JP2017533937A5 - - Google Patents
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- Publication number
- JP2017533937A5 JP2017533937A5 JP2017525933A JP2017525933A JP2017533937A5 JP 2017533937 A5 JP2017533937 A5 JP 2017533937A5 JP 2017525933 A JP2017525933 A JP 2017525933A JP 2017525933 A JP2017525933 A JP 2017525933A JP 2017533937 A5 JP2017533937 A5 JP 2017533937A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- coor
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- 150000001875 compounds Chemical class 0.000 claims description 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 20
- 125000003118 aryl group Chemical group 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- -1 —C 1-6 haloalkyl Chemical group 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 0 CN1C*CC1 Chemical compound CN1C*CC1 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- FFWAQFXCJUHCDZ-UHFFFAOYSA-N C(C1)C11COCC1 Chemical compound C(C1)C11COCC1 FFWAQFXCJUHCDZ-UHFFFAOYSA-N 0.000 description 1
- RFWAAXNLVJXFQD-UHFFFAOYSA-N CN(CC1)CCC1N1CCN(C)CC1 Chemical compound CN(CC1)CCC1N1CCN(C)CC1 RFWAAXNLVJXFQD-UHFFFAOYSA-N 0.000 description 1
- FZYSZYWKHFCLSF-UHFFFAOYSA-N CN(CC1)CCNC1=O Chemical compound CN(CC1)CCNC1=O FZYSZYWKHFCLSF-UHFFFAOYSA-N 0.000 description 1
- FQKYGXLDOAFGCC-UHFFFAOYSA-N CN(CCN1)C(CC(O)=O)C1=O Chemical compound CN(CCN1)C(CC(O)=O)C1=O FQKYGXLDOAFGCC-UHFFFAOYSA-N 0.000 description 1
- KVIZTDNKHOCNAM-UHFFFAOYSA-N CN(CCN1)CC1=O Chemical compound CN(CCN1)CC1=O KVIZTDNKHOCNAM-UHFFFAOYSA-N 0.000 description 1
- UWOHOTTUMMONTJ-UHFFFAOYSA-N CN(CCN1C2CCCC2)CC1=O Chemical compound CN(CCN1C2CCCC2)CC1=O UWOHOTTUMMONTJ-UHFFFAOYSA-N 0.000 description 1
- XKRADRXZXCDDHA-UHFFFAOYSA-N CN(CCNC1)CC1O Chemical compound CN(CCNC1)CC1O XKRADRXZXCDDHA-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- PVOAHINGSUIXLS-UHFFFAOYSA-N CN1CCNCC1 Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462079977P | 2014-11-14 | 2014-11-14 | |
| US62/079,977 | 2014-11-14 | ||
| PCT/US2015/060344 WO2016077561A1 (en) | 2014-11-14 | 2015-11-12 | Oxolupene derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017533937A JP2017533937A (ja) | 2017-11-16 |
| JP2017533937A5 true JP2017533937A5 (enExample) | 2018-11-01 |
Family
ID=54697682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525933A Pending JP2017533937A (ja) | 2014-11-14 | 2015-11-12 | オキソルペン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9969767B2 (enExample) |
| EP (1) | EP3218387A1 (enExample) |
| JP (1) | JP2017533937A (enExample) |
| KR (1) | KR20170087478A (enExample) |
| CN (1) | CN107250153A (enExample) |
| AU (1) | AU2015346303B2 (enExample) |
| BR (1) | BR112017009850A2 (enExample) |
| CA (1) | CA2967679A1 (enExample) |
| RU (1) | RU2017118489A (enExample) |
| WO (1) | WO2016077561A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017017609A1 (en) * | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| CA2993758A1 (en) * | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| AU2016327169A1 (en) * | 2015-09-24 | 2018-04-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds with hiv maturation inhibitory activity |
| EP3405474A1 (en) * | 2016-01-20 | 2018-11-28 | Glaxosmithkline Intellectual Property (No. 2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| MXPA06010592A (es) | 2004-03-17 | 2007-06-12 | Panacos Pharmaceuticals Inc | Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico. |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| AR063546A1 (es) * | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
| WO2009082819A1 (en) * | 2008-01-03 | 2009-07-09 | Virochem Pharma Inc. | Novel lupane derivatives |
| US8269026B2 (en) * | 2008-01-03 | 2012-09-18 | Vertex Pharmaceuticals Incorporated | Lupane derivatives useful for treating HIV |
| EP2257567A1 (en) | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| EA201290632A1 (ru) * | 2010-02-11 | 2013-03-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бетулина |
| MX2012013628A (es) | 2010-06-04 | 2012-12-17 | Bristol Myers Squibb Co | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). |
| CN103038245B (zh) * | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物 |
| US8846647B2 (en) | 2011-01-31 | 2014-09-30 | Bristol-Myers Squibb Company | C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity |
| RS54352B1 (sr) * | 2011-01-31 | 2016-02-29 | Bristol-Myers Squibb Company | C-28 amini c-3 modifikovanih derivata betulinske kiseline kao inhibitori sazrevanja hiv-a |
| JO3387B1 (ar) * | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| CN103242413B (zh) * | 2012-02-08 | 2015-08-26 | 江西青峰药业有限公司 | Lupane三萜系衍生物及其药学用途 |
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
-
2015
- 2015-11-12 US US15/524,298 patent/US9969767B2/en not_active Expired - Fee Related
- 2015-11-12 JP JP2017525933A patent/JP2017533937A/ja active Pending
- 2015-11-12 WO PCT/US2015/060344 patent/WO2016077561A1/en not_active Ceased
- 2015-11-12 KR KR1020177016222A patent/KR20170087478A/ko not_active Withdrawn
- 2015-11-12 RU RU2017118489A patent/RU2017118489A/ru not_active Application Discontinuation
- 2015-11-12 CA CA2967679A patent/CA2967679A1/en not_active Abandoned
- 2015-11-12 BR BR112017009850A patent/BR112017009850A2/pt not_active IP Right Cessation
- 2015-11-12 EP EP15798639.9A patent/EP3218387A1/en not_active Ceased
- 2015-11-12 AU AU2015346303A patent/AU2015346303B2/en not_active Ceased
- 2015-11-12 CN CN201580071098.2A patent/CN107250153A/zh active Pending