JP2017529837A5 - - Google Patents

Download PDF

Info

Publication number
JP2017529837A5
JP2017529837A5 JP2017512760A JP2017512760A JP2017529837A5 JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5 JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5
Authority
JP
Japan
Prior art keywords
optionally substituted
group
independently
carbon atoms
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017512760A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017529837A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/048044 external-priority patent/WO2016036794A1/en
Publication of JP2017529837A publication Critical patent/JP2017529837A/ja
Publication of JP2017529837A5 publication Critical patent/JP2017529837A5/ja
Pending legal-status Critical Current

Links

JP2017512760A 2014-09-03 2015-09-02 細胞結合剤及び細胞毒性剤を含む複合体 Pending JP2017529837A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462045264P 2014-09-03 2014-09-03
US62/045,264 2014-09-03
US201462086986P 2014-12-03 2014-12-03
US62/086,986 2014-12-03
US201562149379P 2015-04-17 2015-04-17
US62/149,379 2015-04-17
US201562186235P 2015-06-29 2015-06-29
US62/186,235 2015-06-29
PCT/US2015/048044 WO2016036794A1 (en) 2014-09-03 2015-09-02 Conjugates comprising cell-binding agents and cytotoxic agents

Publications (2)

Publication Number Publication Date
JP2017529837A JP2017529837A (ja) 2017-10-12
JP2017529837A5 true JP2017529837A5 (enExample) 2018-10-11

Family

ID=54147280

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017512760A Pending JP2017529837A (ja) 2014-09-03 2015-09-02 細胞結合剤及び細胞毒性剤を含む複合体

Country Status (13)

