JP2019534003A5 - - Google Patents
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- JP2019534003A5 JP2019534003A5 JP2019521455A JP2019521455A JP2019534003A5 JP 2019534003 A5 JP2019534003 A5 JP 2019534003A5 JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019534003 A5 JP2019534003 A5 JP 2019534003A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- adi
- nos
- antigen
- rsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 208000015181 infectious disease Diseases 0.000 claims description 25
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 241000342334 Human metapneumovirus Species 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 15
- 241000351643 Metapneumovirus Species 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims description 9
- 229960005486 vaccine Drugs 0.000 claims description 6
- 230000001629 suppression Effects 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- -1 anti-RSV-G antibody Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 2
- 229960000402 palivizumab Drugs 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066241A JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662411510P | 2016-10-21 | 2016-10-21 | |
| US62/411,510 | 2016-10-21 | ||
| PCT/US2017/057708 WO2018075954A2 (en) | 2016-10-21 | 2017-10-20 | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066241A Division JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534003A JP2019534003A (ja) | 2019-11-28 |
| JP2019534003A5 true JP2019534003A5 (cg-RX-API-DMAC7.html) | 2020-11-26 |
| JP7265984B2 JP7265984B2 (ja) | 2023-04-27 |
Family
ID=60263072
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521455A Active JP7265984B2 (ja) | 2016-10-21 | 2017-10-20 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2022066241A Withdrawn JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A Withdrawn JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A Active JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066241A Withdrawn JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A Withdrawn JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A Active JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US11479600B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3529272A2 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7265984B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018075954A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11485775B2 (en) | 2016-10-21 | 2022-11-01 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3529272A2 (en) | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3528840A1 (en) | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| CN112300279A (zh) * | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| CN119836435A (zh) * | 2022-07-27 | 2025-04-15 | 胡默波斯生物医学公司 | 抗rsv和mpv副粘病毒的广泛中和抗体 |
| CN118108812B (zh) * | 2023-05-04 | 2025-04-15 | 国药中生生物技术研究院有限公司 | Rsv f蛋白的突变体 |
| WO2024259075A1 (en) * | 2023-06-14 | 2024-12-19 | Tether Therapeutics, Inc. | Polymer formulations for delivery of polynucleotides |
| WO2025104604A1 (en) * | 2023-11-14 | 2025-05-22 | Janssen Pharmaceuticals, Inc. | Anti-respiratory syncytial virus antibodies and uses thereof |
Family Cites Families (45)
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| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| ATE231002T1 (de) | 1992-09-16 | 2003-02-15 | Scripps Research Inst | Menschliche, neutralisierende, monoklonale antikörper gegen das respiratorische synzytialvirus |
| NZ269735A (en) | 1993-07-30 | 1998-01-26 | Oravax Inc | Monoclonal iga antibody against respiratory syncytial virus (rsv) |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| CA2230127A1 (en) | 1995-09-18 | 1997-03-27 | Intracel Corporation | Neutralizing monoclonal antibodies to respiratory syncytial virus |
| US20020141990A1 (en) | 1996-11-01 | 2002-10-03 | Smithkline Beecham Corporation | Anti-RSV human monoclonal antibodies |
| DE60025019T2 (de) | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| US7229619B1 (en) | 2000-11-28 | 2007-06-12 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| ES2349348T3 (es) | 2000-01-27 | 2010-12-30 | Medimmune, Llc | Anticuerpos neutralizantes de rsv de ultra alta afinidad. |
| AU2001240020B9 (en) | 2000-03-01 | 2008-12-04 | Medimmune, Llc | High potency recombinant antibodies and method for producing them |
| AU2001241918A1 (en) | 2000-03-02 | 2001-09-12 | Med Immune, Inc. | Methods of enhancing activity of vaccines and vaccine compositions |
| ES2338098T3 (es) | 2000-05-03 | 2010-05-04 | Medimmune, Llc | Terapia de combinacion de enfermedades respiratorias usando anticuerpos y agentes antiinflamatorios. |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US6818216B2 (en) | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
| US7179900B2 (en) | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| US7691603B2 (en) | 2003-04-09 | 2010-04-06 | Novo Nordisk A/S | Intracellular formation of peptide conjugates |
| WO2004091519A2 (en) | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Methods of preventing or treating respiratory conditions |
| US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| JP2008513540A (ja) | 2004-09-21 | 2008-05-01 | メディミューン，インコーポレーテッド | 呼吸器合胞体ウイルスに対する抗体及び該ウイルス用のワクチンを製造する方法 |
| US20090030187A1 (en) | 2005-03-14 | 2009-01-29 | Tous Guillermo I | Macromolecules comprising a thioether cross-link |
| HRP20130163T1 (hr) | 2006-09-07 | 2013-03-31 | Crucell Holland B.V. | Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba |
| WO2008106980A2 (en) | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| WO2009030237A2 (en) | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
| CA2704134A1 (en) | 2007-09-24 | 2009-04-02 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
| KR100938998B1 (ko) | 2008-01-08 | 2010-01-28 | (주) 에이프로젠 | 호흡기 신시티움 바이러스에 대한 항체 |
| JP5575377B2 (ja) | 2008-07-18 | 2014-08-20 | シスメックス株式会社 | 抗ｒｓウイルスモノクローナル抗体を用いたｒｓウイルス検出用キット及びイムノクロマトグラフィー用試験具、並びに新規な抗ｒｓウイルスモノクローナル抗体 |
| ES2701649T3 (es) | 2009-01-14 | 2019-02-25 | Ablynx Nv | Administración pulmonar de dominios variables individuales de inmunoglobulina y constructos de los mismos |
| PT2438087T (pt) | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| WO2011050168A2 (en) | 2009-10-21 | 2011-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Rsv immunogens, antibodies and compositions thereof |
| JP6450688B2 (ja) * | 2013-02-01 | 2019-01-09 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスｆタンパク質エピトープ |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| US10156574B2 (en) | 2013-04-29 | 2018-12-18 | Adimab, Llc | Polyspecificity reagents, methods for their preparation and use |
| MX374517B (es) | 2014-01-15 | 2025-03-06 | Medimmune Ltd | Anticuerpos especificos del virus respiratorio sincitial (vrs) y partes funcionales de los mismos. |
| AU2015340056A1 (en) * | 2014-10-27 | 2017-05-25 | Agency For Science, Technology And Research | Anti-TIM-3 antibodies |
| US11485775B2 (en) | 2016-10-21 | 2022-11-01 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3529272A2 (en) | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3528840A1 (en) | 2016-10-21 | 2019-08-28 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
-
2017
- 2017-10-20 EP EP17794544.1A patent/EP3529272A2/en active Pending
- 2017-10-20 WO PCT/US2017/057708 patent/WO2018075954A2/en not_active Ceased
- 2017-10-20 US US16/343,273 patent/US11479600B2/en active Active
- 2017-10-20 JP JP2019521455A patent/JP7265984B2/ja active Active
-
2022
- 2022-04-13 JP JP2022066241A patent/JP2022087247A/ja not_active Withdrawn
- 2022-09-13 US US17/931,629 patent/US12215141B2/en active Active
-
2023
- 2023-09-08 JP JP2023146397A patent/JP2023158193A/ja not_active Withdrawn
- 2023-09-08 JP JP2023146398A patent/JP7616813B2/ja active Active
-
2025
- 2025-01-09 US US19/014,419 patent/US20250313612A1/en active Pending