JP2018140998A5 - - Google Patents
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- Publication number
- JP2018140998A5 JP2018140998A5 JP2018087314A JP2018087314A JP2018140998A5 JP 2018140998 A5 JP2018140998 A5 JP 2018140998A5 JP 2018087314 A JP2018087314 A JP 2018087314A JP 2018087314 A JP2018087314 A JP 2018087314A JP 2018140998 A5 JP2018140998 A5 JP 2018140998A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- gelatin capsule
- soft gelatin
- capsule dosage
- pharmaceutical soft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007903 gelatin capsule Substances 0.000 claims 26
- 239000002552 dosage form Substances 0.000 claims 25
- 229920002907 Guar gum Polymers 0.000 claims 7
- 239000000665 guar gum Substances 0.000 claims 7
- 229960002154 guar gum Drugs 0.000 claims 7
- 235000010417 guar gum Nutrition 0.000 claims 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 claims 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 238000005538 encapsulation Methods 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229930182833 estradiol Natural products 0.000 claims 2
- 229960005309 estradiol Drugs 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 1
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
- 229940062527 alendronate Drugs 0.000 claims 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 1
- 229960002286 clodronic acid Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- HXGBXQDTNZMWGS-RUZDIDTESA-N darifenacin Chemical compound C=1C=CC=CC=1C([C@H]1CN(CCC=2C=C3CCOC3=CC=2)CC1)(C(=O)N)C1=CC=CC=C1 HXGBXQDTNZMWGS-RUZDIDTESA-N 0.000 claims 1
- 229960002677 darifenacin Drugs 0.000 claims 1
- AJIPIJNNOJSSQC-NYLIRDPKSA-N estetrol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 AJIPIJNNOJSSQC-NYLIRDPKSA-N 0.000 claims 1
- 229950009589 estetrol Drugs 0.000 claims 1
- 229960002568 ethinylestradiol Drugs 0.000 claims 1
- 229940009626 etidronate Drugs 0.000 claims 1
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims 1
- 229960002941 etonogestrel Drugs 0.000 claims 1
- 229940015872 ibandronate Drugs 0.000 claims 1
- 229960001652 norethindrone acetate Drugs 0.000 claims 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
- 229940089617 risedronate Drugs 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 125000002640 tocopherol group Chemical group 0.000 claims 1
- IYFNEFQTYQPVOC-UHFFFAOYSA-N udenafil Chemical compound C1=C(C=2NC=3C(CCC)=NN(C)C=3C(=O)N=2)C(OCCC)=CC=C1S(=O)(=O)NCCC1CCCN1C IYFNEFQTYQPVOC-UHFFFAOYSA-N 0.000 claims 1
- 229960000438 udenafil Drugs 0.000 claims 1
- 229960004276 zoledronic acid Drugs 0.000 claims 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361794906P | 2013-03-15 | 2013-03-15 | |
| US61/794,906 | 2013-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502347A Division JP6335270B2 (ja) | 2013-03-15 | 2014-03-14 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084123A Division JP2020147569A (ja) | 2013-03-15 | 2020-05-12 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018140998A JP2018140998A (ja) | 2018-09-13 |
| JP2018140998A5 true JP2018140998A5 (enExample) | 2018-10-25 |
| JP6704430B2 JP6704430B2 (ja) | 2020-06-03 |
Family
ID=50588879
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502347A Expired - Fee Related JP6335270B2 (ja) | 2013-03-15 | 2014-03-14 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
| JP2018087314A Expired - Fee Related JP6704430B2 (ja) | 2013-03-15 | 2018-04-27 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
| JP2020084123A Pending JP2020147569A (ja) | 2013-03-15 | 2020-05-12 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502347A Expired - Fee Related JP6335270B2 (ja) | 2013-03-15 | 2014-03-14 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020084123A Pending JP2020147569A (ja) | 2013-03-15 | 2020-05-12 | 変性グアーガムを用いる医薬ソフトゼラチンカプセル剤形 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9795569B2 (enExample) |
