaches Diseases 0.000 claims description 2
- 208000032843 Hemorrhage Diseases 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000000112 Myalgia Diseases 0.000 claims description 2
- 206010037660 Pyrexia Diseases 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 101150010086 VP24 gene Proteins 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 206010047700 Vomiting Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 230000000740 bleeding effect Effects 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229960001334 corticosteroids Drugs 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 206010016256 fatigue Diseases 0.000 claims description 2
- 229950008454 favipiravir Drugs 0.000 claims description 2
- 231100000869 headache Toxicity 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 239000004055 small Interfering RNA Substances 0.000 claims description 2
- 238000011277 treatment modality Methods 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000008673 vomiting Effects 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000007501 viral attachment Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020081768A JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562107581P | 2015-01-26 | 2015-01-26 | |
| US62/107,581 | 2015-01-26 | ||
| US201562161356P | 2015-05-14 | 2015-05-14 | |
| US62/161,356 | 2015-05-14 | ||
| US201562245703P | 2015-10-23 | 2015-10-23 | |
| US62/245,703 | 2015-10-23 | ||
| PCT/US2016/014720 WO2016123019A1 (en) | 2015-01-26 | 2016-01-25 | Human antibodies to ebola virus glycoprotein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081768A Division JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506966A JP2018506966A (ja) | 2018-03-15 |
| JP2018506966A5 true JP2018506966A5 (cg-RX-API-DMAC7.html) | 2019-02-28 |
| JP6829199B2 JP6829199B2 (ja) | 2021-02-10 |
Family
ID=55300806
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536549A Active JP6829199B2 (ja) | 2015-01-26 | 2016-01-25 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2020081768A Active JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2023034449A Pending JP2023065648A (ja) | 2015-01-26 | 2023-03-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2025019929A Pending JP2025065427A (ja) | 2015-01-26 | 2025-02-10 | エボラウイルス糖タンパク質に対するヒト抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081768A Active JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2023034449A Pending JP2023065648A (ja) | 2015-01-26 | 2023-03-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2025019929A Pending JP2025065427A (ja) | 2015-01-26 | 2025-02-10 | エボラウイルス糖タンパク質に対するヒト抗体 |
Country Status (22)
Families Citing this family (83)
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