JP2017527563A5 - - Google Patents
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- JP2017527563A5 JP2017527563A5 JP2017512775A JP2017512775A JP2017527563A5 JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5 JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5
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- JP
- Japan
- Prior art keywords
- ala
- carbon atoms
- optionally substituted
- val
- alkynyl
- Prior art date
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045248P | 2014-09-03 | 2014-09-03 | |
| US62/045,248 | 2014-09-03 | ||
| US201462087040P | 2014-12-03 | 2014-12-03 | |
| US62/087,040 | 2014-12-03 | ||
| US201562149370P | 2015-04-17 | 2015-04-17 | |
| US62/149,370 | 2015-04-17 | ||
| US201562164305P | 2015-05-20 | 2015-05-20 | |
| US62/164,305 | 2015-05-20 | ||
| PCT/US2015/048059 WO2016036801A1 (en) | 2014-09-03 | 2015-09-02 | Cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Division JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527563A JP2017527563A (ja) | 2017-09-21 |
| JP2017527563A5 true JP2017527563A5 (enExample) | 2019-10-03 |
| JP6606545B2 JP6606545B2 (ja) | 2019-11-13 |
Family
ID=54140691
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512775A Expired - Fee Related JP6606545B2 (ja) | 2014-09-03 | 2015-09-02 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Expired - Fee Related JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Expired - Fee Related JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Country Status (33)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40539A (fr) * | 2014-09-02 | 2016-03-10 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicaments |
| CR20170111A (es) * | 2014-09-03 | 2017-05-23 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| SMT202100092T1 (it) * | 2015-06-29 | 2021-03-15 | Immunogen Inc | Anticorpi anti-cd123 e loro coniugati e derivati |
| EP3778602B1 (en) * | 2015-07-21 | 2023-07-12 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| RS65120B1 (sr) | 2015-11-25 | 2024-02-29 | Immunogen Inc | Farmaceutske formulacije i postupci za njihovu upotrebu |
| AR108825A1 (es) * | 2016-02-05 | 2018-10-03 | Ole Petter Veiby | Conjugados de anticuerpo y fármaco dirigidos contra gcc |
| EP3544983A2 (en) | 2016-11-23 | 2019-10-02 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| MD3558391T2 (ro) | 2016-12-23 | 2022-05-31 | Immunogen Inc | Imunoconjugate care țintesc ADAM9 și procedee de utilizare a acestora |
| TW201825515A (zh) | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Ｍｅｔ抗體以及其免疫結合物及用途 |
| WO2018183494A1 (en) | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| EP3612533A1 (en) | 2017-04-20 | 2020-02-26 | Immunogen, Inc. | Methods of preparing indolinobenzodiazepine derivatives |
| US11638760B2 (en) | 2017-11-27 | 2023-05-02 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| CN111757757A (zh) | 2017-12-21 | 2020-10-09 | 梅尔莎纳医疗公司 | 吡咯并苯并二氮呯抗体共轭物 |
| TWI897855B (zh) | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| AU2020240310A1 (en) * | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| EP3949988A4 (en) * | 2019-03-27 | 2022-11-16 | Daiichi Sankyo Company, Limited | COMBINATION OF AN ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE AND A PARP INHIBITOR |
