JP2017536096A5 - - Google Patents
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- JP2017536096A5 JP2017536096A5 JP2017518955A JP2017518955A JP2017536096A5 JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5 JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A5 JP2017536096 A5 JP 2017536096A5
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- JP
- Japan
- Prior art keywords
- composition
- mir
- exosomes
- derived
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 35
- 210000001808 exosome Anatomy 0.000 claims description 34
- 210000004027 cell Anatomy 0.000 claims description 30
- 230000001464 adherent effect Effects 0.000 claims description 29
- 210000002826 placenta Anatomy 0.000 claims description 15
- 238000012239 gene modification Methods 0.000 claims description 12
- 230000005017 genetic modification Effects 0.000 claims description 12
- 235000013617 genetically modified food Nutrition 0.000 claims description 12
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims description 6
- 102100031780 Endonuclease Human genes 0.000 claims description 6
- 108010042407 Endonucleases Proteins 0.000 claims description 6
- 108020005004 Guide RNA Proteins 0.000 claims description 6
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims description 6
- 102000003729 Neprilysin Human genes 0.000 claims description 6
- 108090000028 Neprilysin Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims description 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 4
- 102100022749 Aminopeptidase N Human genes 0.000 claims description 4
- 102100032912 CD44 antigen Human genes 0.000 claims description 4
- 102100022002 CD59 glycoprotein Human genes 0.000 claims description 4
- 102100025222 CD63 antigen Human genes 0.000 claims description 4
- 102100027221 CD81 antigen Human genes 0.000 claims description 4
- 102100027217 CD82 antigen Human genes 0.000 claims description 4
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims description 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims description 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 4
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims description 4
- 101000934368 Homo sapiens CD63 antigen Proteins 0.000 claims description 4
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 4
- 101000914469 Homo sapiens CD82 antigen Proteins 0.000 claims description 4
- 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 claims description 4
- 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 claims description 4
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 4
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims description 4
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 4
- 102100025305 Integrin alpha-2 Human genes 0.000 claims description 4
- 102100032819 Integrin alpha-3 Human genes 0.000 claims description 4
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 4
- 108700011259 MicroRNAs Proteins 0.000 claims description 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 4
- 239000002679 microRNA Substances 0.000 claims description 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 4
- 229930182490 saponin Natural products 0.000 claims description 4
- 150000007949 saponins Chemical class 0.000 claims description 4
- 230000033115 angiogenesis Effects 0.000 claims description 3
- 230000008774 maternal effect Effects 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 2
- 108091050724 let-7b stem-loop Proteins 0.000 claims description 2
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 2
- 108091079176 let-7d-1 stem-loop Proteins 0.000 claims description 2
- 108091036331 let-7d-2 stem-loop Proteins 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 108091056924 miR-124 stem-loop Proteins 0.000 claims description 2
- 108091079016 miR-133b Proteins 0.000 claims description 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims description 2
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 2
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 2
- 108091027943 miR-16 stem-loop Proteins 0.000 claims description 2
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims description 2
