JP2017537888A5 - - Google Patents
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- Publication number
- JP2017537888A5 JP2017537888A5 JP2017522654A JP2017522654A JP2017537888A5 JP 2017537888 A5 JP2017537888 A5 JP 2017537888A5 JP 2017522654 A JP2017522654 A JP 2017522654A JP 2017522654 A JP2017522654 A JP 2017522654A JP 2017537888 A5 JP2017537888 A5 JP 2017537888A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- fusion protein
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 42
- 102000037240 fusion proteins Human genes 0.000 claims 30
- 108020001507 fusion proteins Proteins 0.000 claims 30
- 229940024142 alpha 1-Antitrypsin Drugs 0.000 claims 16
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 16
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 102000018358 Immunoglobulins Human genes 0.000 claims 6
- 108060003951 Immunoglobulins Proteins 0.000 claims 6
- 200000000018 inflammatory disease Diseases 0.000 claims 6
- 239000003001 serine protease inhibitor Substances 0.000 claims 6
- 201000009910 diseases by infectious agent Diseases 0.000 claims 5
- 102100001249 ALB Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 101710027066 ALB Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 229940050528 albumin Drugs 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims 1
- 206010053555 Arthritis bacterial Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010060945 Bacterial infection Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 206010018651 Graft versus host disease Diseases 0.000 claims 1
- 206010061255 Ischaemia Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000010125 Myocardial Infarction Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 206010047461 Viral infection Diseases 0.000 claims 1
- 208000001756 Virus Disease Diseases 0.000 claims 1
- 230000001594 aberrant Effects 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 201000001263 psoriatic arthritis Diseases 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/524,832 | 2014-10-27 | ||
| US14/524,832 US10400029B2 (en) | 2011-06-28 | 2014-10-27 | Serpin fusion polypeptides and methods of use thereof |
| PCT/US2015/057533 WO2016069574A1 (en) | 2014-10-27 | 2015-10-27 | Serpin fusion polypeptides and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121953A Division JP2020180157A (ja) | 2014-10-27 | 2020-07-16 | セルピン融合ポリペプチド及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537888A JP2017537888A (ja) | 2017-12-21 |
| JP2017537888A5 true JP2017537888A5 (ru) | 2018-10-25 |
| JP6737781B2 JP6737781B2 (ja) | 2020-08-12 |
Family
ID=55858243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522654A Active JP6737781B2 (ja) | 2014-10-27 | 2015-10-27 | セルピン融合ポリペプチド及びその使用方法 |
| JP2020121953A Pending JP2020180157A (ja) | 2014-10-27 | 2020-07-16 | セルピン融合ポリペプチド及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121953A Pending JP2020180157A (ja) | 2014-10-27 | 2020-07-16 | セルピン融合ポリペプチド及びその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP3212290A4 (ru) |
| JP (2) | JP6737781B2 (ru) |
| KR (2) | KR20170091096A (ru) |
| CN (2) | CN114316068A (ru) |
| AU (2) | AU2015339507B2 (ru) |
| BR (1) | BR112017008525A2 (ru) |
| CA (1) | CA2965151A1 (ru) |
| HK (1) | HK1244460A1 (ru) |
| IL (2) | IL251799B2 (ru) |
| MX (2) | MX2017005467A (ru) |
| RU (1) | RU2746550C2 (ru) |
| SG (2) | SG11201703390SA (ru) |
| UA (1) | UA127305C2 (ru) |
| WO (1) | WO2016069574A1 (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210388059A1 (en) * | 2018-10-29 | 2021-12-16 | Spin Therapeutics, Llc | Compositions and methods for alpha-1-antitrypsin disorders |
| CN111989340A (zh) * | 2018-11-18 | 2020-11-24 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素10融合蛋白及其应用 |
| CN112315897A (zh) * | 2020-11-04 | 2021-02-05 | 深圳前海鹰岗生物科技有限公司 | 一种抑制细胞炎症反应释放治疗痛风急性发作的聚合物微针及制备方法 |
| US20240067703A1 (en) * | 2020-12-21 | 2024-02-29 | Macquarie University | Treatment of glaucoma |
| GB202102258D0 (en) | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
| AU2022230745A1 (en) * | 2021-03-03 | 2023-08-17 | Formycon Ag | Formulations of ace2 fc fusion proteins |
