FR3026744B1 - Methode de generation de progeniteurs de cellules t - Google Patents

Methode de generation de progeniteurs de cellules t Download PDF

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Publication number
FR3026744B1
FR3026744B1 FR1459539A FR1459539A FR3026744B1 FR 3026744 B1 FR3026744 B1 FR 3026744B1 FR 1459539 A FR1459539 A FR 1459539A FR 1459539 A FR1459539 A FR 1459539A FR 3026744 B1 FR3026744 B1 FR 3026744B1
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Prior art keywords
cell progenitors
paris
ligand
generation
institute
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FR1459539A
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English (en)
French (fr)
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FR3026744A1 (fr
Inventor
Emmanuelle Six
Marina Cavazzana
Isabelle Andre
Chantal Lagresle-Peyrou
Salima Hacein-Bey-Abina
Christian Reimann
Chappedelaine Corinne De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fondation Imagine Institut Des Maladies Gene Fr
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Cite
Original Assignee
Fondation Imagine Inst Des Maladies Genetiques
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Universite Paris Descartes
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Publication date
Priority to FR1459539A priority Critical patent/FR3026744B1/fr
Application filed by Fondation Imagine Inst Des Maladies Genetiques, Assistance Publique Hopitaux de Paris APHP, Institut National de la Sante et de la Recherche Medicale INSERM, Universite Paris Descartes filed Critical Fondation Imagine Inst Des Maladies Genetiques
Priority to ES15771979T priority patent/ES2914082T3/es
Priority to HUE15771979A priority patent/HUE059468T2/hu
Priority to EP22152734.4A priority patent/EP4036224A1/fr
Priority to DK15771979.0T priority patent/DK3204492T3/da
Priority to PL15771979.0T priority patent/PL3204492T3/pl
Priority to PCT/EP2015/072889 priority patent/WO2016055396A1/fr
Priority to US15/516,731 priority patent/US12071635B2/en
Priority to EP15771979.0A priority patent/EP3204492B1/fr
Priority to PT157719790T priority patent/PT3204492T/pt
Priority to CA2963756A priority patent/CA2963756C/fr
Priority to JP2017537016A priority patent/JP6898240B2/ja
Publication of FR3026744A1 publication Critical patent/FR3026744A1/fr
Priority to JP2020209370A priority patent/JP2021072779A/ja
Application granted granted Critical
Publication of FR3026744B1 publication Critical patent/FR3026744B1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1114—T cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
FR1459539A 2014-10-06 2014-10-06 Methode de generation de progeniteurs de cellules t Active FR3026744B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR1459539A FR3026744B1 (fr) 2014-10-06 2014-10-06 Methode de generation de progeniteurs de cellules t
CA2963756A CA2963756C (fr) 2014-10-06 2015-10-05 Methode de generation de progeniteurs de cellules t
EP22152734.4A EP4036224A1 (fr) 2014-10-06 2015-10-05 Méthode de génération de progéniteurs de cellules t
DK15771979.0T DK3204492T3 (da) 2014-10-06 2015-10-05 Fremgangsmåde til generering af t-celleforløbere
PL15771979.0T PL3204492T3 (pl) 2014-10-06 2015-10-05 Sposób generowania komórek progenitorowych limfocytów t
PCT/EP2015/072889 WO2016055396A1 (fr) 2014-10-06 2015-10-05 Méthode de génération de progéniteurs de cellules t
ES15771979T ES2914082T3 (es) 2014-10-06 2015-10-05 Procedimiento de generación de progenitores de células T
EP15771979.0A EP3204492B1 (fr) 2014-10-06 2015-10-05 Méthode de génération de progéniteurs de cellules t
PT157719790T PT3204492T (pt) 2014-10-06 2015-10-05 Método de geração de progenitores de células t
HUE15771979A HUE059468T2 (hu) 2014-10-06 2015-10-05 Módszer T-sejt progenitorok generálására
JP2017537016A JP6898240B2 (ja) 2014-10-06 2015-10-05 Ｔ細胞前駆細胞を生成するための方法
US15/516,731 US12071635B2 (en) 2014-10-06 2015-10-05 Method for generating T-cell progenitors
JP2020209370A JP2021072779A (ja) 2014-10-06 2020-12-17 Ｔ細胞前駆細胞を生成するための方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1459539A FR3026744B1 (fr) 2014-10-06 2014-10-06 Methode de generation de progeniteurs de cellules t

Publications (2)

