JP2017527563A5 - - Google Patents
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- JP2017527563A5 JP2017527563A5 JP2017512775A JP2017512775A JP2017527563A5 JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5 JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017512775 A JP2017512775 A JP 2017512775A JP 2017527563 A5 JP2017527563 A5 JP 2017527563A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- carbon atoms
- optionally substituted
- val
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045248P | 2014-09-03 | 2014-09-03 | |
| US62/045,248 | 2014-09-03 | ||
| US201462087040P | 2014-12-03 | 2014-12-03 | |
| US62/087,040 | 2014-12-03 | ||
| US201562149370P | 2015-04-17 | 2015-04-17 | |
| US62/149,370 | 2015-04-17 | ||
| US201562164305P | 2015-05-20 | 2015-05-20 | |
| US62/164,305 | 2015-05-20 | ||
| PCT/US2015/048059 WO2016036801A1 (en) | 2014-09-03 | 2015-09-02 | Cytotoxic benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Division JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527563A JP2017527563A (ja) | 2017-09-21 |
| JP2017527563A5 true JP2017527563A5 (enExample) | 2019-10-03 |
| JP6606545B2 JP6606545B2 (ja) | 2019-11-13 |
Family
ID=54140691
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512775A Expired - Fee Related JP6606545B2 (ja) | 2014-09-03 | 2015-09-02 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Active JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192174A Expired - Fee Related JP6802340B2 (ja) | 2014-09-03 | 2019-10-21 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2020195666A Active JP7132311B2 (ja) | 2014-09-03 | 2020-11-26 | 細胞障害性ベンゾジアゼピン誘導体 |
| JP2022133442A Ceased JP2022166293A (ja) | 2014-09-03 | 2022-08-24 | 細胞障害性ベンゾジアゼピン誘導体 |
Country Status (33)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701328XA (en) * | 2014-09-02 | 2017-03-30 | Immunogen Inc | Methods for formulating antibody drug conjugate compositions |
| US9669102B2 (en) * | 2014-09-03 | 2017-06-06 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| EP3842459A1 (en) * | 2015-06-29 | 2021-06-30 | ImmunoGen, Inc. | Anti-cd123 antibodies and conjugates and derivatives thereof |
| KR102660070B1 (ko) | 2015-07-21 | 2024-04-24 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체의 제조 방법 |
| EP3380525B1 (en) | 2015-11-25 | 2023-11-08 | Immunogen, Inc. | Pharmaceutical formulations and methods of use thereof |
| US20190038762A1 (en) * | 2016-02-05 | 2019-02-07 | Millennium Pharmaceuticals, Inc. | Gcc-targeted antibody-drug conjugates |
| KR102576550B1 (ko) | 2016-11-23 | 2023-09-07 | 이뮤노젠 아이엔씨 | 벤조다이아제핀 유도체의 선택적인 설폰화 |
| WO2018119196A1 (en) | 2016-12-23 | 2018-06-28 | Immunogen, Inc. | Immunoconjugates targeting adam9 and methods of use thereof |
| US20180230218A1 (en) | 2017-01-04 | 2018-08-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| WO2018183494A1 (en) | 2017-03-31 | 2018-10-04 | Immunogen, Inc. | Cd19-targeting antibody-drug conjugates |
| US10442809B2 (en) | 2017-04-20 | 2019-10-15 | Immunogen, Inc. | Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones |
| US11638760B2 (en) | 2017-11-27 | 2023-05-02 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| JP2021506883A (ja) | 2017-12-21 | 2021-02-22 | メルサナ セラピューティクス インコーポレイテッド | ピロロベンゾジアゼピン抗体結合体 |
| TWI897855B (zh) | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途 |
| TW202102270A (zh) * | 2019-03-21 | 2021-01-16 | 美商伊繆諾金公司 | 製備細胞結合劑-藥物結合物之方法 |
| BR112021017350A2 (pt) * | 2019-03-27 | 2021-11-16 | Daiichi Sankyo Co Ltd | Combinação de conjugado de anticorpo-derivado de pirrolobenzodiazepina e inibidor de parp |
| EP4028420A1 (en) | 2019-09-13 | 2022-07-20 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| US20250367307A1 (en) | 2022-06-30 | 2025-12-04 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| CN119212735A (zh) * | 2023-04-27 | 2024-12-27 | 石药集团巨石生物制药有限公司 | 一种抗体药物偶联物 |
