JP2017536096A - 胎盤由来の接着細胞エクソソームおよびそれらの使用 - Google Patents

胎盤由来の接着細胞エクソソームおよびそれらの使用 Download PDF

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JP2017536096A
JP2017536096A JP2017518955A JP2017518955A JP2017536096A JP 2017536096 A JP2017536096 A JP 2017536096A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017518955 A JP2017518955 A JP 2017518955A JP 2017536096 A JP2017536096 A JP 2017536096A
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placenta
exosomes
derived adherent
mir
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JP2017536096A5 (enExample
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ロウ エリック
ロウ エリック
モルスチャウセル アンドリュー
モルスチャウセル アンドリュー
フランキ アレクサンダー
フランキ アレクサンダー
パレデス ジェニファー
パレデス ジェニファー
イー．カラシエウィクズ−メンデズ キャシー
イー．カラシエウィクズ−メンデズ キャシー
レデュータ アラン
レデュータ アラン
ジャンコビク ウラジミール
ジャンコビク ウラジミール
ドジュレティク イバナ
ドジュレティク イバナ
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アントフロゲネシス コーポレーション
アントフロゲネシス コーポレーション
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C12N2502/025—Coculture with; Conditioned medium produced by embryonic cells extra-embryonic cells, e.g. amniotic epithelium, placental cells, Wharton's jelly

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  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017518955A 2014-10-09 2015-10-08 胎盤由来の接着細胞エクソソームおよびそれらの使用 Pending JP2017536096A (ja)

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US201462062046P 2014-10-09 2014-10-09
US62/062,046 2014-10-09
PCT/US2015/054629 WO2016057755A1 (en) 2014-10-09 2015-10-08 Placenta-derived adherent cell exosomes and uses thereof

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JP2020185503A Division JP2021040635A (ja) 2014-10-09 2020-11-06 胎盤由来の接着細胞エクソソームおよびそれらの使用

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JP2017536096A5 JP2017536096A5 (enExample) 2018-12-06

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JP2017518955A Pending JP2017536096A (ja) 2014-10-09 2015-10-08 胎盤由来の接着細胞エクソソームおよびそれらの使用
JP2020185503A Withdrawn JP2021040635A (ja) 2014-10-09 2020-11-06 胎盤由来の接着細胞エクソソームおよびそれらの使用
JP2022160666A Pending JP2023011580A (ja) 2014-10-09 2022-10-05 胎盤由来の接着細胞エクソソームおよびそれらの使用

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JP2022160666A Pending JP2023011580A (ja) 2014-10-09 2022-10-05 胎盤由来の接着細胞エクソソームおよびそれらの使用

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US (3) US20170252379A1 (enExample)
EP (1) EP3204022B1 (enExample)
JP (3) JP2017536096A (enExample)
CN (2) CN116731958A (enExample)
AU (2) AU2015330855A1 (enExample)
CA (1) CA2964114A1 (enExample)
DK (1) DK3204022T3 (enExample)
WO (1) WO2016057755A1 (enExample)

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JP2020522996A (ja) * 2018-06-19 2020-08-06 フーワイ ホスピタル， チャイニーズ アカデミー オブ メディカル サイエンシズ アンド ペキン ユニオン メディカル カレッジ 薬剤前処理による間葉系幹細胞由来エクソソームの調製方法
JP2021511833A (ja) * 2018-01-30 2021-05-13 ヒストジェン インコーポレイテッド 低酸素条件下にて培養された細胞に由来する細胞外小胞およびその使用方法
WO2021210852A1 (ko) * 2020-04-14 2021-10-21 (주)녹십자웰빙 태반 유래 물질을 포함하는 항바이러스 조성물

