JP2017530964A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017530964A5 JP2017530964A5 JP2017514844A JP2017514844A JP2017530964A5 JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5 JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017514844 A JP2017514844 A JP 2017514844A JP 2017530964 A5 JP2017530964 A5 JP 2017530964A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- chch
- pharmaceutical composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051760P | 2014-09-17 | 2014-09-17 | |
| US62/051,760 | 2014-09-17 | ||
| PCT/US2015/050275 WO2016044331A1 (en) | 2014-09-17 | 2015-09-15 | Bicyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530964A JP2017530964A (ja) | 2017-10-19 |
| JP2017530964A5 true JP2017530964A5 (https=) | 2018-11-01 |
| JP6833677B2 JP6833677B2 (ja) | 2021-02-24 |
Family
ID=55454101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514844A Expired - Fee Related JP6833677B2 (ja) | 2014-09-17 | 2015-09-15 | 二環式化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10308609B2 (https=) |
| EP (1) | EP3193855B1 (https=) |
| JP (1) | JP6833677B2 (https=) |
| KR (1) | KR20170048588A (https=) |
| CN (1) | CN106999451B (https=) |
| AR (1) | AR101905A1 (https=) |
| CA (1) | CA2961605C (https=) |
| TW (1) | TWI686376B (https=) |
| WO (1) | WO2016044331A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102243637B1 (ko) | 2013-03-14 | 2021-04-26 | 리커리엄 아이피 홀딩스, 엘엘씨 | 바이사이클릭 진통 화합물 |
| CN108947867A (zh) | 2013-12-12 | 2018-12-07 | 卡利拉制药公司 | 双环烷基化合物及合成 |
| CA2942144C (en) | 2014-03-07 | 2023-08-22 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
| CN106999451B (zh) | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| KR101974793B1 (ko) | 2015-07-06 | 2019-05-02 | 길리애드 사이언시즈, 인코포레이티드 | Cot 조정제 및 그의 사용 방법 |
| EP3628043A4 (en) | 2017-05-15 | 2021-04-28 | Recurium IP Holdings, LLC | ANALGESIC COMPOUNDS |
| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| SG11202001733VA (en) * | 2017-09-11 | 2020-03-30 | Recurium Ip Holdings Llc | Continuous flow processes for making bicyclic compounds |
| EP3737681A4 (en) * | 2018-01-10 | 2022-01-12 | Recurium IP Holdings, LLC | BENZAMIDE COMPOUNDS |
| EP3781142A4 (en) * | 2018-04-19 | 2022-03-30 | Merck Sharp & Dohme Corp. | NEW [1.1.1] BICYCLO COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE INHIBITORS |
| EP3810116B1 (en) * | 2018-05-31 | 2023-11-15 | Merck Sharp & Dohme LLC | Novel substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors |
| SG11202108552QA (en) | 2019-02-13 | 2021-09-29 | Denali Therapeutics Inc | Compounds, compositions and methods |
| EP3924341A4 (en) | 2019-02-13 | 2022-11-02 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| IL291665B2 (en) | 2019-09-27 | 2025-07-01 | Univ Texas | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
| JP2023502514A (ja) | 2019-11-26 | 2023-01-24 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤 |
| AU2021249010B2 (en) | 2020-03-30 | 2024-09-26 | Gilead Sciences, Inc. | Solid forms of (S)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1H-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| JP7446475B2 (ja) | 2020-04-02 | 2024-03-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｏｔ阻害剤化合物を調製するためのプロセス |
| CN114349774B (zh) * | 2021-12-23 | 2024-06-04 | 凯美克(上海)医药科技有限公司 | 一种双环[1.1.1]戊基角位硼酸酯类化合物的制备方法 |
| CN115010593B (zh) * | 2022-07-15 | 2023-08-25 | 上海毕得医药科技股份有限公司 | 一种3-甲基双环[1.1.1]戊烷-1-羧酸的合成方法 |
| CN116082201B (zh) * | 2023-02-22 | 2024-06-21 | 浙江工业大学 | 一种氯代双环［1.1.1］戊胺衍生物的合成方法 |
