JP2017532086A5 - - Google Patents
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- JP2017532086A5 JP2017532086A5 JP2017511622A JP2017511622A JP2017532086A5 JP 2017532086 A5 JP2017532086 A5 JP 2017532086A5 JP 2017511622 A JP2017511622 A JP 2017511622A JP 2017511622 A JP2017511622 A JP 2017511622A JP 2017532086 A5 JP2017532086 A5 JP 2017532086A5
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- JP
- Japan
- Prior art keywords
- array
- microstructure
- formulation
- mold
- microstructured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 66
- 238000009472 formulation Methods 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- 238000001035 drying Methods 0.000 claims description 21
- 239000012669 liquid formulation Substances 0.000 claims description 18
- 238000003825 pressing Methods 0.000 claims description 17
- 239000006184 cosolvent Substances 0.000 claims description 14
- 229960005486 vaccine Drugs 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 239000003963 antioxidant agent Substances 0.000 claims description 8
- 230000003078 antioxidant effect Effects 0.000 claims description 8
- 235000006708 antioxidants Nutrition 0.000 claims description 8
- 239000011159 matrix material Substances 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 235000000346 sugar Nutrition 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- 229930091371 Fructose Natural products 0.000 claims description 4
- 239000005715 Fructose Substances 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical group [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000012062 aqueous buffer Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- 239000008121 dextrose Substances 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 4
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 4
- 229930182817 methionine Natural products 0.000 claims description 4
- 235000006109 methionine Nutrition 0.000 claims description 4
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 229940068968 polysorbate 80 Drugs 0.000 claims description 4
- 238000010926 purge Methods 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 229940042585 tocopherol acetate Drugs 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 241000193738 Bacillus anthracis Species 0.000 claims description 2
- 201000006082 Chickenpox Diseases 0.000 claims description 2
- 206010014596 Encephalitis Japanese B Diseases 0.000 claims description 2
- 206010018691 Granuloma Diseases 0.000 claims description 2
- 241000701806 Human papillomavirus Species 0.000 claims description 2
- 201000005807 Japanese encephalitis Diseases 0.000 claims description 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 2
- 208000016604 Lyme disease Diseases 0.000 claims description 2
- 201000005505 Measles Diseases 0.000 claims description 2
- 201000005702 Pertussis Diseases 0.000 claims description 2
- 208000035109 Pneumococcal Infections Diseases 0.000 claims description 2
- 208000000474 Poliomyelitis Diseases 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 2
- 206010037742 Rabies Diseases 0.000 claims description 2
- 241000702670 Rotavirus Species 0.000 claims description 2
- 206010043376 Tetanus Diseases 0.000 claims description 2
- 208000037386 Typhoid Diseases 0.000 claims description 2
- 206010046980 Varicella Diseases 0.000 claims description 2
- 241000700647 Variola virus Species 0.000 claims description 2
- 208000003152 Yellow Fever Diseases 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- 229940103272 aluminum potassium sulfate Drugs 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 206010013023 diphtheria Diseases 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 claims description 2
- 231100000283 hepatitis Toxicity 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 150000002505 iron Chemical class 0.000 claims description 2
