JP2017537165A5 - - Google Patents
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- Publication number
- JP2017537165A5 JP2017537165A5 JP2017548369A JP2017548369A JP2017537165A5 JP 2017537165 A5 JP2017537165 A5 JP 2017537165A5 JP 2017548369 A JP2017548369 A JP 2017548369A JP 2017548369 A JP2017548369 A JP 2017548369A JP 2017537165 A5 JP2017537165 A5 JP 2017537165A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- max
- target
- solabegron
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- LLDXOPKUNJTIRF-QFIPXVFZSA-N solabegron Chemical compound C([C@H](O)C=1C=C(Cl)C=CC=1)NCCNC(C=1)=CC=CC=1C1=CC=CC(C(O)=O)=C1 LLDXOPKUNJTIRF-QFIPXVFZSA-N 0.000 claims description 19
- 229950009659 solabegron Drugs 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 10
- 238000013268 sustained release Methods 0.000 claims description 5
- 239000012730 sustained-release form Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 87
- 238000011282 treatment Methods 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 208000019901 Anxiety disease Diseases 0.000 claims 5
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 5
- 208000008589 Obesity Diseases 0.000 claims 5
- 230000036506 anxiety Effects 0.000 claims 5
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 5
- 239000002677 5-alpha reductase inhibitor Substances 0.000 claims 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 4
- 108030001720 Bontoxilysin Proteins 0.000 claims 4
- 229930003827 cannabinoid Natural products 0.000 claims 4
- 239000003557 cannabinoid Substances 0.000 claims 4
- 238000012377 drug delivery Methods 0.000 claims 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 4
- 239000003149 muscarinic antagonist Substances 0.000 claims 4
- 230000007383 nerve stimulation Effects 0.000 claims 4
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 4
- 150000003180 prostaglandins Chemical class 0.000 claims 4
- 239000012268 protein inhibitor Substances 0.000 claims 4
- 229940121649 protein inhibitor Drugs 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 210000002972 tibial nerve Anatomy 0.000 claims 4
- 230000001052 transient effect Effects 0.000 claims 4
- 206010020853 Hypertonic bladder Diseases 0.000 claims 3
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 3
- 208000005107 Premature Birth Diseases 0.000 claims 3
- 206010036590 Premature baby Diseases 0.000 claims 3
- 229940053031 botulinum toxin Drugs 0.000 claims 3
- 229940065144 cannabinoids Drugs 0.000 claims 3
- 208000020629 overactive bladder Diseases 0.000 claims 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 3
- 108010084938 adenovirus receptor Proteins 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000001022 anti-muscarinic effect Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 230000027939 micturition Effects 0.000 claims 2
- 239000008188 pellet Substances 0.000 claims 2
- 208000017497 prostate disease Diseases 0.000 claims 2
- 239000003422 purinergic receptor affecting agent Substances 0.000 claims 2
- 229940113178 5 Alpha reductase inhibitor Drugs 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010029446 nocturia Diseases 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 206010071289 Lower urinary tract symptoms Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462087021P | 2014-12-03 | 2014-12-03 | |
| US62/087,021 | 2014-12-03 | ||
| PCT/US2015/063795 WO2016090168A1 (en) | 2014-12-03 | 2015-12-03 | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537165A JP2017537165A (ja) | 2017-12-14 |
| JP2017537165A5 true JP2017537165A5 (https=) | 2019-01-10 |
Family
ID=56092482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548369A Ceased JP2017537165A (ja) | 2014-12-03 | 2015-12-03 | 下部尿路系症状を対象とした徐放性ソラベグロンの組成物及び使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9956194B2 (https=) |
| EP (1) | EP3226849A4 (https=) |
| JP (1) | JP2017537165A (https=) |
| KR (1) | KR20170086659A (https=) |
| CN (1) | CN107205964A (https=) |
| AU (1) | AU2015358378A1 (https=) |
| CA (1) | CA2969405A1 (https=) |
| EA (1) | EA201791225A1 (https=) |
| HK (1) | HK1245117A1 (https=) |
| IL (1) | IL252628A0 (https=) |
| MX (1) | MX2017007054A (https=) |
| WO (1) | WO2016090168A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| CN107205964A (zh) | 2014-12-03 | 2017-09-26 | 威力塞帕特治疗股份有限公司 | 使用调节释放索拉贝隆用于下尿路症状的组合物和方法 |
| CN108290824B (zh) | 2015-10-23 | 2022-03-11 | B3Ar治疗股份有限公司 | 索拉贝隆两性离子及其应用 |
| WO2017210700A1 (en) * | 2016-06-03 | 2017-12-07 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
| BR112019004935A2 (pt) | 2016-09-13 | 2019-06-04 | Allergan, Inc. | composições de toxina clostridial não proteíca estabilizada |