Country Link
US (3) US10988531B2 (enExample)
EP (1) EP3188733B1 (enExample)
JP (1) JP2017529837A (enExample)
KR (3) KR102638901B1 (enExample)
CN (1) CN107580604A (enExample)
AU (1) AU2015312075A1 (enExample)
CA (1) CA2957964A1 (enExample)
IL (1) IL250711A0 (enExample)
MA (1) MA40415A (enExample)
RU (1) RU2017110068A (enExample)
SG (2) SG11201701565PA (enExample)
TW (1) TW201609152A (enExample)
WO (1) WO2016036794A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526682A (ja) * 2014-09-02 2017-09-14 イミュノジェン, インコーポレイテッド 抗体薬物複合体組成物の製剤化方法
JP2017529837A (ja) 2014-09-03 2017-10-12 イミュノジェン・インコーポレーテッド 細胞結合剤及び細胞毒性剤を含む複合体
PT3189056T (pt) * 2014-09-03 2020-09-04 Immunogen Inc Derivados citotóxicos de benzodiazepina
EP3253788A4 (en) 2015-02-06 2018-08-08 Cell IDX, Inc. Antigen-coupled immunoreagents
BR112017027254A2 (pt) 2015-06-29 2019-05-14 Immunogen, Inc. anticorpos anti-cd123 e conjugados e derivados dos mesmos
KR20180038460A (ko) 2015-07-21 2018-04-16 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체의 제조 방법
SG11201806142WA (en) * 2016-02-05 2018-08-30 Millennium Pharm Inc Gcc-targeted antibody-drug conjugates
CN108472371B (zh) * 2016-07-05 2022-05-24 江苏恒瑞医药股份有限公司 Egfr抗体-药物偶联物及其在医药上的应用
WO2018017923A1 (en) * 2016-07-22 2018-01-25 Nektar Therapeutics Conjugates of a factor viii moiety having an oxime-containing linkage
KR20190107656A (ko) * 2016-11-02 2019-09-20 이뮤노젠 아이엔씨 항체-약물 콘주게이트 및 parp 억제제로 병용 치료
JP7350313B2 (ja) 2016-12-16 2023-09-26 ブルーフィン バイオメディシン, インコーポレイテッド 抗cubドメイン含有タンパク質1(cdcp1)抗体、抗体薬物コンジュゲート、およびその使用方法
DK3558391T3 (da) * 2016-12-23 2022-05-09 Immunogen Inc Immunkonjugater med adam9 som mål og fremgangsmåder til anvendelse deraf
AU2018229277B2 (en) 2017-02-28 2025-03-20 Immunogen, Inc. Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
WO2018183494A1 (en) * 2017-03-31 2018-10-04 Immunogen, Inc. Cd19-targeting antibody-drug conjugates
EP3658568A4 (en) * 2017-07-26 2021-04-28 The University of Queensland Disulfide bond containing compounds and uses thereof
IL301638B2 (en) 2017-09-29 2024-09-01 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
US20200362054A1 (en) * 2017-11-21 2020-11-19 Brian Granda Trispecific binding molecules against tumor-associated antigents and use thereof
JP7474195B2 (ja) * 2018-01-12 2024-04-24 イミュノジェン, インコーポレイテッド 抗体薬物のコンジュゲーション、精製、及び製剤のための方法
CN115925952A (zh) 2018-03-13 2023-04-07 东莞凡恩世生物医药有限公司 抗叶酸受体1抗体及其用途
TWI865456B (zh) * 2018-07-09 2024-12-11 大陸商沐特圖公司 葉酸受體阿法特異性抗體
US20220047716A1 (en) * 2018-09-17 2022-02-17 Sutro Biopharma, Inc. Combination therapies with anti-folate receptor antibody conjugates
TWI897855B (zh) * 2018-10-26 2025-09-21 美商免疫遺傳股份有限公司 E p C A M 抗體、可活化抗體及免疫偶聯物以及其用途
WO2020092631A1 (en) * 2018-10-31 2020-05-07 Fred Hutchinson Cancer Research Center Compositions and methods for detecting and treating cancers characterized by expression of mesothelin
US20210032285A1 (en) * 2019-03-11 2021-02-04 Cell Idx, Inc. Methods, compositions, and kits for trapping modified biomolecules
KR20220012839A (ko) 2019-03-19 2022-02-04 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론 Omomyc와 pd-1 또는 ctla-4에 결합하는 항체를 이용한 암 치료용 조합 요법
WO2020191306A1 (en) * 2019-03-21 2020-09-24 Immunogen, Inc. Methods of preparing cell-binding agent-drug conjugates
BR112021023048A2 (pt) 2019-05-21 2022-04-19 Novartis Ag Moléculas de ligação a cd19 e usos das mesmas
US12037378B2 (en) 2019-05-21 2024-07-16 Novartis Ag Variant CD58 domains and uses thereof
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆(苏州)医学科技有限公司 可结合cd19的多肽及其应用
CN112794911B (zh) * 2021-04-14 2021-08-03 上海偌妥生物科技有限公司 人源化抗叶酸受体1抗体及其应用
CN113908589B (zh) * 2021-10-08 2022-09-27 天津工业大学 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法
KR20250089547A (ko) 2022-10-25 2025-06-18 펩토믹, 에스.엘. 암 치료를 위한 조합 요법
WO2024251854A1 (en) 2023-06-07 2024-12-12 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy with braf inhibitors for the treatment of cancer
TW202513088A (zh) 2023-06-07 2025-04-01 瓦爾希伯倫私人腫瘤研究基金會 用於治療癌症的與mek抑制劑的組合療法
EP4473974A1 (en) 2023-06-07 2024-12-11 Peptomyc, S.L. Omomyc and kras inhibitors combination therapy for the treatment of cancer
CN117659041A (zh) * 2023-12-08 2024-03-08 联宁(苏州)生物制药有限公司 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362852A (en) * 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
FR2801904B1 (fr) 1999-12-07 2002-02-08 Pasteur Institut Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn
EP1539804B1 (fr) 2002-09-19 2007-01-03 Centre National De La Recherche Scientifique (Cnrs) Synthese et caracterisation de nouveaux systemes de guidage et de vectorisation de molecules d'interet therapeutique vers des cellules cibles.
WO2004060299A2 (en) 2002-12-26 2004-07-22 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
GB0305704D0 (en) 2003-03-13 2003-04-16 Amersham Plc Radiofluorination methods
MXPA06014065A (es) 2004-06-01 2007-01-31 Genentech Inc Conjugados de droga-anticuerpo y metodos.
EP1805216A2 (en) 2004-10-18 2007-07-11 Novo Nordisk A/S Growth hormone conjugates
CA2600749C (en) 2005-03-10 2014-04-15 Nascacell Ip Gmbh Dimeric or multimeric microproteins
US20080206151A1 (en) 2005-04-25 2008-08-28 Alan Cuthbertson Liposomes
JP4938263B2 (ja) * 2005-08-19 2012-05-23 独立行政法人農業生物資源研究所 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用
CA2630415A1 (en) 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
FR2897616B1 (fr) 2006-02-20 2008-05-30 Univ Grenoble 1 Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide
US7985783B2 (en) * 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
MY150531A (en) 2007-07-16 2014-01-30 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
CN101903403B (zh) 2007-10-19 2016-03-16 西雅图基因公司 Cd19结合剂及其应用
JP2011503000A (ja) * 2007-11-02 2011-01-27 セントコア・オーソ・バイオテツク・インコーポレーテツド 半合成GLP−1ペプチド−Fc融合コンストラクト、その方法及び使用
BRPI0911442A2 (pt) * 2008-04-30 2019-03-12 Immunogen, Inc. conjugados potentes e ligantes hidrofílicos
SG10201501342UA (en) * 2010-02-24 2015-04-29 Immunogen Inc Folate receptor 1 antibodies and immunoconjugates and uses thereof
US9381058B2 (en) * 2010-11-05 2016-07-05 Ethicon Endo-Surgery, Llc Recharge system for medical devices
IL279304B (en) * 2011-02-15 2022-07-01 Immunogen Inc Method for producing an indolinobenzodiazepine
AR090903A1 (es) 2012-05-01 2014-12-17 Genentech Inc Anticuerpos e inmunoconjugados anti-pmel17
EP3508497A1 (en) * 2012-05-24 2019-07-10 Mountgate Group Limited Compositions and methods related to prevention and treatment of rabies infection
CA2874923C (en) 2012-06-06 2021-08-31 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
US9834597B2 (en) 2012-09-21 2017-12-05 The Regents Of The University Of California Modified FC polypeptides, FC conjugates, and methods of use thereof
CN107768362B (zh) * 2013-03-28 2020-09-08 东芝北斗电子株式会社 发光装置及其制造方法
MY176175A (en) 2013-05-13 2020-07-24 Vision Global Holdings Ltd Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
CA3222465A1 (en) * 2013-08-30 2015-03-05 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
JP6609563B2 (ja) 2013-11-26 2019-11-20 ノバルティス アーゲー ケトンで修飾されたポリペプチドをオキシム複合化する方法
JP2017529837A (ja) 2014-09-03 2017-10-12 イミュノジェン・インコーポレーテッド 細胞結合剤及び細胞毒性剤を含む複合体

