JP2017533718A5 - - Google Patents
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- Publication number
- JP2017533718A5 JP2017533718A5 JP2017525824A JP2017525824A JP2017533718A5 JP 2017533718 A5 JP2017533718 A5 JP 2017533718A5 JP 2017525824 A JP2017525824 A JP 2017525824A JP 2017525824 A JP2017525824 A JP 2017525824A JP 2017533718 A5 JP2017533718 A5 JP 2017533718A5
- Authority
- JP
- Japan
- Prior art keywords
- kit according
- atp
- aqueous composition
- diphosphohydrolase
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- 102000007347 Apyrase Human genes 0.000 claims 9
- 108010007730 Apyrase Proteins 0.000 claims 9
- VQPIHIGAMRSAAN-WMUFLLRFSA-N (3S)-3-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O VQPIHIGAMRSAAN-WMUFLLRFSA-N 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 8
- 229920005862 polyol Polymers 0.000 claims 7
- 150000003077 polyols Chemical class 0.000 claims 7
- 239000000872 buffer Substances 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 108060001084 Luciferase Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 claims 2
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 claims 2
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 claims 2
- 102000004157 Hydrolases Human genes 0.000 claims 2
- 108090000604 Hydrolases Proteins 0.000 claims 2
- 239000005089 Luciferase Substances 0.000 claims 2
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- AJDONJVWDSZZQF-UHFFFAOYSA-N 1-(2,4,4-trimethylpentan-2-yl)-4-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]benzene Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OC1=CC=C(C(C)(C)CC(C)(C)C)C=C1 AJDONJVWDSZZQF-UHFFFAOYSA-N 0.000 claims 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- CFJZQNZZGQDONE-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;butanedioic acid Chemical compound OCC(N)(CO)CO.OCC(N)(CO)CO.OC(=O)CCC(O)=O CFJZQNZZGQDONE-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001346 alkyl aryl ethers Chemical class 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000029918 bioluminescence Effects 0.000 claims 1
- 238000005415 bioluminescence Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 claims 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 230000003641 microbiacidal effect Effects 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462079156P | 2014-11-13 | 2014-11-13 | |
| US62/079,156 | 2014-11-13 | ||
| PCT/US2015/059654 WO2016077185A1 (en) | 2014-11-13 | 2015-11-09 | Kit comprising atp-diphosphohydrolase for detecting bacterial atp in a sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533718A JP2017533718A (ja) | 2017-11-16 |
| JP2017533718A5 true JP2017533718A5 (enExample) | 2018-12-20 |
| JP6698651B2 JP6698651B2 (ja) | 2020-05-27 |
Family
ID=54754744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525824A Active JP6698651B2 (ja) | 2014-11-13 | 2015-11-09 | 試料中の細菌ａｔｐを検出するためのａｔｐ−ジホスホヒドロラーゼを含むキット |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10415073B2 (enExample) |
| EP (1) | EP3218510B1 (enExample) |
| JP (1) | JP6698651B2 (enExample) |
| CN (1) | CN107109464B (enExample) |
| WO (1) | WO2016077185A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113588612B (zh) * | 2021-07-27 | 2023-08-01 | 中国科学院成都生物研究所 | 一种atp在线检测方法及设备 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1028599A (ja) * | 1996-04-26 | 1998-02-03 | Toyo Ink Mfg Co Ltd | 試料中に存在する微生物細胞に由来するａｔｐを検出及び／または測定する方法、及びその試薬キット |
| JPH10191972A (ja) * | 1997-01-13 | 1998-07-28 | Toyo Ink Mfg Co Ltd | Ａｔｐ加水分解酵素の安定化方法 |
| SE9903831D0 (sv) | 1999-10-22 | 1999-10-22 | Astra Ab | Formulation of substituted benzimidazoles |
| US20030157590A1 (en) | 2002-02-01 | 2003-08-21 | Foote Nicholas Peter Martin | Polyols in bioluminescence assays |
| WO2004035818A1 (en) | 2002-10-21 | 2004-04-29 | Biotage Ab | Use of osmolytes to heat stabilise luciferase and/or apyrase |
| GB0615302D0 (en) * | 2006-08-01 | 2006-09-13 | Biotrace Internat Plc | Assay Method For The Detection Of Viable Microbial Cells In A Sample |
| CN100547388C (zh) * | 2006-08-16 | 2009-10-07 | 中国科学院电子学研究所 | 一种抗干扰的食品细菌总数快速检测方法及试剂 |
| US7888059B2 (en) | 2006-10-05 | 2011-02-15 | Yeda Research And Development Co. Ltd. | Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same |
| WO2009086343A2 (en) * | 2007-12-31 | 2009-07-09 | 3M Innovative Properties Company | Microorganism-capturing compositions and methods |
| WO2014052848A1 (en) | 2012-09-28 | 2014-04-03 | The Regents Of The University Of Michigan | Apyrase treatments |
-
2015
- 2015-11-09 US US15/526,087 patent/US10415073B2/en active Active
- 2015-11-09 WO PCT/US2015/059654 patent/WO2016077185A1/en not_active Ceased
- 2015-11-09 EP EP15802240.0A patent/EP3218510B1/en active Active
- 2015-11-09 JP JP2017525824A patent/JP6698651B2/ja active Active
- 2015-11-09 CN CN201580061856.2A patent/CN107109464B/zh not_active Expired - Fee Related
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