| EP (2) | EP3187170A1 (enExample) |
| JP (3) | JP6335270B2 (enExample) |
| KR (1) | KR20150131070A (enExample) |
| CN (2) | CN105307634B (enExample) |
| AU (2) | AU2014239994B2 (enExample) |
| BR (1) | BR112015022946A8 (enExample) |
| CA (1) | CA2906633C (enExample) |
| ES (1) | ES2619121T3 (enExample) |
| HK (1) | HK1218622A1 (enExample) |
| IL (1) | IL241377B (enExample) |
| MX (2) | MX364440B (enExample) |
| RU (1) | RU2676480C2 (enExample) |
| WO (1) | WO2014152269A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015022946A8 (pt) * | 2013-03-15 | 2022-11-29 | Warner Chilcott Co Llc | Forma de dosagem de cápsula de gelatina macia farmacêutica com goma guar modificada |
| AU2016238337B2 (en) | 2015-03-26 | 2020-08-13 | Patheon Softgels Inc. | Liquisoft capsules |
| JP2017214299A (ja) * | 2016-05-30 | 2017-12-07 | ライオン株式会社 | 半固形製剤及びその製造方法 |
| JP2023548896A (ja) * | 2020-11-13 | 2023-11-21 | ファイザー・インク | タラゾパリブ軟質ゼラチンカプセル剤形 |
| CN116916895A (zh) * | 2020-11-13 | 2023-10-20 | 辉瑞公司 | 他拉唑帕尼软明胶胶囊剂型 |
| CN116531444B (zh) * | 2023-07-06 | 2023-10-10 | 健码制药（广东）有限公司 | 镇咳清肺软胶囊及其制备工艺 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708834A (en) | 1986-05-01 | 1987-11-24 | Pharmacaps, Inc. | Preparation of gelatin-encapsulated controlled release composition |
| US5102666A (en) | 1990-09-11 | 1992-04-07 | Oramed, Inc. | Calcium polycarbophil controlled release composition and method |
| FR2739558B1 (fr) | 1995-10-05 | 1997-11-28 | Innothera Lab Sa | Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale |
| IT1275816B1 (it) * | 1995-10-27 | 1997-10-17 | Montefarmaco Spa | Composizioni farmaceutiche solide per uso vaginale |
| AU1925697A (en) | 1996-03-12 | 1997-10-01 | Novartis Ag | Filled gelatin capsules having a reduced degree of cross-linking |
| US5919481A (en) * | 1996-06-28 | 1999-07-06 | Ncneil-Ppc, Inc. | Fill material for soft gelatin pharmaceutical dosage form |
| US6024980A (en) * | 1996-06-28 | 2000-02-15 | Mcneil-Ppc, Inc. | Multiphase soft gelatin dosage form |
| US5989535A (en) | 1997-08-15 | 1999-11-23 | Soma Technologies | Polymeric bioadhesive emulsions and suspensions and methods of treatment |
| US6187747B1 (en) * | 1997-09-08 | 2001-02-13 | Panacea Biotech Limited | Pharmaceutical composition comprising cyclosporin |
| IN188719B (enExample) * | 1997-09-08 | 2002-11-02 | Panacea Biotec Ltd | |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| US6251426B1 (en) * | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
| US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
| FR2843304B1 (fr) * | 2002-08-07 | 2005-12-16 | Ricarimpex | Extraits de sangsues pour stents |
| EP1599485A2 (en) | 2003-02-18 | 2005-11-30 | Ranbaxy Laboratories, Ltd. | Podophyllotoxin derivatives as antitumor agents |
| KR100570450B1 (ko) * | 2003-09-25 | 2006-04-12 | 한국유나이티드제약 주식회사 | 가용성 로바스타틴의 연질캡슐제 조성물 및 그의 제조방법 |
| US20050142185A1 (en) * | 2003-12-29 | 2005-06-30 | Beleno Alfredo B. | Softgel formulations of bisphosphonates bone resorption inhibitors |
| MXPA06007851A (es) | 2004-01-15 | 2007-01-31 | Warner Chilcott Co Inc | Profarmacos di-esteroidales de etinil estradiol. |
| CN1906206A (zh) | 2004-01-15 | 2007-01-31 | 沃纳奇尔科特公司 | 雌二醇的二－甾族前体药物 |
| US20060110415A1 (en) * | 2004-11-22 | 2006-05-25 | Bioderm Research | Topical Delivery System for Cosmetic and Pharmaceutical Agents |
| US7485323B2 (en) | 2005-05-31 | 2009-02-03 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
| CA2612380C (en) | 2005-06-16 | 2017-06-06 | Warner Chilcott Company, Inc. | Estrogen compositions for vaginal administration |