| WO2026004939A1 (ja) * | 2024-06-28 | 2026-01-02 | キッセイ薬品工業株式会社 | ジ置換ビシクロ［１．１．１］ペンタン化合物 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL54795A (en) | 1978-05-26 | 1980-10-26 | Yeda Res & Dev | Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types |
| EP0449831A4 (en) | 1988-06-03 | 1992-05-20 | Board Of Regents The University Of Texas System | Compounds and methods based on 1.1.1)propellane |
| US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
| JPH04502317A (ja) | 1988-12-06 | 1992-04-23 | ジ・アップジョン・カンパニー | 抗菌性キノロン化合物 |
| AU626949B2 (en) | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
| JP3665567B2 (ja) | 1998-03-17 | 2005-06-29 | ファイザー・プロダクツ・インク | ビシクロ［２．２．１］ヘプタンおよび関連化合物 |
| AU3898000A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of neuropathic pain or fibromyalgia |
| DE10025946A1 (de) | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
| WO2001091736A2 (en) | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| AU2004258751C1 (en) | 2003-07-28 | 2008-07-17 | Merz Pharma Gmbh & Co. Kgaa | The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity |
| EA010132B1 (ru) * | 2003-12-22 | 2008-06-30 | Пфайзер Инк. | Производные триазола в качестве антагонистов вазопрессина |
| GB0329693D0 (en) * | 2003-12-22 | 2004-01-28 | Pfizer Ltd | Compounds useful in therapy |
| EP1789028A2 (en) | 2004-08-24 | 2007-05-30 | Neuromolecular Pharmaceuticals Inc | Compositions for treating nociceptive pain |
| US7763607B2 (en) | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
| JP2008120797A (ja) | 2006-10-19 | 2008-05-29 | Dainippon Sumitomo Pharma Co Ltd | Ｎ−置換フェニルアセトアミド誘導体からなる医薬 |
| RU2468011C2 (ru) | 2006-12-27 | 2012-11-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолина и изохинолинона |
| US20100093696A1 (en) | 2007-02-06 | 2010-04-15 | Pfizer Inc. | 2-amino pyrimidine compounds |
| DK2217597T3 (da) | 2007-10-01 | 2011-06-20 | Comentis Inc | Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom |
| TW201010997A (en) * | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| CA2771710A1 (en) | 2009-09-18 | 2011-03-24 | Zalicus Pharmaceuticals Ltd. | Aryl sulphone derivatives as calcium channel blockers |
| CA2804147A1 (en) | 2010-06-30 | 2012-01-05 | Upsher-Smith Laboratories, Inc. | Sustained release composition comprising an amine as active agent and a salt of a cyclic organic acid |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| ES2581848T3 (es) * | 2011-04-05 | 2016-09-07 | Pfizer Limited | Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas relacionadas con tropomiosina |
| MY162167A (en) | 2011-04-22 | 2017-05-31 | Pfizer | Substituted acetyl-coa carboxylase inhibitors |
| SMT202400031T1 (it) | 2011-04-22 | 2024-03-13 | Signal Pharm Llc | Diamminocarbossammide e diamminocarbonitrile pirimidine sostituite, loro composizioni e metodi di trattamento con esse |
| AU2012295802B2 (en) * | 2011-08-12 | 2017-03-30 | Nissan Chemical Industries, Ltd. | Tricyclic heterocyclic compounds and JAK inhibitors |
| US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9493481B2 (en) | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
| CA2870240A1 (en) | 2012-04-27 | 2013-10-31 | Nippon Zoki Pharmaceutical Co., Ltd. | Analgesic |
| EP3348576A1 (en) | 2012-10-30 | 2018-07-18 | Gilead Sciences, Inc. | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
| KR102243637B1 (ko) | 2013-03-14 | 2021-04-26 | 리커리엄 아이피 홀딩스, 엘엘씨 | 바이사이클릭 진통 화합물 |
| WO2014169226A2 (en) | 2013-04-12 | 2014-10-16 | Philadelphia Health & Education Corporation D/B/A Drexel University Of Medicine | Methods of diagnosing and treating chronic pain |
