TW201609152A - 包含細胞結合劑及細胞毒性劑之偶聯物 - Google Patents

包含細胞結合劑及細胞毒性劑之偶聯物 Download PDF

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TW201609152A
TW201609152A TW104128984A TW104128984A TW201609152A TW 201609152 A TW201609152 A TW 201609152A TW 104128984 A TW104128984 A TW 104128984A TW 104128984 A TW104128984 A TW 104128984A TW 201609152 A TW201609152 A TW 201609152A
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antibody
conjugate
val
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路克Ｂ 哈利思
丹尼爾 塔法瑞
路林元
納森 艾利特 費雪金
馬納迷 席斯卡
麥克 路易斯 米勒
拉維Ｖ Ｊ 洽里
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免疫原公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW104128984A 2014-09-03 2015-09-02 包含細胞結合劑及細胞毒性劑之偶聯物 TW201609152A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462045264P 2014-09-03 2014-09-03
US201462086986P 2014-12-03 2014-12-03
US201562149379P 2015-04-17 2015-04-17
US201562186235P 2015-06-29 2015-06-29

Publications (1)

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TW201609152A true TW201609152A (zh) 2016-03-16

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US (3) US10988531B2 (enExample)
EP (1) EP3188733B1 (enExample)
JP (1) JP2017529837A (enExample)
KR (3) KR102508023B1 (enExample)
CN (1) CN107580604A (enExample)
AU (1) AU2015312075A1 (enExample)
CA (1) CA2957964A1 (enExample)
IL (1) IL250711A0 (enExample)
MA (1) MA40415A (enExample)
RU (1) RU2017110068A (enExample)
SG (2) SG10201901825YA (enExample)
TW (1) TW201609152A (enExample)
WO (1) WO2016036794A1 (enExample)

Cited By (2)

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CN110366431A (zh) * 2017-02-28 2019-10-22 伊缪诺金公司 具有自分解肽接头的类美登素衍生物和其缀合物
TWI750194B (zh) * 2016-07-05 2021-12-21 大陸商江蘇恆瑞醫藥股份有限公司 Ｅｇｆｒ抗體-藥物偶聯物及其在醫藥上的應用

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AU2015311987B2 (en) * 2014-09-03 2020-06-04 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
US11867696B2 (en) 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
AU2016285552B2 (en) 2015-06-29 2022-10-13 Immunogen, Inc. Anti-CD123 antibodies and conjugates and derivatives thereof
EP3325482B1 (en) * 2015-07-21 2020-06-24 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives
EA201891723A1 (ru) * 2016-02-05 2018-12-28 Милленниум Фармасьютикалз, Инк. Gcc-направленные конъюгаты антитело-лекарство
JP7618383B2 (ja) 2016-07-22 2025-01-21 ネクター セラピューティクス オキシム含有リンケージを有する第ｖｉｉｉ因子部分のコンジュゲート
RU2019114863A (ru) * 2016-11-02 2020-12-03 Иммуноджен, Инк. Комбинированное лечение конъюгатами антитело-лекарственное средство и ингибиторами parp
EP3554544A4 (en) 2016-12-16 2020-07-29 Bluefin Biomedicine, Inc. ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
PL3558391T3 (pl) * 2016-12-23 2022-05-16 Immunogen, Inc. Immunokoniugaty skierowane wobec białka adam9 i sposoby ich stosowania
WO2018183494A1 (en) * 2017-03-31 2018-10-04 Immunogen, Inc. Cd19-targeting antibody-drug conjugates
US11566044B2 (en) 2017-07-26 2023-01-31 The University Of Queensland Disulfide bond containing compounds and uses thereof
NZ762505A (en) 2017-09-29 2026-03-27 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
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