JP2014503560A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014503560A5 JP2014503560A5 JP2013550556A JP2013550556A JP2014503560A5 JP 2014503560 A5 JP2014503560 A5 JP 2014503560A5 JP 2013550556 A JP2013550556 A JP 2013550556A JP 2013550556 A JP2013550556 A JP 2013550556A JP 2014503560 A5 JP2014503560 A5 JP 2014503560A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- optionally substituted
- compound
- item
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 210000002966 serum Anatomy 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 208000002249 Diabetes Complications Diseases 0.000 claims description 3
- 206010012655 Diabetic complications Diseases 0.000 claims description 3
- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 125000001475 halogen functional group Chemical group 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 102000017011 Glycated Hemoglobin A Human genes 0.000 claims description 2
- 208000006011 Stroke Diseases 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 108091005995 glycated hemoglobin Proteins 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000010444 Acidosis Diseases 0.000 claims 1
- 206010010071 Coma Diseases 0.000 claims 1
- 208000003790 Foot Ulcer Diseases 0.000 claims 1
- 206010027417 Metabolic acidosis Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 24
- 208000001145 Metabolic Syndrome Diseases 0.000 description 11
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 11
- 125000000304 alkynyl group Chemical group 0.000 description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 10
- 125000001072 heteroaryl group Chemical group 0.000 description 9
- 125000003118 aryl group Chemical group 0.000 description 8
- 125000004452 carbocyclyl group Chemical group 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 7
- 125000000739 C2-C30 alkenyl group Chemical group 0.000 description 6
- 239000000651 prodrug Substances 0.000 description 6
- 229940002612 prodrug Drugs 0.000 description 6
- 239000012453 solvate Substances 0.000 description 6
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 description 4
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 description 4
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 description 4
- 125000004450 alkenylene group Chemical group 0.000 description 4
- 125000002947 alkylene group Chemical group 0.000 description 4
- 125000004419 alkynylene group Chemical group 0.000 description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
- 150000003573 thiols Chemical class 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000032928 Dyslipidaemia Diseases 0.000 description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- -1 amino, monosubstituted amino Chemical group 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 125000004093 cyano group Chemical group *C#N 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000007910 systemic administration Methods 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161434337P | 2011-01-19 | 2011-01-19 | |
| US61/434,337 | 2011-01-19 | ||
| PCT/US2012/021692 WO2012099942A2 (en) | 2011-01-19 | 2012-01-18 | Methods and compositions for treating metabolic syndrome |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015086407A Division JP5881266B2 (ja) | 2011-01-19 | 2015-04-21 | 代謝症候群を治療する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503560A JP2014503560A (ja) | 2014-02-13 |
| JP2014503560A5 true JP2014503560A5 (enExample) | 2015-03-05 |
| JP5778781B2 JP5778781B2 (ja) | 2015-09-16 |
Family
ID=46516342
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013550556A Expired - Fee Related JP5778781B2 (ja) | 2011-01-19 | 2012-01-18 | 代謝症候群を治療する方法および組成物 |
| JP2015086407A Expired - Fee Related JP5881266B2 (ja) | 2011-01-19 | 2015-04-21 | 代謝症候群を治療する方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015086407A Expired - Fee Related JP5881266B2 (ja) | 2011-01-19 | 2015-04-21 | 代謝症候群を治療する方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9089579B2 (enExample) |
| EP (3) | EP2665481B1 (enExample) |
| JP (2) | JP5778781B2 (enExample) |
| CA (2) | CA2866067C (enExample) |
| ES (2) | ES2579990T3 (enExample) |
| WO (1) | WO2012099942A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075449A (zh) | 2005-07-14 | 2016-11-09 | 尼奥塞蒂克斯公司 | 用于局部脂肪组织治疗的持续释放的增强性脂肪分解性制剂 |
| CA2681668C (en) | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| US20110124736A1 (en) | 2009-11-09 | 2011-05-26 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| CA2866067C (en) | 2011-01-19 | 2015-04-21 | Topokine Therapeutics, Inc. | Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia |
| US8426471B1 (en) * | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| GB2507341A (en) * | 2012-10-29 | 2014-04-30 | Peter Kenny | Fat loss composition comprising a prostaglandin F2 alpha analogue and a fragment of amino acids 176-191 of human growth hormone |
