JP2016518868A5 - - Google Patents
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- Publication number
- JP2016518868A5 JP2016518868A5 JP2016500904A JP2016500904A JP2016518868A5 JP 2016518868 A5 JP2016518868 A5 JP 2016518868A5 JP 2016500904 A JP2016500904 A JP 2016500904A JP 2016500904 A JP2016500904 A JP 2016500904A JP 2016518868 A5 JP2016518868 A5 JP 2016518868A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid formulation
- sugar alcohol
- array
- starch
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012669 liquid formulation Substances 0.000 claims description 32
- 150000005846 sugar alcohols Chemical class 0.000 claims description 26
- 150000004676 glycans Chemical class 0.000 claims description 24
- 229920001282 polysaccharide Polymers 0.000 claims description 24
- 239000005017 polysaccharide Substances 0.000 claims description 24
- 239000013543 active substance Substances 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 15
- 229920002472 Starch Polymers 0.000 claims description 14
- 235000019698 starch Nutrition 0.000 claims description 14
- 239000008107 starch Substances 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 12
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 235000010356 sorbitol Nutrition 0.000 claims description 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 10
- 229920000881 Modified starch Polymers 0.000 claims description 9
- 235000019426 modified starch Nutrition 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 229920002307 Dextran Polymers 0.000 claims description 8
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 8
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 8
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 8
- 239000004368 Modified starch Substances 0.000 claims description 7
- 235000011187 glycerol Nutrition 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 239000004386 Erythritol Substances 0.000 claims description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 4
- 229920001503 Glucan Polymers 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 235000019414 erythritol Nutrition 0.000 claims description 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 4
- 229940009714 erythritol Drugs 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 4
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims description 4
- 239000000832 lactitol Substances 0.000 claims description 4
- 235000010448 lactitol Nutrition 0.000 claims description 4
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 4
- 229960003451 lactitol Drugs 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- XJCCHWKNFMUJFE-CGQAXDJHSA-N Maltotriitol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 XJCCHWKNFMUJFE-CGQAXDJHSA-N 0.000 claims description 2
- 239000012062 aqueous buffer Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 230000009089 cytolysis Effects 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000000845 maltitol Substances 0.000 claims description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 2
- 235000010449 maltitol Nutrition 0.000 claims description 2
- 229940035436 maltitol Drugs 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 229960004793 sucrose Drugs 0.000 claims description 2
- 229940074410 trehalose Drugs 0.000 claims description 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 2
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361800543P | 2013-03-15 | 2013-03-15 | |
| US61/800,543 | 2013-03-15 | ||
| PCT/US2014/022087 WO2014150069A1 (en) | 2013-03-15 | 2014-03-07 | Microstructure array for delivery of active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016518868A JP2016518868A (ja) | 2016-06-30 |
| JP2016518868A5 true JP2016518868A5 (enExample) | 2017-04-06 |
Family
ID=50390285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500904A Pending JP2016518868A (ja) | 2013-03-15 | 2014-03-07 | 活性剤の送達のための微細構造物のアレイ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140276378A1 (enExample) |
| EP (2) | EP2967597B1 (enExample) |
| JP (1) | JP2016518868A (enExample) |
| KR (1) | KR102316739B1 (enExample) |
| CN (1) | CN105188569B (enExample) |
| AU (1) | AU2014237499B2 (enExample) |
| BR (1) | BR112015022432B1 (enExample) |
| CA (1) | CA2904335C (enExample) |
| ES (1) | ES2921174T3 (enExample) |
| IL (1) | IL241064A0 (enExample) |
| MX (1) | MX2015012433A (enExample) |
| RU (1) | RU2662432C2 (enExample) |
| WO (1) | WO2014150069A1 (enExample) |
| ZA (1) | ZA201506916B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| EP2146689B1 (en) | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| EP2429627B1 (en) * | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| JP6327852B2 (ja) | 2010-05-04 | 2018-05-23 | コリウム インターナショナル， インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
| EP2765927B1 (en) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Delivery device |
| AU2013364053B2 (en) | 2012-12-21 | 2018-08-30 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| CA2903748C (en) | 2013-03-12 | 2021-11-02 | Corium International, Inc. | Microprojection applicators |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| BR112015022625B1 (pt) | 2013-03-15 | 2023-01-31 | Corium, Inc | Aparelho de microestrutura para entrega de agente terapêutico |
