IL264063B - Combination comprising ep4 antagonist and immune checkpoint inhibitor - Google Patents
Combination comprising ep4 antagonist and immune checkpoint inhibitorInfo
- Publication number
- IL264063B IL264063B IL264063A IL26406319A IL264063B IL 264063 B IL264063 B IL 264063B IL 264063 A IL264063 A IL 264063A IL 26406319 A IL26406319 A IL 26406319A IL 264063 B IL264063 B IL 264063B
- Authority
- IL
- Israel
- Prior art keywords
- antagonist
- immune checkpoint
- checkpoint inhibitor
- combination containing
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662359504P | 2016-07-07 | 2016-07-07 | |
| PCT/JP2017/024753 WO2018008711A1 (ja) | 2016-07-07 | 2017-07-06 | Ｅｐ４拮抗薬と免疫チェックポイント阻害薬を含んでなる組み合わせ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL264063A IL264063A (en) | 2019-01-31 |
| IL264063B true IL264063B (en) | 2022-02-01 |
Family
ID=60912958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL264063A IL264063B (en) | 2016-07-07 | 2019-01-02 | Combination comprising ep4 antagonist and immune checkpoint inhibitor |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11065226B2 (https=) |
| EP (1) | EP3482760B1 (https=) |
| JP (2) | JP6323629B1 (https=) |
| KR (1) | KR102473601B1 (https=) |
| CN (1) | CN109475520B (https=) |
| AU (1) | AU2017292522B2 (https=) |
| CA (1) | CA3029611A1 (https=) |
| DK (1) | DK3482760T3 (https=) |
| ES (1) | ES2900306T3 (https=) |
| HU (1) | HUE057799T2 (https=) |
| IL (1) | IL264063B (https=) |
| MX (1) | MX385428B (https=) |
| MY (1) | MY197673A (https=) |
| PH (1) | PH12019500002B1 (https=) |
| PL (1) | PL3482760T3 (https=) |
| PT (1) | PT3482760T (https=) |
| RU (1) | RU2748731C2 (https=) |
| SG (1) | SG11201811591UA (https=) |
| TW (2) | TWI795362B (https=) |
| WO (1) | WO2018008711A1 (https=) |
| ZA (1) | ZA201900060B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3255624B2 (ja) | 1998-07-03 | 2002-02-12 | 日本電信電話株式会社 | コネクタプラグおよび光コネクタ |
| NZ733575A (en) * | 2015-01-09 | 2022-10-28 | Ono Pharmaceutical Co | Tricyclic spiro compound |
| AU2018255300B2 (en) * | 2017-04-18 | 2021-10-28 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
| JP7159007B2 (ja) | 2017-11-01 | 2022-10-24 | 小野薬品工業株式会社 | 脳腫瘍の治療のための医薬 |
| US20200352906A1 (en) * | 2018-02-05 | 2020-11-12 | Shenzhen Ionova Life Science Co., Ltd. | Heterobicyclic Carboxylic Acids for Treating Cancer or Inflammatory Diseases |
| CN110156674A (zh) * | 2018-02-13 | 2019-08-23 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物 |
| US10973834B2 (en) * | 2018-04-16 | 2021-04-13 | Arrys Therapeutics, Inc. | EP4 inhibitors and use thereof |
| IL277963B2 (en) | 2018-04-17 | 2024-09-01 | Tempest Therapeutics Inc | Bicyclic carboxamides and methods of use thereof |
| US20210315909A1 (en) | 2018-07-11 | 2021-10-14 | Arrys Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| EP3722319A1 (en) * | 2019-04-09 | 2020-10-14 | Rottapharm Biotech S.r.l. | Pharmaceutical combination of an ep4 antagonist and immune checkpoint inhibitors for the treatment of tumours |
| WO2020242773A1 (en) * | 2019-05-31 | 2020-12-03 | Clear Creek Bio, Inc. | Methods of promoting differentiation of myeloid-derived suppressor cells using inhibitors of dihydroorotate dehydrogenase |
| CN110386941A (zh) * | 2019-08-15 | 2019-10-29 | 上海邦耀生物科技有限公司 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
| KR20220122696A (ko) * | 2019-12-25 | 2022-09-02 | 니뽄 신야쿠 가부시키가이샤 | 면역 체크포인트 저해제와 병용으로 이용하는 항종양약 |
| WO2021183640A1 (en) * | 2020-03-10 | 2021-09-16 | Emory University | Methods of treating cancer using checkpoint inhibitors in combination with purine cleaving enzymes |
| US20230390303A1 (en) | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
| CN117377656A (zh) * | 2021-05-28 | 2024-01-09 | 南京明德新药研发有限公司 | 苯并螺杂环衍生物及其应用 |
| US20250002448A1 (en) * | 2021-09-21 | 2025-01-02 | Merck Sharp & Dohme Llc | Allosteric modulators of nicotinic acetylcholine receptors |