Publication Number Publication Date
FR3026744A1 FR3026744A1 (fr) 2016-04-08
FR3026744B1 true FR3026744B1 (fr) 2024-04-19

Family

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FR1459539A Active FR3026744B1 (fr) 2014-10-06 2014-10-06 Methode de generation de progeniteurs de cellules t

Country Status (11)

Country Link
US (1) US12071635B2 (enExample)
EP (2) EP3204492B1 (enExample)
JP (2) JP6898240B2 (enExample)
CA (1) CA2963756C (enExample)
DK (1) DK3204492T3 (enExample)
ES (1) ES2914082T3 (enExample)
FR (1) FR3026744B1 (enExample)
HU (1) HUE059468T2 (enExample)
PL (1) PL3204492T3 (enExample)
PT (1) PT3204492T (enExample)
WO (1) WO2016055396A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3440198A4 (en) 2016-04-08 2019-11-06 The Governing Council of the Universtiy of Toronto PROCESS FOR THE PRODUCTION OF PRE-TREATMENT T CELLS FROM TRUNK AND / OR PRECURSOR CELLS AND USE THEREOF
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors
CN112041431A (zh) * 2018-02-14 2020-12-04 桑尼布鲁克研究所 产生t细胞谱系细胞的方法
FR3079239A1 (fr) * 2018-03-23 2019-09-27 Centre National De La Recherche Scientifique Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations
EP3774867A1 (en) * 2018-04-10 2021-02-17 Stichting Sanquin Bloedvoorziening Chimeric notch receptors
JP2023553313A (ja) 2020-11-30 2023-12-21 チョ ファーマ インコーポレイテッド 細胞を富化するための抗体
EP4426319A1 (en) 2021-11-04 2024-09-11 APHP (Assistance Publique - Hôpitaux de Paris) Method for generating nk cells
WO2024175738A1 (en) 2023-02-22 2024-08-29 Smart Immune Method for thymus regeneration
WO2025012449A1 (en) 2023-07-12 2025-01-16 Smart Immune Biobank of cellular banks having specific homozygous hla haplotypes and uses thereof for treating patients
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
JP2001525176A (ja) 1997-12-04 2001-12-11 デューク・ユニバーシティー Ｃｄ７＋ｃｄ３４−ｌｉｎ−造血細胞を単離し、使用する方法
EA012520B1 (ru) * 2003-08-22 2009-10-30 Такара Био Инк. Способ получения цитотоксических лимфоцитов
US10059923B2 (en) 2008-01-30 2018-08-28 Memorial Sloan Kettering Cancer Center Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
RU2535966C2 (ru) 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
US8772028B2 (en) 2008-11-07 2014-07-08 Sunnybrook Health Sciences Centre CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using
WO2011068962A1 (en) * 2009-12-03 2011-06-09 The University Of Utah Research Foundation Methods for generating t lymphocytes from hematopoietic stem cells
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US9834755B2 (en) 2011-12-08 2017-12-05 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2014110353A1 (en) * 2013-01-11 2014-07-17 The Trustees Of The University Of Pennsylvania Notch ligand bound bicompatible substrates and their use in bone formation
EP3027755B1 (en) 2013-08-02 2019-10-09 The Regents of The University of California Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
US20170128556A1 (en) 2013-12-26 2017-05-11 Thyas Co. Ltd. Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
US10131876B2 (en) 2014-04-24 2018-11-20 Miltenyi Biotec Gmbh Method for automated generation of genetically modified T cells
WO2016039933A1 (en) * 2014-09-11 2016-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral vector for treating hemoglobin disorders

Also Published As

Publication number Publication date
EP3204492A1 (fr) 2017-08-16
WO2016055396A1 (fr) 2016-04-14
ES2914082T8 (es) 2022-06-16
US20180208895A1 (en) 2018-07-26
PL3204492T3 (pl) 2022-07-25
EP4036224A1 (fr) 2022-08-03
HUE059468T2 (hu) 2022-12-28
FR3026744A1 (fr) 2016-04-08
EP3204492B1 (fr) 2022-03-09
CA2963756C (fr) 2024-01-02
JP2021072779A (ja) 2021-05-13
US12071635B2 (en) 2024-08-27
DK3204492T3 (da) 2022-06-07
PT3204492T (pt) 2022-05-30
ES2914082T3 (es) 2022-06-07
CA2963756A1 (fr) 2016-04-14
JP6898240B2 (ja) 2021-07-07
JP2017531448A (ja) 2017-10-26

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