JP2017531424A - ハイブリッド多元ステップ核酸増幅 - Google Patents

ハイブリッド多元ステップ核酸増幅 Download PDF

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Publication number
JP2017531424A
JP2017531424A JP2017514802A JP2017514802A JP2017531424A JP 2017531424 A JP2017531424 A JP 2017531424A JP 2017514802 A JP2017514802 A JP 2017514802A JP 2017514802 A JP2017514802 A JP 2017514802A JP 2017531424 A JP2017531424 A JP 2017531424A
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Prior art keywords
nucleic acid
primer
sample
amplification
reaction
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Withdrawn
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JP2017514802A
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Japanese (ja)
Inventor
プラナブ パテル，
プラナブ パテル，
インディラ ウー，
インディラ ウー，
アーロン リチャードソン，
アーロン リチャードソン，
カミラ ベルホシン，
カミラ ベルホシン，
ジョセフィン リー，
ジョセフィン リー，
スコット タバクマン，
スコット タバクマン，
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Theranos Inc
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Theranos Inc
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Priority claimed from PCT/US2014/056151 external-priority patent/WO2015076919A1/en
Application filed by Theranos Inc filed Critical Theranos Inc
Publication of JP2017531424A publication Critical patent/JP2017531424A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2017514802A 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅 Withdrawn JP2017531424A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201462051912P 2014-09-17 2014-09-17
US201462051945P 2014-09-17 2014-09-17
US62/051,945 2014-09-17
PCT/US2014/056151 WO2015076919A1 (en) 2013-11-22 2014-09-17 Nucleic Acid Amplification
USPCT/US2014/056151 2014-09-17
US62/051,912 2014-09-17
US201462068603P 2014-10-24 2014-10-24
US201462068605P 2014-10-24 2014-10-24
US62/068,603 2014-10-24
US62/068,605 2014-10-24
US201562151358P 2015-04-22 2015-04-22
US62/151,358 2015-04-22
PCT/US2015/050822 WO2016044673A1 (en) 2014-09-17 2015-09-17 Hybrid multi-step nucleic acid amplification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020168379A Division JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅

Publications (1)

Publication Number Publication Date
JP2017531424A true JP2017531424A (ja) 2017-10-26

Family

ID=55533878

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2017514802A Withdrawn JP2017531424A (ja) 2014-09-17 2015-09-17 ハイブリッド多元ステップ核酸増幅
JP2017514803A Withdrawn JP2017532030A (ja) 2014-09-17 2015-09-17 診断方法及び組成物
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2017514803A Withdrawn JP2017532030A (ja) 2014-09-17 2015-09-17 診断方法及び組成物
JP2020167791A Withdrawn JP2021000138A (ja) 2014-09-17 2020-10-02 診断方法及び組成物
JP2020168379A Withdrawn JP2021006056A (ja) 2014-09-17 2020-10-05 ハイブリッド多元ステップ核酸増幅
JP2022085319A Pending JP2022110152A (ja) 2014-09-17 2022-05-25 診断方法及び組成物
JP2022181727A Pending JP2023011943A (ja) 2014-09-17 2022-11-14 ハイブリッド多元ステップ核酸増幅

Country Status (8)

Country Link
US (3) US9909193B2 (enExample)
EP (2) EP3194590A4 (enExample)
JP (6) JP2017531424A (enExample)
CN (3) CN113736863A (enExample)
BR (1) BR112017005392A2 (enExample)
CA (2) CA2961209A1 (enExample)
MX (2) MX366113B (enExample)
WO (2) WO2016044673A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044673A1 (en) 2014-09-17 2016-03-24 Theranos, Inc. Hybrid multi-step nucleic acid amplification
US10822648B1 (en) 2016-07-29 2020-11-03 Labrador Diagnostics Llc Hybrid multi-step nucleic acid amplification
CA3046504A1 (en) 2016-12-15 2018-06-21 Meharry Medical College Antiviral agents
FI130673B1 (en) * 2020-11-24 2024-01-11 Mobidiag Oy Method and system for performing a cumulative nucleic acid amplification reaction

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JP2000511060A (ja) * 1996-05-29 2000-08-29 コーネル・リサーチ・ファンデーション・インコーポレイテッド 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出
JP2004511215A (ja) * 2000-06-06 2004-04-15 エックストラナ、インコーポレイテッド 増幅反応を多重化するための方法および装置
WO2014025337A1 (en) * 2012-08-06 2014-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Methods and reagents for amplifying nucleic acids
JP2014140367A (ja) * 2012-12-27 2014-08-07 Tosoh Corp Ｂ型肝炎ウイルスｄｎａ増幅用プライマーおよびそれを用いたｂ型肝炎ウイルスｄｎａ検出法
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US20170342476A1 (en) 2017-11-30
WO2016044664A1 (en) 2016-03-24
US20160201148A1 (en) 2016-07-14
EP3194629A1 (en) 2017-07-26
CA2961209A1 (en) 2016-03-24
MX2017003473A (es) 2017-08-02
JP2022110152A (ja) 2022-07-28
CA2960859A1 (en) 2016-03-24
JP2021006056A (ja) 2021-01-21
JP2021000138A (ja) 2021-01-07
MX2017003475A (es) 2017-08-02
EP3194590A4 (en) 2018-05-09
CN108026591B (zh) 2021-09-07
US20180223381A1 (en) 2018-08-09
CN107002066A (zh) 2017-08-01
JP2023011943A (ja) 2023-01-24
CN108026591A (zh) 2018-05-11
EP3194629A4 (en) 2018-03-07
EP3194590A1 (en) 2017-07-26
CN113736863A (zh) 2021-12-03
MX366113B (es) 2019-06-26
US9909193B2 (en) 2018-03-06
JP2017532030A (ja) 2017-11-02
BR112017005392A2 (pt) 2017-12-12
WO2016044673A1 (en) 2016-03-24

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