JP2017532030A - 診断方法及び組成物 - Google Patents

診断方法及び組成物 Download PDF

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Publication number
JP2017532030A
JP2017532030A JP2017514803A JP2017514803A JP2017532030A JP 2017532030 A JP2017532030 A JP 2017532030A JP 2017514803 A JP2017514803 A JP 2017514803A JP 2017514803 A JP2017514803 A JP 2017514803A JP 2017532030 A JP2017532030 A JP 2017532030A
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JP
Japan
Prior art keywords
primer
region
amplification reaction
complementary
nucleic acid
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JP2017514803A
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English (en)
Japanese (ja)
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JP2017532030A5 (enExample
Inventor
プラナブ パテル,
プラナブ パテル,
インディラ ウー,
インディラ ウー,
アーロン リチャードソン,
アーロン リチャードソン,
カミラ ベルホシン,
カミラ ベルホシン,
ジョセフィン リー,
ジョセフィン リー,
スコット タバクマン,
スコット タバクマン,
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Theranos Inc
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Theranos Inc
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Priority claimed from PCT/US2014/056151 external-priority patent/WO2015076919A1/en
Application filed by Theranos Inc filed Critical Theranos Inc
Publication of JP2017532030A publication Critical patent/JP2017532030A/ja
Publication of JP2017532030A5 publication Critical patent/JP2017532030A5/ja
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • C12Q1/707Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2017514803A 2014-09-17 2015-09-17 診断方法及び組成物 Withdrawn JP2017532030A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201462051945P 2014-09-17 2014-09-17
US201462051912P 2014-09-17 2014-09-17
PCT/US2014/056151 WO2015076919A1 (en) 2013-11-22 2014-09-17 Nucleic Acid Amplification
US62/051,945 2014-09-17
US62/051,912 2014-09-17
USPCT/US2014/056151 2014-09-17
US201462068603P 2014-10-24 2014-10-24
US201462068605P 2014-10-24 2014-10-24
US62/068,605 2014-10-24
US62/068,603 2014-10-24
US201562151358P 2015-04-22 2015-04-22
US62/151,358 2015-04-22
PCT/US2015/050811 WO2016044664A1 (en) 2014-09-17 2015-09-17 Diagnostic methods and compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020167791A Division JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物

Publications (2)

Publication Number Publication Date
JP2017532030A true JP2017532030A (ja) 2017-11-02
JP2017532030A5 JP2017532030A5 (enExample) 2018-11-01

Family

ID=55533878

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2017514803A Withdrawn JP2017532030A (ja) 2014-09-17 2015-09-17 診断方法及び組成物
JP2017514802A Withdrawn JP2017531424A (ja) 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017514802A Withdrawn JP2017531424A (ja) 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Country Status (8)

Country Link
US (3) US9909193B2 (enExample)
EP (2) EP3194629A4 (enExample)
JP (6) JP2017532030A (enExample)
CN (3) CN113736863A (enExample)
BR (1) BR112017005392A2 (enExample)
CA (2) CA2961209A1 (enExample)
MX (2) MX366113B (enExample)
WO (2) WO2016044673A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2961209A1 (en) 2014-09-17 2016-03-24 Theranos, Inc. Diagnostic methods and compositions
US10822648B1 (en) 2016-07-29 2020-11-03 Labrador Diagnostics Llc Hybrid multi-step nucleic acid amplification
CN110462042B (zh) 2016-12-15 2023-10-27 梅哈里医学院 抗病毒剂
FI130673B1 (en) * 2020-11-24 2024-01-11 Mobidiag Oy Method and system for performing a cumulative nucleic acid amplification reaction

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US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0912761A4 (en) * 1996-05-29 2004-06-09 Cornell Res Foundation Inc DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
AU2001244677A1 (en) * 2000-04-07 2001-10-23 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
US6605451B1 (en) * 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7041447B2 (en) * 2001-04-09 2006-05-09 St. Jude Children's Hospital, Inc. Haplotyping method for multiple distal nucleotide polymorphisms
EP1319718A1 (en) * 2001-12-14 2003-06-18 Keygene N.V. High throughput analysis and detection of multiple target sequences
WO2005014810A1 (ja) * 2003-08-08 2005-02-17 National Institute Of Advanced Industrial Science And Technology ダンベル型dnaの効率的な製造方法
JP4379087B2 (ja) * 2003-11-07 2009-12-09 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸合成酵素及びゲラニルゲラニオールの製造方法
US20100075384A1 (en) * 2004-03-25 2010-03-25 New England Biolabs, Inc. Helicase-dependent amplification of circular nucleic acids
WO2006003721A1 (en) * 2004-07-02 2006-01-12 Kabushiki Kaisha Dnaform Method for preparing sequence tags
EP2458011B1 (en) * 2005-10-03 2013-07-24 Life Technologies Corporation Compositions, methods, and kits for amplifying nucleic acids
EP2162555A4 (en) * 2007-06-22 2011-02-23 Univ Columbia SPECIFIC AMPLIFICATION OF TUMOR-SPECIFIC DNA SEQUENCES
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IT1394539B1 (it) * 2009-05-19 2012-07-05 Sentinel Ch S P A Uso di uno stabilizzante delle polimerasi per la liofilizzazione e la preparazione di kit pronti per l'uso
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Also Published As

Publication number Publication date
BR112017005392A2 (pt) 2017-12-12
JP2023011943A (ja) 2023-01-24
CA2960859A1 (en) 2016-03-24
US9909193B2 (en) 2018-03-06
WO2016044664A1 (en) 2016-03-24
US20180223381A1 (en) 2018-08-09
CN108026591A (zh) 2018-05-11
CA2961209A1 (en) 2016-03-24
JP2017531424A (ja) 2017-10-26
EP3194629A1 (en) 2017-07-26
MX2017003475A (es) 2017-08-02
MX2017003473A (es) 2017-08-02
EP3194590A4 (en) 2018-05-09
CN107002066A (zh) 2017-08-01
CN108026591B (zh) 2021-09-07
MX366113B (es) 2019-06-26
US20170342476A1 (en) 2017-11-30
JP2021006056A (ja) 2021-01-21
CN113736863A (zh) 2021-12-03
US20160201148A1 (en) 2016-07-14
JP2021000138A (ja) 2021-01-07
EP3194590A1 (en) 2017-07-26
WO2016044673A1 (en) 2016-03-24
JP2022110152A (ja) 2022-07-28
EP3194629A4 (en) 2018-03-07

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