| DK3013805T3 (en) * | 2013-06-28 | 2018-04-23 | Evotec Int Gmbh | Sulfoximine-substituted quinazolines and their use as MNK1 and / or MNK2 kinase inhibitors |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| BR112016008632A8 (pt) | 2013-10-21 | 2020-03-17 | Merck Patent Gmbh | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
| CN103588668A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 化合物 |
| CN103588672A (zh) | 2013-10-28 | 2014-02-19 | 史克勇 | 一种治疗癌性疼痛的药物 |
| CN108947867A (zh) | 2013-12-12 | 2018-12-07 | 卡利拉制药公司 | 双环烷基化合物及合成 |
| EP3082819B1 (en) | 2013-12-20 | 2020-06-17 | Signal Pharmaceuticals, LLC | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| CA2942144C (en) * | 2014-03-07 | 2023-08-22 | Kalyra Pharmaceuticals, Inc. | Propellane derivates and synthesis |
| US20150291606A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrrolopyrimidine compounds |
| US20170197939A1 (en) | 2014-04-15 | 2017-07-13 | Pfizer Inc. | Tropomyosin-Related Kinase Inhibitors Containing Both A 1H-Pyrazole And A Pyrimidine Moiety |
| EP3134397A1 (en) | 2014-04-24 | 2017-03-01 | Novartis AG | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| CN107001283B (zh) | 2014-07-31 | 2021-05-25 | 国家健康与医学研究院 | Flt3受体拮抗剂 |
| CN106999451B (zh) | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| HUE049481T2 (hu) * | 2015-04-03 | 2020-09-28 | Recurium Ip Holdings Llc | Spirociklusos vegyületek |
| US20190060257A1 (en) | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
-
2015
- 2015-09-15 CN CN201580061363.9A patent/CN106999451B/zh not_active Expired - Fee Related
- 2015-09-15 WO PCT/US2015/050275 patent/WO2016044331A1/en not_active Ceased
- 2015-09-15 US US14/855,102 patent/US10308609B2/en active Active
- 2015-09-15 KR KR1020177009800A patent/KR20170048588A/ko not_active Ceased
- 2015-09-15 CA CA2961605A patent/CA2961605C/en active Active
- 2015-09-15 EP EP15842230.3A patent/EP3193855B1/en active Active
- 2015-09-15 JP JP2017514844A patent/JP6833677B2/ja not_active Expired - Fee Related
- 2015-09-16 TW TW104130651A patent/TWI686376B/zh not_active IP Right Cessation
- 2015-09-17 AR ARP150102980A patent/AR101905A1/es not_active Application Discontinuation
-
2019
- 2019-04-09 US US16/379,487 patent/US10975035B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017530964A5 (https=) | ||
| JP2013541567A5 (https=) | ||
| NZ612837A (en) | A combination of an opioid agonist and an opioid antagonist in the treatment of parkinson’s disease | |
| JP2010189403A5 (https=) | ||
| JP2008534564A5 (https=) | ||
| JP2005530798A5 (https=) | ||
| JP2014507445A5 (https=) | ||
| JP2012519675A5 (https=) | ||
| AR089130A1 (es) | FORMAS DE DOSIS FARMACEUTICA QUE COMPRENDEN POLI(e-CAPROLACTONA) Y OXIDO DE POLIETILENO | |
| JP2011137020A5 (https=) | ||
| JP2010511683A5 (https=) | ||
| JP2009167214A5 (https=) | ||
| CN111836807A (zh) | 氧杂螺环类化合物及其制备方法和用途 | |
| NZ603170A (en) | Combination of active loaded granules with additional actives | |
| RU2009101082A (ru) | Фармацевтические композиции | |
| RU2009125597A (ru) | Пролекарства и способы их получения и применения | |
| JP2008525321A5 (https=) | ||
| RU2019139286A (ru) | Фармацевтический состав | |
| CN110036005A (zh) | 酰胺衍生物及其在药物中的应用 | |
| JP2014510094A5 (https=) | ||
| MD4551B1 (ro) | Derivaţi pe bază de tetrahidroizochinoline şi N-(fenilfosfat)amide, procedeu de obţinere a lor şi compoziţii farmaceutice care îi conţin | |
| JP2017517565A5 (https=) | ||
| JP2014534269A5 (https=) | ||
| NZ603173A (en) | Manufacturing of active-free granules and tablets comprising the same | |
| JP2006508137A (ja) | Ｎ−アセチル化４−ヒドロキシフェニラミン誘導体を含む相乗作用性の組み合わせ |