RU2662432C2 - Массив микроструктур для доставки действующих агентов - Google Patents
Массив микроструктур для доставки действующих агентов Download PDFInfo
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- RU2662432C2 RU2662432C2 RU2015143551A RU2015143551A RU2662432C2 RU 2662432 C2 RU2662432 C2 RU 2662432C2 RU 2015143551 A RU2015143551 A RU 2015143551A RU 2015143551 A RU2015143551 A RU 2015143551A RU 2662432 C2 RU2662432 C2 RU 2662432C2
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M2037/0053—Methods for producing microneedles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| CA2759850C (en) * | 2009-04-24 | 2019-10-22 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| EP2765927B1 (en) | 2011-10-12 | 2021-02-24 | Vaxxas Pty Limited | Delivery device |
| JP6865524B2 (ja) | 2012-12-21 | 2021-04-28 | コリウム, インコーポレイテッド | 治療剤を送達するためのマイクロアレイおよび使用方法 |
| JP6487899B2 (ja) | 2013-03-12 | 2019-03-20 | コリウム インターナショナル, インコーポレイテッド | 微小突起アプリケータ |
| WO2014144973A1 (en) | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| WO2014150285A2 (en) | 2013-03-15 | 2014-09-25 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| AU2014237279B2 (en) | 2013-03-15 | 2018-11-22 | Corium Pharma Solutions, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| EP2968118B1 (en) | 2013-03-15 | 2022-02-09 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| US20160310412A1 (en) * | 2013-12-16 | 2016-10-27 | Takeda Pharmaceutical Company Limited | Microneedle |
| US20160279401A1 (en) | 2015-03-27 | 2016-09-29 | Allergan, Inc. | Dissolvable microneedles for skin treatment |
| SG11201701024WA (en) * | 2014-08-27 | 2017-03-30 | Neuronano Ab | Method of implantation of a medical device into neural tissue |
| WO2016033540A1 (en) * | 2014-08-29 | 2016-03-03 | Corium International, Inc. | Microstructure array for delivery of active agents |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| JP6906885B2 (ja) * | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| EP4218892A1 (en) | 2015-02-02 | 2023-08-02 | Vaxxas Pty Limited | Microprojection array applicator |
| KR101667216B1 (ko) * | 2015-06-18 | 2016-10-18 | 방철환 | 약물 주입 장치 |
| WO2017004067A1 (en) | 2015-06-29 | 2017-01-05 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| JP2017051312A (ja) * | 2015-09-08 | 2017-03-16 | 富士フイルム株式会社 | マイクロニードルアレイ |
| US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
| KR101610598B1 (ko) * | 2015-09-21 | 2016-04-07 | 비엔엘바이오테크 주식회사 | 잇몸 굴곡에 맞게 유연하며 치과용 물질 전달을 위한 마이크로 니들 및 그 제작방법 |
| AU2016333148B2 (en) | 2015-09-28 | 2021-10-14 | Vaxxas Pty Limited | Microprojection arrays with enhanced skin penetrating properties and methods thereof |
| EP3434314B1 (en) * | 2016-03-25 | 2022-11-09 | Toppan Printing Co., Ltd. | Transdermal delivery device |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| KR102232054B1 (ko) | 2016-04-08 | 2021-03-26 | 알레간 인코포레이티드 | 흡인 및 주입 디바이스 |
| JP6434193B2 (ja) * | 2016-05-31 | 2018-12-05 | Nissha株式会社 | マイクロニードルアレイ及びその製造方法 |
| US20180056053A1 (en) * | 2016-08-26 | 2018-03-01 | Juvic Inc. | Protruding microstructure for transdermal delivery |
| CN106474620A (zh) * | 2016-09-22 | 2017-03-08 | 北京化工大学 | 一种药物可控释放的聚合物微针、制备方法及微针贴片 |
| AU2018222745B2 (en) * | 2017-02-17 | 2021-02-18 | Allergan, Inc. | Microneedle array with active ingredient |
