JP2018123089A - フェオメラニン抑制用組成物 - Google Patents
フェオメラニン抑制用組成物 Download PDFInfo
- Publication number
- JP2018123089A JP2018123089A JP2017016521A JP2017016521A JP2018123089A JP 2018123089 A JP2018123089 A JP 2018123089A JP 2017016521 A JP2017016521 A JP 2017016521A JP 2017016521 A JP2017016521 A JP 2017016521A JP 2018123089 A JP2018123089 A JP 2018123089A
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- JP
- Japan
- Prior art keywords
- pheomelanin
- ascorbic acid
- component
- amount
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
市販されているL−アスコルビン酸 2−グルコシド及びアルブチンをそれぞれ精製水に溶解し、段階希釈して各種濃度のASG溶液とArb溶液を調製した。また、得られたASG溶液にArbを溶解することにより、ASG+Arb溶液を調製した。ASG溶液、Arb溶液及びASG+Arb溶液は、メンブレンフィルターを用いてそれぞれろ過滅菌した。
下記に示す2つの文献に記載の試験方法に準じて、B16−F10マウスメラノーマ細胞の培養を実施した。以下に、試験手順の概要を示す。
(1)岩手大学教育学部研究年報 第40巻第1号(1980.10)93−102
(2)Journal of Applied Pharmaceutical Science Vol.4(01),pp.166−169
(2)の文献に記載の試験方法に準じて、MTTアッセイ(細胞生存率の測定)を実施した。以下に、上記文献との変更点を示す。
3−(4,5−ジメチル−2−チアゾニル)−2,5−ジフェニル−2−H−テトラゾリウムブロマイド(MTT;同仁化学社)溶液の濃度は、2mg/mlではなく2.5mg/mlとし、MTT溶液添加後の培養時間は、3時間ではなく2時間とした。また、ホルマザン抽出は、ジメチルスルホキシド(Dimethyl sulfoxide)ではなく、0.04mol/l 塩酸イソプロパノールを2mL添加して行った。
細胞内のユーメラニンの含有量は、下記(3)に示す伊藤らの文献に記載の分析方法に従って測定した。細胞内のフェオメラニンの含有量は、下記(4)に示す伊藤らの文献に記載の分析方法に準じて、測定した。以下に、フェオメラニン分析における(4)の文献との変更点を示す。
(3)ユーメラニンの分析方法:Pigment Cell Melanoma Research(PCMR),2011,Vol 24,pp.605−613
(4)フェオメラニンの分析方法:PCMR,2002,Vol 15,pp.Pages 225−232
上記4のメラニン分析で得られたユーメラニンマーカー(PTCA)及びフェオメラニンマーカー(4−AHP)の定量値に基づいて、以下の式(I)及び(II)によりユーメラニン量及びフェオメラニン量を算出した。
(I)ユーメラニン量=PTCA量×25(ユーメラニンから得られるPTCAの収率4%から逆算して求めた係数)
(II)フェオメラニン量=4−AHP量×7(フェオメラニンから得られる4−AHPの収率15%から逆算して求めた係数)
例1〜例3及びコントロールの被験溶液を用いて、上記5の解析方法にて評価した結果をまとめたものを図1及び図2に示す。これらの図が示すように、ASGの含有量が多くなるほどにフェオメラニン量及びフェオメラニン比率が減少した。また、ASG及びArbを組み合わせて用いることにより、さらにフェオメラニン量及びフェオメラニン比率が減少した。なお、培養細胞の生存率は、上記被験溶液の間で有意な差はみられなかった。
例2、例4〜例6及びコントロールの被験溶液を用いて、上記5の解析方法にて評価した結果をまとめたものを図3及び図4に示す。図1及び図2と同様に、ASGの含有量が多くなるほどにフェオメラニン量及びフェオメラニン比率が減少し、ASG及びArbを組み合わせて用いることにより、フェオメラニン量及びフェオメラニン比率がさらに減少した。一方、Arbの含有量が多くなるほどにメラニン全体の量が減少した。しかし、メラニン全体に対するフェオメラニンの比率は減少しなかった。なお、培養細胞の生存率は、上記被験溶液の間で有意な差はみられなかった。
Claims (7)
- アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選ばれる第1の成分
を含有する、フェオメラニン抑制用組成物。 - アスコルビン酸、アスコルビン酸誘導体及びそれらの塩からなる群から選ばれる第1の成分と、
ハイドロキノン、ハイドロキノン誘導体及びそれらの塩からなる群から選ばれる第2の成分と
を含有する、フェオメラニン抑制用組成物。 - 前記第1の成分は、アスコルビン酸、アスコルビン酸ナトリウム、アスコルビン酸グルコシド、アスコルビン酸リン酸エステル、アスコルビン酸硫酸エステル、アスコルビン酸脂肪酸エステル及びアスコルビン酸アルキルエーテルからなる群から選ばれる成分である、請求項1〜2のいずれか1項に記載の組成物。
- 前記第2の成分は、置換又は非置換のハイドロキノンと糖との縮合物である、請求項2〜3のいずれか1項に記載の組成物。
- 前記第2の成分は、アルブチンである、請求項2〜4のいずれか1項に記載の組成物。
- 前記フェオメラニン抑制用組成物は、前記第1の成分及び前記第2の成分を、質量比(第1の成分:第2の成分)が1:0.005〜2になるように含有する、請求項1〜5のいずれか1項に記載の組成物。
- 請求項1〜6のいずれか1項に記載の組成物を含有する、化粧品又は医薬部外品に用いるための組成物。
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JP7260942B1 (ja) * | 2022-11-24 | 2023-04-19 | 岩瀬コスファ株式会社 | 皮膚外用剤 |
WO2024080290A1 (ja) * | 2022-10-12 | 2024-04-18 | 一丸ファルコス株式会社 | メラニン色素生成抑制剤 |
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