JP2018008901A - グレリン分泌促進剤 - Google Patents
グレリン分泌促進剤 Download PDFInfo
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- JP2018008901A JP2018008901A JP2016139372A JP2016139372A JP2018008901A JP 2018008901 A JP2018008901 A JP 2018008901A JP 2016139372 A JP2016139372 A JP 2016139372A JP 2016139372 A JP2016139372 A JP 2016139372A JP 2018008901 A JP2018008901 A JP 2018008901A
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- ghrelin
- milk
- lactic acid
- lactobacillus
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- 101800001586 Ghrelin Proteins 0.000 title claims abstract description 55
- 102000012004 Ghrelin Human genes 0.000 title claims abstract description 55
- GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title claims abstract description 55
- 230000000580 secretagogue effect Effects 0.000 title abstract 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 78
- 241000894006 Bacteria Species 0.000 claims abstract description 43
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 39
- 239000004310 lactic acid Substances 0.000 claims abstract description 39
- 230000028327 secretion Effects 0.000 claims abstract description 33
- 235000015140 cultured milk Nutrition 0.000 claims abstract description 27
- 241000186660 Lactobacillus Species 0.000 claims description 19
- 241000186606 Lactobacillus gasseri Species 0.000 claims description 19
- 229940039696 lactobacillus Drugs 0.000 claims description 19
- 241000590002 Helicobacter pylori Species 0.000 claims description 6
- 229940037467 helicobacter pylori Drugs 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 abstract description 9
- 206010061428 decreased appetite Diseases 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 235000013305 food Nutrition 0.000 abstract description 5
- 235000013336 milk Nutrition 0.000 description 25
- 239000008267 milk Substances 0.000 description 25
- 210000004080 milk Anatomy 0.000 description 25
- 235000013618 yogurt Nutrition 0.000 description 21
- 210000002784 stomach Anatomy 0.000 description 12
- 230000001737 promoting effect Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 230000014509 gene expression Effects 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 235000013861 fat-free Nutrition 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 235000013365 dairy product Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 101001076687 Lactobacillus gasseri Inulosucrase Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000020251 goat milk Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 235000020185 raw untreated milk Nutrition 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000725101 Clea Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 102000018997 Growth Hormone Human genes 0.000 description 1
- 108010051696 Growth Hormone Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 235000019393 L-cystine Nutrition 0.000 description 1
- 239000004158 L-cystine Substances 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241001134659 Lactobacillus curvatus Species 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000010806 PrimeScriptTM RT Reagent kit Methods 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 229960004874 choline bitartrate Drugs 0.000 description 1
- QWJSAWXRUVVRLH-UHFFFAOYSA-M choline bitartrate Chemical compound C[N+](C)(C)CCO.OC(=O)C(O)C(O)C([O-])=O QWJSAWXRUVVRLH-UHFFFAOYSA-M 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000005176 gastrointestinal motility Effects 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000020121 low-fat milk Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 235000020270 seed milk Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 1
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/145—Gasseri
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
