JP2017529850A5 - - Google Patents
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- Publication number
- JP2017529850A5 JP2017529850A5 JP2017516332A JP2017516332A JP2017529850A5 JP 2017529850 A5 JP2017529850 A5 JP 2017529850A5 JP 2017516332 A JP2017516332 A JP 2017516332A JP 2017516332 A JP2017516332 A JP 2017516332A JP 2017529850 A5 JP2017529850 A5 JP 2017529850A5
- Authority
- JP
- Japan
- Prior art keywords
- tobacco
- nitrate reductase
- relaxed
- tobacco product
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000019505 tobacco product Nutrition 0.000 claims 30
- 108090000913 Nitrate Reductases Proteins 0.000 claims 29
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 19
- 244000061176 Nicotiana tabacum Species 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 241000208125 Nicotiana Species 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000779 smoke Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- ZJOFAFWTOKDIFH-UHFFFAOYSA-N 3-(1-nitroso-3,6-dihydro-2h-pyridin-2-yl)pyridine Chemical compound O=NN1CC=CCC1C1=CC=CN=C1 ZJOFAFWTOKDIFH-UHFFFAOYSA-N 0.000 claims 3
- 238000002485 combustion reaction Methods 0.000 claims 3
- XKABJYQDMJTNGQ-VIFPVBQESA-N n-nitrosonornicotine Chemical compound O=NN1CCC[C@H]1C1=CC=CN=C1 XKABJYQDMJTNGQ-VIFPVBQESA-N 0.000 claims 3
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical class C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- JORUAYHMUWRFNM-UHFFFAOYSA-N 1-pyridin-3-ylbutan-1-one Chemical compound CCCC(=O)C1=CC=CN=C1 JORUAYHMUWRFNM-UHFFFAOYSA-N 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 241000701489 Cauliflower mosaic virus Species 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003471 mutagenic agent Substances 0.000 claims 1
- 231100000707 mutagenic chemical Toxicity 0.000 claims 1
- 230000003505 mutagenic effect Effects 0.000 claims 1
- 150000002823 nitrates Chemical class 0.000 claims 1
- 150000003751 zinc Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14186705 | 2014-09-26 | ||
| EP14186705.1 | 2014-09-26 | ||
| EP14194798.6 | 2014-11-25 | ||
| EP14194798 | 2014-11-25 | ||
| PCT/EP2015/071919 WO2016046288A1 (en) | 2014-09-26 | 2015-09-23 | Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529850A JP2017529850A (ja) | 2017-10-12 |
| JP2017529850A5 true JP2017529850A5 (enExample) | 2018-11-08 |
| JP6921740B2 JP6921740B2 (ja) | 2021-08-18 |
Family
ID=54148547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516332A Active JP6921740B2 (ja) | 2014-09-26 | 2015-09-23 | 硝酸同化経路の変化によるタバコ特異的ニトロソアミンの低減 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11666082B2 (enExample) |
| EP (1) | EP3198015A1 (enExample) |
| JP (1) | JP6921740B2 (enExample) |
| KR (1) | KR102524798B1 (enExample) |
| CN (1) | CN106998787A (enExample) |
| BR (1) | BR112017003842B1 (enExample) |
| CA (1) | CA2959245A1 (enExample) |
| CO (1) | CO2017004076A2 (enExample) |
| MX (1) | MX2017003932A (enExample) |
| PH (1) | PH12017500313A1 (enExample) |
| RU (1) | RU2721799C2 (enExample) |
| WO (1) | WO2016046288A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
| ES2884838T3 (es) | 2015-04-06 | 2021-12-13 | Univ Leland Stanford Junior | ARN guía químicamente modificados para la regulación génica mediada por CRISPR/CAS |
| BR112017023719A2 (pt) * | 2015-05-05 | 2018-07-17 | Univ North Carolina State | planta de tabaco, parte de planta e/ou célula de planta, semente, cultura de planta, produto de tabaco, método para reduzir pon e/ou nnk, método de produção de uma planta e método para produzir um produto de tabaco |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN106036984B (zh) * | 2016-07-03 | 2017-08-08 | 赖高生 | 一种固定化蜗牛酶制备烟草浸膏的方法 |
| CN111801423A (zh) | 2018-03-28 | 2020-10-20 | 菲利普莫里斯生产公司 | 调节植物中的氨基酸含量 |
| BR112020017430A2 (pt) | 2018-03-28 | 2021-01-19 | Philip Morris Products S.A. | Modulação do teor de açúcar redutor em uma planta |
| CN108424922B (zh) * | 2018-04-20 | 2021-04-16 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m271及其应用 |
| GB201812603D0 (en) * | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| DE102018216970A1 (de) * | 2018-10-04 | 2020-04-09 | Robert Bosch Gmbh | Brennstoffeinspritzvorrichtung |
| CN113271768B (zh) * | 2018-12-30 | 2024-02-06 | 菲利普莫里斯生产公司 | 经由硝酸盐还原酶的突变来调节植物中的硝酸盐水平 |
| WO2022192743A1 (en) * | 2021-03-11 | 2022-09-15 | Thermolife International, Llc | Enhanced nitrate, elemental metal, and amino acid compositions and methods of use |
| BR112022005552A2 (pt) | 2019-10-01 | 2022-06-28 | Philip Morris Products Sa | Modulação da redução do teor de açúcar em uma planta (inv) |
