|
JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
ES2068705T3
(es)
|
1991-01-16 |
1995-04-16 |
Schering Corp |
Tratamiento de la enfermedad neoplastica con interleuquina-10.
|
|
EP0567586B1
(en)
|
1991-01-16 |
1995-07-12 |
Schering Corporation |
Use of interleukin-10 in adoptive immunotherapy of cancer
|
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
JPH08510719A
(ja)
|
1993-02-01 |
1996-11-12 |
ユニヴェルシテ リブル ドゥ ブリュッセル アンスティテュション ダンセニュマン ユニヴェルシテル |
有効量のインターロイキン−１０、その類似体および／または作動薬を含有する医薬組成物の使用
|
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
|
US5552303A
(en)
*
|
1993-03-08 |
1996-09-03 |
Immunex Corporation |
DNA encoding epithelium-derived T-cell factor
|
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
|
NZ269663A
(en)
|
1993-07-26 |
1997-09-22 |
Schering Corp |
Agonists and antagonists of il-10
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
WO1995019780A1
(en)
|
1994-01-20 |
1995-07-27 |
Schering Corporation |
Use of il-10 to stimulate peripheral blood mononuclear cell cytolytic activity
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US7008624B1
(en)
*
|
1995-02-22 |
2006-03-07 |
Immunex Corporation |
Antagonists of interleukin-15
|
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
CA2252557A1
(en)
*
|
1996-04-26 |
1997-11-06 |
Beth Israel Deaconess Medical Center, Inc. |
Antagonists of interleukin-15
|
|
US5945097A
(en)
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
|
EP1012184B1
(en)
|
1997-07-14 |
2007-10-10 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
WO2001005821A2
(en)
|
1999-07-16 |
2001-01-25 |
Maria Teresa Bejarano |
Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis
|
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
|
AU2001231532A1
(en)
|
2000-02-11 |
2001-08-20 |
Maxygen Aps |
Improved interleukin 10
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
ATE516820T1
(de)
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
|
US7611700B2
(en)
|
2002-09-09 |
2009-11-03 |
Hanall Pharmaceuticals, Co., Ltd. |
Protease resistant modified interferon alpha polypeptides
|
|
WO2004044006A1
(en)
|
2002-11-14 |
2004-05-27 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
|
AU2003292137A1
(en)
|
2002-11-29 |
2004-06-23 |
Maria Grazia Roncarolo |
Rapamycin and il-10 for the treatment of immune diseases
|
|
WO2004056850A2
(en)
|
2002-12-19 |
2004-07-08 |
Vib Vzw |
Mutant proteins showing increased secretion
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
CA2511815A1
(en)
|
2002-12-26 |
2004-07-22 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
|
ES2396368T3
(es)
|
2003-03-03 |
2013-02-21 |
Dyax Corporation |
Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
|
|
EP1613274B1
(en)
|
2003-04-15 |
2010-03-03 |
GlaxoSmithKline LLC |
Human il-18 substitution mutants and their conjugates
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
WO2005007121A2
(en)
*
|
2003-07-18 |
2005-01-27 |
Massachusetts Institute Of Technology |
Mutant interleukin-2(il-2) polypeptides
|
|
AU2004293499B2
(en)
|
2003-11-28 |
2009-11-26 |
The University Of Sydney |
Latent phase viral interleukin-10-(VII-10) and uses thereof
|
|
EP1718670B1
(en)
*
|
2004-02-27 |
2011-07-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Il-15 binding site for il 15-ralpha and specific il-15 mutants having agonist/antagonist activity
|
|
DE202005021885U1
(de)
|
2004-03-11 |
2011-03-03 |
Fresenius Kabi Deutschland Gmbh |
Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt
|
|
TW200619227A
(en)
*
|
2004-08-11 |
2006-06-16 |
Hoffmann La Roche |
Mutant interleukin-15-containing compositions and suppression of an immune response
|
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
|
UY29460A1
(es)
|
2005-04-08 |
2006-11-30 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
|
US20100028296A1
(en)
|
2005-05-02 |
2010-02-04 |
Chavez Raymond A |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
|
DE602006011311D1
(de)
|
2005-05-31 |
2010-02-04 |
Univ Colorado |
Il-10 mutante
|
|
CA2655511C
(en)
|
2005-07-01 |
2017-03-21 |
John Schrader |
Methods of isolating cells and generating monoclonal antibodies
|
|
EP1931704B1
(en)
|
2005-10-04 |
2010-12-15 |
ZymoGenetics, L.L.C. |
Production and purification of il-29
|
|
US7939056B2
(en)
|
2005-11-14 |
2011-05-10 |
The Brigham And Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
US7868139B2
(en)
|
2006-01-24 |
2011-01-11 |
Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
|
NO346530B1
(no)
|
2006-09-28 |
2022-09-26 |
Merck Sharp & Dohme |
Anvendelser av pegylert interleukin-10 (PEG-IL-10) for å forebygge metastaser av kreft eller tumor i lungene.