| CN115923337A (zh) | 2017-03-31 | 2023-04-07 | 瓦克萨斯私人有限公司 | 用于涂覆表面的设备和方法 |
| KR102547455B1 (ko) * | 2017-05-30 | 2023-06-23 | 닛샤 가부시키가이샤 | 마이크로 니들 패치와 그 곤포체 |
| WO2018227246A1 (en) | 2017-06-13 | 2018-12-20 | Vaxxas Pty Limited | Quality control of substrate coatings |
| US11464957B2 (en) | 2017-08-04 | 2022-10-11 | Vaxxas Pty Limited | Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP) |
| JP6671616B2 (ja) * | 2017-11-02 | 2020-03-25 | コスメディ製薬株式会社 | 歯科用局所麻酔マイクロニードルアレイ |
| JP7305311B2 (ja) * | 2018-05-30 | 2023-07-10 | ロレアル | マイクロニードルシート |
| JP2020018327A (ja) * | 2018-07-17 | 2020-02-06 | ロレアル | マイクロニードルシート |
| US20210353387A1 (en) * | 2018-10-18 | 2021-11-18 | 3M Innovative Properties Company | Dental appliance with structured surface |
| CN109498804B (zh) * | 2018-12-04 | 2022-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种温度响应型狂犬疫苗递送系统 |
| JP7666887B2 (ja) * | 2018-12-21 | 2025-04-22 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
| JP6778296B2 (ja) * | 2019-04-11 | 2020-10-28 | 富士フイルム株式会社 | マイクロニードルアレイ |
| KR20250056504A (ko) | 2023-10-19 | 2025-04-28 | 연세대학교 산학협력단 | 분리 수율이 높은 마이크로니들 구조체, 이를 포함하는 장치 및 이의 제조 방법 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080269685A1 (en) * | 2007-04-16 | 2008-10-30 | Parminder Singh | Solvent-cast microneedle arrays containing active |
| RU2414255C1 (ru) * | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
| WO2012122163A1 (en) * | 2011-03-07 | 2012-09-13 | 3M Innovative Properties Company | Microneedle devices and methods |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| DE69719761T2 (de) | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| TR200103018T2 (tr) * | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| WO2009048607A1 (en) | 2007-10-10 | 2009-04-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| CN102105108B (zh) * | 2008-05-21 | 2013-12-04 | 谢拉杰克特股份有限公司 | 制作固体溶液穿孔器贴剂的方法及其使用 |
| CA2759850C (en) | 2009-04-24 | 2019-10-22 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
| US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| AU2011248166B2 (en) | 2010-05-04 | 2015-12-17 | Corium Pharma Solutions, Inc. | Applicators for microneedles |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080269685A1 (en) * | 2007-04-16 | 2008-10-30 | Parminder Singh | Solvent-cast microneedle arrays containing active |
| RU2414255C1 (ru) * | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
| WO2012122163A1 (en) * | 2011-03-07 | 2012-09-13 | 3M Innovative Properties Company | Microneedle devices and methods |
Also Published As
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| CA2904335A1 (en) | 2014-09-25 |
| BR112015022432A8 (pt) | 2019-11-26 |
| WO2014150069A1 (en) | 2014-09-25 |
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| EP4059450A1 (en) | 2022-09-21 |
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| US20140276378A1 (en) | 2014-09-18 |
| KR20150126883A (ko) | 2015-11-13 |
| BR112015022432A2 (pt) | 2017-07-18 |
| CN105188569A (zh) | 2015-12-23 |
| ES2921174T3 (es) | 2022-08-19 |
| RU2015143551A (ru) | 2017-04-20 |
| AU2014237499A1 (en) | 2015-09-17 |
| EP2967597A1 (en) | 2016-01-20 |
| EP2967597B1 (en) | 2022-05-04 |
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