JP2018504112A5 - - Google Patents
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- Publication number
- JP2018504112A5 JP2018504112A5 JP2017536271A JP2017536271A JP2018504112A5 JP 2018504112 A5 JP2018504112 A5 JP 2018504112A5 JP 2017536271 A JP2017536271 A JP 2017536271A JP 2017536271 A JP2017536271 A JP 2017536271A JP 2018504112 A5 JP2018504112 A5 JP 2018504112A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- cxcr4
- sequence
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 claims 7
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010016654 Fibrosis Diseases 0.000 claims 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000004761 fibrosis Effects 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 102000053523 human CXCR4 Human genes 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015900054 | 2015-01-09 | ||
| AU2015900054A AU2015900054A0 (en) | 2015-01-09 | CXCR4 binding molecules | |
| PCT/AU2016/050005 WO2016109872A1 (en) | 2015-01-09 | 2016-01-08 | Cxcr4 binding molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121974A Division JP7212009B2 (ja) | 2015-01-09 | 2020-07-16 | Ｃｘｃｒ４結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504112A JP2018504112A (ja) | 2018-02-15 |
| JP2018504112A5 true JP2018504112A5 (enExample) | 2019-11-14 |
| JP6863897B2 JP6863897B2 (ja) | 2021-04-21 |
Family
ID=56355354
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536271A Active JP6863897B2 (ja) | 2015-01-09 | 2016-01-08 | Ｃｘｃｒ４結合分子 |
| JP2020121974A Active JP7212009B2 (ja) | 2015-01-09 | 2020-07-16 | Ｃｘｃｒ４結合分子 |
| JP2022181132A Pending JP2023015277A (ja) | 2015-01-09 | 2022-11-11 | Ｃｘｃｒ４結合分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121974A Active JP7212009B2 (ja) | 2015-01-09 | 2020-07-16 | Ｃｘｃｒ４結合分子 |
| JP2022181132A Pending JP2023015277A (ja) | 2015-01-09 | 2022-11-11 | Ｃｘｃｒ４結合分子 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10538596B2 (enExample) |
| EP (2) | EP3242685B1 (enExample) |
| JP (3) | JP6863897B2 (enExample) |
| CN (2) | CN107427574B (enExample) |
| AU (3) | AU2016206191B2 (enExample) |
| CA (1) | CA2973317A1 (enExample) |
| DK (1) | DK3242685T3 (enExample) |
| ES (1) | ES2924394T3 (enExample) |
| HR (1) | HRP20220860T1 (enExample) |
| LT (1) | LT3242685T (enExample) |
| SG (2) | SG11201705583XA (enExample) |
| WO (1) | WO2016109872A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016109872A1 (en) * | 2015-01-09 | 2016-07-14 | Adalta Pty Ltd | Cxcr4 binding molecules |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| WO2018084712A1 (en) | 2016-11-07 | 2018-05-11 | Crossbeta Biosciences B.V. | Novel amyloid beta oligomer specific binding molecule |
| WO2018130702A1 (en) * | 2017-01-16 | 2018-07-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Improved multi tyrosine kinase inhibitor therapy |
| WO2019124951A1 (en) * | 2017-12-19 | 2019-06-27 | Gpcr Therapeutics, Inc. | Gpcr heteromer inhibitors and uses thereof |
| JP2022527351A (ja) * | 2019-04-02 | 2022-06-01 | イーライ リリー アンド カンパニー | 結合ペプチドを選択し検出するための方法 |
| EP3969007A4 (en) * | 2019-05-17 | 2023-06-07 | GPCR Therapeutics, Inc. | GPCR HETEROMERIC INHIBITORS AND THEIR USES |
| JP7365674B2 (ja) * | 2019-08-29 | 2023-10-20 | 国立大学法人 長崎大学 | アスペルギローマモデル非ヒト動物 |
| CN110804100A (zh) * | 2019-11-01 | 2020-02-18 | 中国人民解放军陆军特色医学中心 | 融合多肽及其在增强干细胞归巢能力和抗凋亡能力中的应用和药物组合物 |
