|
US4603203A
(en)
|
1983-12-14 |
1986-07-29 |
Takeda Chemical Industries, Ltd. |
3-aminopyrazolo[3,4-d]pyrimidine derivatives and production thereof
|
|
CA1251448A
(en)
|
1985-03-27 |
1989-03-21 |
William J. Coates |
Pyridazinone derivatives
|
|
US4666908A
(en)
|
1985-04-05 |
1987-05-19 |
Warner-Lambert Company |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
|
|
DE59009485D1
(de)
|
1989-01-26 |
1995-09-14 |
Bayer Ag |
Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
|
|
NZ238609A
(en)
|
1990-06-21 |
1993-12-23 |
Schering Corp |
Polycyclic guanine derivatives; preparation, pharmaceutical compositions,
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
HUT72640A
(en)
|
1993-02-26 |
1996-05-28 |
Schering Corp |
2-benzyl-polycyclic guanine derivatives, pharmaceutical compositions containing them and process for preparing them
|
|
DE19541264A1
(de)
|
1995-11-06 |
1997-05-07 |
Bayer Ag |
Purin-6-on-derivate
|
|
US5824683A
(en)
|
1995-11-28 |
1998-10-20 |
Schering Corporation |
2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones
|
|
DE19702785A1
(de)
|
1997-01-27 |
1998-07-30 |
Bayer Ag |
Neue cyclische Harnstoffderivate
|
|
SE9701398D0
(sv)
|
1997-04-15 |
1997-04-15 |
Astra Pharma Prod |
Novel compounds
|
|
IT1291372B1
(it)
|
1997-05-21 |
1999-01-07 |
Schering Plough S P A |
Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
|
|
US6013621A
(en)
|
1997-10-17 |
2000-01-11 |
The Rockfeller University |
Method of treating psychosis and/or hyperactivity
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
DE19931206A1
(de)
|
1999-07-07 |
2001-01-11 |
Stief Christian |
Arzneimittel zur Erhöhung des cAMP-Spiegels und deren Verwendung
|
|
AU7547900A
(en)
|
1999-10-11 |
2001-04-23 |
Pfizer Inc. |
5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo(4,3-d)pyrimidin-7-ones as phosphodiesterase inhibitors
|
|
IL139073A0
(en)
|
1999-10-21 |
2001-11-25 |
Pfizer |
Treatment of neuropathy
|
|
US20020006926A1
(en)
|
2000-04-19 |
2002-01-17 |
Roylance H. H. |
Use of cyclic GMP-specific phosphodiesterase inhibitors for treatment of parkinson's disease
|
|
EP1307201B1
(de)
|
2000-08-01 |
2004-11-24 |
Bayer HealthCare AG |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
DE10064105A1
(de)
|
2000-12-21 |
2002-06-27 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
DE10108752A1
(de)
|
2001-02-23 |
2002-09-05 |
Bayer Ag |
Neue Substituierte Imidazotriazinone
|
|
SE0102315D0
(sv)
|
2001-06-28 |
2001-06-28 |
Astrazeneca Ab |
Compounds
|
|
ATE395349T1
(de)
|
2001-08-28 |
2008-05-15 |
Schering Corp |
Polycyclische guanin phosphodiesterase inhibitoren
|
|
AU2002324846B2
(en)
|
2001-08-31 |
2007-05-10 |
Childrens Hospital Medical Center |
Phosphodiesterase activity and regulation of phosphodiesterase 1-B-mediated signaling in brain
|
|
CA2465893A1
(en)
|
2001-11-09 |
2003-05-22 |
Schering Corporation |
Polycyclic guanine derivative phosphodiesterase v inhibitors
|
|
CA2477253A1
(en)
|
2002-02-21 |
2003-09-04 |
The Rockefeller University |
Compositions and method for regulation of calcium-dependent signalling in brain
|
|
ES2315546T3
(es)
|
2002-10-30 |
2009-04-01 |
Via Pharmaceuticals, Inc. |
Inhibidores delas fosfodiesterasas de los nucleotidos ciclicos, que presentan una estructura de benzodiazepina, y su uso en terapia.