Similar Documents

Publication Publication Date Title
JP2017529837A5 (enExample)
RU2017110068A (ru) Конъюгаты, содержащие клеточносвязывающие агенты и цитотоксические агенты
JP7611218B2 (ja) 抗cd123抗体、ならびにその複合体及び誘導体
JP2022191500A (ja) フォレート受容体1抗体及びそのイムノコンジュゲート及び使用
AU2013203459B2 (en) DLL3 modulators and methods of use
CN108290949B (zh) 对asct2具有特异性的结合分子及其用途
RU2017144859A (ru) Конъюгаты сконструированных антител с цистеиновыми заменами
AU2020414996A1 (en) Method for producing eribulin-based antibody-drug conjugate
TW202400644A (zh) 針對FRα之結合分子
US20230084099A1 (en) Anti-meflin antibody for use in treatment of cancer in subject having cancer, and pharmaceutical composition comprising the antibody
US20230310629A1 (en) Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof
US20230183357A1 (en) Anti-human neurotensin receptor 1 antibody and use thereof
EP2281004A1 (en) Prostate specific membrane antigen antibodies and antigen binding fragments
CN120417937A (zh) Ceacam5抗体-药物缀合物及其使用方法
US20160158380A1 (en) Anti-Claudin 1 Antibodies for Use in the Treatment of Colorectal Cancer
CN120936386A (zh) 核定位多肽及其缀合物及其用途
WO2024240227A1 (en) Antibodies and antibody-drug conjugates thereof
Nguyen Development and Optimization of Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia
KR20250172654A (ko) Steap2 항체 약물 접합체 및 이의 용도
CN120936387A (zh) Steap2抗体药物缀合物及其用途
WO2025027554A1 (en) Humanized muc1 antibody and antibody drug conjugate
TW202432186A (zh) 配體-細胞毒藥物綴合物及其醫藥用途
HK40082538A (en) Method for producing eribulin-based antibody-drug conjugate
HK1258317B (en) Binding molecules specific for asct2 and uses thereof