| US20230143003A1 (en) * | 2020-03-13 | 2023-05-11 | Julius-Maximilians-Universität Würzburg | Affinity matured and humanized binding domains targeting ror2 |
| US20250297020A1 (en) * | 2021-11-23 | 2025-09-25 | Adalta Limited | Rank-l binding molecules |
| CN114533884A (zh) * | 2022-04-20 | 2022-05-27 | 澳门大学 | 一种联合治疗癌症的药物及s100a9-cxcl12信号抑制剂的应用 |
| WO2025010469A1 (en) * | 2023-07-07 | 2025-01-16 | Adalta Limited | Linking receptor occupancy to efficacy of cxcr4 antagonists |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4475A (en) | 1846-04-25 | Henry johnson | ||
| US196A (en) | 1837-05-15 | Machine for mowing and heaping grain | ||
| US4439A (en) | 1846-04-04 | Improvement in cleansing fish-oils | ||
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US5206154A (en) | 1985-01-28 | 1993-04-27 | Xoma Corporation | Method of producing cecropins by microbiological techniques |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5215896A (en) | 1987-03-20 | 1993-06-01 | Creative Biomolecules, Inc. | Leader sequences for the production of recombinant proteins |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| SE8804074D0 (sv) | 1988-11-10 | 1988-11-10 | Pharmacia Ab | Sensorenhet och dess anvaendning i biosensorsystem |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5194594A (en) | 1990-09-07 | 1993-03-16 | Techniclone, Inc. | Modified antibodies |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| DE69332740T2 (de) | 1992-08-21 | 2004-02-05 | The University Of British Columbia, Vancouver | Kationische peptide und verfahren zu deren herstellung |
| US5648244A (en) | 1993-09-27 | 1997-07-15 | President And Fellows Of Harvard College | Production, purification, cleavage and use of fusion peptides |
| US5485277A (en) | 1994-07-26 | 1996-01-16 | Physical Optics Corporation | Surface plasmon resonance sensor and methods for the utilization thereof |
| US6037145A (en) | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| US5567301A (en) | 1995-03-01 | 1996-10-22 | Illinois Institute Of Technology | Antibody covalently bound film immunobiosensor |
| US5972639A (en) | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
| DE19818790A1 (de) | 1998-04-27 | 1999-10-28 | Affina Immuntechnik Gmbh | Immunadsorptionsmatrix, Verfahren zu ihrer Herstellung und ihre Verwendung |
| ATE321066T1 (de) | 1998-05-06 | 2006-04-15 | Genentech Inc | Anti-her2 antikörperzusammensetzung |
| AU5220099A (en) | 1998-07-31 | 2000-02-21 | Pierce Chemical Company | Fusion products containing insoluble proteinaceous tag |
| US6190908B1 (en) | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| US6306610B1 (en) | 1998-09-18 | 2001-10-23 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| US6242219B1 (en) | 1999-03-18 | 2001-06-05 | Xoma (Us) Llc | Methods for recombinant peptide production |
| DE60034947T2 (de) | 1999-06-30 | 2008-01-24 | Evotec Ag | Virusähnliche partikel, vorbereitung und verwendung in screening und funktionelle genomanwendung |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US20060228364A1 (en) | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| CA2406873A1 (en) | 2000-04-25 | 2001-11-01 | Chemicon International, Inc. | Cell proliferation assay |
| WO2002026292A1 (de) | 2000-09-28 | 2002-04-04 | Affina Immuntechnik Gmbh | Durchflussvorrichtung zum trennen von substanzen in körperflüssigkeiten, insbesondere blut und dessen verwendung |
