JP2017529837A5 - - Google Patents
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- JP2017529837A5 JP2017529837A5 JP2017512760A JP2017512760A JP2017529837A5 JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5 JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5
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- JP
- Japan
- Prior art keywords
- optionally substituted
- group
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- carbon atoms
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C Chemical compound Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C 0.000 description 17
- DEDHGJRRQDQDKF-UHFFFAOYSA-N CC(C)CC(NC(CSC(C)C)C(O)=O)=O Chemical compound CC(C)CC(NC(CSC(C)C)C(O)=O)=O DEDHGJRRQDQDKF-UHFFFAOYSA-N 0.000 description 1
- VRZKVSKELFLXON-UHFFFAOYSA-N CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O Chemical compound CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O VRZKVSKELFLXON-UHFFFAOYSA-N 0.000 description 1
- XOVULDKOTPBNEY-UHFFFAOYSA-N CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O Chemical compound CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O XOVULDKOTPBNEY-UHFFFAOYSA-N 0.000 description 1
- OKBSQXZHPMPSFN-UHFFFAOYSA-N CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O Chemical compound CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O OKBSQXZHPMPSFN-UHFFFAOYSA-N 0.000 description 1
- CKXHHQSSQIMGIF-YYULCGAYSA-N C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O CKXHHQSSQIMGIF-YYULCGAYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045264P | 2014-09-03 | 2014-09-03 | |
| US62/045,264 | 2014-09-03 | ||
| US201462086986P | 2014-12-03 | 2014-12-03 | |
| US62/086,986 | 2014-12-03 | ||
| US201562149379P | 2015-04-17 | 2015-04-17 | |
| US62/149,379 | 2015-04-17 | ||
| US201562186235P | 2015-06-29 | 2015-06-29 | |
| US62/186,235 | 2015-06-29 | ||
| PCT/US2015/048044 WO2016036794A1 (en) | 2014-09-03 | 2015-09-02 | Conjugates comprising cell-binding agents and cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529837A JP2017529837A (ja) | 2017-10-12 |
| JP2017529837A5 true JP2017529837A5 (enExample) | 2018-10-11 |
Family
ID=54147280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512760A Pending JP2017529837A (ja) | 2014-09-03 | 2015-09-02 | 細胞結合剤及び細胞毒性剤を含む複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10988531B2 (enExample) |
| EP (1) | EP3188733B1 (enExample) |
| JP (1) | JP2017529837A (enExample) |
| KR (3) | KR102508023B1 (enExample) |
| CN (1) | CN107580604A (enExample) |
| AU (1) | AU2015312075A1 (enExample) |
| CA (1) | CA2957964A1 (enExample) |
| IL (1) | IL250711A0 (enExample) |
| MA (1) | MA40415A (enExample) |
| RU (1) | RU2017110068A (enExample) |
| SG (2) | SG10201901825YA (enExample) |
| TW (1) | TW201609152A (enExample) |
| WO (1) | WO2016036794A1 (enExample) |
Families Citing this family (39)
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|---|---|---|---|---|
| SG11201701328XA (en) * | 2014-09-02 | 2017-03-30 | Immunogen Inc | Methods for formulating antibody drug conjugate compositions |
| KR102508023B1 (ko) | 2014-09-03 | 2023-03-10 | 이뮤노젠 아이엔씨 | 세포-결합제 및 세포독성 약물을 포함하는 콘주게이트 |
| AU2015311987B2 (en) * | 2014-09-03 | 2020-06-04 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| US11867696B2 (en) | 2015-02-06 | 2024-01-09 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| AU2016285552B2 (en) | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| EP3325482B1 (en) * | 2015-07-21 | 2020-06-24 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EA201891723A1 (ru) * | 2016-02-05 | 2018-12-28 | Милленниум Фармасьютикалз, Инк. | Gcc-направленные конъюгаты антитело-лекарство |
| WO2018006785A1 (zh) * | 2016-07-05 | 2018-01-11 | 江苏恒瑞医药股份有限公司 | Egfr抗体-药物偶联物及其在医药上的应用 |