- 108091056204 miR-16-2 stem-loop Proteins 0.000 claims description 2
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims description 2
- 108091054980 miR-218-2 stem-loop Proteins 0.000 claims description 2
- 108091086421 miR-223 stem-loop Proteins 0.000 claims description 2
- 108091036689 miR-296 stem-loop Proteins 0.000 claims description 2
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 2
- -1 miR-451 Proteins 0.000 claims description 2
- 108091047658 miR-564 stem-loop Proteins 0.000 claims description 2
- 108091086737 miR-630 stem-loop Proteins 0.000 claims description 2
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims description 2
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims description 2
- 108091027963 non-coding RNA Proteins 0.000 claims description 2
- 102000042567 non-coding RNA Human genes 0.000 claims description 2
- 238000000527 sonication Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 230000008823 permeabilization Effects 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062046P | 2014-10-09 | 2014-10-09 | |
| US62/062,046 | 2014-10-09 | ||
| PCT/US2015/054629 WO2016057755A1 (en) | 2014-10-09 | 2015-10-08 | Placenta-derived adherent cell exosomes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Division JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536096A JP2017536096A (ja) | 2017-12-07 |
| JP2017536096A5 true JP2017536096A5 (enExample) | 2018-12-06 |
Family
ID=55653751
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518955A Pending JP2017536096A (ja) | 2014-10-09 | 2015-10-08 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020185503A Withdrawn JP2021040635A (ja) | 2014-10-09 | 2020-11-06 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
| JP2022160666A Pending JP2023011580A (ja) | 2014-10-09 | 2022-10-05 | 胎盤由来の接着細胞エクソソームおよびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170252379A1 (enExample) |
| EP (1) | EP3204022B1 (enExample) |
| JP (3) | JP2017536096A (enExample) |
| CN (2) | CN116731958A (enExample) |
| AU (2) | AU2015330855A1 (enExample) |
| CA (1) | CA2964114A1 (enExample) |
| DK (1) | DK3204022T3 (enExample) |
| WO (1) | WO2016057755A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| CN107787367B (zh) | 2015-04-06 | 2021-10-26 | 里兰斯坦福初级大学理事会 | 用于crispr/cas介导的基因调控的化学修饰的引导rna |
| EA201890006A1 (ru) | 2015-06-10 | 2018-05-31 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Применение экзосом для лечения болезни |
| KR20190007040A (ko) * | 2016-05-16 | 2019-01-21 | 엑소스템 바이오텍 리미티드 | 간엽 줄기 세포 및 근육 손상 및 근육-관련된 질환의 치료를 위한 이의 용도 |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| US11576872B2 (en) | 2017-05-08 | 2023-02-14 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US20200163993A1 (en) * | 2017-05-09 | 2020-05-28 | Saint Louis University | Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes |
| US20200188440A1 (en) * | 2017-05-16 | 2020-06-18 | Exostem Biotec Ltd. | Methods of inhibiting aging and treating aging-related disorders |
| CA3065999A1 (en) * | 2017-05-24 | 2018-11-29 | Nanosomix, Inc. | Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders |
| KR102109950B1 (ko) * | 2017-06-02 | 2020-05-12 | (주)엑솔런스바이오테크놀로지 | 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법 |
| KR20240033086A (ko) | 2017-08-25 | 2024-03-12 | 코디악 바이오사이언시즈, 인크. | 막 단백질을 사용한 치료용 엑소좀의 제조 |
| KR102335710B1 (ko) * | 2017-10-31 | 2021-12-07 | (주)아모레퍼시픽 | 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물 |
| GB201718681D0 (en) * | 2017-11-13 | 2017-12-27 | Evox Therapeutics Ltd | Protein engineered extracellular vesicles |
| CN119552810A (zh) * | 2017-11-16 | 2025-03-04 | 细胞结构公司 | 用以分离外泌体的胎盘培养 |
| US12036325B2 (en) | 2017-12-14 | 2024-07-16 | Mayo Foundation For Medical Education And Research | Purified exosome products, method of making, and methods of using |
| EP3731849A4 (en) | 2017-12-28 | 2021-12-01 | Codiak BioSciences, Inc. | EXOSOME FOR IMMUNONCOLOGICAL AND ANTI-INFLAMMATORY THERAPY |
| WO2019152522A1 (en) | 2018-01-30 | 2019-08-08 | Histogen, Inc. | Extracellular vesicles derived from cells cultured under hypoxic conditions and uses thereof |