| CN113325181A (zh) * | 2021-04-25 | 2021-08-31 | 苏州市立医院(北区) | 丝氨酸蛋白酶抑制剂在用于脓毒症早期预警的标志物中的应用 |
| CN114874333A (zh) * | 2021-10-18 | 2022-08-09 | 深圳科兴药业有限公司 | 一种生长激素融合蛋白及其应用 |
| US20230364208A1 (en) | 2022-05-16 | 2023-11-16 | Inhibrx, Inc. | Effective dosage of recombinant serpin-fc fusion protein for use in a method of treating aat deficiency in a subject |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002537810A (ja) * | 1999-03-01 | 2002-11-12 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ヒトセルピンタンパク質 |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP4745230B2 (ja) * | 2003-07-18 | 2011-08-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特に、ｈｃｖｎｓ３−ｎｓ４ａプロテアーゼの阻害剤 |
| EP1660094A4 (en) * | 2003-08-26 | 2009-09-16 | Univ Colorado | INHIBITORS OF SERINE PROTEASE ACTIVITY AND USES THEREOF IN METHODS AND PREPARATIONS FOR TREATING BACTERIAL INFECTIONS |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP2845865A1 (en) * | 2004-11-12 | 2015-03-11 | Xencor Inc. | Fc variants with altered binding to FcRn |
| AU2006272759B2 (en) * | 2005-07-22 | 2012-01-12 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| AU2006280004A1 (en) * | 2005-08-12 | 2007-02-22 | Schering Corporation | MCP1 fusions |
| EP2671891A3 (en) * | 2008-06-27 | 2014-03-05 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| SG10201407908VA (en) * | 2008-12-19 | 2015-01-29 | Macrogenics Inc | Covalent diabodies and uses thereof |
| PT2654780T (pt) * | 2010-12-23 | 2017-04-06 | Janssen Biotech Inc | Mutantes ativos de fc de anticorpos resistentes a proteases |
| US8969526B2 (en) * | 2011-03-29 | 2015-03-03 | Roche Glycart Ag | Antibody Fc variants |
| JP2014528913A (ja) * | 2011-06-28 | 2014-10-30 | インヒブルクス リミティド ライアビリティ カンパニー | Ｗａｐドメイン融合ポリペプチド及びその使用方法 |
| MX356517B (es) * | 2011-06-28 | 2018-06-01 | Inhibrx Llc | Polipéptidos de fusión de serpina y métodos de uso de los mismos. |
| KR102348985B1 (ko) * | 2012-01-10 | 2022-01-12 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| JP2015531748A (ja) * | 2012-06-21 | 2015-11-05 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | 改変ｆｃエフェクター機能を有するインクレチン受容体リガンドポリペプチドｆｃ領域融合ポリペプチド及び複合物 |
| BR112014028368A2 (pt) * | 2012-06-27 | 2017-11-14 | Hoffmann La Roche | método de produção de conjugado de região fc de anticorpo, conjugado de região fc de anticorpo e formulação farmacêutica |
| DK2880170T3 (en) * | 2012-08-02 | 2016-10-24 | Hoffmann La Roche | PROCEDURE FOR PREPARING SOLUBLE FcR AS Fc FUSION WITH INERT IMMUNOGLOBULIN Fc REGION AND APPLICATIONS THEREOF |
| US9758807B2 (en) * | 2012-12-05 | 2017-09-12 | SOLA Biosciences, LLC | Protein expression enhancing polypeptides |
-
2015
- 2015-10-27 EP EP15854670.5A patent/EP3212290A4/en active Pending
- 2015-10-27 KR KR1020177014414A patent/KR20170091096A/ko not_active IP Right Cessation
- 2015-10-27 JP JP2017522654A patent/JP6737781B2/ja active Active
- 2015-10-27 SG SG11201703390SA patent/SG11201703390SA/en unknown
- 2015-10-27 CN CN202111439584.9A patent/CN114316068A/zh active Pending
- 2015-10-27 KR KR1020237043666A patent/KR20240005109A/ko active Application Filing
- 2015-10-27 WO PCT/US2015/057533 patent/WO2016069574A1/en active Application Filing
- 2015-10-27 IL IL251799A patent/IL251799B2/en unknown
- 2015-10-27 CA CA2965151A patent/CA2965151A1/en active Pending
- 2015-10-27 CN CN201580071331.7A patent/CN107206257A/zh active Pending
- 2015-10-27 SG SG10201903142RA patent/SG10201903142RA/en unknown
- 2015-10-27 RU RU2017118325A patent/RU2746550C2/ru active
- 2015-10-27 AU AU2015339507A patent/AU2015339507B2/en active Active
- 2015-10-27 MX MX2017005467A patent/MX2017005467A/es unknown
- 2015-10-27 BR BR112017008525-9A patent/BR112017008525A2/pt active Search and Examination
- 2015-10-27 IL IL308589A patent/IL308589A/en unknown
- 2015-10-27 UA UAA201705128A patent/UA127305C2/uk unknown
-
2017
- 2017-04-26 MX MX2021012047A patent/MX2021012047A/es unknown
-
2018
- 2018-03-05 HK HK18103148.5A patent/HK1244460A1/zh unknown
-
2020
- 2020-07-16 JP JP2020121953A patent/JP2020180157A/ja active Pending
-
2021
- 2021-09-28 AU AU2021240153A patent/AU2021240153A1/en active Pending
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