CA2961120C - Enzymatic processing plant and method of enzymatic processing - Google Patents

Enzymatic processing plant and method of enzymatic processing Download PDF

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Publication number
CA2961120C
CA2961120C CA2961120A CA2961120A CA2961120C CA 2961120 C CA2961120 C CA 2961120C CA 2961120 A CA2961120 A CA 2961120A CA 2961120 A CA2961120 A CA 2961120A CA 2961120 C CA2961120 C CA 2961120C
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CA
Canada
Prior art keywords
turbulence
plant
enzymatic processing
generating pipe
reaction mixture
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Active
Application number
CA2961120A
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English (en)
French (fr)
Other versions
CA2961120A1 (en
Inventor
Olav Asle Djupevag
Torstein FRANTZEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marine Bioenergy AS
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Marine Bioenergy AS
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Publication of CA2961120A1 publication Critical patent/CA2961120A1/en
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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4333Mixers with scallop-shaped tubes or surfaces facing each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4338Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B63SHIPS OR OTHER WATERBORNE VESSELS; RELATED EQUIPMENT
    • B63BSHIPS OR OTHER WATERBORNE VESSELS; EQUIPMENT FOR SHIPPING 
    • B63B35/00Vessels or similar floating structures specially adapted for specific purposes and not otherwise provided for
    • B63B35/14Fishing vessels
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/02Apparatus for enzymology or microbiology with agitation means; with heat exchange means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/16Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/40Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16Vibrating; Shaking; Tilting
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/06Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0418Geometrical information
    • B01F2215/0431Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0477Numerical time values
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00Auxiliary or complementary information in relation with mixing
    • B01F2215/04Technical information in relation with mixing
    • B01F2215/0413Numerical information
    • B01F2215/0436Operational information
    • B01F2215/0481Numerical speed values

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Ocean & Marine Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Accessories For Mixers (AREA)
  • Fats And Perfumes (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2961120A 2014-09-15 2015-09-14 Enzymatic processing plant and method of enzymatic processing Active CA2961120C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1416283.8 2014-09-15
GBGB1416283.8A GB201416283D0 (en) 2014-09-15 2014-09-15 Enzymatic processing plant and method of enzymatic processing
PCT/EP2015/070942 WO2016041896A1 (en) 2014-09-15 2015-09-14 Enzymatic processing plant and method of enzymatic processing

Publications (2)

Publication Number Publication Date
CA2961120A1 CA2961120A1 (en) 2016-03-24
CA2961120C true CA2961120C (en) 2023-09-26

Family

ID=51869630

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2961120A Active CA2961120C (en) 2014-09-15 2015-09-14 Enzymatic processing plant and method of enzymatic processing

Country Status (13)

Country Link
US (1) US11286448B2 (enExample)
EP (1) EP3194060A1 (enExample)
JP (2) JP2017529875A (enExample)
CN (1) CN107073415B (enExample)
BR (1) BR112017004952B1 (enExample)
CA (1) CA2961120C (enExample)
CL (2) CL2017000612A1 (enExample)
EC (1) ECSP17018111A (enExample)
GB (1) GB201416283D0 (enExample)
PE (1) PE20171036A1 (enExample)
RU (1) RU2717506C2 (enExample)
WO (1) WO2016041896A1 (enExample)
ZA (1) ZA201702310B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2548386A (en) * 2016-03-17 2017-09-20 Alkymar As Mixing and processing apparatus
GB201807246D0 (en) 2018-05-02 2018-06-13 Biomega Group AS Enzymatic method
MA53857A (fr) * 2018-10-08 2022-01-12 Boehringer Ingelheim Int Réacteur continu d'inactivation virale
WO2021091704A1 (en) * 2019-11-04 2021-05-14 Parker-Hannifin Corporation Inline mixer device, methods of mixing, and methods of making an inline mixer device
WO2022196331A1 (ja) * 2021-03-18 2022-09-22 テルモ株式会社 物質導入装置及び物質導入ユニット
CN113090946B (zh) * 2021-04-06 2022-04-05 西南石油大学 一种促进掺氢天然气管道内天然气与氢气混合的蚌式管道结构

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606436A5 (enExample) * 1974-09-19 1978-10-31 Giovanola Freres Sa
US4434229A (en) * 1979-05-21 1984-02-28 Matsushita Electric Industrial Co., Ltd. Enzyme immobilization with an immobilizing reagent in vapor phase
JPS6248375A (ja) * 1985-08-23 1987-03-03 Lion Corp 固定化酵素反応器
FR2698559B1 (fr) * 1992-11-30 1995-02-17 Univ Nantes Echangeur mélangeur à effet de convection chaotique.
US6258575B1 (en) * 1998-11-26 2001-07-10 Kao Corporation Hydrolyzing fats and oils using an immobilized enzyme column and substrate-feeding chamber that separates phases
CN2540213Y (zh) * 2002-04-17 2003-03-19 徐立群 列管式静态混合器
DK175501B1 (da) * 2002-12-02 2004-11-15 Green Earth Anlæg og fremgangsmåde til kontinuerlig hydrolyse af et proteinholdigt animalsk eller vegetabilsk råmateriale
CN100341800C (zh) * 2003-02-26 2007-10-10 底格里蒙公司 尤其包含悬浮污染物的液体流出物的处理方法和设备
CN103203195A (zh) * 2003-10-29 2013-07-17 风神有限公司 气体扩散处理装置
DE502005010268D1 (de) 2004-07-26 2010-10-28 Kolb Frank R Hydrodynamische homogenisation
US20060051448A1 (en) * 2004-09-03 2006-03-09 Charles Schryver Extruded tubing for mixing reagents
JP4677969B2 (ja) * 2006-10-06 2011-04-27 株式会社日立プラントテクノロジー マイクロリアクタ
KR101502647B1 (ko) * 2008-03-14 2015-03-13 디아이씨 가부시끼가이샤 우레탄(메트)아크릴레이트의 제조 방법
FR2938268B1 (fr) * 2008-11-12 2013-03-29 Centre Nat Rech Scient Procede de culture de micro-organismes, bioreacteur de mise en oeuvre et procede de fabrication d'un tel bioreacteur
RU2490323C1 (ru) * 2012-06-25 2013-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный технологический институт (технический университет)" Микробиореактор и способ его эксплуатации

Also Published As

Publication number Publication date
RU2017112689A3 (enExample) 2019-08-13
JP2020179395A (ja) 2020-11-05
GB201416283D0 (en) 2014-10-29
RU2017112689A (ru) 2018-10-17
ECSP17018111A (es) 2017-06-30
WO2016041896A1 (en) 2016-03-24
EP3194060A1 (en) 2017-07-26
CN107073415A (zh) 2017-08-18
ZA201702310B (en) 2019-09-25
BR112017004952A2 (pt) 2017-12-05
CN107073415B (zh) 2021-02-05
RU2717506C2 (ru) 2020-03-23
CA2961120A1 (en) 2016-03-24
JP7050120B2 (ja) 2022-04-07
CL2019002098A1 (es) 2019-10-25
US11286448B2 (en) 2022-03-29
US20170247649A1 (en) 2017-08-31
JP2017529875A (ja) 2017-10-12
PE20171036A1 (es) 2017-07-17
CL2017000612A1 (es) 2017-12-22
BR112017004952B1 (pt) 2022-08-16

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