JP2018138605A5 - - Google Patents
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- Publication number
- JP2018138605A5 JP2018138605A5 JP2018094298A JP2018094298A JP2018138605A5 JP 2018138605 A5 JP2018138605 A5 JP 2018138605A5 JP 2018094298 A JP2018094298 A JP 2018094298A JP 2018094298 A JP2018094298 A JP 2018094298A JP 2018138605 A5 JP2018138605 A5 JP 2018138605A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- transdermal
- functional group
- containing compound
- absorption enhancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010521 absorption reaction Methods 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000003623 enhancer Substances 0.000 claims 7
- 125000000524 functional group Chemical group 0.000 claims 7
- 230000002378 acidificating effect Effects 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 5
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims 4
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 2
- 229960001231 choline Drugs 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 150000001261 hydroxy acids Chemical class 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 150000004668 long chain fatty acids Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014221315 | 2014-10-30 | ||
| JP2014221315 | 2014-10-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556223A Division JP6482570B2 (ja) | 2014-10-30 | 2015-10-30 | 経皮吸収促進剤及び経皮吸収促進助剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018138605A JP2018138605A (ja) | 2018-09-06 |
| JP2018138605A5 true JP2018138605A5 (enExample) | 2018-12-06 |
| JP6693999B2 JP6693999B2 (ja) | 2020-05-13 |
Family
ID=55857668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556223A Active JP6482570B2 (ja) | 2014-10-30 | 2015-10-30 | 経皮吸収促進剤及び経皮吸収促進助剤 |
| JP2018094298A Active JP6693999B2 (ja) | 2014-10-30 | 2018-05-16 | 経皮吸収促進剤及び経皮吸収促進助剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556223A Active JP6482570B2 (ja) | 2014-10-30 | 2015-10-30 | 経皮吸収促進剤及び経皮吸収促進助剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170239173A1 (enExample) |
| EP (3) | EP3395368A1 (enExample) |
| JP (2) | JP6482570B2 (enExample) |
| WO (1) | WO2016068336A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019131480A (ja) * | 2018-01-29 | 2019-08-08 | 旭化成株式会社 | 経皮吸収促進剤及び経皮製剤 |
| US11446257B2 (en) | 2018-09-27 | 2022-09-20 | BioPhysics Pharma, Inc. | Transdermal drug delivery system |
| US12246098B2 (en) | 2018-09-27 | 2025-03-11 | BioPhysics Pharma, Inc. | Trans-epithelial membrane drug delivery system |
| US20200405609A1 (en) * | 2019-06-26 | 2020-12-31 | Johnson & Johnson Consumer Inc. | Topical compositions containing n-acyl dipeptide derivatives and glycolic acid |
| WO2021010843A1 (en) | 2019-07-16 | 2021-01-21 | Donaghys Limited | Transdermal solvent system and methods of use |
| KR20220080076A (ko) | 2019-10-11 | 2022-06-14 | 도레이 카부시키가이샤 | 온도 응답성 이온 액체를 포함하는 의약 조성물 |
| CN115298190A (zh) * | 2020-03-26 | 2022-11-04 | 国立大学法人九州大学 | 离子液体、溶剂、制剂及经皮吸收剂 |
| CN119300864A (zh) * | 2022-03-31 | 2025-01-10 | 美德阿利克斯株式会社 | 改善了低溶解性和/或低膜渗透性药物的吸收性的制剂 |
| CN116492261B (zh) * | 2023-05-26 | 2025-04-25 | 美出莱(杭州)化妆品有限责任公司 | 一种超分子牡丹肽组合物及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551554A (en) | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| DE2528516A1 (de) | 1974-07-05 | 1976-01-22 | Sandoz Ag | Neue galenische zubereitung |
| FR2314731A1 (fr) | 1975-06-19 | 1977-01-14 | Nelson Res & Dev | Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients |
| JPS5283914A (en) | 1976-01-01 | 1977-07-13 | Sandoz Ag | Improvement of galenus medicine |
| JPS5781409A (en) * | 1980-11-10 | 1982-05-21 | Toko Yakuhin Kogyo Kk | External plaster |
| EP0189861A3 (en) * | 1985-01-26 | 1988-02-17 | Showa Denko Kabushiki Kaisha | Percutaneous absorption accelerator for ionic water-soluble medicine |
| JP2905210B2 (ja) | 1989-01-23 | 1999-06-14 | フロイント産業株式会社 | 経皮、経粘膜吸収促進剤および経皮、経粘膜製剤 |
| JP2651616B2 (ja) | 1989-02-03 | 1997-09-10 | リンテック株式会社 | 経皮吸収製剤 |
| DE4436764A1 (de) * | 1994-10-14 | 1996-04-18 | Henkel Kgaa | Verwendung von Guanidiniumsalzen ungesättigter Fettsäuren als Korrosionsschutzwirkstoff |
| FR2752421B1 (fr) * | 1996-08-13 | 2001-05-04 | Fabre Pierre Dermo Cosmetique | Sels de guanidines anti-seborrheiques |
| US6120779A (en) * | 1998-01-29 | 2000-09-19 | Soma Technologies | Use of partial and complete salts of choline and carboxylic acids for the treatment of skin disorders |
| AU6751000A (en) * | 1999-07-30 | 2001-02-19 | Maxim Pharmaceuticals, Inc. | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
| JP2003160511A (ja) * | 2001-11-29 | 2003-06-03 | Shiseido Co Ltd | 経皮吸収促進剤 |
| US20030143195A1 (en) * | 2002-01-30 | 2003-07-31 | Pinsker Judy Senior | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
| US20060147508A1 (en) * | 2002-10-04 | 2006-07-06 | Bioderm Research | Concurrent Enhancement of Skin Penetration of Organic Base Active Agents and Organic Hydroxy Acid Active Agents as Their Ion-Pair Complexes |
| JP4969065B2 (ja) | 2005-07-13 | 2012-07-04 | 株式会社 メドレックス | 常温性イオン性液体を含有する医薬組成物 |
| JP2008162899A (ja) | 2006-12-27 | 2008-07-17 | Tokyo Univ Of Agriculture & Technology | 生体関連化合物からなるイオン液体 |
| JP5117732B2 (ja) * | 2007-01-29 | 2013-01-16 | 株式会社 メドレックス | 外用剤用の低刺激性溶解助剤 |
| CN103239721B (zh) * | 2007-11-22 | 2016-03-16 | 美德阿利克斯株式会社 | 包括基于脂肪酸的离子型液体作为活性成分的外用制剂组合物 |
| JP5550056B2 (ja) | 2012-09-05 | 2014-07-16 | 株式会社 メドレックス | 外用剤用の低刺激性溶解助剤 |
| EP3062819B1 (en) * | 2013-11-03 | 2021-12-22 | The Regents of The University of California | Ionic liquids for transdermal drug delivery |
-
2015
- 2015-10-30 EP EP18177251.8A patent/EP3395368A1/en not_active Withdrawn
- 2015-10-30 JP JP2016556223A patent/JP6482570B2/ja active Active
- 2015-10-30 WO PCT/JP2015/080841 patent/WO2016068336A1/ja not_active Ceased
- 2015-10-30 US US15/519,246 patent/US20170239173A1/en not_active Abandoned
- 2015-10-30 EP EP15855750.4A patent/EP3213769A4/en not_active Withdrawn
- 2015-10-30 EP EP18177254.2A patent/EP3395369A1/en not_active Withdrawn
-
2018
- 2018-05-16 JP JP2018094298A patent/JP6693999B2/ja active Active
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