| ES2343061T3 (es) | 2002-05-24 | 2010-07-22 | Medtronic, Inc. | Metodos y constructos de dna para produccion de polipeptidos con rendimiento alto. |
| US8574590B2 (en) | 2003-07-30 | 2013-11-05 | Integral Molecular, Inc. | Lipoparticles comprising proteins, methods of making, and using the same |
| WO2005108415A2 (en) * | 2004-04-30 | 2005-11-17 | Biogen Idec Ma Inc. | Membrane associated molecules |
| KR20120133403A (ko) | 2004-06-01 | 2012-12-10 | 도만티스 리미티드 | 증강된 혈청 반감기를 가지는 이특이성 융합 항체 |
| CA2567655C (en) * | 2004-06-02 | 2015-06-30 | Diatech Pty Ltd | Binding moieties based on shark ignar domains |
| WO2007115231A2 (en) | 2006-03-30 | 2007-10-11 | Chemocentryx, Inc. | Cxcr4 modulators |
| US7671069B2 (en) | 2006-03-30 | 2010-03-02 | Chemocentryx, Inc. | Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7 |
| SG178712A1 (en) * | 2006-10-02 | 2012-03-29 | Medarex Inc | Human antibodies that bind cxcr4 and uses thereof |
| US8088895B2 (en) | 2006-10-18 | 2012-01-03 | Chemocentryx, Inc. | Antibodies that bind CXCR7 epitopes |
| CA2669088C (en) | 2006-11-10 | 2016-04-05 | Dimerix Bioscience Pty Ltd | Detection system and uses therefor |
| US20080261978A1 (en) | 2007-03-08 | 2008-10-23 | Clark Michael P | Chemokine receptor modulators |
| JP2011515416A (ja) | 2008-03-20 | 2011-05-19 | カロラス セラピューティクス， インク． | 抗ｍｉｆ抗体を用いる処置方法 |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| WO2010033913A1 (en) * | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| CN102271681B (zh) | 2008-11-04 | 2014-11-12 | 凯莫森特里克斯股份有限公司 | Cxcr7调节剂 |
| WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
| RS58102B1 (sr) * | 2011-11-09 | 2019-02-28 | Bristol Myers Squibb Co | Lečenje hematoloških maligniteta sa anti-cxcr4 antitelom |
| US20160031937A1 (en) * | 2013-03-08 | 2016-02-04 | Curonz Holdings Company Limited | Neural regeneration peptides and uses therefor |
| WO2016109872A1 (en) * | 2015-01-09 | 2016-07-14 | Adalta Pty Ltd | Cxcr4 binding molecules |
-
2016
- 2016-01-08 WO PCT/AU2016/050005 patent/WO2016109872A1/en not_active Ceased
- 2016-01-08 US US15/542,060 patent/US10538596B2/en active Active
- 2016-01-08 DK DK16734863.0T patent/DK3242685T3/da active
- 2016-01-08 EP EP16734863.0A patent/EP3242685B1/en active Active
- 2016-01-08 CA CA2973317A patent/CA2973317A1/en active Pending
- 2016-01-08 ES ES16734863T patent/ES2924394T3/es active Active
- 2016-01-08 EP EP22171019.7A patent/EP4112077A1/en active Pending
- 2016-01-08 CN CN201680010938.9A patent/CN107427574B/zh active Active
- 2016-01-08 SG SG11201705583XA patent/SG11201705583XA/en unknown
- 2016-01-08 HR HRP20220860TT patent/HRP20220860T1/hr unknown
- 2016-01-08 CN CN202210051480.9A patent/CN114478773A/zh not_active Withdrawn
- 2016-01-08 SG SG10202111844VA patent/SG10202111844VA/en unknown
- 2016-01-08 AU AU2016206191A patent/AU2016206191B2/en active Active
- 2016-01-08 LT LTEPPCT/AU2016/050005T patent/LT3242685T/lt unknown
- 2016-01-08 JP JP2017536271A patent/JP6863897B2/ja active Active
-
2017
- 2017-10-31 AU AU2017254863A patent/AU2017254863A1/en not_active Abandoned
-
2019
- 2019-05-20 AU AU2019203511A patent/AU2019203511B2/en active Active
- 2019-12-18 US US16/719,125 patent/US11142588B2/en active Active
-
2020
- 2020-07-16 JP JP2020121974A patent/JP7212009B2/ja active Active
-
2022
- 2022-11-11 JP JP2022181132A patent/JP2023015277A/ja active Pending