JP2017531448A5 - - Google Patents

Info

Publication number

JP2017531448A5

JP2017531448A5 JP2017537016A JP2017537016A JP2017531448A5 JP 2017531448 A5 JP2017531448 A5 JP 2017531448A5 JP 2017537016 A JP2017537016 A JP 2017537016A JP 2017537016 A JP2017537016 A JP 2017537016A JP 2017531448 A5 JP2017531448 A5 JP 2017531448A5

Authority

JP

Japan

Prior art keywords

cell

cells

motif

ligand

fibronectin

Prior art date

2015-10-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims description 34
• 239000003446 ligand Substances 0.000 claims description 21
• 108010067306 Fibronectins Proteins 0.000 claims description 17
• 102000016359 Fibronectins Human genes 0.000 claims description 17
• 239000012634 fragment Substances 0.000 claims description 17
• 210000004027 cell Anatomy 0.000 claims description 12
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 10
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 10
• 210000000173 T-lymphoid precursor cell Anatomy 0.000 claims description 10
• NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 claims description 8
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 8
• 229960002897 heparin Drugs 0.000 claims description 8
• 229920000669 heparin Polymers 0.000 claims description 8
• 108090000623 proteins and genes Proteins 0.000 claims description 8
• 238000004113 cell culture Methods 0.000 claims description 7
• 239000001963 growth medium Substances 0.000 claims description 7
• 102000004169 proteins and genes Human genes 0.000 claims description 7
• 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 6
• 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 6
• 102000000704 Interleukin-7 Human genes 0.000 claims description 6
• 108010002586 Interleukin-7 Proteins 0.000 claims description 6
• 102000036693 Thrombopoietin Human genes 0.000 claims description 6
• 108010041111 Thrombopoietin Proteins 0.000 claims description 6
• 229940100994 interleukin-7 Drugs 0.000 claims description 6
• 239000002609 medium Substances 0.000 claims description 5
• 210000000130 stem cell Anatomy 0.000 claims description 5
• 102000004127 Cytokines Human genes 0.000 claims description 4
• 108090000695 Cytokines Proteins 0.000 claims description 4
• 239000003102 growth factor Substances 0.000 claims description 4
• 101000829980 Homo sapiens Ral guanine nucleotide dissociation stimulator Proteins 0.000 claims description 3
• 102100023320 Ral guanine nucleotide dissociation stimulator Human genes 0.000 claims description 3
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
• 238000000338 in vitro Methods 0.000 claims description 3
• -1 SCF Proteins 0.000 claims description 2
• 238000002347 injection Methods 0.000 claims description 2
• 239000007924 injection Substances 0.000 claims description 2
• 238000004806 packaging method and process Methods 0.000 claims description 2
• 108010056030 retronectin Proteins 0.000 claims description 2
• 239000013603 viral vector Substances 0.000 claims description 2
• 239000011324 bead Substances 0.000 claims 3
• 208000024908 graft versus host disease Diseases 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• 206010061598 Immunodeficiency Diseases 0.000 claims 1
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
• 238000010322 bone marrow transplantation Methods 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 230000003750 conditioning effect Effects 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 210000002865 immune cell Anatomy 0.000 claims 1
• 230000007813 immunodeficiency Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 239000000243 solution Substances 0.000 claims 1
• 238000001890 transfection Methods 0.000 claims 1
• 102000005650 Notch Receptors Human genes 0.000 description 9
• 108010070047 Notch Receptors Proteins 0.000 description 9
• 239000011325 microbead Substances 0.000 description 1
• 239000012429 reaction media Substances 0.000 description 1