AU2015315171A1 - Substituted cyclohexylamine compounds - Google Patents

Info

Publication number

AU2015315171A1

AU2015315171A1 AU2015315171A AU2015315171A AU2015315171A1 AU 2015315171 A1 AU2015315171 A1 AU 2015315171A1 AU 2015315171 A AU2015315171 A AU 2015315171A AU 2015315171 A AU2015315171 A AU 2015315171A AU 2015315171 A1 AU2015315171 A1 AU 2015315171A1

Authority

AU

Australia

Prior art keywords

cancer

cell

tumor

carcinoma

lymphoma

Prior art date

2014-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

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• 150000003946 cyclohexylamines Chemical class 0.000 title abstract description 4
• 150000003839 salts Chemical class 0.000 claims abstract description 74
• 239000012453 solvate Substances 0.000 claims abstract description 62
• 125000000217 alkyl group Chemical group 0.000 claims description 268
• 150000001875 compounds Chemical class 0.000 claims description 193
• -1 alkyoxyalkyl Chemical group 0.000 claims description 121
• 206010028980 Neoplasm Diseases 0.000 claims description 70
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 50
• 238000000034 method Methods 0.000 claims description 49
• 108090000623 proteins and genes Proteins 0.000 claims description 47
• 125000003282 alkyl amino group Chemical group 0.000 claims description 45
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 45
• 102000004169 proteins and genes Human genes 0.000 claims description 45
• 210000004027 cell Anatomy 0.000 claims description 44
• 201000011510 cancer Diseases 0.000 claims description 43
• 125000001072 heteroaryl group Chemical group 0.000 claims description 43
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
• 229910052739 hydrogen Inorganic materials 0.000 claims description 42
• 239000001257 hydrogen Substances 0.000 claims description 42
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 28
• 125000003545 alkoxy group Chemical group 0.000 claims description 25
• 150000002431 hydrogen Chemical class 0.000 claims description 23
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 22
• 208000035475 disorder Diseases 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 20
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 19
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 15
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
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• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 14
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
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