CO2017004076A2 - Reducción de nitrosaminas específicas del tabaco mediante la alteración de la vía de asimilación de nitrato - Google Patents
Reducción de nitrosaminas específicas del tabaco mediante la alteración de la vía de asimilación de nitratoInfo
- Publication number
- CO2017004076A2 CO2017004076A2 CONC2017/0004076A CO2017004076A CO2017004076A2 CO 2017004076 A2 CO2017004076 A2 CO 2017004076A2 CO 2017004076 A CO2017004076 A CO 2017004076A CO 2017004076 A2 CO2017004076 A2 CO 2017004076A2
- Authority
- CO
- Colombia
- Prior art keywords
- tobacco
- altering
- reduction
- specific nitrosamines
- assimilation pathway
- Prior art date
Links
- 235000002637 Nicotiana tabacum Nutrition 0.000 title abstract 4
- 229910002651 NO3 Inorganic materials 0.000 title abstract 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title abstract 3
- 241000208125 Nicotiana Species 0.000 title abstract 2
- 150000004005 nitrosamines Chemical class 0.000 title abstract 2
- 230000037361 pathway Effects 0.000 title abstract 2
- 244000061176 Nicotiana tabacum Species 0.000 abstract 2
- 235000019505 tobacco product Nutrition 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/245—Nitrosamines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/20—Biochemical treatment
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01001—Nitrate reductase (NADH) (1.7.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01002—Nitrate reductase [NAD(P)H] (1.7.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01003—Nitrate reductase (NADPH) (1.7.1.3)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Manufacture Of Tobacco Products (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Physiology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14186705 | 2014-09-26 | ||
| EP14194798 | 2014-11-25 | ||
| PCT/EP2015/071919 WO2016046288A1 (en) | 2014-09-26 | 2015-09-23 | Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017004076A2 true CO2017004076A2 (es) | 2017-09-20 |
Family
ID=54148547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0004076A CO2017004076A2 (es) | 2014-09-26 | 2017-04-26 | Reducción de nitrosaminas específicas del tabaco mediante la alteración de la vía de asimilación de nitrato |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11666082B2 (enExample) |
| EP (1) | EP3198015A1 (enExample) |
| JP (1) | JP6921740B2 (enExample) |
| KR (1) | KR102524798B1 (enExample) |
| CN (1) | CN106998787A (enExample) |
| BR (1) | BR112017003842B1 (enExample) |
| CA (1) | CA2959245A1 (enExample) |
| CO (1) | CO2017004076A2 (enExample) |
| MX (1) | MX2017003932A (enExample) |
| PH (1) | PH12017500313A1 (enExample) |
| RU (1) | RU2721799C2 (enExample) |
| WO (1) | WO2016046288A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
| ES2884838T3 (es) | 2015-04-06 | 2021-12-13 | Univ Leland Stanford Junior | ARN guía químicamente modificados para la regulación génica mediada por CRISPR/CAS |
| BR112017023719A2 (pt) * | 2015-05-05 | 2018-07-17 | Univ North Carolina State | planta de tabaco, parte de planta e/ou célula de planta, semente, cultura de planta, produto de tabaco, método para reduzir pon e/ou nnk, método de produção de uma planta e método para produzir um produto de tabaco |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN106036984B (zh) * | 2016-07-03 | 2017-08-08 | 赖高生 | 一种固定化蜗牛酶制备烟草浸膏的方法 |
| CN111801423A (zh) | 2018-03-28 | 2020-10-20 | 菲利普莫里斯生产公司 | 调节植物中的氨基酸含量 |
| BR112020017430A2 (pt) | 2018-03-28 | 2021-01-19 | Philip Morris Products S.A. | Modulação do teor de açúcar redutor em uma planta |
| CN108424922B (zh) * | 2018-04-20 | 2021-04-16 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m271及其应用 |
| GB201812603D0 (en) * | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| DE102018216970A1 (de) * | 2018-10-04 | 2020-04-09 | Robert Bosch Gmbh | Brennstoffeinspritzvorrichtung |
| CN113271768B (zh) * | 2018-12-30 | 2024-02-06 | 菲利普莫里斯生产公司 | 经由硝酸盐还原酶的突变来调节植物中的硝酸盐水平 |
| WO2022192743A1 (en) * | 2021-03-11 | 2022-09-15 | Thermolife International, Llc | Enhanced nitrate, elemental metal, and amino acid compositions and methods of use |
| BR112022005552A2 (pt) | 2019-10-01 | 2022-06-28 | Philip Morris Products Sa | Modulação da redução do teor de açúcar em uma planta (inv) |
| US12419264B2 (en) | 2019-10-01 | 2025-09-23 | Philip Morris Products S.A. | Modulating sugar and amino acid content in a plant (SULTR3) |
| CN110747208B (zh) * | 2019-11-28 | 2022-04-22 | 海南大学 | 一种木薯硝酸还原酶基因及其过量表达载体的构建和抗病应用 |
| CN110819640B (zh) * | 2019-12-19 | 2022-06-21 | 中国烟草总公司郑州烟草研究院 | 烟草NtNRP1基因其应用 |
| CN115516098A (zh) * | 2020-01-17 | 2022-12-23 | 奥驰亚客户服务有限公司 | 与改进的氮利用效率有关的方法和组合物 |
| WO2022104157A1 (en) | 2020-11-12 | 2022-05-19 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| CN116583176B (zh) * | 2020-12-09 | 2024-12-31 | 日本烟草产业株式会社 | 烟草植物及烟草制品 |
