JP2018168169A5 - - Google Patents
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- JP2018168169A5 JP2018168169A5 JP2018111642A JP2018111642A JP2018168169A5 JP 2018168169 A5 JP2018168169 A5 JP 2018168169A5 JP 2018111642 A JP2018111642 A JP 2018111642A JP 2018111642 A JP2018111642 A JP 2018111642A JP 2018168169 A5 JP2018168169 A5 JP 2018168169A5
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361802075P | 2013-03-15 | 2013-03-15 | |
| US61/802,075 | 2013-03-15 |
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| WO2014145909A2 (en) * | 2013-03-15 | 2014-09-18 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone compounds and methods of treating disorders |
| EP3189051A1 (en) * | 2014-09-02 | 2017-07-12 | Pierre Fabre Médicament | Isoquinolinone derivatives useful in the treatment of cancer |
| CN104803914B (zh) * | 2015-03-05 | 2017-11-14 | 成都理工大学 | 作为Rho激酶抑制剂的六氢氮杂卓氧基苯甲酰胺类化合物 |
| EP3307069B1 (en) * | 2015-06-10 | 2021-08-04 | Hackensack University Medical Center | Use of telmisartan to prevent and treat graft versus host disease and other alloimmune and autoimmune diseases |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| MX387025B (es) * | 2016-03-04 | 2025-03-19 | Anhui New Star Pharmaceutical Dev Co Ltd | Compuestos de anillo de siete miembros de pirimidina |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| SG11201808106YA (en) * | 2016-03-25 | 2018-10-30 | Ab Science | Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation |
| KR20180132812A (ko) * | 2016-04-07 | 2018-12-12 | 다나-파버 캔서 인스티튜트 인크. | 피리미도-디아제피논 키나아제 스캐폴드 화합물 및 ｐｉ3ｋ-매개된 장애의 치료 방법 |
| SMT202100699T1 (it) | 2016-06-16 | 2022-01-10 | Denali Therapeutics Inc | Pirimidin-2-ilammino-1h-pirazoli come inibitori di lrrk2 per l'uso nel trattamento di disturbi neurodegenerativi |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| AU2017346845B2 (en) * | 2016-10-18 | 2021-12-02 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating DCLK1/2-mediated disorders |
| SG11201903911UA (en) | 2016-11-02 | 2019-05-30 | Novartis Ag | Combinations of fgfr4 inhibitors and bile acid sequestrants |
| KR101923852B1 (ko) * | 2017-02-24 | 2018-11-29 | 재단법인 대구경북첨단의료산업진흥재단 | 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물 |
| US10298137B2 (en) * | 2017-03-10 | 2019-05-21 | Semiconductor Components Industries, Llc | Advanced frequency reduction of quasi-resonant converters |
| EP3728268A4 (en) * | 2017-12-22 | 2021-07-28 | Dana-Farber Cancer Institute, Inc. | NEK INHIBITORS AND METHODS OF USE |
| EP3775185A4 (en) * | 2018-04-13 | 2022-05-04 | The Regents Of The University Of California | DETECTION OF PHOSPHOKINASE SIGNATURES |
| EP3858819A4 (en) | 2018-09-30 | 2022-05-18 | Medshine Discovery Inc. | 3,9-DIAZASPIRO[5,5] UNDECAN COMPOUND AS FLT3 AND AXL INHIBITORS |
| CN111039944B (zh) * | 2018-10-12 | 2021-11-23 | 中国科学院合肥物质科学研究院 | Mst1激酶抑制剂及其用途 |
| CN109824678B (zh) * | 2019-03-20 | 2020-06-19 | 浙江大学 | 一种氮杂卓吲哚类生物碱及制备和抗疟疾用途 |
| WO2020206608A1 (en) | 2019-04-09 | 2020-10-15 | Ranok Therapeutics (Hangzhou) Co., Ltd. | Methods and compositions for targeted protein degradation |
| EP3965803B1 (en) | 2019-05-10 | 2025-08-20 | Dana-Farber Cancer Institute, Inc. | Small-molecule focal adhesion kinase (fak) inhibitors |
| EP3994132A1 (en) * | 2019-07-03 | 2022-05-11 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
| US20220280530A1 (en) * | 2019-08-08 | 2022-09-08 | Anhui Newstar Pharmaceutical Development Co., Ltd. | Prevention or treatment of diseases and disorders associated with tissue damage |
| KR102498531B1 (ko) * | 2020-06-29 | 2023-02-13 | 한국과학기술연구원 | 단백질 카이네이즈 trkc에 선택적인 억제제로서의 신규 피리미도디아제핀 유도체 |
| WO2022061019A1 (en) * | 2020-09-16 | 2022-03-24 | Collaborations Pharmaceuticals, Inc. | The antiviral drug tilorone is a potent and selective inhibitor of acetylcholinesterase |
| WO2022078350A1 (en) * | 2020-10-14 | 2022-04-21 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Methods and compositions for targeted protein degradation |
| CN117088878A (zh) * | 2020-10-28 | 2023-11-21 | 杭州阿诺生物医药科技有限公司 | 一种高活性Wnt通路抑制剂化合物 |
| EP4274567A1 (en) * | 2021-01-05 | 2023-11-15 | Sumitomo Pharma Oncology, Inc. | Forms and formulations of a tyrosine kinase non-receptor 1 (tnk1) inhibitor |
| CN121537408A (zh) | 2021-02-08 | 2026-02-17 | 上海复星医药产业发展有限公司 | 5，6-二氢噻吩并[3，4-h]喹唑啉类化合物 |
| TW202321244A (zh) * | 2021-07-26 | 2023-06-01 | 大陸商杭州阿諾生物醫藥科技有限公司 | 一種Ｗｎｔ通路抑制劑化合物 |
| AR127170A1 (es) * | 2021-09-30 | 2023-12-27 | Crinetics Pharmaceuticals Inc | Antagonistas del receptor de la hormona paratiroidea (pth) y sus usos |
| CN114478539B (zh) * | 2022-02-09 | 2024-02-02 | 中国人民解放军海军军医大学 | 一种新型dclk1抑制剂及其制备方法和应用 |
| CN115877004B (zh) * | 2022-08-09 | 2024-12-20 | 重庆大学 | 一种taok3抑制剂以及taok3及其抑制剂在调控天然免疫系统中的应用 |
| CN116173040B (zh) * | 2022-08-23 | 2025-05-23 | 杭州天玑济世生物科技有限公司 | Xmd17109作为arih1激动剂的用途 |
| EP4509142A1 (en) | 2023-08-16 | 2025-02-19 | Ona Therapeutics S.L. | Fgfr4 as target in cancer treatment |
| CN121154824A (zh) * | 2025-11-19 | 2025-12-19 | 安徽省立医院(中国科学技术大学附属第一医院) | Nuak1作为生物标志物在骨质疏松临床诊断和预防中的应用及其试剂盒 |
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| US7622463B2 (en) | 2006-02-14 | 2009-11-24 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
| AU2008228303B2 (en) | 2007-03-22 | 2012-04-19 | Takeda Pharmaceutical Company Limited | Substituted pyrimidodiazepines useful as PLK1 inhibitors |
| PL2205603T3 (pl) * | 2007-09-28 | 2014-07-31 | Cyclacel Ltd | Pochodne pirymidyny jako inhibitory kinaz białkowych |
| EP3828185B1 (en) * | 2009-01-06 | 2024-11-20 | Dana-Farber Cancer Institute, Inc. | Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders |
| GB201205752D0 (en) | 2012-03-30 | 2012-05-16 | Cyclacel Ltd | Treatment |
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