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EA201890006A1 (ru) 2015-06-10 2018-05-31 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Применение экзосом для лечения болезни
KR20190007040A (ko) * 2016-05-16 2019-01-21 엑소스템 바이오텍 리미티드 간엽 줄기 세포 및 근육 손상 및 근육-관련된 질환의 치료를 위한 이의 용도
US10767175B2 (en) 2016-06-08 2020-09-08 Agilent Technologies, Inc. High specificity genome editing using chemically modified guide RNAs
US11576872B2 (en) 2017-05-08 2023-02-14 Flagship Pioneering Innovations V, Inc. Compositions for facilitating membrane fusion and uses thereof
US20200163993A1 (en) * 2017-05-09 2020-05-28 Saint Louis University Treatment of cancer and infectious diseases with natural killer (nk) cell-derived exosomes
US20200188440A1 (en) * 2017-05-16 2020-06-18 Exostem Biotec Ltd. Methods of inhibiting aging and treating aging-related disorders
CA3065999A1 (en) * 2017-05-24 2018-11-29 Nanosomix, Inc. Detection of biomarkers on vesicles for the diagnosis and prognosis of diseases and disorders
KR102109950B1 (ko) * 2017-06-02 2020-05-12 (주)엑솔런스바이오테크놀로지 체외충격파를 이용한 세포외소포체 내로의 표적물질 전달방법
KR20240033086A (ko) 2017-08-25 2024-03-12 코디악 바이오사이언시즈, 인크. 막 단백질을 사용한 치료용 엑소좀의 제조
KR102335710B1 (ko) * 2017-10-31 2021-12-07 (주)아모레퍼시픽 유산균 유래의 세포밖 베지클을 포함하는 면역조절용 조성물
GB201718681D0 (en) * 2017-11-13 2017-12-27 Evox Therapeutics Ltd Protein engineered extracellular vesicles
CN119552810A (zh) * 2017-11-16 2025-03-04 细胞结构公司 用以分离外泌体的胎盘培养
US12036325B2 (en) 2017-12-14 2024-07-16 Mayo Foundation For Medical Education And Research Purified exosome products, method of making, and methods of using
EP3731849A4 (en) 2017-12-28 2021-12-01 Codiak BioSciences, Inc. EXOSOME FOR IMMUNONCOLOGICAL AND ANTI-INFLAMMATORY THERAPY
US20210259969A1 (en) * 2018-07-24 2021-08-26 Mayo Foundation For Medical Education And Research Compositions and methods involving transforming extracellular vesicles
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN109554341B (zh) * 2018-12-18 2021-11-19 深圳先进技术研究院 无创超声处理细胞在制备外泌体中的应用、外泌体及其制备方法和应用
CN110093274B (zh) * 2019-05-13 2020-08-11 山东大学 一种增加细胞产生的细胞外囊泡数量的挤压装置及其应用
CN114302731A (zh) * 2019-06-19 2022-04-08 细胞结构公司 用于治疗疾病的外泌体
KR20220030552A (ko) * 2020-09-03 2022-03-11 (주)녹십자웰빙 태반 유래 엑소좀을 포함하는 간세포 증식 또는 항염증 효능 조성물
WO2023039586A1 (en) 2021-09-10 2023-03-16 Agilent Technologies, Inc. Guide rnas with chemical modification for prime editing
US20260191911A1 (en) * 2022-11-10 2026-07-09 Board Of Regents, The University Of Texas System Use of fecal derivatives and fecal derived extracellular vesicles to enhance immunity
CN117050936B (zh) * 2023-07-11 2026-06-12 清华大学 新亚群的人脐带间充质干细胞、其外泌体、制剂和应用

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US20130195899A1 (en) * 2012-01-31 2013-08-01 Medistem, Inc. Therapeutic immune modulation by stem cell secreted exosomes
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511833A (ja) * 2018-01-30 2021-05-13 ヒストジェン インコーポレイテッド 低酸素条件下にて培養された細胞に由来する細胞外小胞およびその使用方法
JP2020522996A (ja) * 2018-06-19 2020-08-06 フーワイ ホスピタル， チャイニーズ アカデミー オブ メディカル サイエンシズ アンド ペキン ユニオン メディカル カレッジ 薬剤前処理による間葉系幹細胞由来エクソソームの調製方法
WO2021210852A1 (ko) * 2020-04-14 2021-10-21 (주)녹십자웰빙 태반 유래 물질을 포함하는 항바이러스 조성물

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CN107106615A (zh) 2017-08-29
EP3204022A1 (en) 2017-08-16
CA2964114A1 (en) 2016-04-14
AU2021204332A1 (en) 2021-07-22
JP2023011580A (ja) 2023-01-24
US20170252379A1 (en) 2017-09-07
CN116731958A (zh) 2023-09-12
US20220241347A1 (en) 2022-08-04
DK3204022T3 (da) 2021-03-08
EP3204022A4 (en) 2018-06-13
JP2021040635A (ja) 2021-03-18
WO2016057755A1 (en) 2016-04-14
EP3204022B1 (en) 2020-12-02
US11173182B1 (en) 2021-11-16
AU2015330855A1 (en) 2017-04-27

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