JP2017536096A5 - - Google Patents
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- JP2017536096A5 JP2017536096A5 JP2017518955A JP2017518955A JP2017536096A5 JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5 JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5
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- JP
- Japan
- Prior art keywords
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- mir
- exosomes
- derived
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 35
- 210000001808 exosome Anatomy 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 30
- 230000001464 adherent effect Effects 0.000 claims description 29
- 210000002826 placenta Anatomy 0.000 claims description 15
- 238000012239 gene modification Methods 0.000 claims description 12
- 230000005017 genetic modification Effects 0.000 claims description 12
- 235000013617 genetically modified food Nutrition 0.000 claims description 12
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 6
- 102100031780 Endonuclease Human genes 0.000 claims description 6
- 108010042407 Endonucleases Proteins 0.000 claims description 6
- 108020005004 Guide RNA Proteins 0.000 claims description 6
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 6
- 102000003729 Neprilysin Human genes 0.000 claims description 6
- 108090000028 Neprilysin Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 4
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 4
- 102100032912 CD44 antigen Human genes 0.000 claims description 4
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 4
- 102100025222 CD63 antigen Human genes 0.000 claims description 4
- 102100027221 CD81 antigen Human genes 0.000 claims description 4
- 102100027217 CD82 antigen Human genes 0.000 claims description 4
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 4
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 4
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 4
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 4
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims description 4
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims description 4
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims description 4
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 4
- 102100025305 Integrin alpha-2 Human genes 0.000 claims description 4
- 102100032819 Integrin alpha-3 Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 108700011259 MicroRNAs Proteins 0.000 claims description 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 230000008774 maternal effect Effects 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 2
- 108091050724 let-7b stem-loop Proteins 0.000 claims description 2
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 2
- 108091079176 let-7d-1 stem-loop Proteins 0.000 claims description 2
- 108091036331 let-7d-2 stem-loop Proteins 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 2
- 108091079016 miR-133b Proteins 0.000 claims description 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims description 2
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 2
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 2
- 108091027943 miR-16 stem-loop Proteins 0.000 claims description 2
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims description 2
- 108091056204 miR-16-2 stem-loop Proteins 0.000 claims description 2
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims description 2
- 108091054980 miR-218-2 stem-loop Proteins 0.000 claims description 2
- 108091086421 miR-223 stem-loop Proteins 0.000 claims description 2
- 108091036689 miR-296 stem-loop Proteins 0.000 claims description 2
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 2
- -1 miR-451 Proteins 0.000 claims description 2
- 108091047658 miR-564 stem-loop Proteins 0.000 claims description 2
- 108091086737 miR-630 stem-loop Proteins 0.000 claims description 2
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims description 2
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims description 2
- 108091027963 non-coding RNA Proteins 0.000 claims description 2
- 102000042567 non-coding RNA Human genes 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000008823 permeabilization Effects 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062046P | 2014-10-09 | 2014-10-09 | |
| US62/062,046 | 2014-10-09 | ||
| PCT/US2015/054629 WO2016057755A1 (en) | 2014-10-09 | 2015-10-08 | Placenta-derived adherent cell exosomes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Division JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536096A JP2017536096A (ja) | 2017-12-07 |
| JP2017536096A5 true JP2017536096A5 (enExample) | 2018-12-06 |
Family
ID=55653751
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518955A Pending JP2017536096A (ja) | 2014-10-09 | 2015-10-08 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170252379A1 (enExample) |
| EP (1) | EP3204022B1 (enExample) |
| JP (3) | JP2017536096A (enExample) |
| CN (2) | CN107106615A (enExample) |
| AU (2) | AU2015330855A1 (enExample) |
| CA (1) | CA2964114A1 (enExample) |
| DK (1) | DK3204022T3 (enExample) |
| WO (1) | WO2016057755A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
| ES2884838T3 (es) | 2015-04-06 | 2021-12-13 | Univ Leland Stanford Junior | ARN guía químicamente modificados para la regulación génica mediada por CRISPR/CAS |
| CA2988585A1 (en) | 2015-06-10 | 2016-12-15 | Raghu Kalluri | Use of exosomes for the treatment of disease |