|
|
EP1559716B1
(en)
|
2002-11-06 |
2011-09-14 |
ASKA Pharmaceutical Co., Ltd. |
Pyrazolonaphthyridine derivative
|
|
US20060106037A1
(en)
|
2003-03-04 |
2006-05-18 |
Thomas Bar |
Purin-6-one-derivatives
|
|
EP1613747A1
(en)
|
2003-03-31 |
2006-01-11 |
Pfizer Products Inc. |
Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
|
EA200501548A1
(ru)
|
2003-04-01 |
2006-02-24 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Ингибиторы фосфодиэстераз при бесплодии
|
|
US7268133B2
(en)
*
|
2003-04-23 |
2007-09-11 |
Pfizer, Inc. Patent Department |
Cannabinoid receptor ligands and uses thereof
|
|
WO2005041957A1
(en)
|
2003-10-29 |
2005-05-12 |
Pfizer Products Inc. |
Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
|
|
ES2299888T3
(es)
|
2003-12-16 |
2008-06-01 |
Pfizer Products Incorporated |
Pirid (2,3-d)pirimidin-2,4-diaminas como inhibidores de pde 2.
|
|
EP1548011A1
(en)
|
2003-12-23 |
2005-06-29 |
Neuro3D |
Benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof
|
|
WO2005083069A1
(en)
*
|
2004-01-30 |
2005-09-09 |
Pfizer Products Inc. |
Pde2 crystal structures for structure based drug design
|
|
DE602005021894D1
(de)
|
2004-09-02 |
2010-07-29 |
Nycomed Gmbh |
Triazolophthalazine
|
|
EP1874775B1
(en)
|
2005-01-05 |
2012-10-10 |
Nycomed GmbH |
Triazolophthalazines as pde2-inhibitors
|
|
WO2006072615A2
(en)
|
2005-01-05 |
2006-07-13 |
Nycomed Gmbh |
Triazolophthalazines as pde2-inhibitors
|
|
DOP2006000009A
(es)
*
|
2005-01-13 |
2006-08-15 |
Arena Pharm Inc |
Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
|
|
JP5084725B2
(ja)
|
2005-06-06 |
2012-11-28 |
武田薬品工業株式会社 |
有機化合物
|
|
EP1749824A1
(en)
|
2005-08-03 |
2007-02-07 |
Neuro3D |
Benzodiazepine derivatives, their preparation and the therapeutic use thereof
|
|
US20080194592A1
(en)
|
2005-08-23 |
2008-08-14 |
Intra-Cellular Therapies, Inc. |
Organic Compounds
|
|
WO2007032466A1
(ja)
|
2005-09-15 |
2007-03-22 |
Aska Pharmaceutical Co., Ltd. |
複素環化合物、その製造方法並びに用途
|
|
CA2625153A1
(en)
|
2005-10-21 |
2007-04-26 |
Braincells, Inc. |
Modulation of neurogenesis by pde inhibition
|
|
CA2651519A1
(en)
|
2006-06-06 |
2007-12-13 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
JP2010509399A
(ja)
|
2006-11-13 |
2010-03-25 |
イントラ−セルラー・セラピーズ・インコーポレイテッド |
有機化合物
|
|
EP2089034A4
(en)
|
2006-12-05 |
2010-07-28 |
Intra Cellular Therapies Inc |
NEW USES
|
|
AU2008249750B2
(en)
|
2007-05-11 |
2011-07-14 |
Pfizer Inc. |
Amino-heterocyclic compounds
|
|
US7807629B1
(en)
|
2007-06-05 |
2010-10-05 |
Alcon Research, Ltd. |
Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma
|
|
US8846693B2
(en)
|
2007-12-06 |
2014-09-30 |
Intra-Cellular Therapies, Inc. |
Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones
|
|
CN104370922A
(zh)
|
2007-12-06 |
2015-02-25 |
武田药品工业株式会社 |
有机化合物
|
|
WO2010062366A1
(en)
|
2008-10-31 |
2010-06-03 |
Arginetix, Inc. |
Compositions and methods of treating endothelial disorders
|
|
WO2010054260A1
(en)
|
2008-11-07 |
2010-05-14 |
Biotie Therapies Gmbh |
Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
|
|
US20100120762A1
(en)
|
2008-11-07 |
2010-05-13 |
Wyeth |
Triazine derivatives as inhibitors of phosphodiesterases
|
|
EP2358723B1
(en)
|
2008-12-06 |