| US20220306751A1 (en) | 2019-09-13 | 2022-09-29 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| WO2024222841A1 (zh) * | 2023-04-27 | 2024-10-31 | 石药集团巨石生物制药有限公司 | 一种抗体药物偶联物 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3453266A (en) | 1966-03-14 | 1969-07-01 | American Home Prod | 1,2,5-benzothiadiazepine 1,1-dioxides |
| US3506646A (en) | 1966-06-27 | 1970-04-14 | American Home Prod | Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides |
| US3875162A (en) | 1973-07-26 | 1975-04-01 | Squibb & Sons Inc | Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds |
| US4003905A (en) | 1974-12-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Diels-alder adducts of benzdiazepines |
| US4444688A (en) | 1981-05-11 | 1984-04-24 | Ciba-Geigy Corporation | Imidazobenzothiadiazepines |
| JP2920385B2 (ja) | 1988-08-18 | 1999-07-19 | 武田薬品工業株式会社 | １，２，５‐ベンゾチアジアゼピン誘導体，その製造法および用途 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| EP0563475B1 (en) | 1992-03-25 | 2000-05-31 | Immunogen Inc | Cell binding agent conjugates of derivatives of CC-1065 |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US20080152586A1 (en) | 1992-09-25 | 2008-06-26 | Avipep Pty Limited | High avidity polyvalent and polyspecific reagents |
| US6355780B1 (en) | 1995-02-22 | 2002-03-12 | Yeda Research And Development Co. Ltd. | Antibodies to the death domain motifs of regulatory proteins |
| WO1999006587A2 (en) | 1997-08-01 | 1999-02-11 | Morphosys Ag | Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex |
| US6156746A (en) | 1998-08-25 | 2000-12-05 | Bristol-Myers Squibb Company | 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents |
| ES2260570T3 (es) | 1998-08-27 | 2006-11-01 | Spirogen Limited | Pirrolobenziodiazepinas dimericas. |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| HK1049997B (en) | 1999-11-24 | 2007-02-23 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| EP1534674A4 (en) | 2002-08-02 | 2007-11-28 | Immunogen Inc | CYTOTOXIC AGENTS CONTAINING NEW, EFFECTIVE TAXANES AND THEIR THERAPEUTIC USE |
| EP1542723B1 (en) | 2002-08-16 | 2011-02-23 | ImmunoGen, Inc. | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs |
| DK1578446T3 (en) | 2002-11-07 | 2015-06-29 | Immunogen Inc | ANTI-CD33 ANTIBODIES AND PROCEDURES FOR TREATING ACUTE MYELOID LEUKEMIA BY USING IT |
| FR2850654A1 (fr) | 2003-02-03 | 2004-08-06 | Servier Lab | Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| EP1651162B1 (en) | 2003-05-20 | 2015-10-21 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| EA014640B1 (ru) | 2003-07-21 | 2010-12-30 | Иммьюноджен, Инк. | Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения |
| US7834155B2 (en) | 2003-07-21 | 2010-11-16 | Immunogen Inc. | CA6 antigen-specific cytotoxic conjugate and methods of using the same |
| AU2004284075A1 (en) * | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
| EP1723152B1 (en) | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
| US8039588B2 (en) | 2004-05-21 | 2011-10-18 | The Uab Research Foundation | Variable lymphocyte receptors |
| NZ551180A (en) | 2004-06-01 | 2009-10-30 | Genentech Inc | Antibody drug conjugates and methods |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| US20080305044A1 (en) | 2004-11-29 | 2008-12-11 | Seattle Genetics, Inc. | Engineered Antibodies and Immunoconjugates |
| US7811572B2 (en) | 2005-08-24 | 2010-10-12 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| AU2006213662B2 (en) | 2005-02-11 | 2010-08-05 | Immunogen, Inc. | Process for preparing stable drug conjugates |
| KR101268939B1 (ko) | 2005-07-08 | 2013-05-30 | 유니버시티 오브 취리히 | 융합 폴리펩티드의 공번역 전좌를 사용한 파아지디스플레이 |