| US12419264B2 (en) | 2019-10-01 | 2025-09-23 | Philip Morris Products S.A. | Modulating sugar and amino acid content in a plant (SULTR3) |
| CN110747208B (zh) * | 2019-11-28 | 2022-04-22 | 海南大学 | 一种木薯硝酸还原酶基因及其过量表达载体的构建和抗病应用 |
| CN110819640B (zh) * | 2019-12-19 | 2022-06-21 | 中国烟草总公司郑州烟草研究院 | 烟草NtNRP1基因其应用 |
| CN115516098A (zh) * | 2020-01-17 | 2022-12-23 | 奥驰亚客户服务有限公司 | 与改进的氮利用效率有关的方法和组合物 |
| WO2022104157A1 (en) | 2020-11-12 | 2022-05-19 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| CN116583176B (zh) * | 2020-12-09 | 2024-12-31 | 日本烟草产业株式会社 | 烟草植物及烟草制品 |
| IL315206A (en) | 2021-02-11 | 2024-10-01 | Thermolife Int Llc | A method of administering nitric oxide gas |
| US11884915B2 (en) | 2021-09-10 | 2024-01-30 | Agilent Technologies, Inc. | Guide RNAs with chemical modification for prime editing |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| US20240132900A1 (en) * | 2022-02-24 | 2024-04-25 | University Of Florida Research Foundation, Incorporated | T-DNA Free Gene Editing through Transient Suppressing POLQ in Plants |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| KR20250139371A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 당 수송체의 조절 |
| CN120476136A (zh) | 2023-02-02 | 2025-08-12 | 菲利普莫里斯生产公司 | 编码赖氨酸酮戊二酸还原酶的基因的调节 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| EP0652965A1 (en) | 1992-07-27 | 1995-05-17 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| KR20030029885A (ko) * | 2000-08-30 | 2003-04-16 | 노쓰 캐롤라이나 스테이트 유니버시티 | 단백질 함량을 변화시키는 분자 미끼를 포함하는유전자이식 식물 |
| WO2002100199A2 (en) * | 2001-06-08 | 2002-12-19 | Vector Tobacco Ltd. | Modifying nicotine and nitrosamine levels in tobacco |
| KR20060128821A (ko) * | 2003-08-19 | 2006-12-14 | 22엔디 센츄리 리미티드, 엘엘씨 | 감소된 노출 담배 제품 |
| RU2257711C2 (ru) * | 2003-10-06 | 2005-08-10 | Всероссийский научно-исследовательский институт защиты растений | Композиция на основе хитозана, снижающая содержание нитратов в растениеводческой продукции |
| EP2330191A1 (en) * | 2003-10-16 | 2011-06-08 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from nicotiana |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| EP2087123B1 (en) | 2006-10-13 | 2011-08-10 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| BRPI0807783A2 (pt) * | 2007-02-23 | 2014-06-24 | Us Smokeless Tobacco Co | Composição de tabaco sem fumaça, métodos para produzir uma variedade de planta e para preparar tabaco tendo amargor reduzido, planta de tabaco, variedade de planta, e, tabaco curado. |
| CA2681193C (en) * | 2007-03-16 | 2016-01-26 | New York University | Pericycle-specific expression of microrna167 in transgenic plants |
| BRPI0820042B1 (pt) * | 2007-11-12 | 2020-05-19 | North Carolina State University | método de obtenção de uma planta de tabaco, ou célula ou parte desta, tendo níveis reduzidos de nornicotina, produto de tabaco, método para fabricar um produto de tabaco, polinucleotídeo isolado, cassete de expressão, polipetpídeo isolado e método de obtenção de uma planta, ou parte de planta desta, do gênero nicotiana |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| EP2537929B1 (en) * | 2010-02-17 | 2017-04-12 | Japan Tobacco, Inc. | Plant component regulation factor, and use thereof |
| AP2013006825A0 (en) * | 2010-09-22 | 2013-04-30 | British American Tabacco Investments Ltd | Transgenic plants |
| BR112013021515A2 (pt) | 2011-02-28 | 2018-06-12 | Univ North Carolina State | plantas congênitas de tabaco ncbex1f, ncbex1ms e nc ex90 |
| GB201204869D0 (en) * | 2012-03-20 | 2012-05-02 | Cambridge Advanced Tech | Transgenic plants |
| ITMI20121419A1 (it) * | 2012-08-08 | 2014-02-09 | Fattoria Autonoma Tabacchi S C A R L | Metodo per la produzione di tabacco volto a ridurre il tenore di nitrosammine. |
-
2015
- 2015-09-23 BR BR112017003842-0A patent/BR112017003842B1/pt active IP Right Grant
- 2015-09-23 KR KR1020177008015A patent/KR102524798B1/ko active Active
- 2015-09-23 WO PCT/EP2015/071919 patent/WO2016046288A1/en not_active Ceased
- 2015-09-23 US US15/513,229 patent/US11666082B2/en active Active
- 2015-09-23 EP EP15766550.6A patent/EP3198015A1/en active Pending
- 2015-09-23 RU RU2017114356A patent/RU2721799C2/ru active
- 2015-09-23 JP JP2017516332A patent/JP6921740B2/ja active Active
- 2015-09-23 CN CN201580049814.7A patent/CN106998787A/zh active Pending
- 2015-09-23 CA CA2959245A patent/CA2959245A1/en not_active Abandoned
- 2015-09-23 MX MX2017003932A patent/MX2017003932A/es unknown
-
2017
- 2017-02-21 PH PH12017500313A patent/PH12017500313A1/en unknown
- 2017-04-26 CO CONC2017/0004076A patent/CO2017004076A2/es unknown
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