JP2017529837A5 - - Google Patents
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- JP2017529837A5 JP2017529837A5 JP2017512760A JP2017512760A JP2017529837A5 JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5 JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- independently
- carbon atoms
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C Chemical compound Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C 0.000 description 17
- DEDHGJRRQDQDKF-UHFFFAOYSA-N CC(C)CC(NC(CSC(C)C)C(O)=O)=O Chemical compound CC(C)CC(NC(CSC(C)C)C(O)=O)=O DEDHGJRRQDQDKF-UHFFFAOYSA-N 0.000 description 1
- VRZKVSKELFLXON-UHFFFAOYSA-N CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O Chemical compound CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O VRZKVSKELFLXON-UHFFFAOYSA-N 0.000 description 1
- XOVULDKOTPBNEY-UHFFFAOYSA-N CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O Chemical compound CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O XOVULDKOTPBNEY-UHFFFAOYSA-N 0.000 description 1
- OKBSQXZHPMPSFN-UHFFFAOYSA-N CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O Chemical compound CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O OKBSQXZHPMPSFN-UHFFFAOYSA-N 0.000 description 1
- CKXHHQSSQIMGIF-YYULCGAYSA-N C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O CKXHHQSSQIMGIF-YYULCGAYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045264P | 2014-09-03 | 2014-09-03 | |
| US62/045,264 | 2014-09-03 | ||
| US201462086986P | 2014-12-03 | 2014-12-03 | |
| US62/086,986 | 2014-12-03 | ||
| US201562149379P | 2015-04-17 | 2015-04-17 | |
| US62/149,379 | 2015-04-17 | ||
| US201562186235P | 2015-06-29 | 2015-06-29 | |
| US62/186,235 | 2015-06-29 | ||
| PCT/US2015/048044 WO2016036794A1 (en) | 2014-09-03 | 2015-09-02 | Conjugates comprising cell-binding agents and cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529837A JP2017529837A (ja) | 2017-10-12 |
| JP2017529837A5 true JP2017529837A5 (enExample) | 2018-10-11 |
Family
ID=54147280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512760A Pending JP2017529837A (ja) | 2014-09-03 | 2015-09-02 | 細胞結合剤及び細胞毒性剤を含む複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10988531B2 (enExample) |
| EP (1) | EP3188733B1 (enExample) |
| JP (1) | JP2017529837A (enExample) |
| KR (3) | KR20240027148A (enExample) |
| CN (1) | CN107580604A (enExample) |
| AU (1) | AU2015312075A1 (enExample) |
| CA (1) | CA2957964A1 (enExample) |
| IL (1) | IL250711A0 (enExample) |
| MA (1) | MA40415A (enExample) |
| RU (1) | RU2017110068A (enExample) |
| SG (2) | SG11201701565PA (enExample) |
| TW (1) | TW201609152A (enExample) |
| WO (1) | WO2016036794A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015311951B2 (en) * | 2014-09-02 | 2021-04-08 | Immunogen, Inc. | Methods for formulating antibody drug conjugate compositions |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
| PT3189056T (pt) * | 2014-09-03 | 2020-09-04 | Immunogen Inc | Derivados citotóxicos de benzodiazepina |
| CA2976005A1 (en) | 2015-02-06 | 2016-08-11 | Cell Idx, Inc. | Antigen-coupled immunoreagents |
| SMT202100092T1 (it) | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| SMT202000004T1 (it) * | 2015-07-21 | 2020-03-13 | Immunogen Inc | Metodi di preparazione dei derivati citotossici di benzodiazepina |
| BR112018015917A2 (pt) * | 2016-02-05 | 2018-12-26 | Immunogen Inc | conjugados de anticorpos-fármaco direcionados a gcc |
| WO2018006785A1 (zh) * | 2016-07-05 | 2018-01-11 | 江苏恒瑞医药股份有限公司 | Egfr抗体-药物偶联物及其在医药上的应用 |
| WO2018017923A1 (en) | 2016-07-22 | 2018-01-25 | Nektar Therapeutics | Conjugates of a factor viii moiety having an oxime-containing linkage |
| RU2019114863A (ru) * | 2016-11-02 | 2020-12-03 | Иммуноджен, Инк. | Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp |
| JP7350313B2 (ja) | 2016-12-16 | 2023-09-26 | ブルーフィン バイオメディシン， インコーポレイテッド | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 |