| ES2523045T3 (es) | 2005-07-12 | 2014-11-20 | Warner Chilcott Company, Llc | Derivado éster de etinil estradiol |
| MX2008000412A (es) | 2005-07-12 | 2008-03-10 | Warner Chilcott Co Inc | Profarmacos de 3-ester de estradiol. |
| US7468970B2 (en) | 2005-10-24 | 2008-12-23 | Honeywell International Inc. | Routing of mobile agents in a network |
| EP1959935A2 (en) * | 2005-10-26 | 2008-08-27 | Banner Pharmacaps Inc. | Hydrophilic vehicle-based dual controlled release matrix system as capsule fill |
| WO2007056424A2 (en) | 2005-11-07 | 2007-05-18 | Penwest Pharmaceuticals, Co. | Controlled-release emulsion compositions |
| WO2007066837A1 (en) | 2005-12-06 | 2007-06-14 | Lg Household & Health Care Ltd. | Delivery system for tooth whitening component using in situ gelling |
| EP1986591A1 (en) | 2006-02-10 | 2008-11-05 | LG Household & Health Care Ltd. | In-situ melting and gelling tablet composition for oral care |
| US20080090569A1 (en) | 2006-10-13 | 2008-04-17 | At&T Knowledge Ventures, L.P. | Method and apparatus for performing signal processing in an ip multimedia subsystem network |
| US20080122993A1 (en) | 2006-11-29 | 2008-05-29 | Sanyo Electric Co., Ltd. | Television image receiver |
| MX2009007913A (es) | 2007-01-25 | 2009-07-31 | Panacea Biotec Ltd | Composicion farmaceutica de liberacion modificada y un procedimiento para elaborarla. |
| WO2008122993A1 (en) | 2007-04-09 | 2008-10-16 | Panacea Biotec Limited | Controlled release formulation of coated microparticles |
| JP2011518367A (ja) | 2008-03-26 | 2011-06-23 | クルーシャル テック カンパニー リミテッド | 光ポインティング装置及びこれを備える携帯電子機器 |
| CN101474167A (zh) * | 2009-01-23 | 2009-07-08 | 西安德天药业股份有限公司 | 雌二醇阴道用胶囊的制备方法 |
| US20110003000A1 (en) | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
| WO2011018800A2 (en) | 2009-08-13 | 2011-02-17 | Fdc Limited | A novel in-situ gel forming solution for ocular drug delivery |
| BR112015022946A8 (pt) * | 2013-03-15 | 2022-11-29 | Warner Chilcott Co Llc | Forma de dosagem de cápsula de gelatina macia farmacêutica com goma guar modificada |
-
2014
- 2014-03-14 BR BR112015022946A patent/BR112015022946A8/pt not_active Application Discontinuation
- 2014-03-14 HK HK16106609.2A patent/HK1218622A1/zh unknown
- 2014-03-14 EP EP16205027.2A patent/EP3187170A1/en not_active Withdrawn
- 2014-03-14 US US14/210,680 patent/US9795569B2/en active Active
- 2014-03-14 RU RU2015137612A patent/RU2676480C2/ru active
- 2014-03-14 KR KR1020157026413A patent/KR20150131070A/ko not_active Ceased
- 2014-03-14 MX MX2015012057A patent/MX364440B/es active IP Right Grant
- 2014-03-14 ES ES14719974.9T patent/ES2619121T3/es active Active
- 2014-03-14 AU AU2014239994A patent/AU2014239994B2/en active Active
- 2014-03-14 CN CN201480022804.XA patent/CN105307634B/zh not_active Expired - Fee Related
- 2014-03-14 EP EP14719974.9A patent/EP2950781B1/en active Active
- 2014-03-14 CN CN202010063854.XA patent/CN111374959A/zh active Pending
- 2014-03-14 JP JP2016502347A patent/JP6335270B2/ja not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/027145 patent/WO2014152269A1/en not_active Ceased
- 2014-03-14 CA CA2906633A patent/CA2906633C/en active Active
- 2014-10-27 US US14/524,512 patent/US9820946B2/en active Active
-
2015
- 2015-09-09 IL IL241377A patent/IL241377B/en active IP Right Grant
- 2015-09-09 MX MX2019004554A patent/MX2019004554A/es unknown
-
2017
- 2017-10-18 US US15/787,296 patent/US10744096B2/en active Active
-
2018
- 2018-04-27 JP JP2018087314A patent/JP6704430B2/ja not_active Expired - Fee Related
-
2019
- 2019-01-09 AU AU2019200116A patent/AU2019200116A1/en not_active Abandoned
-
2020
- 2020-05-12 JP JP2020084123A patent/JP2020147569A/ja active Pending
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