| US7772485B2 (en) | 2005-07-14 | 2010-08-10 | Konarka Technologies, Inc. | Polymers with low band gaps and high charge mobility |
| ITRM20050416A1 (it) | 2005-08-03 | 2007-02-04 | Uni Degli Studi Di Roma Tor Vergata | Derivati delle benzodiazepine e loro usi in campo medico. |
| EA020130B9 (ru) | 2005-08-22 | 2014-10-30 | Иммьюноджен, Инк. | Специфичное к антигену са6 антитело, содержащий его цитотоксический конъюгат и способы применения конъюгата |
| EP1962961B1 (en) | 2005-11-29 | 2013-01-09 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
| DK1813614T3 (da) | 2006-01-25 | 2012-01-23 | Sanofi Sa | Cytotoksiske midler, der omfatter nye tomaymycinderivater |
| EP1996612A4 (en) | 2006-03-03 | 2010-10-20 | Univ Kingston | COMPOSITIONS FOR THE TREATMENT OF CANCER |
| PT2032606E (pt) | 2006-05-30 | 2014-02-05 | Genentech Inc | Anticorpos e imunoconjugados e respetivas utilizações |
| CA2655379A1 (en) | 2006-06-22 | 2007-12-27 | Walter And Eliza Hall Institute Of Medical Research | Structure of the insulin receptor ectodomain |
| PT2019104E (pt) | 2007-07-19 | 2013-12-03 | Sanofi Sa | Agentes citotóxicos compreendendo novos derivados de tomaimicina e sua utilização terapêutica |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| UA108598C2 (xx) | 2008-04-30 | 2015-05-25 | Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери) | |
| NZ588884A (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Cross-linkers and their uses |
| MX2011004550A (es) | 2008-10-31 | 2011-07-20 | Centocor Ortho Biotech Inc | Composiciones de de supercóntigos a base de dominios de fibronectina tipo iii, métodos y usos. |
| CA3014224C (en) | 2009-02-05 | 2022-05-24 | Immunogen, Inc. | Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives |
| CN102596992B (zh) | 2009-02-12 | 2015-09-09 | 詹森生物科技公司 | 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途 |
| FR2947269B1 (fr) * | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
| CA2784610C (en) | 2009-12-23 | 2020-07-14 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them |
| CN105777907B (zh) | 2010-02-24 | 2020-03-17 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| LT2544719T (lt) | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
| HUE029622T2 (en) | 2010-04-30 | 2017-03-28 | Janssen Biotech Inc | Stabilized fibronectin domain compositions, methods and uses |
| CA2815277A1 (en) | 2010-10-29 | 2012-05-03 | Immunogen, Inc. | Novel egfr-binding molecules and immunoconjugates thereof |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| SI2675480T1 (sl) * | 2011-02-15 | 2019-05-31 | Immunogen, Inc. | Metode priprave konjugatov |
| ES2661466T3 (es) | 2011-04-01 | 2018-04-02 | Immunogen, Inc. | Métodos para aumentar la eficacia de la terapia contra el cáncer con FOLR1 |
| HK1211208A1 (zh) | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| MX340090B (es) * | 2012-11-05 | 2016-06-23 | Pfizer | Analogos de spliceostatina. |
| SG11201701565PA (en) * | 2014-09-03 | 2017-03-30 | Immunogen Inc | Conjugates comprising cell-binding agents and cytotoxic agents |
| CR20170111A (es) * | 2014-09-03 | 2017-05-23 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
-
2015
- 2015-09-02 CR CR20170111A patent/CR20170111A/es unknown
- 2015-09-02 EP EP20178715.7A patent/EP3778601A1/en not_active Withdrawn
- 2015-09-02 TN TN2017000070A patent/TN2017000070A1/en unknown