| WO2023198060A1 (zh) * | 2022-04-12 | 2023-10-19 | 正大天晴药业集团股份有限公司 | 蛋白酶体抑制剂与抗pd-1抗体的药物组合 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1071648A2 (en) | 1998-03-13 | 2001-01-31 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| US6211197B1 (en) | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
| CA2420042A1 (en) | 2000-08-22 | 2003-02-18 | Mikio Ogawa | Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical agents comprising the same as active ingredient |
| MXPA04001253A (es) | 2001-08-09 | 2004-06-03 | Ono Pharmaceutical Co | Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo. |
| JP5301469B2 (ja) | 2007-02-26 | 2013-09-25 | メルク カナダ インコーポレイテッド | Ｅｐ４受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
| US20150004175A1 (en) | 2011-12-13 | 2015-01-01 | Yale University | Compositions and Methods for Reducing CTL Exhaustion |
| KR102535283B1 (ko) | 2014-05-23 | 2023-05-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 암의 치료를 위한 조합 요법 |
| NZ733575A (en) | 2015-01-09 | 2022-10-28 | Ono Pharmaceutical Co | Tricyclic spiro compound |
-
2017
- 2017-07-06 HU HUE17824314A patent/HUE057799T2/hu unknown
- 2017-07-06 WO PCT/JP2017/024753 patent/WO2018008711A1/ja not_active Ceased
- 2017-07-06 TW TW106122678A patent/TWI795362B/zh active
- 2017-07-06 PT PT178243143T patent/PT3482760T/pt unknown
- 2017-07-06 JP JP2017559144A patent/JP6323629B1/ja active Active
- 2017-07-06 CA CA3029611A patent/CA3029611A1/en active Pending
- 2017-07-06 SG SG11201811591UA patent/SG11201811591UA/en unknown
- 2017-07-06 KR KR1020197000093A patent/KR102473601B1/ko active Active
- 2017-07-06 MX MX2018015567A patent/MX385428B/es unknown
- 2017-07-06 MY MYPI2018002961A patent/MY197673A/en unknown
- 2017-07-06 US US16/315,063 patent/US11065226B2/en active Active
- 2017-07-06 DK DK17824314.3T patent/DK3482760T3/da active
- 2017-07-06 AU AU2017292522A patent/AU2017292522B2/en active Active
- 2017-07-06 ES ES17824314T patent/ES2900306T3/es active Active
- 2017-07-06 TW TW111107751A patent/TWI805255B/zh active
- 2017-07-06 PL PL17824314T patent/PL3482760T3/pl unknown
- 2017-07-06 EP EP17824314.3A patent/EP3482760B1/en active Active
- 2017-07-06 PH PH1/2019/500002A patent/PH12019500002B1/en unknown
- 2017-07-06 RU RU2018146479A patent/RU2748731C2/ru active
- 2017-07-06 CN CN201780042306.5A patent/CN109475520B/zh active Active
-
2018
- 2018-03-20 JP JP2018053140A patent/JP7020218B2/ja active Active
-
2019
- 2019-01-02 IL IL264063A patent/IL264063B/en unknown
- 2019-01-04 ZA ZA2019/00060A patent/ZA201900060B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL264063B (en) | Combination comprising ep4 antagonist and immune checkpoint inhibitor | |
| IL263586A (en) | Inhibitors of the menin-mll interaction | |
| CL2015003522A1 (es) | Combinaciones de un anticuerpo anti-pd-l1 y un inhibidor de mek y/o inhibidor de raf-b | |
| HUE053755T2 (hu) | Szemcsésanyag-érzékelõ eszköz | |
| IL265274A (en) | Combined treatment of antibody and checkpoint inhibitor | |
| IL280863A (en) | Autotaxin inhibitors and uses thereof | |
| EP3559648C0 (en) | DETECTION DEVICE AND METHODS | |
| PL3739299T3 (pl) | Wykrywanie obiektów | |
| EP3408402A4 (en) | MAGNETIC ELECTROCHEMICAL DETECTION | |
| DK3442972T3 (da) | Bromdomænehæmmere | |
| IL240153B (en) | Line of block detection | |
| ME03325B (me) | Inhibitor aurora a kinaze | |
| DK3414422T3 (da) | Brøndredskabsanordning med sprængskive | |
| DK3230318T3 (da) | Immune checkpoint-inhibitor-kombinationer | |
| HUE053907T2 (hu) | A menin-MLL kölcsönhatás spiro-biciklusos inhibitorai | |
| IL261584A (en) | Combination of cxcr4 antagonist and immune checkpoint inhibitor | |
| EP3565457C0 (en) | DETECTION DEVICE | |
| DE112017004618T8 (de) | Objekterfassungsvorrichtung | |
| DK3481826T3 (da) | Tyrosinkinaseinhibitorer | |
| ME03735B (me) | Inhibitori beta-laktamaze | |
| EP3628374C0 (en) | BCL-3 INHIBITORS | |
| EP3528810A4 (en) | BROMDOMAIN INHIBITOR | |
| EP3623841A4 (en) | OBJECT DETECTION DEVICE | |
| DK3688233T3 (da) | Modulær detekteringsindretning | |
| DE112017001408B8 (de) | Objekterfassungsgerät |