JP2018083799A - ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 - Google Patents

２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 Download PDF

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JP2018083799A
JP2018083799A JP2016250981A JP2016250981A JP2018083799A JP 2018083799 A JP2018083799 A JP 2018083799A JP 2016250981 A JP2016250981 A JP 2016250981A JP 2016250981 A JP2016250981 A JP 2016250981A JP 2018083799 A JP2018083799 A JP 2018083799A
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membered
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Japanese (ja)
Inventor
浩之 北野
Hiroyuki Kitano
浩之 北野
和土 森
Kazuto Mori
和土 森
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Bioelectron Technology Corp
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Bioelectron Technology Corp
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Application filed by Bioelectron Technology Corp filed Critical Bioelectron Technology Corp
Priority to PCT/US2017/061879 priority Critical patent/WO2018093957A1/en
Priority to PL17817338T priority patent/PL3541814T3/pl
Priority to CA3082764A priority patent/CA3082764A1/en
Priority to JP2019524868A priority patent/JP7083826B2/ja
Priority to FIEP21202648.8T priority patent/FI3971182T3/fi
Priority to PT178173381T priority patent/PT3541814T/pt
Priority to CN201780070427.0A priority patent/CN110023311B/zh
Priority to EP17817338.1A priority patent/EP3541814B1/en
Priority to PT212026488T priority patent/PT3971182T/pt
Priority to PL21202648.8T priority patent/PL3971182T3/pl
Priority to ES17817338T priority patent/ES2898836T3/es
Priority to DK21202648.8T priority patent/DK3971182T3/da
Priority to ES21202648T priority patent/ES3067619T3/es
Priority to US16/349,940 priority patent/US10738014B2/en
Priority to EP21202648.8A priority patent/EP3971182B1/en
Priority to HUE17817338A priority patent/HUE056922T2/hu
Publication of JP2018083799A publication Critical patent/JP2018083799A/ja
Priority to US16/989,582 priority patent/US11390588B2/en
Priority to JP2022089435A priority patent/JP2022107730A/ja
Priority to US17/862,290 priority patent/US12281083B2/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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JP2016250981A 2016-11-15 2016-12-26 ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩 Pending JP2018083799A (ja)

Priority Applications (19)

Application Number Priority Date Filing Date Title
PL21202648.8T PL3971182T3 (pl) 2016-11-15 2017-11-15 2-podstawione związki aminonaft[1,2-d]imidazol-5-onowe lub ich farmaceutycznie dopuszczalne sole
ES17817338T ES2898836T3 (es) 2016-11-15 2017-11-15 Compuestos de amino-naft[1,2-d]imidazol-5-ona 2-sustituida o sales farmacéuticamente aceptables de los mismos
CA3082764A CA3082764A1 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
JP2019524868A JP7083826B2 (ja) 2016-11-15 2017-11-15 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩
FIEP21202648.8T FI3971182T3 (fi) 2016-11-15 2017-11-15 2-substituoituja amino-naft[1,2-d]imidatsol-5-oni-yhdisteitä tai niiden farmaseuttisesti hyväksyttäviä suoloja
PT178173381T PT3541814T (pt) 2016-11-15 2017-11-15 Compostos de amino-naft[1,2-d]imidazol-5-ona 2-substituída ou seus sais farmaceuticamente aceitáveis
CN201780070427.0A CN110023311B (zh) 2016-11-15 2017-11-15 2-取代的氨基-萘并[1,2-d]咪唑-5-酮类化合物或其药学上可接受的盐
EP17817338.1A EP3541814B1 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof
PT212026488T PT3971182T (pt) 2016-11-15 2017-11-15 Compostos de amino-naft[1,2-d]imidazol-5-ona 2-substituída ou seus sais farmaceuticamente aceitáveis
PCT/US2017/061879 WO2018093957A1 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof cross reference to related applications
ES21202648T ES3067619T3 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof
PL17817338T PL3541814T3 (pl) 2016-11-15 2017-11-15 2-podstawione związki aminonaft[1,2-d]imidazol-5-onowe albo ich farmaceutycznie dopuszczalne sole
DK21202648.8T DK3971182T3 (da) 2016-11-15 2017-11-15 2-substituerede aminonafth[1,2-d]imidazol-5-on-forbindelser eller farmaceutisk acceptable salte deraf
US16/349,940 US10738014B2 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth (1,2-d) imidazol-5-one compounds or pharmaceutically acceptable salts thereof
EP21202648.8A EP3971182B1 (en) 2016-11-15 2017-11-15 2-substituted amino-naphth[1,2-d]imidazol-5-one compounds or pharmaceutically acceptable salts thereof
HUE17817338A HUE056922T2 (hu) 2016-11-15 2017-11-15 2-szubsztituált amino-naft[1,2-D]imidazol-5-on vegyületek vagy azok gyógyszerészetileg elfogadható sói
US16/989,582 US11390588B2 (en) 2016-11-15 2020-08-10 2-substituted amino-naphth (1,2-d) imidazol-5-one compounds of pharmaceutically acceptable salts thereof
JP2022089435A JP2022107730A (ja) 2016-11-15 2022-06-01 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩
US17/862,290 US12281083B2 (en) 2016-11-15 2022-07-11 2-substituted amino-naphth (1,2-d) imidazol-5-one compounds of pharmaceutically acceptable salts thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016222028 2016-11-15
JP2016222028 2016-11-15

Publications (1)

Publication Number Publication Date
JP2018083799A true JP2018083799A (ja) 2018-05-31

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JP2016250981A Pending JP2018083799A (ja) 2016-11-15 2016-12-26 ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
JP2019524868A Active JP7083826B2 (ja) 2016-11-15 2017-11-15 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩
JP2022089435A Withdrawn JP2022107730A (ja) 2016-11-15 2022-06-01 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩

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JP2019524868A Active JP7083826B2 (ja) 2016-11-15 2017-11-15 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩
JP2022089435A Withdrawn JP2022107730A (ja) 2016-11-15 2022-06-01 ２－置換アミノ－ナフト［１，２－ｄ］イミダゾール－５－オン化合物またはその製薬学上許容される塩

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US (3) US10738014B2 (enExample)
EP (2) EP3541814B1 (enExample)
JP (3) JP2018083799A (enExample)
CN (1) CN110023311B (enExample)
CA (1) CA3082764A1 (enExample)
DK (1) DK3971182T3 (enExample)
ES (2) ES2898836T3 (enExample)
FI (1) FI3971182T3 (enExample)
HU (1) HUE056922T2 (enExample)
PL (2) PL3971182T3 (enExample)
PT (2) PT3541814T (enExample)

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PL2220030T3 (pl) 2007-11-06 2016-07-29 Bioelectron Tech Corp Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
HUE058877T2 (hu) 2014-12-16 2022-09-28 Ptc Therapeutics Inc (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociklohexa-1,4-dienil)butánamid polimorf és amorf alakjai
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