| EP3663394B1 (en) * | 2018-06-19 | 2022-10-05 | Fuwai Hospital, Chinese Academy Of Medical Sciences And Peking Union Medical College | Method for preparing mesenchymal stem cell-derived exosomes on basis of drug pretreatment |
| US20210259969A1 (en) * | 2018-07-24 | 2021-08-26 | Mayo Foundation For Medical Education And Research | Compositions and methods involving transforming extracellular vesicles |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109554341B (zh) * | 2018-12-18 | 2021-11-19 | 深圳先进技术研究院 | 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用 |
| CN110093274B (zh) * | 2019-05-13 | 2020-08-11 | 山东大学 | 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用 |
| CN114302731A (zh) * | 2019-06-19 | 2022-04-08 | 细胞结构公司 | 用于治疗疾病的外泌体 |
| KR102922847B1 (ko) * | 2020-04-14 | 2026-02-05 | (주)녹십자웰빙 | 태반 유래 물질을 포함하는 항바이러스 조성물 |
| KR20220030552A (ko) * | 2020-09-03 | 2022-03-11 | (주)녹십자웰빙 | 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물 |
| WO2023039586A1 (en) | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
| US20260191911A1 (en) * | 2022-11-10 | 2026-07-09 | Board Of Regents, The University Of Texas System | Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity |
| CN117050936B (zh) * | 2023-07-11 | 2026-06-12 | 清华大学 | 新亚群的人脐带间充质干细胞、其外泌体、制剂和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002251935B2 (en) | 2001-02-14 | 2007-11-29 | Celularity Inc. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| KR20180105266A (ko) | 2005-12-29 | 2018-09-27 | 안트로제네시스 코포레이션 | 태반 줄기 세포 집단 |
| CA2734237C (en) | 2008-08-20 | 2019-07-02 | Anthrogenesis Corporation | Treatment of stroke using isolated placental cells |
| CA2735790C (en) * | 2008-09-02 | 2017-02-28 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| EP2350320A4 (en) * | 2008-11-12 | 2012-11-14 | Caris Life Sciences Luxembourg Holdings | METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES |
| FR2950360B1 (fr) * | 2009-09-22 | 2011-11-25 | Centre Nat Rech Scient | Procede d'imagerie cellulaire pour la visualisation de la biogenese des microarns dans les cellules |
| PL2556145T3 (pl) * | 2010-04-07 | 2017-02-28 | Anthrogenesis Corporation | Angiogeneza z zastosowaniem łożyskowych komórek macierzystych |
| CA2831613A1 (en) * | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP2721179A4 (en) * | 2011-06-16 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | BIOMARKER COMPOSITIONS AND METHOD THEREFOR |
| US11391741B2 (en) * | 2011-12-22 | 2022-07-19 | Theoria Science Inc. | Method of exosome analysis, reagent for exosome analysis, and analyzer for exosome |
| US9427450B2 (en) * | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| WO2014022852A1 (en) * | 2012-08-03 | 2014-02-06 | Aptamir Therapeutics, Inc. | Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders |
| EP3563859B1 (en) * | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| SG10201707569YA (en) * | 2012-12-12 | 2017-10-30 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| AU2013361323B2 (en) * | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| CN113512522A (zh) * | 2013-03-15 | 2021-10-19 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
-
2015
- 2015-10-08 AU AU2015330855A patent/AU2015330855A1/en not_active Abandoned
- 2015-10-08 JP JP2017518955A patent/JP2017536096A/ja active Pending
- 2015-10-08 CA CA2964114A patent/CA2964114A1/en active Pending
- 2015-10-08 DK DK15849339.5T patent/DK3204022T3/da active
- 2015-10-08 US US15/517,438 patent/US20170252379A1/en not_active Abandoned
- 2015-10-08 CN CN202310711769.3A patent/CN116731958A/zh active Pending
- 2015-10-08 CN CN201580054280.7A patent/CN107106615A/zh active Pending
- 2015-10-08 EP EP15849339.5A patent/EP3204022B1/en not_active Revoked
- 2015-10-08 WO PCT/US2015/054629 patent/WO2016057755A1/en not_active Ceased
-
2020
- 2020-01-10 US US16/740,054 patent/US11173182B1/en not_active Expired - Fee Related
- 2020-11-06 JP JP2020185503A patent/JP2021040635A/ja not_active Withdrawn
-
2021
- 2021-06-25 AU AU2021204332A patent/AU2021204332A1/en not_active Abandoned
- 2021-10-07 US US17/495,985 patent/US20220241347A1/en not_active Abandoned
-
2022
- 2022-10-05 JP JP2022160666A patent/JP2023011580A/ja active Pending
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