| JP7618383B2 (ja) | 2016-07-22 | 2025-01-21 | ネクター セラピューティクス | オキシム含有リンケージを有する第ｖｉｉｉ因子部分のコンジュゲート |
| RU2019114863A (ru) * | 2016-11-02 | 2020-12-03 | Иммуноджен, Инк. | Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| PL3558391T3 (pl) * | 2016-12-23 | 2022-05-16 | Immunogen, Inc. | Immunokoniugaty skierowane wobec białka adam9 i sposoby ich stosowania |
| TWI781145B (zh) * | 2017-02-28 | 2022-10-21 | 美商伊繆諾金公司 | 具有自分解肽連接子之類美登素衍生物及其結合物 |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| US11566044B2 (en) | 2017-07-26 | 2023-01-31 | The University Of Queensland | Disulfide bond containing compounds and uses thereof |
| NZ762505A (en) | 2017-09-29 | 2026-03-27 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| JP7542438B2 (ja) * | 2017-11-21 | 2024-08-30 | ノバルティス アーゲー | 腫瘍関連抗原に対する三重特異性結合分子及びその使用 |
| US11274121B2 (en) * | 2018-01-12 | 2022-03-15 | Immunogen, Inc. | Methods for antibody drug conjugation, purification, and formulation |
| AU2019236091B2 (en) | 2018-03-13 | 2025-06-05 | Phanes Therapeutics, Inc. | Anti-folate receptor 1 antibodies and uses thereof |
| CA3095515A1 (en) | 2018-04-10 | 2019-10-17 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| CN112955548B (zh) * | 2018-07-09 | 2023-11-24 | 普众发现医药科技(上海)有限公司 | 叶酸受体α特异性抗体 |
| JP2022500454A (ja) * | 2018-09-17 | 2022-01-04 | ストロ バイオファーマ インコーポレーテッド | 抗葉酸受容体抗体コンジュゲートによる併用療法 |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| WO2020092631A1 (en) * | 2018-10-31 | 2020-05-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting and treating cancers characterized by expression of mesothelin |
| US20210032285A1 (en) * | 2019-03-11 | 2021-02-04 | Cell Idx, Inc. | Methods, compositions, and kits for trapping modified biomolecules |
| CN113795264A (zh) | 2019-03-19 | 2021-12-14 | 瓦尔希伯伦私人肿瘤研究基金会 | 采用Omomyc和结合PD-1或CTLA-4的抗体治疗癌症的联合疗法 |
| KR20220022112A (ko) * | 2019-03-21 | 2022-02-24 | 이뮤노젠 아이엔씨 | 세포-결합 제제-약물 콘쥬게이트를 준비하는 방법 |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| BR112022006739B1 (pt) | 2019-10-10 | 2024-01-23 | Cellectar Biosciences, Inc | Conjugados fosfolipídio-flavagina e métodos de uso do mesmo para terapia direcionada a câncer |
| CN110922482B (zh) * | 2019-12-25 | 2021-08-31 | 源道隆（苏州）医学科技有限公司 | 可结合cd19的多肽及其应用 |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| EP4608429A1 (en) | 2022-10-25 | 2025-09-03 | Peptomyc, S.L. | Combination therapy for the treatment of cancer |
| EP4473974A1 (en) | 2023-06-07 | 2024-12-11 | Peptomyc, S.L. | Omomyc and kras inhibitors combination therapy for the treatment of cancer |
| IL325025A (en) | 2023-06-07 | 2026-01-01 | Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron | Combination therapy with BRAF inhibitors for cancer treatment |
| IL324909A (en) | 2023-06-07 | 2026-01-01 | Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron | Combination therapy with mek inhibitors for the treatment of cancer |
| CN117659041A (zh) * | 2023-12-08 | 2024-03-08 | 联宁（苏州）生物制药有限公司 | 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用 |
| KR20250146159A (ko) * | 2024-03-29 | 2025-10-13 | 진메디신 주식회사 | 약물 및 항체를 연결하는 링커 화합물 및 이를 이용한 항체-약물 복합체 |
Family Cites Families (29)
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|---|---|---|---|---|
| US5362852A (en) * | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| FR2801904B1 (fr) | 1999-12-07 | 2002-02-08 | Pasteur Institut | Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn |
| EP1539804B1 (fr) | 2002-09-19 | 2007-01-03 | Centre National De La Recherche Scientifique (Cnrs) | Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles. |
