JP2018100297A5 - - Google Patents
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- Publication number
- JP2018100297A5 JP2018100297A5 JP2018053140A JP2018053140A JP2018100297A5 JP 2018100297 A5 JP2018100297 A5 JP 2018100297A5 JP 2018053140 A JP2018053140 A JP 2018053140A JP 2018053140 A JP2018053140 A JP 2018053140A JP 2018100297 A5 JP2018100297 A5 JP 2018100297A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- phenyl
- amino
- cyano
- butanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359504P | 2016-07-07 | 2016-07-07 | |
| US62/359,504 | 2016-07-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559144A Division JP6323629B1 (ja) | 2016-07-07 | 2017-07-06 | Ｅｐ４拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018100297A JP2018100297A (ja) | 2018-06-28 |
| JP2018100297A5 true JP2018100297A5 (https=) | 2020-07-30 |
| JP7020218B2 JP7020218B2 (ja) | 2022-02-16 |
Family
ID=60912958
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559144A Active JP6323629B1 (ja) | 2016-07-07 | 2017-07-06 | Ｅｐ４拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ |
| JP2018053140A Active JP7020218B2 (ja) | 2016-07-07 | 2018-03-20 | Ｅｐ４拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017559144A Active JP6323629B1 (ja) | 2016-07-07 | 2017-07-06 | Ｅｐ４拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11065226B2 (https=) |
| EP (1) | EP3482760B1 (https=) |
| JP (2) | JP6323629B1 (https=) |
| KR (1) | KR102473601B1 (https=) |
| CN (1) | CN109475520B (https=) |
| AU (1) | AU2017292522B2 (https=) |
| CA (1) | CA3029611A1 (https=) |
| DK (1) | DK3482760T3 (https=) |
| ES (1) | ES2900306T3 (https=) |
| HU (1) | HUE057799T2 (https=) |
| IL (1) | IL264063B (https=) |
| MX (1) | MX385428B (https=) |
| MY (1) | MY197673A (https=) |
| PH (1) | PH12019500002B1 (https=) |
| PL (1) | PL3482760T3 (https=) |
| PT (1) | PT3482760T (https=) |
| RU (1) | RU2748731C2 (https=) |
| SG (1) | SG11201811591UA (https=) |
| TW (2) | TWI795362B (https=) |
| WO (1) | WO2018008711A1 (https=) |
| ZA (1) | ZA201900060B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3255624B2 (ja) | 1998-07-03 | 2002-02-12 | 日本電信電話株式会社 | コネクタプラグおよび光コネクタ |
| NZ733575A (en) * | 2015-01-09 | 2022-10-28 | Ono Pharmaceutical Co | Tricyclic spiro compound |
| AU2018255300B2 (en) * | 2017-04-18 | 2021-10-28 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| JP7159007B2 (ja) | 2017-11-01 | 2022-10-24 | 小野薬品工業株式会社 | 脳腫瘍の治療のための医薬 |
| US20200352906A1 (en) * | 2018-02-05 | 2020-11-12 | Shenzhen Ionova Life Science Co., Ltd. | Heterobicyclic Carboxylic Acids for Treating Cancer or Inflammatory Diseases |
| CN110156674A (zh) * | 2018-02-13 | 2019-08-23 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物 |
| US10973834B2 (en) * | 2018-04-16 | 2021-04-13 | Arrys Therapeutics, Inc. | EP4 inhibitors and use thereof |
| IL277963B2 (en) | 2018-04-17 | 2024-09-01 | Tempest Therapeutics Inc | Bicyclic carboxamides and methods of use thereof |
| US20210315909A1 (en) | 2018-07-11 | 2021-10-14 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3722319A1 (en) * | 2019-04-09 | 2020-10-14 | Rottapharm Biotech S.r.l. | Pharmaceutical combination of an ep4 antagonist and immune checkpoint inhibitors for the treatment of tumours |