| EP4410295A3 (en) | 2017-06-06 | 2024-10-16 | Urovant Sciences GmbH | Use of vibegron to treat overactive bladder |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| KR102940911B1 (ko) | 2018-12-05 | 2026-03-17 | 유로반트 사이언시즈 게엠베하 | 과민성 방광 증상의 치료를 위한 비베그론 |
| US20240197660A1 (en) * | 2021-03-31 | 2024-06-20 | B3Ar Therapeutics, Inc. | Compositions of micronized solabegron and methods of use |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (71)
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| NL267508A (https=) | 1960-07-26 | |||
| EP0006735B1 (en) | 1978-06-28 | 1983-06-15 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
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| JPH0236571B2 (ja) * | 1986-04-11 | 1990-08-17 | Otsuka Pharma Co Ltd | Jizokuseiseizai |
| DE3934436A1 (de) | 1989-06-01 | 1991-04-18 | Thomae Gmbh Dr K | 2-hydroxy-n-propylamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5061727A (en) | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
| NO179246C (no) | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
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| DE10352132A1 (de) | 2003-11-04 | 2005-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten |
| JP4838724B2 (ja) | 2003-11-27 | 2011-12-14 | デヴェロゲン アクチエンゲゼルシャフト | ニュールツリンを用いる糖尿病の予防と治療方法 |
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| WO2006042679A1 (de) | 2004-10-18 | 2006-04-27 | Boehringer Ingelheim International Gmbh | Verwendung eines beta-3-agonisten zur behandlung von beschwerden der prostata und des unteren urogenitaltrakts |
| CA2606207C (en) | 2005-04-19 | 2014-11-18 | Smithkline Beecham (Cork) Limited | Pharmaceutical composition |
| JP2008546781A (ja) * | 2005-06-20 | 2008-12-25 | エラン・ファルマ・インターナショナル・リミテッド | アリール−複素環式化合物を含んでなるナノ粒状及び制御放出の組成物 |
| EP1769792A1 (de) | 2005-09-30 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verwendung eines beta-3-Adrenozeptor-Agonisten zur Behandlung von Nieren- und Blasenbeschwerden |
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| EP1967202A1 (en) | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
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| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
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| EA201590449A1 (ru) | 2012-08-31 | 2015-06-30 | Астеллас Фарма Инк. | Перорально вводимая лекарственная композиция |
| US20150306170A1 (en) | 2012-11-21 | 2015-10-29 | Ferring B.V. | Composition for immediate and extended release |
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| WO2014171542A1 (ja) * | 2013-04-19 | 2014-10-23 | 武田薬品工業株式会社 | 放出制御製剤 |
| KR20160033220A (ko) | 2013-07-23 | 2016-03-25 | 알러간, 인코포레이티드 | 베타-3-아드레날린 수용체 작용제와 함께 데스모프레신을 포함하는 방법 및 조성물 |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| JP2017078023A (ja) | 2014-02-28 | 2017-04-27 | アステラス製薬株式会社 | 経口投与用医薬組成物 |
| CN107205964A (zh) | 2014-12-03 | 2017-09-26 | 威力塞帕特治疗股份有限公司 | 使用调节释放索拉贝隆用于下尿路症状的组合物和方法 |
| CN108290824B (zh) | 2015-10-23 | 2022-03-11 | B3Ar治疗股份有限公司 | 索拉贝隆两性离子及其应用 |
| EP3448366A1 (en) | 2016-04-25 | 2019-03-06 | Synthon B.V. | Modified release tablet composition comprising mirabegron |
| WO2017210700A1 (en) | 2016-06-03 | 2017-12-07 | Velicept Therapeutics, Inc. | Compositions and methods of using modified release solabegron for lower urinary tract symptoms |
| WO2017210696A1 (en) | 2016-06-03 | 2017-12-07 | Velicept Therapeutics, Inc. | Dosing regimens for beta-3 adrenoceptor agonists and anti-muscarinic agents for the treatment and prevention of lower urinary tract symptoms and overactive bladder |
-
2015
- 2015-12-03 CN CN201580074649.0A patent/CN107205964A/zh active Pending
- 2015-12-03 WO PCT/US2015/063795 patent/WO2016090168A1/en not_active Ceased
- 2015-12-03 HK HK18104631.7A patent/HK1245117A1/zh unknown
- 2015-12-03 US US14/958,610 patent/US9956194B2/en active Active
- 2015-12-03 CA CA2969405A patent/CA2969405A1/en not_active Abandoned
- 2015-12-03 MX MX2017007054A patent/MX2017007054A/es unknown
- 2015-12-03 EA EA201791225A patent/EA201791225A1/ru unknown
- 2015-12-03 JP JP2017548369A patent/JP2017537165A/ja not_active Ceased
- 2015-12-03 EP EP15865588.6A patent/EP3226849A4/en not_active Withdrawn
- 2015-12-03 AU AU2015358378A patent/AU2015358378A1/en not_active Abandoned
- 2015-12-03 KR KR1020177018393A patent/KR20170086659A/ko not_active Withdrawn
-
2017
- 2017-06-01 IL IL252628A patent/IL252628A0/en unknown
-
2018
- 2018-04-12 US US15/951,953 patent/US20190083433A1/en not_active Abandoned
- 2018-04-12 US US15/951,968 patent/US10751311B2/en active Active
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