| JP5207590B2 (ja) | 2002-12-26 | 2013-06-12 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | 増強された生物学的能力を有するインターフェロン−βのポリマー結合体 |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| NZ579482A (en) | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| JP2008516621A (ja) | 2004-10-18 | 2008-05-22 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン結合体 |
| EP1861417B1 (en) | 2005-03-10 | 2013-05-15 | BioNTech AG | Dimeric or multimeric microproteins |
| WO2006115416A2 (en) | 2005-04-25 | 2006-11-02 | Ge Healthcare As | Liposomes |
| JP4938263B2 (ja) * | 2005-08-19 | 2012-05-23 | 独立行政法人農業生物資源研究所 | 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用 |
| US20070122408A1 (en) | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
| FR2897616B1 (fr) | 2006-02-20 | 2008-05-30 | Univ Grenoble 1 | Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide |
| US7985783B2 (en) * | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| PE20090943A1 (es) | 2007-07-16 | 2009-08-05 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados |
| DK2211904T3 (en) | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| JP2011503000A (ja) * | 2007-11-02 | 2011-01-27 | セントコア・オーソ・バイオテツク・インコーポレーテツド | 半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用 |
| SG189817A1 (en) * | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
| TWI622402B (zh) * | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| US9381058B2 (en) * | 2010-11-05 | 2016-07-05 | Ethicon Endo-Surgery, Llc | Recharge system for medical devices |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| US9056910B2 (en) * | 2012-05-01 | 2015-06-16 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| IN2014KN02831A (enExample) * | 2012-05-24 | 2015-05-08 | Mountgate Group Ltd | |
| IN2014KN02769A (enExample) | 2012-06-06 | 2015-05-08 | Bionor Immuno As | |
| US9834597B2 (en) | 2012-09-21 | 2017-12-05 | The Regents Of The University Of California | Modified FC polypeptides, FC conjugates, and methods of use thereof |
| JP5723497B2 (ja) * | 2013-03-28 | 2015-05-27 | 東芝ホクト電子株式会社 | 発光装置の製造方法 |
| US9636404B2 (en) | 2013-05-13 | 2017-05-02 | Vision Global Holdings Ltd. | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| CN113150145B (zh) * | 2013-08-30 | 2025-02-14 | 伊缪诺金公司 | 用于检测叶酸受体1的抗体和测定 |
| EA201691075A1 (ru) | 2013-11-26 | 2016-09-30 | Новартис Аг | Способы оксимной конъюгации с кетон-модифицированными полипептидами |
| KR102508023B1 (ko) | 2014-09-03 | 2023-03-10 | 이뮤노젠 아이엔씨 | 세포-결합제 및 세포독성 약물을 포함하는 콘주게이트 |
-
2015
- 2015-09-02 KR KR1020177009020A patent/KR102508023B1/ko active Active
- 2015-09-02 CN CN201580059534.4A patent/CN107580604A/zh active Pending
- 2015-09-02 TW TW104128984A patent/TW201609152A/zh unknown
- 2015-09-02 SG SG10201901825YA patent/SG10201901825YA/en unknown
- 2015-09-02 JP JP2017512760A patent/JP2017529837A/ja active Pending
- 2015-09-02 EP EP15766288.3A patent/EP3188733B1/en active Active
- 2015-09-02 KR KR1020247005372A patent/KR20240027148A/ko active Pending
- 2015-09-02 WO PCT/US2015/048044 patent/WO2016036794A1/en not_active Ceased
- 2015-09-02 RU RU2017110068A patent/RU2017110068A/ru not_active Application Discontinuation
- 2015-09-02 KR KR1020237007792A patent/KR102638901B1/ko active Active
- 2015-09-02 US US14/843,429 patent/US10988531B2/en not_active Expired - Fee Related
- 2015-09-02 SG SG11201701565PA patent/SG11201701565PA/en unknown
- 2015-09-02 CA CA2957964A patent/CA2957964A1/en not_active Abandoned
- 2015-09-02 MA MA040415A patent/MA40415A/fr unknown
- 2015-09-02 AU AU2015312075A patent/AU2015312075A1/en not_active Abandoned
-
2017
- 2017-02-22 IL IL250711A patent/IL250711A0/en unknown
-
2021
- 2021-02-12 US US17/174,911 patent/US11732038B2/en active Active
-
2023
- 2023-06-28 US US18/343,455 patent/US20240190956A1/en active Pending
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