|
|
EP2078201A2
(en)
|
2006-10-05 |
2009-07-15 |
Agency for Science, Technology and Research |
Dengue diagnosis and treatment
|
|
US8247370B2
(en)
|
2006-12-04 |
2012-08-21 |
Promedior, Inc. |
Conjoint therapy for treating fibrotic diseases
|
|
CA2989778C
(en)
|
2007-01-19 |
2020-06-30 |
Kai Pharmaceuticals, Inc. |
Method of modifying peptide compositions
|
|
CA2690825C
(en)
*
|
2007-05-11 |
2019-02-12 |
Altor Bioscience Corporation |
Fusion molecules and il-15 variants
|
|
DE08786222T1
(de)
|
2007-07-31 |
2010-11-25 |
Affibody Ab |
Neue albuminbindende zusammensetzungen, verfahren und anwendungen
|
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
|
CA2702494A1
(en)
|
2007-10-19 |
2009-04-23 |
The Regents Of The University Of California |
Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss
|
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
|
CN102105787A
(zh)
|
2008-05-29 |
2011-06-22 |
百时美施贵宝公司 |
用于预测患者对共刺激通道调节的应答的方法
|
|
WO2010022227A1
(en)
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
|
CN102256625B
(zh)
|
2008-12-17 |
2013-11-20 |
默沙东公司 |
单和双peg il10的生产和用途
|
|
MX2012004793A
(es)
|
2009-10-30 |
2012-07-20 |
Novozymes Biopharma Dk As |
Variantes de albumina.
|
|
NZ604013A
(en)
|
2010-06-16 |
2014-10-31 |
Abbott Lab |
Comparison of protein samples
|
|
CN110437321A
(zh)
|
2010-07-09 |
2019-11-12 |
阿菲博迪公司 |
多肽
|
|
US9084761B2
(en)
*
|
2010-07-09 |
2015-07-21 |
The Regents Of The University Of California |
Use of interleukin-15 to treat cardiovascular diseases
|
|
EA024507B1
(ru)
|
2010-09-28 |
2016-09-30 |
Амилин Фармасьютикалс, Ллк |
Хорошо растворимые лептины
|
|
EP3028720A1
(en)
|
2010-09-28 |
2016-06-08 |
Amylin Pharmaceuticals, LLC |
Engineered polypeptides having enhanced duration of action
|
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
|
EP2537933A1
(en)
*
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
US9249426B2
(en)
*
|
2011-09-29 |
2016-02-02 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Lentiviral vectors pseudotyped with mutant BaEV glycoproteins
|
|
MX2014009129A
(es)
|
2012-01-26 |
2014-11-21 |
Amgen Inc |
Polipeptidos de factor 15 de diferenciacion de crecimiento (gdf-15).
|
|
CN104245722A
(zh)
|
2012-02-29 |
2014-12-24 |
Ambrx公司 |
白细胞介素-10多肽结合物和其用途
|
|
JP2016519108A
(ja)
|
2013-04-18 |
2016-06-30 |
アルモ・バイオサイエンシーズ・インコーポレイテッド |
インターロイキン−１０を疾病及び疾患の治療に用いる方法
|
|
CN105848674A
(zh)
|
2013-11-11 |
2016-08-10 |
阿尔莫生物科技股份有限公司 |
将白细胞介素-10用于治疗疾病和病症的方法
|
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|