JP2018505196A5 - - Google Patents
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- Publication number
- JP2018505196A5 JP2018505196A5 JP2017542001A JP2017542001A JP2018505196A5 JP 2018505196 A5 JP2018505196 A5 JP 2018505196A5 JP 2017542001 A JP2017542001 A JP 2017542001A JP 2017542001 A JP2017542001 A JP 2017542001A JP 2018505196 A5 JP2018505196 A5 JP 2018505196A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- alkyl
- acyl
- aryl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C(CC1)C(*)(*)C2=O)(C=C2C#N)C2=C1N(*)C(*)N2* Chemical compound CC(C(CC1)C(*)(*)C2=O)(C=C2C#N)C2=C1N(*)C(*)N2* 0.000 description 2
- CQCQJTLAFJFRRY-LCMPSIMXSA-N C[C@@H]([C@@H]([C@]1(C)C=C2C#N)C=Cc3c1nc(-c1ccccc1)[nH]3)C2=O Chemical compound C[C@@H]([C@@H]([C@]1(C)C=C2C#N)C=Cc3c1nc(-c1ccccc1)[nH]3)C2=O CQCQJTLAFJFRRY-LCMPSIMXSA-N 0.000 description 1
- WPSDBDOIRYODBP-CAASOKRLSA-N C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N(C)C3)=C1N3c(cc1)ccc1-c1ccccc1)C2=O Chemical compound C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N(C)C3)=C1N3c(cc1)ccc1-c1ccccc1)C2=O WPSDBDOIRYODBP-CAASOKRLSA-N 0.000 description 1
- LWJLVUSSTVDXDT-AKUOWQNMSA-N C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N=C(C3)c4ccccc4)=C1N3c1cccc(CCCOC(C)=O)c1)C2=O Chemical compound C[C@@H]([C@H](CC1)[C@](C)(C=C2C#N)C(N=C(C3)c4ccccc4)=C1N3c1cccc(CCCOC(C)=O)c1)C2=O LWJLVUSSTVDXDT-AKUOWQNMSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562115247P | 2015-02-12 | 2015-02-12 | |
| US62/115,247 | 2015-02-12 | ||
| PCT/US2016/017769 WO2016130927A1 (en) | 2015-02-12 | 2016-02-12 | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018505196A JP2018505196A (ja) | 2018-02-22 |
| JP2018505196A5 true JP2018505196A5 (enExample) | 2019-03-22 |
| JP6748652B2 JP6748652B2 (ja) | 2020-09-02 |
Family
ID=55442884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542001A Active JP6748652B2 (ja) | 2015-02-12 | 2016-02-12 | 抗酸化性炎症調節剤としてのイミダゾリル三環式エノン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11059792B2 (enExample) |
| EP (1) | EP3256451B1 (enExample) |
| JP (1) | JP6748652B2 (enExample) |
| KR (2) | KR20240035818A (enExample) |
| CN (1) | CN107428698B (enExample) |
| AU (1) | AU2016219109B2 (enExample) |
| CA (1) | CA2974726C (enExample) |
| EA (1) | EA038328B1 (enExample) |
| IL (1) | IL253923B (enExample) |
| MX (1) | MX370586B (enExample) |
| NZ (1) | NZ734292A (enExample) |
| WO (1) | WO2016130927A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| AR096046A1 (es) | 2013-04-24 | 2015-12-02 | Abbvie Inc | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| US11993574B2 (en) * | 2018-06-15 | 2024-05-28 | Reata Pharmaceuticals, Inc | Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| WO2002047611A2 (en) | 2000-11-28 | 2002-06-20 | Board Of Regents, The University Of Texas System | Cddo-compounds and combination therapies thereof |
| US7435755B2 (en) | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| JP2006515859A (ja) | 2002-05-13 | 2006-06-08 | トラスティーズ オブ ダートマス カレッジ | 阻害剤およびその使用法 |
| WO2006089406A1 (en) | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| US8299046B2 (en) | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| EP2094651A1 (en) | 2006-11-17 | 2009-09-02 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| WO2008136838A1 (en) | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| WO2009023845A2 (en) | 2007-08-15 | 2009-02-19 | The Board Of Regents Of The University Of Texas System | Combination therapy with synthetic triterpenoids and gemcitabine |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| BRPI0907423A2 (pt) * | 2008-01-11 | 2020-10-27 | Reata Pharmaceuticals, Inc. | composto triterpenoide sintético para uso em um método de melhoria da função renal em um indivíduo, e uso do referido composto |
| WO2009146218A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| MX2010011439A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17. |
| KR101713140B1 (ko) * | 2008-04-18 | 2017-03-08 | 리타 파마슈티컬스 잉크. | Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체 |
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| US8071632B2 (en) | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| EP2309860B1 (en) | 2008-07-22 | 2014-01-08 | Trustees of Dartmouth College | Monocyclic cyanoenones and methods of use thereof |
| WO2010053817A1 (en) | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| SI2395979T1 (sl) | 2009-02-13 | 2017-12-29 | Reata Pharmaceuticals, Inc. | Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem |
| DK2558105T3 (da) | 2010-04-12 | 2020-01-27 | Reata Pharmaceuticals Inc | Bardoxolonmethyl til behandling af fedme |
| CN103596929B (zh) | 2010-12-17 | 2016-10-19 | 里亚塔医药公司 | 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮 |
| MX348862B (es) | 2011-03-11 | 2017-07-03 | Reata Pharmaceuticals Inc | Derivados c4-monometil triterpenoides y sus metodos de uso. |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| SMT201700501T1 (it) | 2012-09-10 | 2017-11-15 | Reata Pharmaceuticals Inc | Derivati c17-eteroarilici dell'acido oleanolico e metodi d'uso degli stessi |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| EP4736949A2 (en) | 2013-08-23 | 2026-05-06 | Reata Pharmaceuticals Holdings, LLC | Methods of treating and preventing endothelial dysfunction using bardoxolone methyl or analogs thereof |
| WO2015112792A1 (en) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| TWI831738B (zh) * | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
-
2016
- 2016-02-12 EP EP16706722.2A patent/EP3256451B1/en active Active
- 2016-02-12 EA EA201791814A patent/EA038328B1/ru unknown
- 2016-02-12 AU AU2016219109A patent/AU2016219109B2/en active Active
- 2016-02-12 JP JP2017542001A patent/JP6748652B2/ja active Active
- 2016-02-12 MX MX2017010422A patent/MX370586B/es active IP Right Grant
- 2016-02-12 CA CA2974726A patent/CA2974726C/en active Active
- 2016-02-12 KR KR1020247004058A patent/KR20240035818A/ko not_active Ceased
- 2016-02-12 KR KR1020177023589A patent/KR102686868B1/ko active Active
- 2016-02-12 WO PCT/US2016/017769 patent/WO2016130927A1/en not_active Ceased
- 2016-02-12 CN CN201680011160.3A patent/CN107428698B/zh active Active
- 2016-02-12 NZ NZ734292A patent/NZ734292A/en unknown
- 2016-02-12 US US15/548,909 patent/US11059792B2/en active Active
-
2017
- 2017-08-09 IL IL253923A patent/IL253923B/en active IP Right Grant
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