JP2017538711A - Ｇｌｐ−１レセプターモジュレーター - Google Patents

Ｇｌｐ−１レセプターモジュレーター Download PDF

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JP2017538711A
JP2017538711A JP2017531306A JP2017531306A JP2017538711A JP 2017538711 A JP2017538711 A JP 2017538711A JP 2017531306 A JP2017531306 A JP 2017531306A JP 2017531306 A JP2017531306 A JP 2017531306A JP 2017538711 A JP2017538711 A JP 2017538711A
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compound
compound according
chr
certain embodiments
alkyl
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JP2017531306A
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Japanese (ja)
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JP2017538711A5 (enExample
Inventor
マルクス エフ． ベーム，
マルクス エフ． ベーム，
エスター マーティンボロー，
エスター マーティンボロー，
マニシャ ムーアジャニ，
マニシャ ムーアジャニ，
淳子 田宮
淳子 田宮
リミン フアン，
リミン フアン，
アダム アール． イーガー，
アダム アール． イーガー，
エヌガーシ ブラーマチャリー，
エヌガーシ ブラーマチャリー，
トーマス フォウラー，
トーマス フォウラー，
アンドリュー ノバク，
アンドリュー ノバク，
プレムジ メガーニ，
プレムジ メガーニ，
マイケル ナッグス，
マイケル ナッグス，
ダニエル グリン，
ダニエル グリン，
マーク ミルズ，
マーク ミルズ，
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Celgene International II SARL
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Celgene International II SARL
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Publication of JP2017538711A publication Critical patent/JP2017538711A/ja
Publication of JP2017538711A5 publication Critical patent/JP2017538711A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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