| WO2014081941A1 (en) | 2012-11-21 | 2014-05-30 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
| BR112015021859A2 (pt) * | 2013-03-15 | 2017-07-18 | Allergan Inc | bimatoprost para potencialização da produção de leptina |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) * | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) * | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| MA42953A (fr) | 2015-09-22 | 2018-08-01 | Graybug Vision Inc | Composés et compositions pour le traitement de troubles oculaires |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| EP3845232B1 (en) * | 2018-08-30 | 2024-10-09 | Daisankasei Co., Ltd. | Transdermal use of phytostenone for reducing subcutaneous fat |
| US10835502B2 (en) | 2018-10-16 | 2020-11-17 | Polithera, Inc. | Alcohol-based compositions and uses thereof |
| US11452703B2 (en) * | 2020-05-21 | 2022-09-27 | Peregrine Ophthalmic PTE LTD. | Methods and compositions for reducing adipocyte numbers |
| WO2023065203A1 (en) * | 2021-10-21 | 2023-04-27 | Givaudan Sa | Organic compounds |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| EP0302147A1 (en) | 1987-08-03 | 1989-02-08 | The Procter & Gamble Company | Topical tanning compositions |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| EP0569046B1 (en) | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5296504A (en) | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5011062A (en) | 1990-05-09 | 1991-04-30 | Delco Electronics Corporation | Ultrasonic welding mask |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5972991A (en) | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5510383A (en) | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| JPH07138258A (ja) | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| RU2157689C2 (ru) | 1996-07-24 | 2000-10-20 | Панацея Биотек Лтд. | Фармацевтические композиции терапевтического антивоспалительного и болеутоляющего средства для местного нанесения и способ их получения |
| JP3480549B2 (ja) | 1996-12-26 | 2003-12-22 | 参天製薬株式会社 | ジフルオロプロスタグランジン誘導体およびその用途 |
| DE69823852T2 (de) | 1997-02-04 | 2005-05-19 | Johnstone, Murray A., Seattle | Verfahren zur förderung des haarwuchses und entwicklung des haarsystems |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| AU1709699A (en) | 1997-12-22 | 1999-07-12 | Alcon Laboratories, Inc. | 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| CA2398901C (en) | 2000-02-10 | 2010-11-16 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| ES2172415B2 (es) | 2000-07-28 | 2003-11-16 | Univ Madrid Complutense | Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina. |
| IL158131A0 (en) | 2001-03-27 | 2004-03-28 | Univ California | Methods, compounds, and compositions for reducing body fat and modulating fatty acid metabolism |
| GB0202159D0 (en) | 2002-01-30 | 2002-03-20 | Sensor Highway Ltd | OPtical time domain reflectometry |
| IL147921A0 (en) | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US6864282B2 (en) * | 2002-08-05 | 2005-03-08 | Allergan, Inc. | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
| US20040115234A1 (en) | 2002-09-24 | 2004-06-17 | Gewirtz Joan T. | Cosmetic composition |
| US20050261641A1 (en) | 2002-09-26 | 2005-11-24 | Warchol Mark P | Method for ophthalmic administration of medicament |
| WO2004037268A1 (en) | 2002-10-23 | 2004-05-06 | Sucampo Ag | Prostaglandin compounds for the treatment of obesity |
| US7074827B2 (en) | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| MXPA05009816A (es) | 2003-03-21 | 2005-12-05 | Nexmed Holdings Inc | Composiciones y metodos para el tratamiento de la eyaculacion precoz. |
| US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
| US20050058614A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods for the treatment of gray hair using cyclopentane(ene) heptan(en)oic acid amides |
| US7070768B2 (en) | 2003-09-25 | 2006-07-04 | Allergan, Inc. | Method for imparting artificial tan to human skin |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7799336B2 (en) * | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| CA2585735A1 (en) * | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
| ES2314354T3 (es) | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
| US20080233053A1 (en) | 2005-02-07 | 2008-09-25 | Pharmalight Inc. | Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients |
| KR101396731B1 (ko) | 2005-03-31 | 2014-05-19 | 산텐 세이야꾸 가부시키가이샤 | 프로스타글란딘 Ｆ２ａ 유도체를 유효 성분으로서 함유하는망막신경세포 보호제 |
| US9393218B2 (en) | 2005-12-23 | 2016-07-19 | Epinamics Gmbh | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers |
| CA2681668C (en) | 2006-03-23 | 2014-04-01 | Michael S. Singer | Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat |
| WO2007123818A2 (en) * | 2006-04-18 | 2007-11-01 | Nitromed, Inc. | Organic nitric oxide enhancing salts of prostaglandins, compositions and methods of use |
| RU2325912C1 (ru) | 2006-09-06 | 2008-06-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция противовоспалительного и антимикробного действия в форме мази на гидрофобной основе для лечения кожных заболеваний (варианты) |
| US8796282B2 (en) | 2007-03-28 | 2014-08-05 | Case Western Reserve University | Method of treating dermatological disorders |
| WO2008120249A1 (en) | 2007-03-30 | 2008-10-09 | Sifi S.P.A. | Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use |
| WO2010039535A1 (en) | 2008-09-23 | 2010-04-08 | Meta Cosmetics, Llc | Compositions and methods to treat epithelial-related conditions |
| US20100104654A1 (en) * | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US8722739B2 (en) * | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| CN101427993A (zh) | 2008-11-20 | 2009-05-13 | 沈阳万爱普利德医药科技有限公司 | 前列腺素微乳凝胶制剂及其制备方法 |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| US20110124736A1 (en) | 2009-11-09 | 2011-05-26 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| WO2012068515A2 (en) | 2010-11-18 | 2012-05-24 | Steven Yoelin | Compositions and methods for hair growth |
| CA2866067C (en) | 2011-01-19 | 2015-04-21 | Topokine Therapeutics, Inc. | Uses of certain f-series prostaglandin analogs for treating diabetes and dyslipidemia |
| WO2012112451A1 (en) | 2011-02-14 | 2012-08-23 | Allergan, Inc. | Ester derivatives of bimatoprost compositions and methods |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| US20150164765A1 (en) | 2012-05-17 | 2015-06-18 | Steven G. Yoelin | Compositions and methods for hair growth |
| KR20140043562A (ko) | 2012-09-24 | 2014-04-10 | 한국콜마주식회사 | 무복계면 라타노프로스트 및 그 제조방법 |
| WO2014081941A1 (en) | 2012-11-21 | 2014-05-30 | Topokine Therapeutics, Inc. | Methods and compositions for locally increasing body fat |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
-
2012
- 2012-01-18 CA CA2866067A patent/CA2866067C/en not_active Expired - Fee Related
- 2012-01-18 EP EP12736090.7A patent/EP2665481B1/en not_active Not-in-force
- 2012-01-18 WO PCT/US2012/021692 patent/WO2012099942A2/en not_active Ceased
- 2012-01-18 EP EP18166647.0A patent/EP3378480A1/en not_active Withdrawn
- 2012-01-18 ES ES12736090.7T patent/ES2579990T3/es active Active
- 2012-01-18 CA CA2824317A patent/CA2824317C/en not_active Expired - Fee Related
- 2012-01-18 US US13/980,179 patent/US9089579B2/en active Active
- 2012-01-18 ES ES15180363.2T patent/ES2687494T3/es active Active
- 2012-01-18 EP EP15180363.2A patent/EP2982373B1/en not_active Not-in-force
- 2012-01-18 JP JP2013550556A patent/JP5778781B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-08 US US14/509,680 patent/US9504695B2/en active Active
-
2015
- 2015-04-21 JP JP2015086407A patent/JP5881266B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-22 US US15/359,061 patent/US10335418B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014503560A5 (enExample) | ||
| CA2711834C (en) | Synthetic triterpenoids and methods of use in the treatment of disease | |
| US20220000824A1 (en) | Treatment of pulmonary arterial hypertension using therapeutically effective oral doses of 10-nitro-9(e)-octadec-9-enoic acid | |
| EP2665481B1 (en) | Methods and compositions for treating metabolic syndrome | |
| US12201622B2 (en) | Continuous delivery of lenalidomide and other immunomodulatory agents | |
| JP2010525050A5 (enExample) | ||
| CN103998035A (zh) | 包含格列酮和nrf2激活剂的药物组合物 | |
| JP2013519653A5 (enExample) | ||
| JP2015518897A5 (enExample) | ||
| JP6038132B2 (ja) | ニチシノンを含む液体薬学的組成物 | |
| EP3226873B1 (en) | Compositions comprising 15-hepe and its use for treating or preventing idiopathic pulomonary fibrosis | |
| JP2020100627A (ja) | １５−ｈｅｐｅを含む組成物及びそれを使用する方法 | |
| Paccaly et al. | Absence of clinically relevant drug interaction between delamanid, a new drug for multidrug-resistant tuberculosis (MDR-TB) and tenofovir or lopinavir/ritonavir in healthy subjects | |
| EP4122495A1 (en) | Treatment or prevention method for chronic heart failure | |
| US20210093628A1 (en) | Tesofensine and metoprolol for treatment of hypertension | |
| US20160220550A1 (en) | Losmapimod for use in treating glomerular disease | |
| US20250161286A1 (en) | Use of novel pomalidomide derivative for treating brain diseases | |
| US20200246314A1 (en) | Dyslipidemia therapeutic agent | |
| CN114945360A (zh) | 用于治疗心脏病的大麻二酚组合物 | |
| CN104507478A (zh) | 用于治疗急性冠状动脉综合征的烟酰胺衍生物 | |
| KR20230050472A (ko) | 지질 이상증 치료제 | |
| KR101262123B1 (ko) | 지질 대사 이상의 예방 또는 치료용 의약 조성물 | |
| US20230128304A1 (en) | Benzimidazole compound for the treatment of metabolic disorders | |
| US20140249122A1 (en) | Anti-diabetic aminosteroid derivatives | |
| KR20230060465A (ko) | 장내 glp-1 분비 촉진 및 염증 완화 효능을 가지는 아젤라산 조성물 |