JP2017529837A5 - - Google Patents
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- JP2017529837A5 JP2017529837A5 JP2017512760A JP2017512760A JP2017529837A5 JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5 JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A5 JP2017529837 A5 JP 2017529837A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- independently
- carbon atoms
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C Chemical compound Cc1c(C[C@@](C(*)=Cc2c3cc(*)c(*Cc(cc4C*c(c(*)c5)cc(C(*)CC(*)[C@](C6)N7c8c6c(*)c(*)c(*)c8*)c5C7=O)c(C)c(I)c4I)c2)N2C3=O)c2c(*=C)c(C)c1C 0.000 description 17
- DEDHGJRRQDQDKF-UHFFFAOYSA-N CC(C)CC(NC(CSC(C)C)C(O)=O)=O Chemical compound CC(C)CC(NC(CSC(C)C)C(O)=O)=O DEDHGJRRQDQDKF-UHFFFAOYSA-N 0.000 description 1
- VRZKVSKELFLXON-UHFFFAOYSA-N CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O Chemical compound CC(C)NC(C(C)NC(C(C)NC(CCCC(C)=O)=O)=O)=O VRZKVSKELFLXON-UHFFFAOYSA-N 0.000 description 1
- XOVULDKOTPBNEY-UHFFFAOYSA-N CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O Chemical compound CCC(NCC(NCC(NCC(C(C)C)=O)=O)=O)=O XOVULDKOTPBNEY-UHFFFAOYSA-N 0.000 description 1
- OKBSQXZHPMPSFN-UHFFFAOYSA-N CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O Chemical compound CCC(NCCNC(C(C)NC(C(C)NC(C(C)NC(COCC(C)=O)=O)=O)=O)=O)=O OKBSQXZHPMPSFN-UHFFFAOYSA-N 0.000 description 1
- CKXHHQSSQIMGIF-YYULCGAYSA-N C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O Chemical compound C[C@@H](C(O[C@@H](CC(N(C)c1cc(C/C(/C)=C/C=C/C(C(C2)N3)OC)cc(OC)c1Cl)=O)[C@]1(C)O[C@H]1[C@H](C)[C@H]2OC3=O)=O)N(C)C(CCC(C)(C)SC)=O CKXHHQSSQIMGIF-YYULCGAYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045264P | 2014-09-03 | 2014-09-03 | |
| US62/045,264 | 2014-09-03 | ||
| US201462086986P | 2014-12-03 | 2014-12-03 | |
| US62/086,986 | 2014-12-03 | ||
| US201562149379P | 2015-04-17 | 2015-04-17 | |
| US62/149,379 | 2015-04-17 | ||
| US201562186235P | 2015-06-29 | 2015-06-29 | |
| US62/186,235 | 2015-06-29 | ||
| PCT/US2015/048044 WO2016036794A1 (en) | 2014-09-03 | 2015-09-02 | Conjugates comprising cell-binding agents and cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529837A JP2017529837A (ja) | 2017-10-12 |
| JP2017529837A5 true JP2017529837A5 (enExample) | 2018-10-11 |
Family
ID=54147280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512760A Pending JP2017529837A (ja) | 2014-09-03 | 2015-09-02 | 細胞結合剤及び細胞毒性剤を含む複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10988531B2 (enExample) |
| EP (1) | EP3188733B1 (enExample) |
| JP (1) | JP2017529837A (enExample) |
| KR (3) | KR102508023B1 (enExample) |
| CN (1) | CN107580604A (enExample) |
| AU (1) | AU2015312075A1 (enExample) |
| CA (1) | CA2957964A1 (enExample) |
| IL (1) | IL250711A0 (enExample) |
| MA (1) | MA40415A (enExample) |
| RU (1) | RU2017110068A (enExample) |
| SG (2) | SG11201701565PA (enExample) |
| TW (1) | TW201609152A (enExample) |
| WO (1) | WO2016036794A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40539A (fr) * | 2014-09-02 | 2016-03-10 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicaments |
| CR20170111A (es) * | 2014-09-03 | 2017-05-23 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| SG11201701565PA (en) | 2014-09-03 | 2017-03-30 | Immunogen Inc | Conjugates comprising cell-binding agents and cytotoxic agents |
| IL282614B2 (en) | 2015-02-06 | 2024-02-01 | Cell Idx Inc | Antigen-conjugated immune reagents |
| SMT202100092T1 (it) * | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| EP3778602B1 (en) * | 2015-07-21 | 2023-07-12 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| AR108825A1 (es) * | 2016-02-05 | 2018-10-03 | Ole Petter Veiby | Conjugados de anticuerpo y fármaco dirigidos contra gcc |
| TWI750194B (zh) * | 2016-07-05 | 2021-12-21 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｅｇｆｒ抗體-藥物偶聯物及其在醫藥上的應用 |
| WO2018017923A1 (en) | 2016-07-22 | 2018-01-25 | Nektar Therapeutics | Conjugates of a factor viii moiety having an oxime-containing linkage |
