ES2579990T3 - Métodos y composiciones para tratar el síndrome metabólico - Google Patents
Métodos y composiciones para tratar el síndrome metabólico Download PDFInfo
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- ES2579990T3 ES2579990T3 ES12736090.7T ES12736090T ES2579990T3 ES 2579990 T3 ES2579990 T3 ES 2579990T3 ES 12736090 T ES12736090 T ES 12736090T ES 2579990 T3 ES2579990 T3 ES 2579990T3
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- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161434337P | 2011-01-19 | 2011-01-19 | |
| US201161434337P | 2011-01-19 | ||
| PCT/US2012/021692 WO2012099942A2 (en) | 2011-01-19 | 2012-01-18 | Methods and compositions for treating metabolic syndrome |
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| ES2579990T3 true ES2579990T3 (es) | 2016-08-18 |
| ES2579990T8 ES2579990T8 (es) | 2016-08-26 |
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| ES12736090.7T Active ES2579990T3 (es) | 2011-01-19 | 2012-01-18 | Métodos y composiciones para tratar el síndrome metabólico |
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| Application Number | Title | Priority Date | Filing Date |
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| ES15180363.2T Active ES2687494T3 (es) | 2011-01-19 | 2012-01-18 | Métodos y composiciones para reducir la grasa corporal |
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| US (3) | US9089579B2 (enExample) |
| EP (3) | EP3378480A1 (enExample) |
| JP (2) | JP5778781B2 (enExample) |
| CA (2) | CA2824317C (enExample) |
| ES (2) | ES2687494T3 (enExample) |
| WO (1) | WO2012099942A2 (enExample) |
Families Citing this family (19)
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| BRPI0613034A8 (pt) | 2005-07-14 | 2018-01-02 | Lipothera Inc | formulação injetável para acúmulo de tecido adiposo, formulação injetável e método para o tratamento de acúmulo de gordura, e, método para reduzir o tecido adiposo. |
| US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| HUE040019T2 (hu) | 2009-11-09 | 2019-02-28 | Allergan Inc | Hajnövekedést stimuláló készítmények és módszerek |
| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| US8426471B1 (en) * | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| GB2507341A (en) * | 2012-10-29 | 2014-04-30 | Peter Kenny | Fat loss composition comprising a prostaglandin F2 alpha analogue and a fragment of amino acids 176-191 of human growth hormone |
| CA2869676C (en) | 2012-11-21 | 2015-06-23 | Topokine Therapeutics, Inc. | Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat |
| US20140275272A1 (en) * | 2013-03-15 | 2014-09-18 | Allergan, Inc. | Prostamides for enhancement of leptin production |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| KR102854260B1 (ko) * | 2018-08-30 | 2025-09-03 | 다이산카세이 컴파니 리미티드 | 피토스테논의 신규 용도 |
| US10835502B2 (en) | 2018-10-16 | 2020-11-17 | Polithera, Inc. | Alcohol-based compositions and uses thereof |
| US12509469B2 (en) | 2019-08-07 | 2025-12-30 | Ripple Therapeutics Corporation | Compositions and methods for the treatment of pain and dependence disorders |
| US11452703B2 (en) * | 2020-05-21 | 2022-09-27 | Peregrine Ophthalmic PTE LTD. | Methods and compositions for reducing adipocyte numbers |