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| US9669102B2 (en) * | 2014-09-03 | 2017-06-06 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
-
2015
- 2015-09-02 US US14/843,520 patent/US9669102B2/en not_active Expired - Fee Related
- 2015-09-02 SI SI201531320T patent/SI3189056T1/sl unknown
- 2015-09-02 ES ES15763739T patent/ES2815353T3/es active Active
- 2015-09-02 BR BR112017002963A patent/BR112017002963A2/pt not_active Application Discontinuation
- 2015-09-02 TW TW104128985A patent/TWI697493B/zh not_active IP Right Cessation
- 2015-09-02 DK DK15763739.8T patent/DK3189056T3/da active
- 2015-09-02 TN TN2017000070A patent/TN2017000070A1/en unknown
- 2015-09-02 SG SG10201901824UA patent/SG10201901824UA/en unknown
- 2015-09-02 MX MX2017002758A patent/MX2017002758A/es unknown
- 2015-09-02 KR KR1020247003505A patent/KR20240023671A/ko not_active Abandoned
- 2015-09-02 EP EP20178715.7A patent/EP3778601A1/en not_active Withdrawn
- 2015-09-02 TW TW109118465A patent/TWI757759B/zh not_active IP Right Cessation
- 2015-09-02 EA EA201790446A patent/EA034138B1/ru unknown
- 2015-09-02 CN CN202210858832.1A patent/CN116514903A/zh active Pending
- 2015-09-02 TW TW112135631A patent/TW202417447A/zh unknown
- 2015-09-02 CN CN201580047847.8A patent/CN106604927B/zh not_active Expired - Fee Related
- 2015-09-02 CA CA2959630A patent/CA2959630A1/en active Pending
- 2015-09-02 JP JP2017512775A patent/JP6606545B2/ja not_active Expired - Fee Related
- 2015-09-02 CR CR20170111A patent/CR20170111A/es unknown
- 2015-09-02 SM SM20200449T patent/SMT202000449T1/it unknown
- 2015-09-02 EP EP15763739.8A patent/EP3189056B1/en active Active
- 2015-09-02 PE PE2017000378A patent/PE20170775A1/es unknown
- 2015-09-02 AU AU2015311987A patent/AU2015311987B2/en not_active Ceased
- 2015-09-02 LT LTEP15763739.8T patent/LT3189056T/lt unknown
- 2015-09-02 PL PL15763739T patent/PL3189056T3/pl unknown
- 2015-09-02 RS RS20201000A patent/RS60751B1/sr unknown
- 2015-09-02 WO PCT/US2015/048059 patent/WO2016036801A1/en not_active Ceased
- 2015-09-02 TW TW111102997A patent/TWI819474B/zh not_active IP Right Cessation
- 2015-09-02 MA MA054254A patent/MA54254A/fr unknown
- 2015-09-02 SG SG11201701455SA patent/SG11201701455SA/en unknown
- 2015-09-02 KR KR1020177009021A patent/KR102632830B1/ko active Active
- 2015-09-02 PT PT157637398T patent/PT3189056T/pt unknown
- 2015-09-02 HU HUE15763739A patent/HUE051002T2/hu unknown
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2017
- 2017-02-22 IL IL250712A patent/IL250712B/en active IP Right Grant
- 2017-02-28 PH PH12017500358A patent/PH12017500358A1/en unknown
- 2017-03-02 DO DO2017000053A patent/DOP2017000053A/es unknown
- 2017-03-03 CL CL2017000507A patent/CL2017000507A1/es unknown
- 2017-03-28 CO CONC2017/0003011A patent/CO2017003011A2/es unknown
- 2017-04-03 EC ECIEPI201720133A patent/ECSP17020133A/es unknown
- 2017-04-28 US US15/581,749 patent/US10238751B2/en active Active
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2019
- 2019-02-13 US US16/274,665 patent/US10722588B2/en active Active
- 2019-10-21 JP JP2019192174A patent/JP6802340B2/ja not_active Expired - Fee Related
-
2020
- 2020-04-21 IL IL274114A patent/IL274114A/en unknown
- 2020-04-21 IL IL281317A patent/IL281317B/en unknown
- 2020-06-15 US US16/901,754 patent/US11116845B2/en not_active Expired - Fee Related
- 2020-08-31 AU AU2020227006A patent/AU2020227006B2/en not_active Ceased
- 2020-09-04 CY CY20201100835T patent/CY1123325T1/el unknown
- 2020-11-26 JP JP2020195666A patent/JP7132311B2/ja active Active
-
2022
- 2022-03-22 IL IL291598A patent/IL291598A/en unknown
- 2022-04-12 AU AU2022202418A patent/AU2022202418B2/en not_active Expired - Fee Related
- 2022-08-24 JP JP2022133442A patent/JP2022166293A/ja not_active Ceased
- 2022-10-25 US US17/973,209 patent/US20230233697A1/en not_active Abandoned
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