| US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| US20160310412A1 (en) * | 2013-12-16 | 2016-10-27 | Takeda Pharmaceutical Company Limited | Microneedle |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| EP3341070B1 (en) * | 2014-08-27 | 2019-12-11 | Neuronano AB | Apparatus for implantation of a medical device into neural tissue |
| JP7109188B2 (ja) * | 2014-08-29 | 2022-07-29 | コリウム， インコーポレイテッド | 活性剤の送達のための微細構造アレイ |
| WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| JP6906885B2 (ja) * | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| US11147954B2 (en) | 2015-02-02 | 2021-10-19 | Vaxxas Pty Limited | Microprojection array applicator and method |
| KR101667216B1 (ko) * | 2015-06-18 | 2016-10-18 | 방철환 | 약물 주입 장치 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| JP2017051312A (ja) * | 2015-09-08 | 2017-03-16 | 富士フイルム株式会社 | マイクロニードルアレイ |
| US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| KR101610598B1 (ko) * | 2015-09-21 | 2016-04-07 | 비엔엘바이오테크 주식회사 | 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법 |
| US20180264244A1 (en) | 2015-09-28 | 2018-09-20 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| CN108883262B (zh) * | 2016-03-25 | 2021-05-28 | 凸版印刷株式会社 | 经皮给药装置 |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| US10596321B2 (en) | 2016-04-08 | 2020-03-24 | Allergan, Inc. | Aspiration and injection device |
| WO2017208962A1 (ja) * | 2016-05-31 | 2017-12-07 | Ｎｉｓｓｈａ株式会社 | マイクロニードルアレイ及びその製造方法 |
| US20180056053A1 (en) * | 2016-08-26 | 2018-03-01 | Juvic Inc. | Protruding microstructure for transdermal delivery |
| CN106474620A (zh) * | 2016-09-22 | 2017-03-08 | 北京化工大学 | 一种药物可控释放的聚合物微针、制备方法及微针贴片 |
| KR102401856B1 (ko) * | 2017-02-17 | 2022-05-26 | 알레간 인코포레이티드 | 활성 성분을 갖는 마이크로니들 어레이 |
| AU2018241251B2 (en) | 2017-03-31 | 2024-06-27 | Vaxxas Pty Limited | Device and method for coating surfaces |
| JP6968805B2 (ja) * | 2017-05-30 | 2021-11-17 | Ｎｉｓｓｈａ株式会社 | マイクロニードルパッチとその梱包体 |
| EP3639010B1 (en) | 2017-06-13 | 2025-08-06 | Vaxxas Pty Limited | Quality control of substrate coatings |
| EP4548954A3 (en) | 2017-08-04 | 2025-07-30 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map) |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| JP7305311B2 (ja) * | 2018-05-30 | 2023-07-10 | ロレアル | マイクロニードルシート |
| JP2020018327A (ja) * | 2018-07-17 | 2020-02-06 | ロレアル | マイクロニードルシート |
| AU2019360713B2 (en) * | 2018-10-18 | 2023-03-02 | 3M Innovative Properties Company | Dental appliance with structured surface |
| CN109498804B (zh) * | 2018-12-04 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种温度响应型狂犬疫苗递送系统 |
| JP7666887B2 (ja) * | 2018-12-21 | 2025-04-22 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
| JP6778296B2 (ja) * | 2019-04-11 | 2020-10-28 | 富士フイルム株式会社 | マイクロニードルアレイ |
| KR20250056504A (ko) | 2023-10-19 | 2025-04-28 | 연세대학교 산학협력단 | 분리 수율이 높은 마이크로니들 구조체, 이를 포함하는 장치 및 이의 제조 방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| US7184826B2 (en) | 1996-06-18 | 2007-02-27 | Alza Corporation | Device and method for enhancing transdermal flux of agents being delivered or sampled |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| CN1227030C (zh) * | 1999-04-19 | 2005-11-16 | 史密丝克莱恩比彻姆生物有限公司 | 包含皂甙和免疫刺激寡核苷酸的佐剂组合物 |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| EP1345646A2 (en) | 2000-12-14 | 2003-09-24 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| EP2146689B1 (en) * | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
| WO2009142741A1 (en) * | 2008-05-21 | 2009-11-26 | Theraject, Inc. | Method of manufacturing solid solution peforator patches and uses thereof |
| EP2429627B1 (en) | 2009-04-24 | 2017-06-14 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| RU2414255C1 (ru) * | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
| JP6327852B2 (ja) * | 2010-05-04 | 2018-05-23 | コリウム インターナショナル， インコーポレイテッド | 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス |
| BR112012028263B1 (pt) | 2010-05-04 | 2020-06-02 | Corium, Inc. | Aplicador e dispositivo para matriz de microprojeção |
| CA2829354C (en) * | 2011-03-07 | 2020-09-29 | 3M Innovative Properties Company | Microneedle devices and methods |
-
2014
- 2014-03-07 RU RU2015143551A patent/RU2662432C2/ru active
- 2014-03-07 KR KR1020157026947A patent/KR102316739B1/ko active Active
- 2014-03-07 ES ES14713727T patent/ES2921174T3/es active Active
- 2014-03-07 JP JP2016500904A patent/JP2016518868A/ja active Pending
- 2014-03-07 WO PCT/US2014/022087 patent/WO2014150069A1/en not_active Ceased
- 2014-03-07 AU AU2014237499A patent/AU2014237499B2/en not_active Ceased
- 2014-03-07 EP EP14713727.7A patent/EP2967597B1/en active Active
- 2014-03-07 BR BR112015022432-6A patent/BR112015022432B1/pt not_active IP Right Cessation
- 2014-03-07 US US14/201,709 patent/US20140276378A1/en not_active Abandoned
- 2014-03-07 CN CN201480015948.2A patent/CN105188569B/zh active Active
- 2014-03-07 CA CA2904335A patent/CA2904335C/en active Active
- 2014-03-07 EP EP22156402.4A patent/EP4059450A1/en not_active Withdrawn
- 2014-03-07 MX MX2015012433A patent/MX2015012433A/es unknown
-
2015
- 2015-09-02 IL IL241064A patent/IL241064A0/en unknown
- 2015-09-17 ZA ZA2015/06916A patent/ZA201506916B/en unknown
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