JP2017529875A - 酵素処理プラントおよび酵素処理方法 - Google Patents

酵素処理プラントおよび酵素処理方法 Download PDF

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Publication number
JP2017529875A
JP2017529875A JP2017534001A JP2017534001A JP2017529875A JP 2017529875 A JP2017529875 A JP 2017529875A JP 2017534001 A JP2017534001 A JP 2017534001A JP 2017534001 A JP2017534001 A JP 2017534001A JP 2017529875 A JP2017529875 A JP 2017529875A
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enzyme treatment
stage
plant
reaction mixture
flow
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Pending
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JP2017534001A
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Japanese (ja)
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JP2017529875A5 (enExample
Inventor
オラヴ アスル デュペヴォーグ，
オラヴ アスル デュペヴォーグ，
トルステイン フランツェン，
トルステイン フランツェン，
Original Assignee
アルキマル， アクティーゼルスカブ
アルキマル， アクティーゼルスカブ
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Publication of JP2017529875A publication Critical patent/JP2017529875A/ja
Publication of JP2017529875A5 publication Critical patent/JP2017529875A5/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4333—Mixers with scallop-shaped tubes or surfaces facing each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4338—Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B63—SHIPS OR OTHER WATERBORNE VESSELS; RELATED EQUIPMENT
    • B63B—SHIPS OR OTHER WATERBORNE VESSELS; EQUIPMENT FOR SHIPPING 
    • B63B35/00—Vessels or similar floating structures specially adapted for specific purposes and not otherwise provided for
    • B63B35/14—Fishing vessels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/16—Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/40—Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0477—Numerical time values
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0436—Operational information
    • B01F2215/0481—Numerical speed values

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Ocean & Marine Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Accessories For Mixers (AREA)
  • Fats And Perfumes (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2017534001A 2014-09-15 2015-09-14 酵素処理プラントおよび酵素処理方法 Pending JP2017529875A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1416283.8 2014-09-15
GBGB1416283.8A GB201416283D0 (en) 2014-09-15 2014-09-15 Enzymatic processing plant and method of enzymatic processing
PCT/EP2015/070942 WO2016041896A1 (en) 2014-09-15 2015-09-14 Enzymatic processing plant and method of enzymatic processing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020114837A Division JP7050120B2 (ja) 2014-09-15 2020-07-02 酵素処理プラントおよび酵素処理方法

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JP2017529875A true JP2017529875A (ja) 2017-10-12
JP2017529875A5 JP2017529875A5 (enExample) 2018-10-18

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JP2017534001A Pending JP2017529875A (ja) 2014-09-15 2015-09-14 酵素処理プラントおよび酵素処理方法
JP2020114837A Active JP7050120B2 (ja) 2014-09-15 2020-07-02 酵素処理プラントおよび酵素処理方法

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US (1) US11286448B2 (enExample)
EP (1) EP3194060A1 (enExample)
JP (2) JP2017529875A (enExample)
CN (1) CN107073415B (enExample)
BR (1) BR112017004952B1 (enExample)
CA (1) CA2961120C (enExample)
CL (2) CL2017000612A1 (enExample)
EC (1) ECSP17018111A (enExample)
GB (1) GB201416283D0 (enExample)
PE (1) PE20171036A1 (enExample)
RU (1) RU2717506C2 (enExample)
WO (1) WO2016041896A1 (enExample)
ZA (1) ZA201702310B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210073553A (ko) * 2018-10-08 2021-06-18 베링거 인겔하임 인터내셔날 게엠베하 바이러스 비활성화를 위한 연속 유동 반응기
JPWO2022196331A1 (enExample) * 2021-03-18 2022-09-22

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Publication number Priority date Publication date Assignee Title
GB2548386A (en) * 2016-03-17 2017-09-20 Alkymar As Mixing and processing apparatus
GB201807246D0 (en) 2018-05-02 2018-06-13 Biomega Group AS Enzymatic method
WO2021091704A1 (en) * 2019-11-04 2021-05-14 Parker-Hannifin Corporation Inline mixer device, methods of mixing, and methods of making an inline mixer device
CN113090946B (zh) * 2021-04-06 2022-04-05 西南石油大学 一种促进掺氢天然气管道内天然气与氢气混合的蚌式管道结构

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JPS6248375A (ja) * 1985-08-23 1987-03-03 Lion Corp 固定化酵素反応器
JP2006507838A (ja) * 2002-12-02 2006-03-09 グリーン、アース、インダストリーズ、リミテッド、ライアビリティー、カンパニー タンパク質含有原料の加水分解のための装置および方法ならびに得られた加水分解産物の用途
RU2490323C1 (ru) * 2012-06-25 2013-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный технологический институт (технический университет)" Микробиореактор и способ его эксплуатации

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FR2698559B1 (fr) * 1992-11-30 1995-02-17 Univ Nantes Echangeur mélangeur à effet de convection chaotique.
US6258575B1 (en) * 1998-11-26 2001-07-10 Kao Corporation Hydrolyzing fats and oils using an immobilized enzyme column and substrate-feeding chamber that separates phases
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JPS6248375A (ja) * 1985-08-23 1987-03-03 Lion Corp 固定化酵素反応器
JP2006507838A (ja) * 2002-12-02 2006-03-09 グリーン、アース、インダストリーズ、リミテッド、ライアビリティー、カンパニー タンパク質含有原料の加水分解のための装置および方法ならびに得られた加水分解産物の用途
RU2490323C1 (ru) * 2012-06-25 2013-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный технологический институт (технический университет)" Микробиореактор и способ его эксплуатации

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210073553A (ko) * 2018-10-08 2021-06-18 베링거 인겔하임 인터내셔날 게엠베하 바이러스 비활성화를 위한 연속 유동 반응기
JP2022504398A (ja) * 2018-10-08 2022-01-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス不活化のための連続フロー反応器
JP7340602B2 (ja) 2018-10-08 2023-09-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス不活化のための連続フロー反応器
JP2023126863A (ja) * 2018-10-08 2023-09-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス不活化のための連続フロー反応器
JP7665683B2 (ja) 2018-10-08 2025-04-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス不活化のための連続フロー反応器
KR102877256B1 (ko) * 2018-10-08 2025-10-28 베링거 인겔하임 인터내셔날 게엠베하 바이러스 비활성화를 위한 연속 유동 반응기
JPWO2022196331A1 (enExample) * 2021-03-18 2022-09-22
WO2022196331A1 (ja) * 2021-03-18 2022-09-22 テルモ株式会社 物質導入装置及び物質導入ユニット

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RU2017112689A3 (enExample) 2019-08-13
JP2020179395A (ja) 2020-11-05
GB201416283D0 (en) 2014-10-29
RU2017112689A (ru) 2018-10-17
ECSP17018111A (es) 2017-06-30
WO2016041896A1 (en) 2016-03-24
EP3194060A1 (en) 2017-07-26
CA2961120C (en) 2023-09-26
CN107073415A (zh) 2017-08-18
ZA201702310B (en) 2019-09-25
BR112017004952A2 (pt) 2017-12-05
CN107073415B (zh) 2021-02-05
RU2717506C2 (ru) 2020-03-23
CA2961120A1 (en) 2016-03-24
JP7050120B2 (ja) 2022-04-07
CL2019002098A1 (es) 2019-10-25
US11286448B2 (en) 2022-03-29
US20170247649A1 (en) 2017-08-31
PE20171036A1 (es) 2017-07-17
CL2017000612A1 (es) 2017-12-22
BR112017004952B1 (pt) 2022-08-16

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