JP2017529837A - 細胞結合剤及び細胞毒性剤を含む複合体 - Google Patents
細胞結合剤及び細胞毒性剤を含む複合体 Download PDFInfo
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- JP2017529837A JP2017529837A JP2017512760A JP2017512760A JP2017529837A JP 2017529837 A JP2017529837 A JP 2017529837A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017512760 A JP2017512760 A JP 2017512760A JP 2017529837 A JP2017529837 A JP 2017529837A
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- 0 CC(C1=CC2*)N3C4=CC=CCC4CC3C=NC1=CC2OCC(C1)CC(COC(CC(C2=C3)NC[C@](CC4C5=CCCC4)N5C2=O)=C3OC)=CC1NC(CC[C@@](C)(*)SSCCCC(NNC)O)=O Chemical compound CC(C1=CC2*)N3C4=CC=CCC4CC3C=NC1=CC2OCC(C1)CC(COC(CC(C2=C3)NC[C@](CC4C5=CCCC4)N5C2=O)=C3OC)=CC1NC(CC[C@@](C)(*)SSCCCC(NNC)O)=O 0.000 description 3
- KRKFIDSLBDGGLR-HUPUERQYSA-N CC(C)(CCC(NC1=CC(COc(cc(c2c3)N=CC(Cc4ccccc44)N4C2=O)c3OC)CC(COc(c(OC)c2)cc(NC[C@H]3N4c5ccccc5C3)c2C4=O)=C1)=O)SSCCC(C(NN=C)=O)S(O)(=O)=O Chemical compound CC(C)(CCC(NC1=CC(COc(cc(c2c3)N=CC(Cc4ccccc44)N4C2=O)c3OC)CC(COc(c(OC)c2)cc(NC[C@H]3N4c5ccccc5C3)c2C4=O)=C1)=O)SSCCC(C(NN=C)=O)S(O)(=O)=O KRKFIDSLBDGGLR-HUPUERQYSA-N 0.000 description 1
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
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- Medicinal Preparation (AREA)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045264P | 2014-09-03 | 2014-09-03 | |
| US62/045,264 | 2014-09-03 | ||
| US201462086986P | 2014-12-03 | 2014-12-03 | |
| US62/086,986 | 2014-12-03 | ||
| US201562149379P | 2015-04-17 | 2015-04-17 | |
| US62/149,379 | 2015-04-17 | ||
| US201562186235P | 2015-06-29 | 2015-06-29 | |
| US62/186,235 | 2015-06-29 | ||
| PCT/US2015/048044 WO2016036794A1 (en) | 2014-09-03 | 2015-09-02 | Conjugates comprising cell-binding agents and cytotoxic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529837A true JP2017529837A (ja) | 2017-10-12 |
| JP2017529837A5 JP2017529837A5 (enExample) | 2018-10-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512760A Pending JP2017529837A (ja) | 2014-09-03 | 2015-09-02 | 細胞結合剤及び細胞毒性剤を含む複合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10988531B2 (enExample) |
| EP (1) | EP3188733B1 (enExample) |
| JP (1) | JP2017529837A (enExample) |
| KR (3) | KR102638901B1 (enExample) |
| CN (1) | CN107580604A (enExample) |
| AU (1) | AU2015312075A1 (enExample) |
| CA (1) | CA2957964A1 (enExample) |
| IL (1) | IL250711A0 (enExample) |
| MA (1) | MA40415A (enExample) |
| RU (1) | RU2017110068A (enExample) |
| SG (2) | SG11201701565PA (enExample) |
| TW (1) | TW201609152A (enExample) |
| WO (1) | WO2016036794A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017527563A (ja) * | 2014-09-03 | 2017-09-21 | イミュノジェン・インコーポレーテッド | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2019511462A (ja) * | 2016-02-05 | 2019-04-25 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Gcc標的化抗体−薬物コンジュゲート |
| JP2021510694A (ja) * | 2018-01-12 | 2021-04-30 | イミュノジェン, インコーポレイテッド | 抗体薬物のコンジュゲーション、精製、及び製剤のための方法 |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017526682A (ja) * | 2014-09-02 | 2017-09-14 | イミュノジェン, インコーポレイテッド | 抗体薬物複合体組成物の製剤化方法 |
| JP2017529837A (ja) | 2014-09-03 | 2017-10-12 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
| EP3253788A4 (en) | 2015-02-06 | 2018-08-08 | Cell IDX, Inc. | Antigen-coupled immunoreagents |
| BR112017027254A2 (pt) | 2015-06-29 | 2019-05-14 | Immunogen, Inc. | anticorpos anti-cd123 e conjugados e derivados dos mesmos |
| KR20180038460A (ko) | 2015-07-21 | 2018-04-16 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체의 제조 방법 |
| CN108472371B (zh) * | 2016-07-05 | 2022-05-24 | 江苏恒瑞医药股份有限公司 | Egfr抗体-药物偶联物及其在医药上的应用 |
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| RU2017110068A3 (enExample) | 2019-08-26 |
| AU2015312075A1 (en) | 2017-03-09 |
| KR20170054430A (ko) | 2017-05-17 |
| EP3188733B1 (en) | 2019-11-06 |
| TW201609152A (zh) | 2016-03-16 |
| EP3188733A1 (en) | 2017-07-12 |
| SG11201701565PA (en) | 2017-03-30 |
| KR102508023B1 (ko) | 2023-03-10 |
| CN107580604A (zh) | 2018-01-12 |
| US20210299271A1 (en) | 2021-09-30 |
| MA40415A (fr) | 2016-03-10 |
| KR102638901B1 (ko) | 2024-02-22 |
| RU2017110068A (ru) | 2018-10-03 |
| IL250711A0 (en) | 2017-08-31 |
| WO2016036794A1 (en) | 2016-03-10 |
| US11732038B2 (en) | 2023-08-22 |
| US20160095938A1 (en) | 2016-04-07 |
| CA2957964A1 (en) | 2016-03-10 |
| US20240190956A1 (en) | 2024-06-13 |
| KR20240027148A (ko) | 2024-02-29 |
| US10988531B2 (en) | 2021-04-27 |
| SG10201901825YA (en) | 2019-03-28 |
| KR20230039755A (ko) | 2023-03-21 |
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