CA2960271A1 - Substituted cyclohexylamine compounds - Google Patents

Info

Publication number

CA2960271A1

CA2960271A1 CA2960271A CA2960271A CA2960271A1 CA 2960271 A1 CA2960271 A1 CA 2960271A1 CA 2960271 A CA2960271 A CA 2960271A CA 2960271 A CA2960271 A CA 2960271A CA 2960271 A1 CA2960271 A1 CA 2960271A1

Authority

CA

Canada

Prior art keywords

cancer

cell

tumor

carcinoma

lymphoma

Prior art date

2014-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

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• CIPO
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• 150000003946 cyclohexylamines Chemical class 0.000 title abstract description 5
• 150000001875 compounds Chemical class 0.000 claims abstract description 195
• 150000003839 salts Chemical class 0.000 claims abstract description 75
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 71
• 239000012453 solvate Substances 0.000 claims abstract description 62
• 108090000623 proteins and genes Proteins 0.000 claims abstract description 48
• 102000004169 proteins and genes Human genes 0.000 claims abstract description 46
• 201000011510 cancer Diseases 0.000 claims abstract description 44
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 43
• 125000000217 alkyl group Chemical group 0.000 claims description 249
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 65
• 238000000034 method Methods 0.000 claims description 50
• 125000003282 alkyl amino group Chemical group 0.000 claims description 45
• 210000004027 cell Anatomy 0.000 claims description 45
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 45
• 125000001072 heteroaryl group Chemical group 0.000 claims description 43
• 229910052739 hydrogen Inorganic materials 0.000 claims description 43
• 239000001257 hydrogen Substances 0.000 claims description 42
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 27
• 125000003545 alkoxy group Chemical group 0.000 claims description 25
• 150000002431 hydrogen Chemical class 0.000 claims description 23
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 22
• 208000035475 disorder Diseases 0.000 claims description 20
• 239000008194 pharmaceutical composition Substances 0.000 claims description 20
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
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• 125000006310 cycloalkyl amino group Chemical group 0.000 claims description 17
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• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 14
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
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• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 10
• LKYNGTHMKCTTQC-UHFFFAOYSA-N 1,2-oxazole-3-carboxamide Chemical compound NC(=O)C=1C=CON=1 LKYNGTHMKCTTQC-UHFFFAOYSA-N 0.000 claims description 9
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• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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