JP2017527576A - 置換シクロヘキシルアミン化合物 - Google Patents
置換シクロヘキシルアミン化合物 Download PDFInfo
- Publication number
- JP2017527576A JP2017527576A JP2017513205A JP2017513205A JP2017527576A JP 2017527576 A JP2017527576 A JP 2017527576A JP 2017513205 A JP2017513205 A JP 2017513205A JP 2017513205 A JP2017513205 A JP 2017513205A JP 2017527576 A JP2017527576 A JP 2017527576A
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- cell
- lymphoma
- carcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(C(*)C(C(*)C1*)N(*)C(c2n[o]c(*)c2)=O)C1N(*)* Chemical compound *C(C(*)C(C(*)C1*)N(*)C(c2n[o]c(*)c2)=O)C1N(*)* 0.000 description 3
- BGVCJXUZYOQCLT-WPHBZYBLSA-N CC(C)(C)OC(NC(CC[C@H]1[O]=C)C/C1=C/C)=O Chemical compound CC(C)(C)OC(NC(CC[C@H]1[O]=C)C/C1=C/C)=O BGVCJXUZYOQCLT-WPHBZYBLSA-N 0.000 description 1
- CMMSSPVRJYDRJZ-SCVCMEIPSA-N CC[C@H](C[C@H](CC1)N)[C@H]1NC(c1n[o]c(CC)c1)=O Chemical compound CC[C@H](C[C@H](CC1)N)[C@H]1NC(c1n[o]c(CC)c1)=O CMMSSPVRJYDRJZ-SCVCMEIPSA-N 0.000 description 1
- WNBABXGLSNEXPQ-GODLZYDGSA-N CC[C@H](C[C@H](CC1)NC(C[C@H](C)N)=O)/C1=N/C(c1n[o]c(CC)c1)=O Chemical compound CC[C@H](C[C@H](CC1)NC(C[C@H](C)N)=O)/C1=N/C(c1n[o]c(CC)c1)=O WNBABXGLSNEXPQ-GODLZYDGSA-N 0.000 description 1
- PDWWBNNZOGKLML-SRVKXCTJSA-N CCc1cc(C(N[C@H](CC2)CC[C@@H]2NC(C[C@H](C)N)=O)=O)n[o]1 Chemical compound CCc1cc(C(N[C@H](CC2)CC[C@@H]2NC(C[C@H](C)N)=O)=O)n[o]1 PDWWBNNZOGKLML-SRVKXCTJSA-N 0.000 description 1
- OWMVXHFZCCPOTD-UHFFFAOYSA-N OC(c1n[o]c(C2CC2)c1)=O Chemical compound OC(c1n[o]c(C2CC2)c1)=O OWMVXHFZCCPOTD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048756P | 2014-09-10 | 2014-09-10 | |
| US62/048,756 | 2014-09-10 | ||
| PCT/US2015/049217 WO2016040502A1 (en) | 2014-09-10 | 2015-09-09 | Substituted cyclohexylamine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527576A true JP2017527576A (ja) | 2017-09-21 |
| JP2017527576A5 JP2017527576A5 (enExample) | 2018-10-18 |
Family
ID=55459525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513205A Pending JP2017527576A (ja) | 2014-09-10 | 2015-09-09 | 置換シクロヘキシルアミン化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10106510B2 (enExample) |
| EP (1) | EP3190891B1 (enExample) |
| JP (1) | JP2017527576A (enExample) |
| AU (1) | AU2015315171A1 (enExample) |
| CA (1) | CA2960271A1 (enExample) |
| WO (1) | WO2016040502A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム，インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| KR102496364B1 (ko) | 2014-09-10 | 2023-02-06 | 에피자임, 인코포레이티드 | Ｓｍｙｄ 억제제 |
| JP2017528460A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| AU2024258350A1 (en) * | 2023-04-19 | 2025-10-30 | Alcon Inc. | N-substituted c6 cyclyl carboxamide compounds and uses thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060089398A1 (en) * | 2003-03-19 | 2006-04-27 | Gang Liu | Isoxazole carboxamide derivatives as ghrelin receptor modulators |
| JP2006528624A (ja) * | 2003-07-25 | 2006-12-21 | ファイザー インコーポレイテッド | Ｐｄｅ４阻害剤として有用なニコチンアミド誘導体 |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| WO2008137834A2 (en) * | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| JP2011521938A (ja) * | 2008-05-27 | 2011-07-28 | アストラゼネカ・アクチエボラーグ | フェノキシピリジニルアミド誘導体およびｐｄｅ４仲介疾患状態におけるその使用 |
| JP2011529057A (ja) * | 2008-07-25 | 2011-12-01 | ハー・ルンドベック・アクチエゼルスカベット | アダマンチルジアミド誘導体およびそれらの使用 |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6135391B2 (ja) | 2013-08-16 | 2017-05-31 | ソニー株式会社 | 撮像装置、画像処理装置、および画像処理方法、並びにプログラム |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| KR102496364B1 (ko) | 2014-09-10 | 2023-02-06 | 에피자임, 인코포레이티드 | Ｓｍｙｄ 억제제 |
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム，インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| US20170247326A1 (en) | 2014-09-10 | 2017-08-31 | Epizyme, Inc. | Substituted Pyrrolidine Carboxamide Compounds |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
-
2015
- 2015-09-09 AU AU2015315171A patent/AU2015315171A1/en not_active Abandoned
- 2015-09-09 EP EP15839333.0A patent/EP3190891B1/en active Active
- 2015-09-09 US US15/510,605 patent/US10106510B2/en active Active
- 2015-09-09 JP JP2017513205A patent/JP2017527576A/ja active Pending
- 2015-09-09 CA CA2960271A patent/CA2960271A1/en not_active Abandoned
- 2015-09-09 WO PCT/US2015/049217 patent/WO2016040502A1/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060089398A1 (en) * | 2003-03-19 | 2006-04-27 | Gang Liu | Isoxazole carboxamide derivatives as ghrelin receptor modulators |
| JP2006528624A (ja) * | 2003-07-25 | 2006-12-21 | ファイザー インコーポレイテッド | Ｐｄｅ４阻害剤として有用なニコチンアミド誘導体 |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| WO2008137834A2 (en) * | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| JP2011521938A (ja) * | 2008-05-27 | 2011-07-28 | アストラゼネカ・アクチエボラーグ | フェノキシピリジニルアミド誘導体およびｐｄｅ４仲介疾患状態におけるその使用 |
| JP2011529057A (ja) * | 2008-07-25 | 2011-12-01 | ハー・ルンドベック・アクチエゼルスカベット | アダマンチルジアミド誘導体およびそれらの使用 |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3190891A4 (en) | 2018-03-28 |
| CA2960271A1 (en) | 2016-03-17 |
| US10106510B2 (en) | 2018-10-23 |
| US20170362191A1 (en) | 2017-12-21 |
| EP3190891B1 (en) | 2020-01-15 |
| AU2015315171A1 (en) | 2017-03-16 |
| WO2016040502A1 (en) | 2016-03-17 |
| EP3190891A1 (en) | 2017-07-19 |
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| US20200123142A1 (en) | Substituted Cyclohexylamine Compounds |
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| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180907 |
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| A621 | Written request for application examination |
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