| SI3558391T1 (sl) * | 2016-12-23 | 2022-06-30 | Immunogen, Inc. | Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe |
| CN116785450A (zh) * | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| US11566044B2 (en) | 2017-07-26 | 2023-01-31 | The University Of Queensland | Disulfide bond containing compounds and uses thereof |
| SG11202001430SA (en) | 2017-09-29 | 2020-04-29 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| CN121591910A (zh) * | 2017-11-21 | 2026-03-03 | 诺华股份有限公司 | 针对肿瘤相关抗原的三特异性结合分子及其用途 |
| CA3087993A1 (en) * | 2018-01-12 | 2019-07-18 | Immunogen, Inc. | Methods for antibody drug conjugation, purification, and formulation |
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| SI3773544T1 (sl) | 2018-04-10 | 2026-01-30 | Cellectar Biosciences, Inc. | Fosfolipid-flavaglin konjugati ter postopki njihove uporabe za ciljno zdravljenje raka |
| JP7623939B2 (ja) | 2018-07-09 | 2025-01-29 | マルチチュード インコーポレーテッド | 葉酸受容体アルファに特異的な抗体 |
| US20220047716A1 (en) * | 2018-09-17 | 2022-02-17 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| WO2020092631A1 (en) * | 2018-10-31 | 2020-05-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting and treating cancers characterized by expression of mesothelin |
| US20210032285A1 (en) * | 2019-03-11 | 2021-02-04 | Cell Idx, Inc. | Methods, compositions, and kits for trapping modified biomolecules |
| WO2020187998A1 (en) | 2019-03-19 | 2020-09-24 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Combination therapy with omomyc and an antibody binding pd-1 or ctla-4 for the treatment of cancer |
| AU2020240310A1 (en) * | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| UY38701A (es) | 2019-05-21 | 2020-12-31 | Novartis Ag | Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas |
| CN118994397A (zh) | 2019-05-21 | 2024-11-22 | 诺华股份有限公司 | 针对bcma的三特异性结合分子及其用途 |
| WO2020236797A1 (en) | 2019-05-21 | 2020-11-26 | Novartis Ag | Variant cd58 domains and uses thereof |
| JP7631329B2 (ja) | 2019-10-10 | 2025-02-18 | セレクター・バイオサイエンシズ・インコーポレイテッド | リン脂質－フラバグリン抱合体及び標的化されたがん治療のためのリン脂質－フラバグリン抱合体の使用方法 |
| CN110922482B (zh) * | 2019-12-25 | 2021-08-31 | 源道隆（苏州）医学科技有限公司 | 可结合cd19的多肽及其应用 |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| AU2023370106A1 (en) | 2022-10-25 | 2025-05-08 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Combination therapy for the treatment of cancer |
| EP4473974A1 (en) | 2023-06-07 | 2024-12-11 | Peptomyc, S.L. | Omomyc and kras inhibitors combination therapy for the treatment of cancer |
| KR20260020418A (ko) | 2023-06-07 | 2026-02-11 | 펀다시오 프리바다 인스티튜트 드인베스티가시오 온콜로지카 데 발 헤브론 | Braf 저해제를 이용한 암 치료용 조합 요법 |
| WO2024251846A1 (en) | 2023-06-07 | 2024-12-12 | Fundació Privada Institut D'investigació Oncològica De Vall Hebron | Combination therapy with mek inhibitors for the treatment of cancer |
| CN117659041A (zh) * | 2023-12-08 | 2024-03-08 | 联宁（苏州）生物制药有限公司 | 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用 |
| WO2025206561A1 (ko) * | 2024-03-29 | 2025-10-02 | 진메디신 주식회사 | 약물 및 항체를 연결하는 링커 화합물 및 이를 이용한 항체-약물 복합체 |
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| US5362852A (en) | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| FR2801904B1 (fr) | 1999-12-07 | 2002-02-08 | Pasteur Institut | Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn |
| ATE350393T1 (de) | 2002-09-19 | 2007-01-15 | Centre Nat Rech Scient | Synthese und charakterisierung neuer systeme zum hinführen und zur vektorisierung von molekülen von therapeutischem interesse zu targetzellen |
| CN102319437B (zh) | 2002-12-26 | 2017-10-13 | 山景医药公司 | 具有增强的生物学效用的干扰素‑β的聚合物缀合物 |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| WO2006042848A2 (en) | 2004-10-18 | 2006-04-27 | Novo Nordisk A/S | Growth hormone conjugates |
| CA2600749C (en) | 2005-03-10 | 2014-04-15 | Nascacell Ip Gmbh | Dimeric or multimeric microproteins |
