JP2008525321A5 - - Google Patents
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- Publication number
- JP2008525321A5 JP2008525321A5 JP2007547107A JP2007547107A JP2008525321A5 JP 2008525321 A5 JP2008525321 A5 JP 2008525321A5 JP 2007547107 A JP2007547107 A JP 2007547107A JP 2007547107 A JP2007547107 A JP 2007547107A JP 2008525321 A5 JP2008525321 A5 JP 2008525321A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- thiol
- alkenyl
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 176
- 125000003118 aryl group Chemical group 0.000 claims 64
- 239000000203 mixture Substances 0.000 claims 50
- -1 alkenyl thiol Chemical class 0.000 claims 48
- 229910052799 carbon Inorganic materials 0.000 claims 44
- 239000002840 nitric oxide donor Substances 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 36
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 28
- 125000006649 (C2-C20) alkynyl group Chemical group 0.000 claims 24
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 238000013268 sustained release Methods 0.000 claims 23
- 239000012730 sustained-release form Substances 0.000 claims 23
- 125000004104 aryloxy group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 13
- 239000000014 opioid analgesic Substances 0.000 claims 13
- 125000002252 acyl group Chemical group 0.000 claims 12
- 125000004423 acyloxy group Chemical group 0.000 claims 12
- 150000001356 alkyl thiols Chemical class 0.000 claims 12
- 150000001504 aryl thiols Chemical class 0.000 claims 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 12
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 12
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 150000003573 thiols Chemical class 0.000 claims 12
- 230000000202 analgesic effect Effects 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 125000003302 alkenyloxy group Chemical group 0.000 claims 8
- 125000005133 alkynyloxy group Chemical group 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 7
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 6
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 6
- 229960005181 morphine Drugs 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- 230000036407 pain Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003320 C2-C6 alkenyloxy group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229940005483 opioid analgesics Drugs 0.000 claims 4
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 3
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 3
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 3
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 3
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims 3
- GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical compound O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 claims 3
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims 3
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 3
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 3
- 229960001391 alfentanil Drugs 0.000 claims 3
- 229960004126 codeine Drugs 0.000 claims 3
- 229960002069 diamorphine Drugs 0.000 claims 3
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims 3
- 229960000920 dihydrocodeine Drugs 0.000 claims 3
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 3
- 229960002428 fentanyl Drugs 0.000 claims 3
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 3
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 3
- 229960000240 hydrocodone Drugs 0.000 claims 3
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 3
- 229960001410 hydromorphone Drugs 0.000 claims 3
- 229960003406 levorphanol Drugs 0.000 claims 3
- 229960001797 methadone Drugs 0.000 claims 3
- 229960002085 oxycodone Drugs 0.000 claims 3
- 229960005118 oxymorphone Drugs 0.000 claims 3
- 229960000482 pethidine Drugs 0.000 claims 3
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims 3
- 229960004739 sufentanil Drugs 0.000 claims 3
- 229960004380 tramadol Drugs 0.000 claims 3
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 3
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 2
- CMFNMSMUKZHDEY-UHFFFAOYSA-N peroxynitrous acid Chemical compound OON=O CMFNMSMUKZHDEY-UHFFFAOYSA-N 0.000 claims 2
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010065016 Post-traumatic pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 230000036592 analgesia Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 claims 1
- 0 CONc1*(O)[o]*c1* Chemical compound CONc1*(O)[o]*c1* 0.000 description 6
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2004907352A AU2004907352A0 (en) | 2004-12-24 | Methods of treating pain | |
| PCT/AU2005/001976 WO2006066362A1 (en) | 2004-12-24 | 2005-12-23 | Methods of treating pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525321A JP2008525321A (ja) | 2008-07-17 |
| JP2008525321A5 true JP2008525321A5 (https=) | 2009-10-22 |
Family
ID=36601296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547107A Withdrawn JP2008525321A (ja) | 2004-12-24 | 2005-12-23 | 疼痛治療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090143417A1 (https=) |
| EP (1) | EP1838714A4 (https=) |
| JP (1) | JP2008525321A (https=) |
| CA (1) | CA2592407A1 (https=) |
| WO (1) | WO2006066362A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| IL273422B (en) | 2004-10-07 | 2022-07-01 | Transmedics Inc | Methods and systems for extracorporeal organ treatment |
| US9301519B2 (en) * | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| CA2980782C (en) * | 2006-04-19 | 2020-10-27 | Transmedics, Inc. | Systems and methods for ex vivo organ care |
| WO2008080194A1 (en) * | 2006-12-29 | 2008-07-10 | The University Of Queensland | Pain-relieving compositions and uses therefor |
| US8822509B2 (en) | 2006-12-29 | 2014-09-02 | The University Of Queensland | Pain-relieving compositions and uses therefor |
| US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| US9814230B2 (en) * | 2008-01-31 | 2017-11-14 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| WO2009152483A2 (en) * | 2008-06-12 | 2009-12-17 | University Of Alabama Huntsville | Nitric oxide induced adaptive resistance as a therapy for central nervous system diseases and trauma |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| WO2012142487A1 (en) * | 2011-04-14 | 2012-10-18 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| CA3185937A1 (en) | 2014-06-02 | 2015-12-10 | Transmedics, Inc. | Ex vivo organ care system |
| AU2015361996B2 (en) | 2014-12-12 | 2019-09-26 | Transmedics, Inc. | Apparatus and method for organ perfusion |
| EP3265118B1 (en) * | 2015-03-06 | 2019-08-28 | Centre National De La Recherche Scientifique | Use of creatine kinase and derived peptides thereof to relief pain |
| DK3824731T3 (da) | 2015-09-09 | 2025-05-26 | Transmedics Inc | Aortakanyle til ex vivo-organplejesystem |
| EP4238417A3 (en) | 2016-05-30 | 2023-12-06 | Tevosol, Inc. | Apparatus and method for ex vivo lung ventilation with a varying exterior pressure |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| EP0984012A3 (en) | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
| CA2400708A1 (en) | 2000-02-22 | 2001-08-30 | Cellegy Canada Inc. | Methods and compositions for improving sleep |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| US20030219494A1 (en) | 2002-03-20 | 2003-11-27 | Smith Maree Therese | Compositions and methods of using them |
| JP2005537223A (ja) * | 2002-04-05 | 2005-12-08 | ニトロメッド，インク． | 酸化窒素供与体、組成物および使用法 |
-
2005
- 2005-12-23 US US11/794,137 patent/US20090143417A1/en not_active Abandoned
- 2005-12-23 WO PCT/AU2005/001976 patent/WO2006066362A1/en not_active Ceased
- 2005-12-23 CA CA002592407A patent/CA2592407A1/en not_active Abandoned
- 2005-12-23 EP EP05821596A patent/EP1838714A4/en not_active Withdrawn
- 2005-12-23 JP JP2007547107A patent/JP2008525321A/ja not_active Withdrawn
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