DOP2015000162A - Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos - Google Patents
Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstosInfo
- Publication number
- DOP2015000162A DOP2015000162A DO2015000162A DO2015000162A DOP2015000162A DO P2015000162 A DOP2015000162 A DO P2015000162A DO 2015000162 A DO2015000162 A DO 2015000162A DO 2015000162 A DO2015000162 A DO 2015000162A DO P2015000162 A DOP2015000162 A DO P2015000162A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- lamp1
- cancer
- antibodies
- patient
- gain
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 7
- 201000011510 cancer Diseases 0.000 abstract 7
- 108010009254 Lysosomal-Associated Membrane Protein 1 Proteins 0.000 abstract 4
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 abstract 3
- 241000282567 Macaca fascicularis Species 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract
SE PROPORCIONAN ANTICUERPOS QUE SE UNEN ESPECÍFICAMENTE A LAS PROTEÍNAS PROTEÍNA ASOCIADA A LA MEMBRANA LISOSOMAL 1 (LAMP1) HUMANA Y DE MACACA FASCICULARIS E INMUNOCONJUGADOS QUE COMPRENDEN DICHOS ANTICUERPOS CONJUGADOS O UNIDOS A UN AGENTE INHIBIDOR DEL CRECIMIENTO. TAMBIÉN SE PROPORCIONAN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN ANTICUERPOS O INMUNOCONJUGADOS DE LA INVENCIÓN Y USO DE LOS ANTICUERPOS O INMUNOCONJUGADOS PARA EL TRATAMIENTO DEL CÁNCER., ASÍ COMO ANTICUERPOS LAMP1, ÁCIDOS NUCLEICOS AISLADOS, VECTORES Y CÉLULAS HUÉSPED QUE COMPRENDEN UNA SECUENCIA QUE CODIFICA DICHOS ANTICUERPOS Y EL USO DE DICHO ANTICUERPO COMO UNA HERRAMIENTA DE DIAGNÓSTICO. LA SOLICITUD PROPORCIONA ADEMÁS LA DETECCIÓN DE LA AMPLIFICACIÓN O GANANCIA DEL GEN LAMP1 EN CÉLULAS CANCEROSAS QUE DA LUGAR A LA DETERMINACIÓN DE SI ES PROBABLE QUE LOS PACIENTES CON CÁNCER RESPONDAN A TERAPIA ANTI-LAMP1. POR LO TANTO, SE PROPONE UN MÉTODO IN VITRO PARA SELECCIONAR PACIENTES CON CÁNCER QUE COMPRENDE DETERMINAR, EN UNA MUESTRA BIOLÓGICA DE UN PACIENTE CON CÁNCER QUE INCLUYE CÉLULAS CANCEROSAS, SI DICHO PACIENTE PORTA UNA GANANCIA EN EL NÚMERO DE COPIAS DEL GEN LAMP1; Y SELECCIONAR AL PACIENTE TOMANDO COMO BASE LA PRESENCIA DE LA GANANCIA EN EL NÚMERO DE COPIAS DEL GEN LAMP1. ADEMÁS SE PROPORCIONA UN AGENTE TERAPÉUTICO ANTI-LAMP1 PARA USO PARA TRATAR CÁNCER EN UN PACIENTE QUE PORTA UNA GANANCIA EN EL NÚMERO DE COPIAS DEL GEN LAMP1 EN CÉLULAS CANCEROSAS.
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EP12306691 | 2012-12-27 | ||
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US (2) | US9809653B2 (es) |
EP (2) | EP2938358A2 (es) |
JP (1) | JP6441232B2 (es) |
KR (1) | KR20150100848A (es) |
CN (1) | CN105007941B (es) |
AR (1) | AR094292A1 (es) |
AU (1) | AU2013369339B2 (es) |
CA (1) | CA2896248A1 (es) |
CL (1) | CL2015001849A1 (es) |
DO (1) | DOP2015000162A (es) |
EA (2) | EA201690004A1 (es) |
EC (1) | ECSP15028696A (es) |
ES (1) | ES2871816T3 (es) |
HK (1) | HK1210713A1 (es) |
IL (1) | IL239578A0 (es) |
MX (1) | MX2015008448A (es) |
PE (1) | PE20151603A1 (es) |
PH (1) | PH12015501467A1 (es) |
SG (1) | SG11201504920SA (es) |
TN (1) | TN2015000291A1 (es) |
TW (1) | TW201441260A (es) |
UY (1) | UY35250A (es) |
WO (1) | WO2014102299A2 (es) |
ZA (1) | ZA201504538B (es) |
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CN111868077A (zh) * | 2018-01-17 | 2020-10-30 | 南特生物公司 | Gpi锚定抗原的增强的免疫原性 |
CN110893236A (zh) * | 2019-10-09 | 2020-03-20 | 中山大学 | 溶酶体靶向的抗体药物偶联物及其应用 |
KR102298278B1 (ko) * | 2019-11-20 | 2021-09-07 | 대한민국 | 돼지 인플루엔자 바이러스에 특이적인 단일클론항체 및 이의 용도 |
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MX2015008448A (es) | 2016-04-07 |
IL239578A0 (en) | 2015-08-31 |
TW201441260A (zh) | 2014-11-01 |
SG11201504920SA (en) | 2015-07-30 |
EP2938358A2 (en) | 2015-11-04 |
EP3400961B1 (en) | 2021-02-24 |
CL2015001849A1 (es) | 2016-01-08 |
PE20151603A1 (es) | 2015-11-20 |
US20160280793A1 (en) | 2016-09-29 |
KR20150100848A (ko) | 2015-09-02 |
CN105007941B (zh) | 2019-01-25 |
JP2016504342A (ja) | 2016-02-12 |
WO2014102299A3 (en) | 2014-10-02 |
JP6441232B2 (ja) | 2018-12-19 |
ES2871816T3 (es) | 2021-11-02 |
AU2013369339A1 (en) | 2015-07-16 |
US20180142032A1 (en) | 2018-05-24 |
EA201591219A1 (ru) | 2015-12-30 |
ZA201504538B (en) | 2016-11-30 |
PH12015501467A1 (en) | 2015-09-21 |
EA201690004A1 (ru) | 2016-07-29 |
WO2014102299A2 (en) | 2014-07-03 |
UY35250A (es) | 2014-07-31 |
ECSP15028696A (es) | 2016-01-29 |
AR094292A1 (es) | 2015-07-22 |
CN105007941A (zh) | 2015-10-28 |
AU2013369339B2 (en) | 2018-11-15 |
US9809653B2 (en) | 2017-11-07 |
TN2015000291A1 (en) | 2016-10-03 |
EP3400961A1 (en) | 2018-11-14 |
CA2896248A1 (en) | 2014-07-03 |
HK1210713A1 (en) | 2016-05-06 |
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