- 210000003681 parotid gland Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims description 2
- 201000005404 rubella Diseases 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 201000008297 typhoid fever Diseases 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 2
- 150000003754 zirconium Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000606790 Haemophilus Species 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
- 238000007792 addition Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 241000606768 Haemophilus influenzae Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462044051P | 2014-08-29 | 2014-08-29 | |
| US62/044,051 | 2014-08-29 | ||
| PCT/US2015/047563 WO2016033540A1 (en) | 2014-08-29 | 2015-08-28 | Microstructure array for delivery of active agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020194262A Division JP2021035605A (ja) | 2014-08-29 | 2020-11-24 | 活性剤の送達のための微細構造アレイ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532086A JP2017532086A (ja) | 2017-11-02 |
| JP2017532086A5 true JP2017532086A5 (enExample) | 2018-10-04 |
| JP7109188B2 JP7109188B2 (ja) | 2022-07-29 |
Family
ID=54073029
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511622A Active JP7109188B2 (ja) | 2014-08-29 | 2015-08-28 | 活性剤の送達のための微細構造アレイ |
| JP2020194262A Withdrawn JP2021035605A (ja) | 2014-08-29 | 2020-11-24 | 活性剤の送達のための微細構造アレイ |
| JP2022194121A Pending JP2023014378A (ja) | 2014-08-29 | 2022-12-05 | 活性剤の送達のための微細構造アレイ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020194262A Withdrawn JP2021035605A (ja) | 2014-08-29 | 2020-11-24 | 活性剤の送達のための微細構造アレイ |
| JP2022194121A Pending JP2023014378A (ja) | 2014-08-29 | 2022-12-05 | 活性剤の送達のための微細構造アレイ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160058992A1 (enExample) |
| EP (2) | EP3193828B8 (enExample) |
| JP (3) | JP7109188B2 (enExample) |
| AU (1) | AU2015308618B2 (enExample) |
| CA (1) | CA2959506C (enExample) |
| ES (1) | ES2944885T3 (enExample) |
| WO (1) | WO2016033540A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| US11524058B2 (en) | 2008-09-29 | 2022-12-13 | The Corporation Of Mercer University | Oral dissolving films containing microencapsulated vaccines and methods of making same |
| US10004790B2 (en) | 2008-09-29 | 2018-06-26 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| JP6865524B2 (ja) | 2012-12-21 | 2021-04-28 | コリウム， インコーポレイテッド | 治療剤を送達するためのマイクロアレイおよび使用方法 |
| JP6487899B2 (ja) | 2013-03-12 | 2019-03-20 | コリウム インターナショナル， インコーポレイテッド | 微小突起アプリケータ |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US11628208B2 (en) | 2015-10-05 | 2023-04-18 | The Corporation Of Mercer University | System and method for microneedle delivery of microencapsulated vaccine and bioactive proteins |
| WO2017062463A1 (en) | 2015-10-05 | 2017-04-13 | The Corporation Of Mercer University | Nanospheres encapsulating bioactive material and method for formulation of nanospheres |
| EP3434314B1 (en) * | 2016-03-25 | 2022-11-09 | Toppan Printing Co., Ltd. | Transdermal delivery device |
| JP6736337B2 (ja) * | 2016-04-15 | 2020-08-05 | 富士フイルム株式会社 | マイクロニードルアレイ |
| WO2017179613A1 (ja) * | 2016-04-15 | 2017-10-19 | 富士フイルム株式会社 | マイクロニードルアレイの製造方法 |
| WO2018089918A1 (en) * | 2016-11-14 | 2018-05-17 | The Corporation Of Mercer University | Microneedle-based transdermal delivery system and method of making same |
| CN107334495A (zh) | 2017-08-24 | 2017-11-10 | 广州新诚生物科技有限公司 | 用于植发的可溶针以及其制作方法 |
| JP7398606B2 (ja) * | 2018-06-25 | 2023-12-15 | コリウム ファーマ ソリューションズ， インコーポレイテッド | 微小構造アレイ成形型を形成するハイブリッド方法、微小構造アレイを作製する方法、および使用方法 |
| CN109674738A (zh) * | 2019-01-21 | 2019-04-26 | 武汉长联来福制药股份有限公司 | 炎琥宁制剂、贴片及其制备方法 |
| KR102281776B1 (ko) * | 2019-09-10 | 2021-07-27 | 주식회사 제네웰 | 동결건조용 몰드 및 이를 사용하는 수용성 고분자 구의 제조방법 |
| DE102020204651A1 (de) * | 2020-04-09 | 2021-10-14 | Lts Lohmann Therapie-Systeme Ag | Einrichtung zum Herstellen von Mikro-Arrays sowie Verfahren zum Herstellen eines Mikro-Arrays |