2015-05-13 |
Intra-Cellular Therapies, Inc. |
4,5,7,8-tetrahydro-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine compounds as PDE1 inhibitors
|
|
US8859564B2
(en)
|
2008-12-06 |
2014-10-14 |
Intra-Cellular Therapies, Inc. |
Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1
|
|
CN102238873A
(zh)
|
2008-12-06 |
2011-11-09 |
细胞内治疗公司 |
有机化合物
|
|
AU2009322900A1
(en)
|
2008-12-06 |
2010-06-10 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
SG171775A1
(en)
|
2008-12-06 |
2011-07-28 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
EP2367431B1
(en)
|
2008-12-06 |
2015-08-05 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
US11464781B2
(en)
|
2009-02-25 |
2022-10-11 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitors for ophthalmic disorders
|
|
WO2010132127A1
(en)
|
2009-05-13 |
2010-11-18 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
US8680116B2
(en)
|
2009-07-22 |
2014-03-25 |
Merck Sharp & Dohme Corp. |
Quinolinone PDE2 inhibitors
|
|
EP2485771A4
(en)
|
2009-10-08 |
2014-11-12 |
Intra Cellular Therapies Inc |
TRACER AND METHODS TAGGED ON PHOSPHODIESTERASE 1
|
|
EP2490693A4
(en)
|
2009-10-19 |
2013-02-27 |
Merck Sharp & Dohme |
Pyrazolo [3,4-B] PYRIDINE-4-ON-KINASE INHIBITORS
|
|
WO2011153136A1
(en)
|
2010-05-31 |
2011-12-08 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
|
TW201206937A
(en)
|
2010-05-31 |
2012-02-16 |
Intra Cellular Therapies Inc |
Organic compounds
|
|
US9371327B2
(en)
|
2010-05-31 |
2016-06-21 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitor compounds
|
|
US9763948B2
(en)
|
2010-05-31 |
2017-09-19 |
Intra-Cellular Therapies, Inc. |
PDE1 inhibitory compounds and methods
|
|
US9540379B2
(en)
|
2011-01-31 |
2017-01-10 |
Boehringer Ingelheim International Gmbh |
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
|
|
BR112013021366A2
(pt)
|
2011-02-23 |
2016-09-13 |
Pfizer |
imidazo[5,1-f][1,2,4]triazinas para o tratamento de desordens neurológicas
|
|
SG195085A1
(en)
|
2011-06-07 |
2013-12-30 |
Pfizer |
Pyrazolo[3,4-d]pyrimidine compounds and their use as pde2 inhibitors and/or cyp3a4 inhibitors
|
|
JP6051210B2
(ja)
|
2011-06-10 |
2016-12-27 |
イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． |
有機化合物
|
|
EP2723744B1
(en)
|
2011-06-27 |
2016-03-23 |
Janssen Pharmaceutica, N.V. |
1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
|
|
WO2013034758A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Substituted triazolopyrazines and uses thereof
|
|
US9056863B2
(en)
|
2011-09-09 |
2015-06-16 |
H. Lundbeck A/S |
Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
|
|
WO2013034755A1
(en)
|
2011-09-09 |
2013-03-14 |
H. Lundbeck A/S |
Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
|
|
AR091507A1
(es)
|
2012-06-21 |
2015-02-11 |
Intra Cellular Therapies Inc |
SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA
|
|
KR102240326B1
(ko)
|
2013-03-15 |
2021-04-13 |
인트라-셀룰라 써래피스, 인코퍼레이티드. |
유기 화합물
|
|
WO2014154586A1
(en)
|
2013-03-25 |
2014-10-02 |
Sanofi |
Pyrazolonaphthyridinone derivatives as metap2 inhibitors (methionine aminopeptidase type-2)
|
|
US9546175B2
(en)
|
2014-08-07 |
2017-01-17 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|