| WO2006115416A2 (en) | 2005-04-25 | 2006-11-02 | Ge Healthcare As | Liposomes |
| JP4938263B2 (ja) * | 2005-08-19 | 2012-05-23 | 独立行政法人農業生物資源研究所 | 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用 |
| WO2007048127A2 (en) | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| FR2897616B1 (fr) | 2006-02-20 | 2008-05-30 | Univ Grenoble 1 | Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide |
| US7985783B2 (en) * | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| ATE543835T1 (de) | 2007-07-16 | 2012-02-15 | Genentech Inc | Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren |
| WO2009052431A2 (en) | 2007-10-19 | 2009-04-23 | Seattle Genetics, Inc. | Cd19 binding agents and uses thereof |
| JP2011503000A (ja) * | 2007-11-02 | 2011-01-27 | セントコア・オーソ・バイオテツク・インコーポレーテツド | 半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用 |
| RU2487877C2 (ru) | 2008-04-30 | 2013-07-20 | Иммьюноджен, Инк. | Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры) |
| AR080301A1 (es) * | 2010-02-24 | 2012-03-28 | Immunogen Inc | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos |
| US9381058B2 (en) * | 2010-11-05 | 2016-07-05 | Ethicon Endo-Surgery, Llc | Recharge system for medical devices |
| KR20140010076A (ko) * | 2011-02-15 | 2014-01-23 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| BR112014027166A2 (pt) * | 2012-05-01 | 2017-06-27 | Genentech Inc | anticorpo, ácido nucleico, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, método de tratamento, método de inibir proliferação e métodos de detecção. |
| MX369626B (es) * | 2012-05-24 | 2019-11-13 | Mountgate Group Ltd | Composiciones y metodos relacionados con la prevencion y el tratamiento de infecciones por rabia. |
| MX2014014683A (es) | 2012-06-06 | 2015-02-24 | Bionor Immuno As | Peptidos derivados de proteinas virales para usarse como inmunogenos y reactivos de dosificacion. |
| WO2014047357A1 (en) | 2012-09-21 | 2014-03-27 | The Regents Of The University Of California | Modified fc polypeptides, fc conjugates, and methods of use thereof |
| EP2980871B1 (en) * | 2013-03-28 | 2018-02-14 | Toshiba Hokuto Electronics Corporation | Light-emitting device and production method therefor |
| SG11201509042YA (en) | 2013-05-13 | 2015-12-30 | Vision Global Holdings Ltd | Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| PT3038650T (pt) * | 2013-08-30 | 2021-08-25 | Immunogen Inc | Anticorpos e ensaios para a deteção do recetor de folato 1 |
| JP6609563B2 (ja) | 2013-11-26 | 2019-11-20 | ノバルティス アーゲー | ケトンで修飾されたポリペプチドをオキシム複合化する方法 |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
-
2015
- 2015-09-02 TW TW104128984A patent/TW201609152A/zh unknown
- 2015-09-02 WO PCT/US2015/048044 patent/WO2016036794A1/en not_active Ceased
- 2015-09-02 SG SG11201701565PA patent/SG11201701565PA/en unknown
- 2015-09-02 RU RU2017110068A patent/RU2017110068A/ru not_active Application Discontinuation
- 2015-09-02 SG SG10201901825YA patent/SG10201901825YA/en unknown
- 2015-09-02 MA MA040415A patent/MA40415A/fr unknown
- 2015-09-02 AU AU2015312075A patent/AU2015312075A1/en not_active Abandoned
- 2015-09-02 KR KR1020247005372A patent/KR20240027148A/ko active Pending
- 2015-09-02 US US14/843,429 patent/US10988531B2/en not_active Expired - Fee Related
- 2015-09-02 EP EP15766288.3A patent/EP3188733B1/en active Active
- 2015-09-02 CA CA2957964A patent/CA2957964A1/en not_active Abandoned
- 2015-09-02 JP JP2017512760A patent/JP2017529837A/ja active Pending
- 2015-09-02 KR KR1020177009020A patent/KR102508023B1/ko active Active
- 2015-09-02 CN CN201580059534.4A patent/CN107580604A/zh active Pending
- 2015-09-02 KR KR1020237007792A patent/KR102638901B1/ko active Active
-
2017
- 2017-02-22 IL IL250711A patent/IL250711A0/en unknown
-
2021
- 2021-02-12 US US17/174,911 patent/US11732038B2/en active Active
-
2023
- 2023-06-28 US US18/343,455 patent/US20240190956A1/en active Pending
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