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Abstract
Description
[1]ラクトバチルス属の乳酸菌を有効成分として含有することを特徴とする、グレリン分泌促進剤。
[2]前記ラクトバチルス属の乳酸菌が、ラクトバチルス・ガセリであることを特徴とする[1]に記載のグレリン分泌促進剤。
[3]前記ラクトバチルス属乳酸菌が、ラクトバチルス・ガセリOLL2716(FERM BP−6999)であることを特徴とする[1]又は[2]に記載のグレリン分泌促進剤。
[4]ヘリコバクター・ピロリの陰性者用であることを特徴とする[1]〜[3]のいずれかに記載のグレリン分泌促進剤。
[5][1]〜[4]のいずれか一つに記載のグレリン分泌促進剤を含む発酵乳。
[6]ラクトバチルス属の乳酸菌を用いて調製した発酵乳を対象に摂取させる工程を含む、グレリン分泌を促進させるための方法。
[7]ラクトバチルス属の乳酸菌が、ラクトバチルス・ガセリである、[6]に記載のグレリン分泌を促進させるための方法。
[8]ラクトバチルス・ガセリが、ラクトバチルス・ガセリOLL2716(FERM BP−6999)である、[6]又は[7]に記載のグレリン分泌を促進させるための方法。
[9]グレリン分泌促進剤の製造における、ラクトバチルス属の乳酸菌の使用。
[10]ラクトバチルス属の乳酸菌が、ラクトバチルス・ガセリである、[9]に記載の使用。
[11]ラクトバチルス・ガセリが、ラクトバチルス・ガセリOLL2716(FERM BP−6999)である、[9]又は[10]に記載の使用。
[12]グレリン分泌促進剤の製造に使用するための、ラクトバチルス属の乳酸菌。
[13]グレリン分泌促進剤の製造に使用するための、ラクトバチルス属の乳酸菌であるラクトバチルス・ガセリOLL2716(FERM BP−6999)。
ddyマウス(日本エスエルシー株式会社、4週齢、オス)12匹について、1週間の馴化期間後、コントロール群と、LG21ヨーグルト群の2群に分けた。コントロール群にはAIN−93M飼料(日本クレア株式会社、組成;コーンスターチ46.5692%、ミルクカゼイン14.0%、アルファ化コーンスターチ15.5%、グラニュー糖10.0%、精製大豆油4.0%、セルロースパウダー5.0%、ミネラルミックス(AIN-93M-MX)3.5%、ビタミンミックス(AIN-93VX)1.0%、L−シスチン0.18%、重酒石酸コリン0.25%、第3ブチルヒドロキノン 0.0008%)を4週間投与した。LG21ヨーグルト群には、1.11g/dayの投与量となるように、LG21ヨーグルト(株式会社明治が販売している「明治プロビオヨーグルトLG21」で、ラクトバチルス・ガセリOLL2716(FERM BP−6999)が含まれている)を混合したAIN−93M飼料を4週間給与した。4週間経過後、剖検し、血液と胃組織を採取した。
ICRマウス(日本エスエルシー株式会社、10週齢、オス)15匹を、1週間の馴化期間後、3群に分けた。5時間絶食後、1群をコントロール群として、生理食塩水500μLを投与し、剖検し、胃組織を採取した。その他の2群には、ラクトバチルス・ガセリOLL2716(FERM BP−6999)の生菌を2×1010cfu/mL含む生理食塩水500μLを投与し、投与後、1、2時間後に剖検し、胃組織を採取した。胃組織のグレリン遺伝子発現量を、実施例1と同様の方法で測定した。
Claims (5)
- ラクトバチルス属の乳酸菌を有効成分として含有することを特徴とする、グレリン分泌促進剤。
- 前記ラクトバチルス属の乳酸菌が、ラクトバチルス・ガセリであることを特徴とする請求項1に記載のグレリン分泌促進剤。
- 前記ラクトバチルス属乳酸菌が、ラクトバチルス・ガセリOLL2716(FERM BP−6999)であることを特徴とする請求項1又は2に記載のグレリン分泌促進剤。
- ヘリコバクター・ピロリの陰性者用であることを特徴とする請求項1〜3のいずれかに記載のグレリン分泌促進剤。
- 請求項1〜4のいずれか一項に記載のグレリン分泌促進剤を含む発酵乳。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016139372A JP6813974B2 (ja) | 2016-07-14 | 2016-07-14 | グレリン分泌促進剤 |
US16/316,078 US20210290699A1 (en) | 2016-07-14 | 2017-07-13 | Ghrelin secretion promotor |
CN202211713707.8A CN115918726A (zh) | 2016-07-14 | 2017-07-13 | 饥饿素分泌促进剂 |
CN201780043060.3A CN109715180B (zh) | 2016-07-14 | 2017-07-13 | 饥饿素分泌促进剂 |
PCT/JP2017/025506 WO2018012578A1 (ja) | 2016-07-14 | 2017-07-13 | グレリン分泌促進剤 |
SG11201900005YA SG11201900005YA (en) | 2016-07-14 | 2017-07-13 | Ghrelin secretion promotor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016139372A JP6813974B2 (ja) | 2016-07-14 | 2016-07-14 | グレリン分泌促進剤 |
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WO2012102277A1 (ja) * | 2011-01-25 | 2012-08-02 | 株式会社明治 | ガストリン産生抑制剤およびそれを含有する食品組成物 |
JP2014005225A (ja) * | 2012-06-22 | 2014-01-16 | National Institute Of Advanced Industrial & Technology | 食欲増進かつ体重増加抑制剤 |
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DK2123168T3 (da) * | 2008-05-16 | 2012-04-10 | Nestec Sa | Lactobacillus paracasei og vægtkontrol |
JP5116731B2 (ja) * | 2009-06-29 | 2013-01-09 | 株式会社明治 | 発酵乳の製造方法 |
JP2015205829A (ja) * | 2014-04-18 | 2015-11-19 | 雪印メグミルク株式会社 | ホルモン分泌促進剤 |
WO2015172191A1 (en) * | 2014-05-12 | 2015-11-19 | Medlab Ip Pty Ltd | Probiotic compositions and uses thereof for treatment of obesity-related disorders |
JP5950993B2 (ja) * | 2014-12-25 | 2016-07-13 | アサヒグループホールディングス株式会社 | 迷走神経活性化剤 |
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JP2009524640A (ja) * | 2006-01-27 | 2009-07-02 | ダニスコ エー/エス | 肥満及びそれに関連する疾患の治療及び予防のためのプロバイオティック微生物の使用 |
WO2012102277A1 (ja) * | 2011-01-25 | 2012-08-02 | 株式会社明治 | ガストリン産生抑制剤およびそれを含有する食品組成物 |
JP2014005225A (ja) * | 2012-06-22 | 2014-01-16 | National Institute Of Advanced Industrial & Technology | 食欲増進かつ体重増加抑制剤 |
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US20210290699A1 (en) | 2021-09-23 |
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CN109715180B (zh) | 2022-11-29 |
WO2018012578A1 (ja) | 2018-01-18 |
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