| WO2020242773A1 (en) * | 2019-05-31 | 2020-12-03 | Clear Creek Bio, Inc. | Methods of promoting differentiation of myeloid-derived suppressor cells using inhibitors of dihydroorotate dehydrogenase |
| CN110386941A (zh) * | 2019-08-15 | 2019-10-29 | 上海邦耀生物科技有限公司 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
| KR20220122696A (ko) * | 2019-12-25 | 2022-09-02 | 니뽄 신야쿠 가부시키가이샤 | 면역 체크포인트 저해제와 병용으로 이용하는 항종양약 |
| WO2021183640A1 (en) * | 2020-03-10 | 2021-09-16 | Emory University | Methods of treating cancer using checkpoint inhibitors in combination with purine cleaving enzymes |
| US20230390303A1 (en) | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
| CN117377656A (zh) * | 2021-05-28 | 2024-01-09 | 南京明德新药研发有限公司 | 苯并螺杂环衍生物及其应用 |
| US20250002448A1 (en) * | 2021-09-21 | 2025-01-02 | Merck Sharp & Dohme Llc | Allosteric modulators of nicotinic acetylcholine receptors |
| WO2023198060A1 (zh) * | 2022-04-12 | 2023-10-19 | 正大天晴药业集团股份有限公司 | 蛋白酶体抑制剂与抗pd-1抗体的药物组合 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1071648A2 (en) | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| US6211197B1 (en) | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| CA2420042A1 (en) | 2000-08-22 | 2003-02-18 | Mikio Ogawa | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient |
| MXPA04001253A (es) | 2001-08-09 | 2004-06-03 | Ono Pharmaceutical Co | Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. |
| JP5301469B2 (ja) | 2007-02-26 | 2013-09-25 | メルク カナダ インコーポレイテッド | Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
| US20150004175A1 (en) | 2011-12-13 | 2015-01-01 | Yale University | Compositions and Methods for Reducing CTL Exhaustion |
| KR102535283B1 (ko) | 2014-05-23 | 2023-05-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 암의 치료를 위한 조합 요법 |
| NZ733575A (en) | 2015-01-09 | 2022-10-28 | Ono Pharmaceutical Co | Tricyclic spiro compound |
-
2017
- 2017-07-06 HU HUE17824314A patent/HUE057799T2/hu unknown
- 2017-07-06 WO PCT/JP2017/024753 patent/WO2018008711A1/ja not_active Ceased
- 2017-07-06 TW TW106122678A patent/TWI795362B/zh active
- 2017-07-06 PT PT178243143T patent/PT3482760T/pt unknown
- 2017-07-06 JP JP2017559144A patent/JP6323629B1/ja active Active
- 2017-07-06 CA CA3029611A patent/CA3029611A1/en active Pending
- 2017-07-06 SG SG11201811591UA patent/SG11201811591UA/en unknown
- 2017-07-06 KR KR1020197000093A patent/KR102473601B1/ko active Active
- 2017-07-06 MX MX2018015567A patent/MX385428B/es unknown
- 2017-07-06 MY MYPI2018002961A patent/MY197673A/en unknown
- 2017-07-06 US US16/315,063 patent/US11065226B2/en active Active
- 2017-07-06 DK DK17824314.3T patent/DK3482760T3/da active
- 2017-07-06 AU AU2017292522A patent/AU2017292522B2/en active Active
- 2017-07-06 ES ES17824314T patent/ES2900306T3/es active Active
- 2017-07-06 TW TW111107751A patent/TWI805255B/zh active
- 2017-07-06 PL PL17824314T patent/PL3482760T3/pl unknown
- 2017-07-06 EP EP17824314.3A patent/EP3482760B1/en active Active
- 2017-07-06 PH PH1/2019/500002A patent/PH12019500002B1/en unknown
- 2017-07-06 RU RU2018146479A patent/RU2748731C2/ru active
- 2017-07-06 CN CN201780042306.5A patent/CN109475520B/zh active Active
-
2018
- 2018-03-20 JP JP2018053140A patent/JP7020218B2/ja active Active
-
2019
- 2019-01-02 IL IL264063A patent/IL264063B/en unknown
- 2019-01-04 ZA ZA2019/00060A patent/ZA201900060B/en unknown
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