|
US5204466A
(en)
|
1990-02-01 |
1993-04-20 |
Emory University |
Method and compositions for the synthesis of bch-189 and related compounds
|
|
US6703396B1
(en)
|
1990-02-01 |
2004-03-09 |
Emory University |
Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
|
|
US5914331A
(en)
|
1990-02-01 |
1999-06-22 |
Emory University |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
US5935946A
(en)
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
GB2345058A
(en)
|
1998-12-01 |
2000-06-28 |
Cerebrus Pharm Ltd |
Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
|
|
PL348596A1
(en)
|
1998-12-25 |
2002-06-03 |
Shionogi & Co |
Aromatic heterocycle compounds having hiv integrase inhibiting activities
|
|
US20040039060A1
(en)
|
2000-06-14 |
2004-02-26 |
Ryuichi Kiyama |
Inhibitor for enzyme having two divalent metal ions as active centers
|
|
ES2572030T3
(es)
|
2001-08-10 |
2017-07-19 |
Shionogi & Co., Ltd. |
Agente antiviral
|
|
KR20040048936A
(ko)
|
2001-10-03 |
2004-06-10 |
유씨비 소시에떼아노님 |
피롤리디논 유도체
|
|
IL161337A0
(en)
|
2001-10-26 |
2004-09-27 |
Angeletti P Ist Richerche Bio |
N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
|
|
US7109186B2
(en)
|
2002-07-09 |
2006-09-19 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
CA2498111A1
(en)
|
2002-09-11 |
2004-03-25 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
|
|
SK2662004A3
(sk)
|
2002-11-20 |
2005-06-02 |
Japan Tobacco, Inc. |
Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz
|
|
DK1583542T3
(da)
|
2003-01-14 |
2008-09-22 |
Gilead Sciences Inc |
Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
|
|
EA014685B1
(ru)
|
2003-04-25 |
2010-12-30 |
Джилид Сайэнс, Инк. |
Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
TW200528440A
(en)
|
2003-10-31 |
2005-09-01 |
Fujisawa Pharmaceutical Co |
2-cyanopyrrolidinecarboxamide compound
|
|
WO2005074513A2
(en)
|
2004-01-30 |
2005-08-18 |
Merck & Co., Inc. |
N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as hiv integrase inhibitors
|
|
CN101014574A
(zh)
|
2004-03-09 |
2007-08-08 |
默克公司 |
Hiv整合酶抑制剂
|
|
US7538112B2
(en)
|
2004-05-07 |
2009-05-26 |
Merck & Co., Inc. |
HIV integrase inhibitors
|
|
US7273859B2
(en)
|
2004-05-12 |
2007-09-25 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors: cyclic pyrimidinone compounds
|
|
US7531554B2
(en)
|
2004-05-20 |
2009-05-12 |
Japan Tobacco Inc. |
4-oxoquinoline compound and use thereof as HIV integrase inhibitor
|
|
MY134672A
(en)
|
2004-05-20 |
2007-12-31 |
Japan Tobacco Inc |
Stable crystal of 4-oxoquinoline compound
|
|
EP1758581A1
(en)
|
2004-05-21 |
2007-03-07 |
Japan Tobacco, Inc. |
Combinations comprising a 4-isoquinolone derivative and anti-hiv agents
|
|
AU2005330489B2
(en)
|
2004-07-27 |
2011-08-25 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates as anti HIV agents
|
|
JP4953297B2
(ja)
|
2004-09-15 |
2012-06-13 |
塩野義製薬株式会社 |
Hivインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体
|
|
WO2006066414A1
(en)
|
2004-12-23 |
2006-06-29 |
Virochem Pharma Inc. |
Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
|
|
ATE516026T1
(de)
*
|
2005-02-21 |
2011-07-15 |
Shionogi & Co |
Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung
|
|
KR101363875B1
(ko)
|
2005-04-28 |
2014-02-21 |
시오노기세야쿠 가부시키가이샤 |
Hiv 통합효소 억제 활성을 가지는 다환식카르바모일피리돈 유도체
|
|
UA96568C2
(en)
*
|
2005-04-28 |
2011-11-25 |
Глаксосмиткляйн Ллк |
Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor
|
|
AR057023A1
(es)
|
2005-05-16 |
2007-11-14 |
Gilead Sciences Inc |
Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa
|
|
EP1906971A2
(en)
|
2005-07-27 |
2008-04-09 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
MX2008005137A
(es)
|
2005-10-27 |
2008-09-29 |
Shionogi & Co |
Derivado de carbamoilpiridona policiclica que tiene actividad inhibidora en vih integrasa.
