JP6777911B2 - 抗インフルエンザ薬による獲得免疫機能低下抑制用発酵乳およびその製造方法 - Google Patents
抗インフルエンザ薬による獲得免疫機能低下抑制用発酵乳およびその製造方法 Download PDFInfo
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- JP6777911B2 JP6777911B2 JP2016159824A JP2016159824A JP6777911B2 JP 6777911 B2 JP6777911 B2 JP 6777911B2 JP 2016159824 A JP2016159824 A JP 2016159824A JP 2016159824 A JP2016159824 A JP 2016159824A JP 6777911 B2 JP6777911 B2 JP 6777911B2
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/123—Bulgaricus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Description
本発明にかかる獲得免疫機能低下抑制用組成物は、有効成分としてラクトバチルス属乳酸菌による乳酸菌産生物を含んでいる。ここで、乳酸菌産生物には、乳酸菌発酵物、乳酸菌培養物、乳酸菌代謝物等が含まれる。乳酸菌発酵物とは、乳酸菌を用いて乳酸発酵を行った後に得られる結果物(培養物および生成物を含む)である。また、乳酸菌培養物は、乳酸菌の培養に適した培地の存在下で乳酸菌を培養して得られる結果物(培養物および生成物を含む)である。乳酸菌代謝物は、乳酸菌の代謝作用によって得られる結果物(生成物を含む)である。なお、乳酸菌発酵物と乳酸菌培養物とは、同一のものを意味する場合もあり、このような場合には、互いに言い換えて使用することもできる。
続いて、本発明にかかる獲得免疫機能低下抑制用組成物の製造方法について説明する。本発明の獲得免疫機能低下抑制用組成物の製造方法は、ラクトバチルス属乳酸菌に乳原料を供給するという工程を含む。使用するラクトバチルス属乳酸菌については、上記(1)で説明したものを採用することができる。
試験1では、ブルガリクス菌R−1株を用いて製造したヨーグルト(以下、「R−1ヨーグルト」と称する)を摂取することによる抗インフルエンザ特異的抗体量(IgA抗体およびIgG抗体)への影響を検証した。具体的には、R−1ヨーグルトを事前に投与したマウスと投与しなかったマウスとの間で、インフルエンザウイルスに軽微感染させた後に産生される抗体量に違いがあるか否かを検証した。
生乳、脱脂粉乳、クリーム、砂糖、ステビアを含む混合物に、ラクトバチルス・デルブルッキー・サブスピーシーズ・ブルガリクスOLL1073R−1菌(受託番号:FERM BP−10741)(以下では、「ブルガリクス菌R−1株」と称する)とサーモフィルス菌をスターターとして添加して発酵させ、ヨーグルトを製造した。
試験対象として、6週齢のメスのBALB/cマウス(日本SLC株式会社)を使用した。試験を行うにあたって、マウスを以下の4つのグループにグループ分けした。マウスは、各グループについて9匹または10匹使用した。
MC:超純水(R−1ヨーグルトの代替物)および0.5%メチルセルロース溶液を投与したコントロール群(R1群の比較対照群)
R1:R−1ヨーグルトおよび0.5%メチルセルロース溶液を投与した群
OSV:超純水および0.5%メチルセルロース溶液に溶解したオセルタミビルを投
与した群
OSV+R1:R−1ヨーグルトおよび0.5%メチルセルロース溶液に溶解したオセルタミビルを投与した群
上記(1−2)の各グループのマウスに対して、インフルエンザウイルスを0.5pfu(plaque−forming unit)/mouseで経鼻感染させた。使用したインフルエンザウイルスは、インフルエンザAウイルス(IAV)/Puerto Rico/8/1934(PR8)(H1N1)である(以下PR8と略称する)。
ウイルス感染から14日目に、ELISAにより抗インフルエンザ特異抗体価を評価した。具体的には、マウスの肺洗浄液中のIgAの抗体価、およびマウスの血清中のIgGの抗体価を評価した。
試験2では、上記の試験1の(1−3)で得られた各グループ(MC群、OSV群、R1群、OSV+R1群)のマウスから、鼻腔洗浄液を採取した。この鼻腔洗浄液50μLをインフルエンザウイルスPR8(100pfu)と中和させた。その後、MDCK細胞(イヌ腎由来細胞)に作用させ、16時間後に感染細胞数を計測することで、R−1ヨーグルトのインフルエンザウイルス感染の中和活性を評価した。
Claims (6)
- 有効成分として、ラクトバチルス・デルブルッキー・サブスピーシーズ・ブルガリクスOLL1073R−1菌(受託番号:FERM BP−10741)およびサーモフィルス菌による乳酸菌産生物を含み、抗インフルエンザ薬の使用による獲得免疫機能の低下を抑制する獲得免疫機能低下抑制用発酵乳。
- インフルエンザウイルスの感染抑制作用をさらに有している、請求項1に記載の獲得免疫機能低下抑制用発酵乳。
- インフルエンザウイルスに対する中和活性の向上作用を有する、請求項2に記載の獲得免疫機能低下抑制用発酵乳。
- 前記インフルエンザウイルスは、インフルエンザAウイルス(H1N1)である、請求項2または3に記載の獲得免疫機能低下抑制用発酵乳。
- 前記抗インフルエンザ薬は、ノイラミニダーゼ阻害活性を有するものである、請求項1から4の何れか1項に記載の獲得免疫機能低下抑制用発酵乳。
- ラクトバチルス・デルブルッキー・サブスピーシーズ・ブルガリクスOLL1073R−1菌(受託番号:FERM BP−10741)およびサーモフィルス菌をスターターとして乳原料に添加して発酵させることによって、抗インフルエンザ薬の使用による獲得免疫機能の低下を抑制するための獲得免疫機能低下抑制用発酵乳を製造する方法。
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JP2016159824A JP6777911B2 (ja) | 2016-08-17 | 2016-08-17 | 抗インフルエンザ薬による獲得免疫機能低下抑制用発酵乳およびその製造方法 |
PCT/JP2017/029355 WO2018034279A1 (ja) | 2016-08-17 | 2017-08-15 | 抗インフルエンザ薬による獲得免疫機能低下抑制用組成物およびその製造方法 |
SG11201900210PA SG11201900210PA (en) | 2016-08-17 | 2017-08-15 | Composition for controlling acquired immune function suppression due to anti-influenza drug, and production method for same |
US16/317,684 US20190150463A1 (en) | 2016-08-17 | 2017-08-15 | Composition for controlling acquired immune function suppression due to anti-influenza drug, and production method for same |
CN201780042693.2A CN109475585A (zh) | 2016-08-17 | 2017-08-15 | 用于抑制因抗流感药引起的获得性免疫功能降低的组合物及其制造方法 |
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