| CN115734798A (zh) * | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
| CA3180268A1 (en) * | 2020-05-28 | 2021-12-02 | Monica Serban | Devices comprising hyaluronic acid and silk fibroin |
| WO2022174040A1 (en) | 2021-02-11 | 2022-08-18 | 10X Technology Llc | Method and apparatus for fabricating brittle microneedle |
| DE102021112136A1 (de) * | 2021-05-10 | 2022-11-10 | Lts Lohmann Therapie-Systeme Ag. | Verfahren und Vorrichtung zur Herstellung von Mikronadelelementen, sowie Mikronadelelement |
| KR102382088B1 (ko) * | 2021-12-14 | 2022-04-04 | 주식회사 대웅테라퓨틱스 | 마이크로니들 제조방법 |
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| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| DE69719761T2 (de) | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
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| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
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| BRPI0509493A (pt) * | 2004-04-01 | 2007-09-11 | Alza Corp | aparelho e método para a liberação transdérmica de vacina da influenza |
| WO2006037070A2 (en) * | 2004-09-28 | 2006-04-06 | Alza Corporation | Stabilization of alum-adjuvanted immunologically active agents |
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| US7785301B2 (en) | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
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| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| US20090041810A1 (en) * | 2007-07-09 | 2009-02-12 | Andrianov Alexander K | Immunostimulating polyphosphazene compounds for intradermal immunization |
| AU2008280755B9 (en) | 2007-07-26 | 2014-09-25 | Sanofi Pasteur Limited | Antigen-adjuvant compositions and methods |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| CA2759850C (en) | 2009-04-24 | 2019-10-22 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| UY32560A (es) | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| US8834423B2 (en) * | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| BR112012018904A2 (pt) | 2010-02-10 | 2020-09-01 | Glaxosmithkline Llc | composto, adjuvante de vacina, composições imunogênica, de vacina e farmacêutica, e uso de um composto" |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| AU2011248166B2 (en) | 2010-05-04 | 2015-12-17 | Corium Pharma Solutions, Inc. | Applicators for microneedles |
| US9517205B2 (en) * | 2010-08-20 | 2016-12-13 | Seqirus UK Limited | Soluble needle arrays for delivery of influenza vaccines |
| WO2012122163A1 (en) | 2011-03-07 | 2012-09-13 | 3M Innovative Properties Company | Microneedle devices and methods |
| JP6865524B2 (ja) | 2012-12-21 | 2021-04-28 | コリウム， インコーポレイテッド | 治療剤を送達するためのマイクロアレイおよび使用方法 |
| CN104027324B (zh) * | 2013-03-06 | 2017-12-15 | 中国科学院理化技术研究所 | 一种可溶性微针疫苗贴片及其制备方法 |
| JPWO2014142135A1 (ja) * | 2013-03-12 | 2017-02-16 | 武田薬品工業株式会社 | マイクロニードルパッチ |
| WO2014144973A1 (en) * | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| EP2968118B1 (en) * | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| EP4059450A1 (en) * | 2013-03-15 | 2022-09-21 | Corium, Inc. | Microstructure array for delivery of active agents |
-
2015
- 2015-08-28 WO PCT/US2015/047563 patent/WO2016033540A1/en not_active Ceased
- 2015-08-28 ES ES15762884T patent/ES2944885T3/es active Active
- 2015-08-28 EP EP15762884.3A patent/EP3193828B8/en active Active
- 2015-08-28 CA CA2959506A patent/CA2959506C/en active Active
- 2015-08-28 US US14/839,690 patent/US20160058992A1/en not_active Abandoned
- 2015-08-28 AU AU2015308618A patent/AU2015308618B2/en not_active Ceased
- 2015-08-28 JP JP2017511622A patent/JP7109188B2/ja active Active
- 2015-08-28 EP EP23158884.9A patent/EP4218724A3/en not_active Withdrawn
-
2020
- 2020-11-24 JP JP2020194262A patent/JP2021035605A/ja not_active Withdrawn
-
2022
- 2022-12-05 JP JP2022194121A patent/JP2023014378A/ja active Pending
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