|
|
EP1976517A1
(en)
|
2005-12-30 |
2008-10-08 |
Gilead Sciences, Inc. |
Methods for improving the pharmacokinetics of hiv integrase inhibitors
|
|
EP2452682A1
(en)
|
2006-02-01 |
2012-05-16 |
Japan Tobacco, Inc. |
Use of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or salt thereof for treating retrovirus infection
|
|
ES2531190T3
(es)
|
2006-03-06 |
2015-03-11 |
Japan Tobacco Inc |
Método para producir un compuesto de 4-oxoquinolina
|
|
WO2007102499A1
(ja)
|
2006-03-06 |
2007-09-13 |
Japan Tobacco Inc. |
4-オキソキノリン化合物の製造方法
|
|
US7893055B2
(en)
|
2006-06-28 |
2011-02-22 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
JP2009543865A
(ja)
|
2006-07-19 |
2009-12-10 |
ユニバーシティ オブ ジョージア リサーチ ファウンデーション, インコーポレーテッド |
ピリジノンジケト酸:併用療法におけるhiv複製の阻害剤
|
|
WO2008033836A2
(en)
|
2006-09-12 |
2008-03-20 |
Gilead Sciences, Inc. |
Process and intermediates for preparing integrase inhibitors
|
|
WO2008048538A1
(en)
|
2006-10-18 |
2008-04-24 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
MX2009008935A
(es)
|
2007-02-23 |
2009-11-02 |
Gilead Sciences Inc |
Moduladores de las propiedades farmacocineticas de productos terapeuticos.
|
|
US20080280945A1
(en)
|
2007-05-09 |
2008-11-13 |
Sachin Lohani |
Crystalline forms of an HIV integrase inhibitor
|
|
US20100331331A1
(en)
|
2007-06-29 |
2010-12-30 |
Therapeutic Compositons And Use Thereof |
Therapeutic compositions and the use thereof
|
|
AR067184A1
(es)
|
2007-06-29 |
2009-09-30 |
Gilead Sciences Inc |
Uso de 6-(3-cloro-2-fluorbencil)-1-[(2s)-1-hidroxi-3-metilbutan-2-il]-7-metoxi-4-oxo-1,4-dihidroquinolina-3-carboxilico. composicion farmaceutica
|
|
AR068403A1
(es)
|
2007-09-11 |
2009-11-18 |
Gilead Sciences Inc |
Proceso e intermediarios para la preparacion de inhibidores de integrasa
|
|
EA019259B1
(ru)
|
2007-11-16 |
2014-02-28 |
Джилид Сайенсиз, Инк. |
Ингибиторы репликации вируса иммунодефицита человека
|
|
US8129398B2
(en)
|
2008-03-19 |
2012-03-06 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
US20100272811A1
(en)
|
2008-07-23 |
2010-10-28 |
Alkermes,Inc. |
Complex of trospium and pharmaceutical compositions thereof
|
|
WO2010011814A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011819A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
JP5551697B2
(ja)
|
2008-07-25 |
2014-07-16 |
ビーブ・ヘルスケア・カンパニー |
化合物
|
|
WO2010011818A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011815A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
ES2448766T3
(es)
|
2008-07-25 |
2014-03-17 |
Viiv Healthcare Company |
Profármacos de dolutegravir
|
|
KR101733625B1
(ko)
|
2008-12-11 |
2017-05-10 |
시오노기세야쿠 가부시키가이샤 |
카르바모일피리돈 hiv 인테그라제 억제제 및 중간체의 합성
|
|
TWI518084B
(zh)
|
2009-03-26 |
2016-01-21 |
鹽野義製藥股份有限公司 |
哌喃酮與吡啶酮衍生物之製造方法
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
LT3494972T
(lt)
|
2010-01-27 |
2024-03-12 |
Viiv Healthcare Company |
Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
|
|
CA2789457A1
(en)
|
2010-02-26 |
2011-09-01 |
Susumu Miyazaki |
1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor
|
|
TWI582097B
(zh)
|
2010-03-23 |
2017-05-11 |
Viiv醫療保健公司 |
製備胺甲醯吡啶酮衍生物及中間體之方法
|
|
WO2011139637A1
(en)
|
2010-05-03 |
2011-11-10 |
Philadelphia Health & Education Corporation |
Small-molecule modulators of hiv-1 capsid stability and methods thereof
|
|
EP2588455B1
(en)
|
2010-07-02 |
2018-04-04 |
Gilead Sciences, Inc. |
2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
|
|
MX2012015097A
(es)
|
2010-07-02 |
2013-05-28 |
Gilead Sciences Inc |
Derivados de acido naft-2-ilacetico para tratar sida.