| WO2023065203A1 (en) * | 2021-10-21 | 2023-04-27 | Givaudan Sa | Organic compounds |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| EP0302147A1 (en) | 1987-08-03 | 1989-02-08 | The Procter & Gamble Company | Topical tanning compositions |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US5296504A (en) | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| ATE101342T1 (de) | 1988-09-06 | 1994-02-15 | Kabi Pharmacia Ab | Prostaglandinderivate zur behandlung des gruenen stars oder einer okularen hypertension. |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5011062A (en) | 1990-05-09 | 1991-04-30 | Delco Electronics Corporation | Ultrasonic welding mask |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5972991A (en) | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5510383A (en) | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| JPH07138258A (ja) | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| RU2157689C2 (ru) | 1996-07-24 | 2000-10-20 | Панацея Биотек Лтд. | Фармацевтические композиции терапевтического антивоспалительного и болеутоляющего средства для местного нанесения и способ их получения |
| JP3480549B2 (ja) | 1996-12-26 | 2003-12-22 | 参天製薬株式会社 | ジフルオロプロスタグランジン誘導体およびその用途 |
| JP4397973B2 (ja) | 1997-02-04 | 2010-01-13 | ジョンストン， マーレイ エイ． | 瞼の毛髪の成長を刺激するための局所的組成物 |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| AU1709699A (en) | 1997-12-22 | 1999-07-12 | Alcon Laboratories, Inc. | 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| ATE552855T1 (de) | 2000-02-10 | 2012-04-15 | Massachusetts Eye & Ear Infirm | Kombinationen und zubereitung zur anwendung in pdt zur behandlung von augenleiden mit unerwünschter choriodaler neovascularisation |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| ES2172415B2 (es) | 2000-07-28 | 2003-11-16 | Univ Madrid Complutense | Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina. |
| AU2002338329B2 (en) | 2001-03-27 | 2006-09-07 | The Regents Of The University Of California | Methods, compounds, and compositions for reducing body fat and modulating fatty acid metabolism |
| GB0202159D0 (en) | 2002-01-30 | 2002-03-20 | Sensor Highway Ltd | OPtical time domain reflectometry |
| IL147921A0 (en) | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US6864282B2 (en) | 2002-08-05 | 2005-03-08 | Allergan, Inc. | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
| US20040115234A1 (en) | 2002-09-24 | 2004-06-17 | Gewirtz Joan T. | Cosmetic composition |
| US20050261641A1 (en) * | 2002-09-26 | 2005-11-24 | Warchol Mark P | Method for ophthalmic administration of medicament |
| ES2379652T3 (es) * | 2002-10-23 | 2012-04-30 | Sucampo Ag | Compuestos de prostaglandina para el tratamiento de obesidad |
| US7074827B2 (en) | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| AU2004224329B2 (en) | 2003-03-21 | 2009-07-09 | Nexmed (Holdings), Inc. | Compositions and methods for treatment of premature ejaculation |
| US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
| US20050058614A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods for the treatment of gray hair using cyclopentane(ene) heptan(en)oic acid amides |
| US7070768B2 (en) | 2003-09-25 | 2006-07-04 | Allergan, Inc. | Method for imparting artificial tan to human skin |
| US7799336B2 (en) * | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US20090093463A1 (en) | 2004-11-02 | 2009-04-09 | Agouron Pharmaceuticals Inc. | Novel compounds of substituted and unsubtituted adamantyl amides |
| DE602004017477D1 (de) | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential |
| EP1848541A4 (en) | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR THE OPHTHALMIC ADMINISTRATION OF PHARMACEUTICAL ACTIVE SUBSTANCES |
| PT1864666E (pt) | 2005-03-31 | 2012-09-06 | Santen Pharmaceutical Co Ltd | Agente protector para célula neuronal retiniana contendo derivado de prostaglandina f2 alfa como ingrediente activo |
| US9393218B2 (en) | 2005-12-23 | 2016-07-19 | Epinamics Gmbh | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers |
| US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
| WO2007123818A2 (en) * | 2006-04-18 | 2007-11-01 | Nitromed, Inc. | Organic nitric oxide enhancing salts of prostaglandins, compositions and methods of use |