| AU2017355402A1 (en) * | 2016-11-02 | 2019-05-30 | Health Research, Inc. | Combination treatment with antibody-drug conjugates and PARP inhibitors |
| EP3554544A4 (en) | 2016-12-16 | 2020-07-29 | Bluefin Biomedicine, Inc. | ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE |
| MD3558391T2 (ro) * | 2016-12-23 | 2022-05-31 | Immunogen Inc | Imunoconjugate care țintesc ADAM9 și procedee de utilizare a acestora |
| IL298414B2 (en) | 2017-02-28 | 2024-12-01 | Immunogen Inc | Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof |
| WO2018183494A1 (en) * | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| WO2019018892A1 (en) | 2017-07-26 | 2019-01-31 | The University Of Queensland | COMPOUNDS CONTAINING DISULFIDE BOND AND USES THEREOF |
| CA3177215C (en) | 2017-09-29 | 2026-06-09 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
| CN121591910A (zh) * | 2017-11-21 | 2026-03-03 | 诺华股份有限公司 | 针对肿瘤相关抗原的三特异性结合分子及其用途 |
| AU2019206587A1 (en) * | 2018-01-12 | 2020-08-06 | Immunogen, Inc. | Methods for antibody drug conjugation, purification, and formulation |
| EP3765521A4 (en) | 2018-03-13 | 2022-03-23 | Phanes Therapeutics, Inc. | ANTI-FOLATE RECEPTOR-1 ANTIBODIES AND USES THEREOF |
| WO2019200017A1 (en) | 2018-04-10 | 2019-10-17 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| JP7623939B2 (ja) * | 2018-07-09 | 2025-01-29 | マルチチュード インコーポレーテッド | 葉酸受容体アルファに特異的な抗体 |
| JP2022500454A (ja) * | 2018-09-17 | 2022-01-04 | ストロ バイオファーマ インコーポレーテッド | 抗葉酸受容体抗体コンジュゲートによる併用療法 |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| WO2020092631A1 (en) * | 2018-10-31 | 2020-05-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for detecting and treating cancers characterized by expression of mesothelin |
| US20210032285A1 (en) * | 2019-03-11 | 2021-02-04 | Cell Idx, Inc. | Methods, compositions, and kits for trapping modified biomolecules |
| CA3133155A1 (en) | 2019-03-19 | 2020-09-24 | Fundacio Privada Institut D'investigacio Oncologica De Vall Hebron | Combination therapy for the treatment for cancer |
| AU2020240310A1 (en) * | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| AU2020279224B2 (en) | 2019-05-21 | 2024-12-05 | Novartis Ag | Trispecific binding molecules against BCMA and uses thereof |
| UY38701A (es) | 2019-05-21 | 2020-12-31 | Novartis Ag | Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas |
| US12037378B2 (en) | 2019-05-21 | 2024-07-16 | Novartis Ag | Variant CD58 domains and uses thereof |
| KR102973364B1 (ko) | 2019-10-10 | 2026-06-04 | 셀렉타 바이오사이언시스, 인코퍼레이티드 | 인지질-플라바글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법 |
| CN110922482B (zh) * | 2019-12-25 | 2021-08-31 | 源道隆（苏州）医学科技有限公司 | 可结合cd19的多肽及其应用 |
| CN112794911B (zh) * | 2021-04-14 | 2021-08-03 | 上海偌妥生物科技有限公司 | 人源化抗叶酸受体1抗体及其应用 |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| WO2024089013A1 (en) | 2022-10-25 | 2024-05-02 | Peptomyc, S.L. | Combination therapy for the treatment of cancer |
| IL325025A (en) | 2023-06-07 | 2026-01-01 | Fundaci? Privada Inst Dinvestigaci? Oncol?Gica De Vall Hebron | Combination therapy with BRAF inhibitors for cancer treatment |
| EP4724100A1 (en) | 2023-06-07 | 2026-04-15 | Fundació Privada Institut d'Investigació Oncològica de Vall Hebron | Combination therapy with mek inhibitors for the treatment of cancer |
| EP4473974A1 (en) | 2023-06-07 | 2024-12-11 | Peptomyc, S.L. | Omomyc and kras inhibitors combination therapy for the treatment of cancer |
| CN117659041A (zh) * | 2023-12-08 | 2024-03-08 | 联宁（苏州）生物制药有限公司 | 用于抗体偶联药物的氘代蒽环类毒素连接子及其合成方法和应用 |
| KR20250146159A (ko) * | 2024-03-29 | 2025-10-13 | 진메디신 주식회사 | 약물 및 항체를 연결하는 링커 화합물 및 이를 이용한 항체-약물 복합체 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362852A (en) * | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| FR2801904B1 (fr) | 1999-12-07 | 2002-02-08 | Pasteur Institut | Produits comprenant un support sur lequel sont fixes des acides nucleiques et leur utilisation comme puce a adn |
| JP4657721B2 (ja) | 2002-09-19 | 2011-03-23 | センター ナショナル デ ラ レシェルシェ サイエンティフィック（シーエヌアールエス） | 新規な誘導システムの合成及び特徴付け、並びに標的細胞への治療対象分子のベクター化 |