|
|
ES2608377T3
(es)
|
2010-08-05 |
2017-04-10 |
Shionogi & Co., Ltd. |
Procedimiento de preparación de un compuesto que tiene actividad inhibidora de la integrasa del HIV
|
|
DK2620436T3
(en)
|
2010-09-24 |
2018-07-30 |
Shionogi & Co |
Substituted polycyclic carbamoylpyridone derivative prodrug
|
|
UA111841C2
(uk)
|
2011-04-21 |
2016-06-24 |
Гіліад Сайєнсіз, Інк. |
Сполуки бензотіазолу та їх фармацевтичне застосування
|
|
WO2012151361A1
(en)
|
2011-05-03 |
2012-11-08 |
Concert Pharmaceuticals Inc. |
Carbamoylpyridone derivatives
|
|
US9328075B2
(en)
|
2011-05-05 |
2016-05-03 |
St. Jude Children's Research Hospital |
Pyrimidinone compounds and methods for treating influenza
|
|
AU2012278976B2
(en)
|
2011-07-06 |
2017-05-11 |
Gilead Sciences, Inc. |
Compounds for the treatment of HIV
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
US9206197B2
(en)
|
2011-09-14 |
2015-12-08 |
Mapi Pharma Ltd. |
Amorphous form of dolutegravir
|
|
RU2014113230A
(ru)
|
2011-10-12 |
2015-11-20 |
Шионоги Энд Ко., Лтд. |
Полициклическое производное пиридона, обладающее ингибирующей активностью в отношении интегразы
|
|
US9399645B2
(en)
|
2011-12-20 |
2016-07-26 |
Boehringer Ingelheim International Gmbh |
Inhibitors of HIV replication
|
|
UY34750A
(es)
|
2012-04-20 |
2013-11-29 |
Gilead Sciences Inc |
?compuestos para el tratamiento del hiv, composiciones,métodos de preparación, intermediarios y métodos terapéuticos?.
|
|
WO2014008636A1
(en)
|
2012-07-11 |
2014-01-16 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as hiv integrase inhibitors
|
|
US20150166520A1
(en)
|
2012-07-20 |
2015-06-18 |
Merck Sharp & Dohme Corp. |
Amido-substituted pyrimidinone derivatives useful for the treatment of hiv infection
|
|
EP2877469A4
(en)
|
2012-07-25 |
2016-04-06 |
Merck Sharp & Dohme |
SUBSTITUTED NAPHTHYRIDEINDION DERIVATIVES AS HIV INTEGRASE INHIBITORS
|
|
AU2013296289B2
(en)
|
2012-08-03 |
2017-10-05 |
Gilead Sciences, Inc. |
Process and intermediates for preparing integrase inhibitors
|
|
SG10201704467SA
(en)
|
2012-12-14 |
2017-06-29 |
Glaxosmithkline Llc |
Pharmaceutical compositions
|
|
EP2931730B1
(en)
*
|
2012-12-17 |
2019-08-07 |
Merck Sharp & Dohme Corp. |
4-pyridinonetriazine derivatives as hiv integrase inhibitors
|
|
US20140221355A1
(en)
|
2012-12-21 |
2014-08-07 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
|
|
EP2934482A4
(en)
|
2012-12-21 |
2016-07-20 |
Merck Sharp & Dohme |
ADMINISTRATIVE FORMULATIONS
|
|
EA030003B1
(ru)
*
|
2012-12-21 |
2018-06-29 |
Джилид Сайэнс, Инк. |
Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
|
|
PE20151063A1
(es)
|
2012-12-27 |
2015-08-03 |
Japan Tobacco Inc |
DERIVADO SUSTITUIDO DE ESPIROPIRIDO[1,2-a]PIRAZINA Y USO MEDICO DEL MISMO COMO INHIBIDOR DE LA INTEGRASA DEL VIH
|
|
EP3008044B1
(en)
*
|
2013-06-13 |
2018-11-21 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
|
|
NO2865735T3
(cg-RX-API-DMAC7.html)
*
|
2013-07-12 |
2018-07-21 |
|
|
|
ES2859102T3
(es)
*
|
2013-07-12 |
2021-10-01 |
Gilead Sciences Inc |
Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
|
|
WO2015039348A1
(en)
|
2013-09-23 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
UA117499C2
(uk)
|
2013-09-27 |
2018-08-10 |
Мерк Шарп Енд Доум Корп. |
Заміщені похідні хінолізину, які можна використовувати як інгібітори інтегрази віл
|
|
WO2015089847A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
TWI695003B
(zh)
*
|
2014-12-23 |
2020-06-01 |
美商基利科學股份有限公司 |
多環胺甲醯基吡啶酮化合物及其醫藥用途
|
|
KR20190057158A
(ko)
*
|
2015-04-02 |
2019-05-27 |
길리애드 사이언시즈, 인코포레이티드 |
폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도
|