| IL315206A (en) | 2021-02-11 | 2024-10-01 | Thermolife Int Llc | A method of administering nitric oxide gas |
| US11884915B2 (en) | 2021-09-10 | 2024-01-30 | Agilent Technologies, Inc. | Guide RNAs with chemical modification for prime editing |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| US20240132900A1 (en) * | 2022-02-24 | 2024-04-25 | University Of Florida Research Foundation, Incorporated | T-DNA Free Gene Editing through Transient Suppressing POLQ in Plants |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| KR20250139371A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 당 수송체의 조절 |
| CN120476136A (zh) | 2023-02-02 | 2025-08-12 | 菲利普莫里斯生产公司 | 编码赖氨酸酮戊二酸还原酶的基因的调节 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| EP0652965A1 (en) | 1992-07-27 | 1995-05-17 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| KR20030029885A (ko) * | 2000-08-30 | 2003-04-16 | 노쓰 캐롤라이나 스테이트 유니버시티 | 단백질 함량을 변화시키는 분자 미끼를 포함하는유전자이식 식물 |
| WO2002100199A2 (en) * | 2001-06-08 | 2002-12-19 | Vector Tobacco Ltd. | Modifying nicotine and nitrosamine levels in tobacco |
| KR20060128821A (ko) * | 2003-08-19 | 2006-12-14 | 22엔디 센츄리 리미티드, 엘엘씨 | 감소된 노출 담배 제품 |
| RU2257711C2 (ru) * | 2003-10-06 | 2005-08-10 | Всероссийский научно-исследовательский институт защиты растений | Композиция на основе хитозана, снижающая содержание нитратов в растениеводческой продукции |
| EP2330191A1 (en) * | 2003-10-16 | 2011-06-08 | U.S. Smokeless Tobacco Company | Cloning of cytochrome P450 genes from nicotiana |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| EP2087123B1 (en) | 2006-10-13 | 2011-08-10 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| BRPI0807783A2 (pt) * | 2007-02-23 | 2014-06-24 | Us Smokeless Tobacco Co | Composição de tabaco sem fumaça, métodos para produzir uma variedade de planta e para preparar tabaco tendo amargor reduzido, planta de tabaco, variedade de planta, e, tabaco curado. |
| CA2681193C (en) * | 2007-03-16 | 2016-01-26 | New York University | Pericycle-specific expression of microrna167 in transgenic plants |
| BRPI0820042B1 (pt) * | 2007-11-12 | 2020-05-19 | North Carolina State University | método de obtenção de uma planta de tabaco, ou célula ou parte desta, tendo níveis reduzidos de nornicotina, produto de tabaco, método para fabricar um produto de tabaco, polinucleotídeo isolado, cassete de expressão, polipetpídeo isolado e método de obtenção de uma planta, ou parte de planta desta, do gênero nicotiana |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| EP2537929B1 (en) * | 2010-02-17 | 2017-04-12 | Japan Tobacco, Inc. | Plant component regulation factor, and use thereof |
| AP2013006825A0 (en) * | 2010-09-22 | 2013-04-30 | British American Tabacco Investments Ltd | Transgenic plants |
| BR112013021515A2 (pt) | 2011-02-28 | 2018-06-12 | Univ North Carolina State | plantas congênitas de tabaco ncbex1f, ncbex1ms e nc ex90 |
| GB201204869D0 (en) * | 2012-03-20 | 2012-05-02 | Cambridge Advanced Tech | Transgenic plants |
| ITMI20121419A1 (it) * | 2012-08-08 | 2014-02-09 | Fattoria Autonoma Tabacchi S C A R L | Metodo per la produzione di tabacco volto a ridurre il tenore di nitrosammine. |
-
2015
- 2015-09-23 BR BR112017003842-0A patent/BR112017003842B1/pt active IP Right Grant
- 2015-09-23 KR KR1020177008015A patent/KR102524798B1/ko active Active
- 2015-09-23 WO PCT/EP2015/071919 patent/WO2016046288A1/en not_active Ceased
- 2015-09-23 US US15/513,229 patent/US11666082B2/en active Active
- 2015-09-23 EP EP15766550.6A patent/EP3198015A1/en active Pending
- 2015-09-23 RU RU2017114356A patent/RU2721799C2/ru active
- 2015-09-23 JP JP2017516332A patent/JP6921740B2/ja active Active
- 2015-09-23 CN CN201580049814.7A patent/CN106998787A/zh active Pending
- 2015-09-23 CA CA2959245A patent/CA2959245A1/en not_active Abandoned
- 2015-09-23 MX MX2017003932A patent/MX2017003932A/es unknown
-
2017
- 2017-02-21 PH PH12017500313A patent/PH12017500313A1/en unknown
- 2017-04-26 CO CONC2017/0004076A patent/CO2017004076A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20170303582A1 (en) | 2017-10-26 |
| KR102524798B1 (ko) | 2023-04-24 |
| PH12017500313A1 (en) | 2017-07-17 |
| RU2017114356A (ru) | 2018-10-29 |
| JP6921740B2 (ja) | 2021-08-18 |
| RU2017114356A3 (enExample) | 2019-04-29 |
| KR20170078599A (ko) | 2017-07-07 |
| JP2017529850A (ja) | 2017-10-12 |
| BR112017003842B1 (pt) | 2024-02-20 |
| CA2959245A1 (en) | 2016-03-31 |
| US11666082B2 (en) | 2023-06-06 |
| CN106998787A (zh) | 2017-08-01 |
| WO2016046288A1 (en) | 2016-03-31 |
| RU2721799C2 (ru) | 2020-05-22 |
| BR112017003842A2 (pt) | 2017-12-19 |
| EP3198015A1 (en) | 2017-08-02 |
| MX2017003932A (es) | 2017-06-30 |
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