| GEP20084486B (en) | 2002-12-26 | 2008-09-25 | Mountain View Pharmaceuticals | Polymer conjugates of interferon-beta with enhanced biological potency |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
| JP2008516621A (ja) | 2004-10-18 | 2008-05-22 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン結合体 |
| JP5517450B2 (ja) | 2005-03-10 | 2014-06-11 | バイオンテック アーゲー | 二量体または多量体のマイクロタンパク質 |
| US20080206151A1 (en) | 2005-04-25 | 2008-08-28 | Alan Cuthbertson | Liposomes |
| JP4938263B2 (ja) * | 2005-08-19 | 2012-05-23 | 独立行政法人農業生物資源研究所 | 一本鎖抗体によるサイトゾルタンパク質の機能阻害法およびその利用 |
| WO2007048127A2 (en) | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| FR2897616B1 (fr) | 2006-02-20 | 2008-05-30 | Univ Grenoble 1 | Presentation de motifs de reconnaissance par une matrice multivalente greffee sur un support solide |
| US7985783B2 (en) * | 2006-09-21 | 2011-07-26 | The Regents Of The University Of California | Aldehyde tags, uses thereof in site-specific protein modification |
| PT2474557E (pt) | 2007-07-16 | 2014-12-03 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| CN101903403B (zh) | 2007-10-19 | 2016-03-16 | 西雅图基因公司 | Cd19结合剂及其应用 |
| CN101918027A (zh) | 2007-11-02 | 2010-12-15 | 森托科尔奥索生物科技公司 | 半合成GLP-1肽-Fc融合构造、方法及其用途 |
| UA108598C2 (xx) * | 2008-04-30 | 2015-05-25 | Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери) | |
| CN105777907B (zh) * | 2010-02-24 | 2020-03-17 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| US9381058B2 (en) * | 2010-11-05 | 2016-07-05 | Ethicon Endo-Surgery, Llc | Recharge system for medical devices |
| SI2675480T1 (sl) * | 2011-02-15 | 2019-05-31 | Immunogen, Inc. | Metode priprave konjugatov |
| KR20150006000A (ko) * | 2012-05-01 | 2015-01-15 | 제넨테크, 인크. | 항-pmel17 항체 및 면역접합체 |
| SG11201408330XA (en) * | 2012-05-24 | 2015-01-29 | Mountgate Group Ltd | Compositions and methods related to prevention and treatment of rabies infection |
| WO2013182661A1 (en) | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
| WO2014047357A1 (en) | 2012-09-21 | 2014-03-27 | The Regents Of The University Of California | Modified fc polypeptides, fc conjugates, and methods of use thereof |
| WO2014156159A1 (ja) * | 2013-03-28 | 2014-10-02 | 東芝ホクト電子株式会社 | 発光装置とその製造方法 |
| CA2911414C (en) | 2013-05-13 | 2018-09-11 | Vision Global Holdings Ltd. | Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging |
| NZ717140A (en) * | 2013-08-30 | 2022-05-27 | Immunogen Inc | Antibodies and assays for detection of folate receptor 1 |
| ES2729643T3 (es) | 2013-11-26 | 2019-11-05 | Novartis Ag | Métodos para la conjugación de oxima con polipéptidos modificados con cetona |
| SG11201701565PA (en) | 2014-09-03 | 2017-03-30 | Immunogen Inc | Conjugates comprising cell-binding agents and cytotoxic agents |
-
2015
- 2015-09-02 SG SG11201701565PA patent/SG11201701565PA/en unknown
- 2015-09-02 US US14/843,429 patent/US10988531B2/en not_active Expired - Fee Related
- 2015-09-02 KR KR1020177009020A patent/KR102508023B1/ko active Active
- 2015-09-02 WO PCT/US2015/048044 patent/WO2016036794A1/en not_active Ceased
- 2015-09-02 TW TW104128984A patent/TW201609152A/zh unknown
- 2015-09-02 KR KR1020247005372A patent/KR20240027148A/ko active Pending
- 2015-09-02 EP EP15766288.3A patent/EP3188733B1/en active Active
- 2015-09-02 CN CN201580059534.4A patent/CN107580604A/zh active Pending
- 2015-09-02 JP JP2017512760A patent/JP2017529837A/ja active Pending
- 2015-09-02 AU AU2015312075A patent/AU2015312075A1/en not_active Abandoned
- 2015-09-02 MA MA040415A patent/MA40415A/fr unknown
- 2015-09-02 CA CA2957964A patent/CA2957964A1/en not_active Abandoned
- 2015-09-02 RU RU2017110068A patent/RU2017110068A/ru not_active Application Discontinuation
- 2015-09-02 KR KR1020237007792A patent/KR102638901B1/ko active Active
- 2015-09-02 SG SG10201901825YA patent/SG10201901825YA/en unknown
-
2017
- 2017-02-22 IL IL250711A patent/IL250711A0/en unknown
-
2021
- 2021-02-12 US US17/174,911 patent/US11732038B2/en active Active
-
2023
- 2023-06-28 US US18/343,455 patent/US20240190956A1/en active Pending
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