- 2015-09-02 RS RS20201000A patent/RS60751B1/sr unknown
- 2015-09-02 PL PL15763739T patent/PL3189056T3/pl unknown
- 2015-09-02 ES ES15763739T patent/ES2815353T3/es active Active
- 2015-09-02 WO PCT/US2015/048059 patent/WO2016036801A1/en not_active Ceased
- 2015-09-02 TW TW112135631A patent/TW202417447A/zh unknown
- 2015-09-02 EA EA201790446A patent/EA034138B1/ru unknown
- 2015-09-02 AU AU2015311987A patent/AU2015311987B2/en not_active Ceased
- 2015-09-02 BR BR112017002963A patent/BR112017002963A2/pt not_active Application Discontinuation
- 2015-09-02 EP EP15763739.8A patent/EP3189056B1/en active Active
- 2015-09-02 PT PT157637398T patent/PT3189056T/pt unknown
- 2015-09-02 MA MA054254A patent/MA54254A/fr unknown
- 2015-09-02 SM SM20200449T patent/SMT202000449T1/it unknown
- 2015-09-02 CN CN201580047847.8A patent/CN106604927B/zh not_active Expired - Fee Related
- 2015-09-02 SG SG11201701455SA patent/SG11201701455SA/en unknown
- 2015-09-02 KR KR1020177009021A patent/KR102632830B1/ko active Active
- 2015-09-02 KR KR1020247003505A patent/KR20240023671A/ko not_active Abandoned
- 2015-09-02 US US14/843,520 patent/US9669102B2/en not_active Expired - Fee Related
- 2015-09-02 SG SG10201901824UA patent/SG10201901824UA/en unknown
- 2015-09-02 HU HUE15763739A patent/HUE051002T2/hu unknown
- 2015-09-02 SI SI201531320T patent/SI3189056T1/sl unknown
- 2015-09-02 CN CN202210858832.1A patent/CN116514903A/zh active Pending
- 2015-09-02 CA CA2959630A patent/CA2959630A1/en active Pending
- 2015-09-02 TW TW104128985A patent/TWI697493B/zh not_active IP Right Cessation
- 2015-09-02 TW TW111102997A patent/TWI819474B/zh not_active IP Right Cessation
- 2015-09-02 LT LTEP15763739.8T patent/LT3189056T/lt unknown
- 2015-09-02 TW TW109118465A patent/TWI757759B/zh not_active IP Right Cessation
- 2015-09-02 DK DK15763739.8T patent/DK3189056T3/da active
- 2015-09-02 PE PE2017000378A patent/PE20170775A1/es unknown
- 2015-09-02 JP JP2017512775A patent/JP6606545B2/ja not_active Expired - Fee Related
- 2015-09-02 MX MX2017002758A patent/MX2017002758A/es unknown
-
2017
- 2017-02-22 IL IL250712A patent/IL250712B/en active IP Right Grant
- 2017-02-28 PH PH12017500358A patent/PH12017500358A1/en unknown
- 2017-03-02 DO DO2017000053A patent/DOP2017000053A/es unknown
- 2017-03-03 CL CL2017000507A patent/CL2017000507A1/es unknown
- 2017-03-28 CO CONC2017/0003011A patent/CO2017003011A2/es unknown
- 2017-04-03 EC ECIEPI201720133A patent/ECSP17020133A/es unknown
- 2017-04-28 US US15/581,749 patent/US10238751B2/en active Active
-
2019
- 2019-02-13 US US16/274,665 patent/US10722588B2/en active Active
- 2019-10-21 JP JP2019192174A patent/JP6802340B2/ja not_active Expired - Fee Related
-
2020
- 2020-04-21 IL IL281317A patent/IL281317B/en unknown
- 2020-04-21 IL IL274114A patent/IL274114A/en unknown
- 2020-06-15 US US16/901,754 patent/US11116845B2/en not_active Expired - Fee Related
- 2020-08-31 AU AU2020227006A patent/AU2020227006B2/en not_active Ceased
- 2020-09-04 CY CY20201100835T patent/CY1123325T1/el unknown
- 2020-11-26 JP JP2020195666A patent/JP7132311B2/ja not_active Expired - Fee Related
-
2022
- 2022-03-22 IL IL291598A patent/IL291598A/en unknown
- 2022-04-12 AU AU2022202418A patent/AU2022202418B2/en not_active Expired - Fee Related
- 2022-08-24 JP JP2022133442A patent/JP2022166293A/ja not_active Ceased
- 2022-10-25 US US17/973,209 patent/US20230233697A1/en not_active Abandoned
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