| RU2325912C1 (ru) | 2006-09-06 | 2008-06-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция противовоспалительного и антимикробного действия в форме мази на гидрофобной основе для лечения кожных заболеваний (варианты) |
| US8796282B2 (en) | 2007-03-28 | 2014-08-05 | Case Western Reserve University | Method of treating dermatological disorders |
| WO2008120249A1 (en) | 2007-03-30 | 2008-10-09 | Sifi S.P.A. | Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use |
| WO2010039535A1 (en) | 2008-09-23 | 2010-04-08 | Meta Cosmetics, Llc | Compositions and methods to treat epithelial-related conditions |
| US20100104654A1 (en) * | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US8722739B2 (en) * | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| CN101427993A (zh) | 2008-11-20 | 2009-05-13 | 沈阳万爱普利德医药科技有限公司 | 前列腺素微乳凝胶制剂及其制备方法 |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| HUE040019T2 (hu) | 2009-11-09 | 2019-02-28 | Allergan Inc | Hajnövekedést stimuláló készítmények és módszerek |
| WO2013172838A1 (en) | 2012-05-17 | 2013-11-21 | Steven Yoelin | Compositions and methods for hair growth |
| CA2818610C (en) | 2010-11-18 | 2020-02-18 | Steven Yoelin | Compositions and methods for hair growth |
| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| CN103459368B (zh) | 2011-02-14 | 2016-06-08 | 阿勒根公司 | 比马前列素组合物的酯衍生物和方法 |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| KR20140043562A (ko) | 2012-09-24 | 2014-04-10 | 한국콜마주식회사 | 무복계면 라타노프로스트 및 그 제조방법 |
| CA2869676C (en) | 2012-11-21 | 2015-06-23 | Topokine Therapeutics, Inc. | Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat |
| NO2753788T3 (enExample) | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
-
2012
- 2012-01-18 US US13/980,179 patent/US9089579B2/en active Active
- 2012-01-18 WO PCT/US2012/021692 patent/WO2012099942A2/en not_active Ceased
- 2012-01-18 ES ES15180363.2T patent/ES2687494T3/es active Active
- 2012-01-18 CA CA2824317A patent/CA2824317C/en not_active Expired - Fee Related
- 2012-01-18 ES ES12736090.7T patent/ES2579990T3/es active Active
- 2012-01-18 EP EP18166647.0A patent/EP3378480A1/en not_active Withdrawn
- 2012-01-18 EP EP15180363.2A patent/EP2982373B1/en not_active Not-in-force
- 2012-01-18 CA CA2866067A patent/CA2866067C/en not_active Expired - Fee Related
- 2012-01-18 JP JP2013550556A patent/JP5778781B2/ja not_active Expired - Fee Related
- 2012-01-18 EP EP12736090.7A patent/EP2665481B1/en not_active Not-in-force
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2014
- 2014-10-08 US US14/509,680 patent/US9504695B2/en active Active
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2015
- 2015-04-21 JP JP2015086407A patent/JP5881266B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-22 US US15/359,061 patent/US10335418B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1190936A1 (zh) | 2014-07-18 |
| CA2824317A1 (en) | 2012-07-26 |
| US20150025150A1 (en) | 2015-01-22 |
| JP2014503560A (ja) | 2014-02-13 |
| ES2687494T3 (es) | 2018-10-25 |
| WO2012099942A3 (en) | 2013-06-27 |
| US20170136032A1 (en) | 2017-05-18 |
| JP2015155440A (ja) | 2015-08-27 |
| CA2824317C (en) | 2014-12-16 |
| US9089579B2 (en) | 2015-07-28 |
| ES2579990T8 (es) | 2016-08-26 |
| WO2012099942A2 (en) | 2012-07-26 |
| EP3378480A1 (en) | 2018-09-26 |
| CA2866067A1 (en) | 2012-07-26 |
| JP5778781B2 (ja) | 2015-09-16 |
| EP2665481A2 (en) | 2013-11-27 |
| EP2665481B1 (en) | 2016-03-30 |
| EP2982373A1 (en) | 2016-02-10 |
| US9504695B2 (en) | 2016-11-29 |
| EP2982373B1 (en) | 2018-06-13 |
| JP5881266B2 (ja) | 2016-03-09 |
| US10335418B2 (en) | 2019-07-02 |
| EP2665481A4 (en) | 2014-08-06 |
| HK1220912A1 (en) | 2017-05-19 |
| US20140045933A1 (en) | 2014-02-13 |
| CA2866067C (en) | 2015-04-21 |
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