| CN109477072A (zh) * | 2016-05-16 | 2019-03-15 | 埃克森蒂姆生物技术公司 | 间充质干细胞及其用于治疗肌肉损伤和肌肉相关疾病的用途 |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| US11576872B2 (en) | 2017-05-08 | 2023-02-14 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| WO2018208702A1 (en) * | 2017-05-09 | 2018-11-15 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| AU2018270408A1 (en) * | 2017-05-16 | 2019-12-12 | Exostem Biotec Ltd. | Methods of inhibiting aging and treating aging-related disorders |
| US20180340945A1 (en) * | 2017-05-24 | 2018-11-29 | Nanosomix, Inc. | Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders |
| KR102109950B1 (ko) * | 2017-06-02 | 2020-05-12 | (주)엑솔런스바이오테크놀로지 | 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법 |
| BR112020003354A2 (pt) | 2017-08-25 | 2020-08-18 | Codiak Biosciences, Inc. | preparação de exossomas terapêuticos usando proteínas de membrana |
| KR102335710B1 (ko) * | 2017-10-31 | 2021-12-07 | (주)아모레퍼시픽 | 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물 |
| GB201718681D0 (en) * | 2017-11-13 | 2017-12-27 | Evox Therapeutics Ltd | Protein engineered extracellular vesicles |
| AU2018370157A1 (en) * | 2017-11-16 | 2020-05-28 | Celularity Inc. | Cultivation of placenta to isolate exosomes |
| US12036325B2 (en) | 2017-12-14 | 2024-07-16 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| AU2018394238A1 (en) | 2017-12-28 | 2020-06-18 | Lonza Sales Ag | Exosomes for immuno-oncology and anti-inflammatory therapy |
| CN112384200A (zh) * | 2018-01-30 | 2021-02-19 | 希斯托金公司 | 低氧条件下培养的细胞衍生的胞外囊泡及其用途 |
| WO2019241910A1 (zh) * | 2018-06-19 | 2019-12-26 | 中国医学科学院阜外医院 | 基于药物预处理的间充质干细胞来源外泌体的制备方法 |
| CA3107386A1 (en) * | 2018-07-24 | 2020-01-30 | Mayo Foundation For Medical Education And Research | Compositions and methods involving transforming extracellular vesicles |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109554341B (zh) * | 2018-12-18 | 2021-11-19 | 深圳先进技术研究院 | 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用 |
| CN110093274B (zh) * | 2019-05-13 | 2020-08-11 | 山东大学 | 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用 |
| CN114302731A (zh) * | 2019-06-19 | 2022-04-08 | 细胞结构公司 | 用于治疗疾病的外泌体 |
| KR20220167294A (ko) * | 2020-04-14 | 2022-12-20 | (주)녹십자웰빙 | 태반 유래 물질을 포함하는 항바이러스 조성물 |
| KR20220030552A (ko) * | 2020-09-03 | 2022-03-11 | (주)녹십자웰빙 | 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물 |
| US11884915B2 (en) | 2021-09-10 | 2024-01-30 | Agilent Technologies, Inc. | Guide RNAs with chemical modification for prime editing |
| WO2024102969A1 (en) * | 2022-11-10 | 2024-05-16 | Board Of Regents, The University Of Texas System | Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ527849A (en) | 2001-02-14 | 2006-09-29 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| DK2471904T3 (en) | 2005-12-29 | 2019-02-18 | Celularity Inc | Placenta stem cell populations |
| JP5950577B2 (ja) | 2008-08-20 | 2016-07-13 | アンスロジェネシス コーポレーション | 単離胎盤細胞を使用した脳卒中の治療 |
| CN102282249A (zh) * | 2008-09-02 | 2011-12-14 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| FR2950360B1 (fr) * | 2009-09-22 | 2011-11-25 | Centre Nat Rech Scient | Procede d'imagerie cellulaire pour la visualisation de la biogenese des microarns dans les cellules |
| TW201703777A (zh) * | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
| WO2012135805A2 (en) * | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| BR112013032232A2 (pt) * | 2011-06-16 | 2016-09-20 | Caris Life Sciences Switzerland Holdings S A R L | método de caracterização de câncer através do uso de biomarcador de ácido nucleico |
| JP6029112B2 (ja) * | 2011-12-22 | 2016-11-24 | テオリアサイエンス株式会社 | エクソソームの分析方法、エクソソーム分析用試薬およびエクソソーム分析装置 |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| WO2014022852A1 (en) * | 2012-08-03 | 2014-02-06 | Aptamir Therapeutics, Inc. | Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders |
| US9828603B2 (en) * | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| KR20150105956A (ko) * | 2012-12-12 | 2015-09-18 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화 |
| WO2014100434A1 (en) * | 2012-12-19 | 2014-06-26 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| EP3608022A1 (en) * | 2013-03-15 | 2020-02-12 | The Trustees of Princeton University | Methods and devices for high throughput purification |
-
2015
- 2015-10-08 CN CN201580054280.7A patent/CN107106615A/zh active Pending
- 2015-10-08 DK DK15849339.5T patent/DK3204022T3/da active
- 2015-10-08 CA CA2964114A patent/CA2964114A1/en active Pending
- 2015-10-08 EP EP15849339.5A patent/EP3204022B1/en not_active Revoked
- 2015-10-08 AU AU2015330855A patent/AU2015330855A1/en not_active Abandoned
- 2015-10-08 US US15/517,438 patent/US20170252379A1/en not_active Abandoned
- 2015-10-08 CN CN202310711769.3A patent/CN116731958A/zh active Pending
- 2015-10-08 JP JP2017518955A patent/JP2017536096A/ja active Pending
- 2015-10-08 WO PCT/US2015/054629 patent/WO2016057755A1/en not_active Ceased
-
2020
- 2020-01-10 US US16/740,054 patent/US11173182B1/en not_active Expired - Fee Related
- 2020-11-06 JP JP2020185503A patent/JP2021040635A/ja not_active Withdrawn
-
2021
- 2021-06-25 AU AU2021204332A patent/AU2021204332A1/en not_active Abandoned
- 2021-10-07 US US17/495,985 patent/US20220241347A1/en not_active Abandoned
-
2022
- 2022-10-05 JP JP2022160666A patent/JP2023011580A/ja active Pending
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